CA2203844A1 - Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii - Google Patents
Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iiiInfo
- Publication number
- CA2203844A1 CA2203844A1 CA 2203844 CA2203844A CA2203844A1 CA 2203844 A1 CA2203844 A1 CA 2203844A1 CA 2203844 CA2203844 CA 2203844 CA 2203844 A CA2203844 A CA 2203844A CA 2203844 A1 CA2203844 A1 CA 2203844A1
- Authority
- CA
- Canada
- Prior art keywords
- dihydro
- paclitaxel
- isolation
- acetylbaccatin iii
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WPPPFZJNKLMYBW-FAEUQDRCSA-N 13-acetyl-9-dihydrobaccatin iii Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(C)=O)[C@H](O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]31)OC(C)=O)C2(C)C)C)OC(=O)C)C(=O)C1=CC=CC=C1 WPPPFZJNKLMYBW-FAEUQDRCSA-N 0.000 title abstract 2
- FFCWRLFQIKDRNO-UHFFFAOYSA-N 9-dihydro-13-acetyl baccatin III Natural products CC(=O)OC1C2C(O)CC(OC(=O)C)C3(CO3)C2C(OC(=O)C)C4(O)CC(OC(=O)C)C(=C(C1OC(=O)C)C4(C)C)C FFCWRLFQIKDRNO-UHFFFAOYSA-N 0.000 title abstract 2
- 229930012538 Paclitaxel Natural products 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960001592 paclitaxel Drugs 0.000 title abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 241001116500 Taxus Species 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000000287 crude extract Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2203844 CA2203844C (fr) | 1997-04-28 | 1997-04-28 | Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2203844 CA2203844C (fr) | 1997-04-28 | 1997-04-28 | Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2203844A1 true CA2203844A1 (fr) | 1998-10-28 |
| CA2203844C CA2203844C (fr) | 2004-01-27 |
Family
ID=29274791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2203844 Expired - Fee Related CA2203844C (fr) | 1997-04-28 | 1997-04-28 | Procede d'isolement du paclitaxel et de la 9-dihydro-13-acetylbaccatine iii |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2203844C (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066535A1 (fr) * | 2000-03-10 | 2001-09-13 | Baker Norton Pharmaceuticals, Inc. | Procede permettant la preparation de paclitaxel et de 13-acetyl-9-dihydrobaccatine iii |
| US6878832B2 (en) | 2000-11-13 | 2005-04-12 | Lahu Saiji | Isolation of taxanes |
| AU2006201733B2 (en) * | 2000-03-10 | 2007-05-24 | Ivax Research, Inc. | Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III |
| CN1328269C (zh) * | 2004-03-18 | 2007-07-25 | 中国科学院大连化学物理研究所 | 一种紫杉醇的制备方法 |
| CN103588736A (zh) * | 2013-12-03 | 2014-02-19 | 云南汉德生物技术有限公司 | 13-乙酰基-9-羟基巴卡亭iii的提取分离方法 |
-
1997
- 1997-04-28 CA CA 2203844 patent/CA2203844C/fr not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001066535A1 (fr) * | 2000-03-10 | 2001-09-13 | Baker Norton Pharmaceuticals, Inc. | Procede permettant la preparation de paclitaxel et de 13-acetyl-9-dihydrobaccatine iii |
| AU2006201733B2 (en) * | 2000-03-10 | 2007-05-24 | Ivax Research, Inc. | Process for manufacturing paclitaxel and 13-acetyl-9-dihydrobaccatin III |
| US6878832B2 (en) | 2000-11-13 | 2005-04-12 | Lahu Saiji | Isolation of taxanes |
| CN1328269C (zh) * | 2004-03-18 | 2007-07-25 | 中国科学院大连化学物理研究所 | 一种紫杉醇的制备方法 |
| CN103588736A (zh) * | 2013-12-03 | 2014-02-19 | 云南汉德生物技术有限公司 | 13-乙酰基-9-羟基巴卡亭iii的提取分离方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2203844C (fr) | 2004-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |