CA2194564C - Aqueous risperidone formulations - Google Patents
Aqueous risperidone formulationsInfo
- Publication number
- CA2194564C CA2194564C CA002194564A CA2194564A CA2194564C CA 2194564 C CA2194564 C CA 2194564C CA 002194564 A CA002194564 A CA 002194564A CA 2194564 A CA2194564 A CA 2194564A CA 2194564 C CA2194564 C CA 2194564C
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- Canada
- Prior art keywords
- solution
- water
- solution according
- oral
- risperidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Abstract
The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral and parenteral administration; processes for preparing such formulations.
Description
2 1 q 4 5 6 4 P~ ;l 9S~2G15 -AQUEOUS RISPERIDONE FORMULATIONS
5 The present invention is conc~ - ..ed with pl~ och. .. ir~lly stable S~ f~OUC solutinnC of ricp~.ri~on~. for oral and IJa~ lt~ liOll.
EP-0,196,132 (1984) rliscloses an unbuffered oral solutis~n contAil.;..g a 1,2-bc.i,;co~-azol-3-yl delivali~e as an anli~ycholic in~lient, ~ ,lhyl~ ben, ~ ben, 10 tartaric acid (ca. 1.37 eq of the active ingl~ienl), sodium s~cl-~ -, las~bell~ and goosebelly eScence~ the polyhydric ~ ohnlc sorbitol and glycerol (1,2,3-pl(~ ;ol) and a relatively small amount water (< 30~o V/V). It further ~licrlnses oral drops cnnt~ining 10 mg/ml of a 1,2-b~n7icoY~7~1-3-yl d,.ivativt;, lactic acid (5.5 eq.), sodium s~cc~ n, cocoa flavour and a very minor amount of water (5% v/v) in pol~el~lylene 15 glycol. Also .licclose~l iS an unbuffered nq~leo~c inje~t~lc snl.~ co~ g 4 mg/ml of a 1,2-ben~;co~ 1-3-yl de.iva~ ,lLyl~ ben, plu~l~ ben, lactic acid and propylene glycol. The aque(,us ri idol~e rO~ l;onc of the present invention differ from these prior art forrn~ tionc in that they are burr~.~l and do not contain sorbitol.
Moreover, the present formnlflti~nc co~r~ ... more readily to current regnl~t~-y20 requirements.
12ogulAtnry le~lui~ nls for pkA. "~Ac~ Jalalions over the years have becomemore stnng~nt For eYAmplo, the use of pl~. vdli~es such as the parabens is no~adbeing dicco~ gbrl Also stability l~u l~.llent~ during storage, when cQ~-cidb."blo 25 ~ ChAr~C. S may occur which may affect the integ~ity of the pharmaceutical product, have become more 1~lU~ in the re~ Ty a~-u~al phase, h~l)os;ug new chAlkonges to be faced, and solved, during the development of present day phArmAce~ltic~l products. Yet another c~ l~ .. uttered by the A~lho~ s relates to the fact th~t the bioavailability of l-hA- . . .~ l ;rAl p.~xlu.,~ should be ~ ble and 30 ~~l, ollu~;h'~ ForeYAmplo,this l~uil~ enl impliesthatthe~l,c~l,-l;m~behaviou. ofthe p~udu~ upon o~ ~;,I;ol-, as well as upon inj~1;C'~ should be pl~;- 1dhle and l~luduc-;bl~o.
lhe present i.l~,ntion relates to the finding that an l~tl~eOuc burr~, ~d SQllltinn ~h~.~in the 35 ben7icoYA7~le d~ivalive is ~ , idc~ub has s~ti~r~V;~ oral bioavailability, can be l,les~ ,d without or with very little preser~atives, and can easily be diluted. It relates in particular to the fact that oral solutionc were found to have an u~C~t;~r - t ~- y physico-wo 96/01652 PcT/~;l 55~615 21~4564 chrmir~l stability when sorbitol was comrnce~ in the formula. Une~l~t~ Aly, sorbitolwas found to cause ~leco- . ,pO~;I ;OI- of ricperidone upon storage of the solvtirJn at elevated t~ ulcs, i.e. under conditionc which imitate those of a long storage time. A similar observation lccenlly made with the polyhydric alcohol rn~ltitl?l s~gf stc that ri~
may well be ;nro~ ;hle with other poly}lydlic ~lr,Qhc lc A ph~ico-ch~ -..ic~lly stable oral risperidone sQh-tion was obtained after s)mitting the sorbitol co~ nt *om the collll~os;l;nn The advantages over the prior art colllposilions thus are col-r~, I.PA with ease of dihltion in other ~ eo~c systems and with illl~o.cd ph~icorl-. ..,ir~l stability.
10 The present ill~cnlion concerns an a~lueuus sQllltirn for oral and ~ ,llt~ lminictration cc....p. ;cing water, ricperiflnne or a ~ha,..~%re..l;r~lly acceptable acid ~d~lition salt thereof, cl-A. i~ct~ . i~d in that said solntinn co. ~ 'l" ;~es a buffer to m~int~in the pH in the range of 2 to 6 and is e ssc ~.t;~lly free of sorbitol.
1~ The subject co...l~o,;l;r,nC are cl.%~ t~ by their illl~ .edphys~ - ~.,ir~l stability when cc,lll~alcd to the art cc....pQ~ n~ The term ''phycirocl~f .~ic~lly stable" as herein defined refers to a solutif n wh~,.cin, after storage for a period up to 4 weeks at a t~ alulc of 80~C c)r below, the residual amount of ri~,ridone is 80f~o or more of the initial ric~.ridc nf, cm~r~ u~ lio~ Several co~ ;l;nnc of the subject invention are 20 char~cteri7~dbyanImchqngf~co.~ .l;onofric~riclc~neunderevenmore ~h;~
contlitionc, in particular an e.~ n-l~d storage time at an elevated ~IIl~.alulc.
II~e;ll~lf~r, the ~...n~...l~ of each of the i~ diel~t~ in the collll~oc;l;onc are eAyl~;.sed as pe.~- -k1~es by weight based on the total volume of the fonnl~lqtiQn (w/v), or as volume 2~ or weight per ml of final sollltiQn Ratios are ;n~ ~ to define weight-by-weight rados.
Risperidone is generic to 3-[2-[~(6-fluf~1,2-~ ~ l-3-yl)-1-pi~itlinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]~,ylinlidi,l 1 one. The ~ nl;on and ph~rrn~cnlQ~ir~l activity thereof are ~esrrihe~ in EP-0,196,132. The term ri~;peridone as 30 used herein co..~ es the free base form and the pk~ tul;~lly acceptable acid itlf~n salts thereof. The solu~ility of .;~ nne is incl~,ascd upon the ff~ l;nn of such salt forms, which can be obtailled by reaction of the base form with an applul~liàlc acid. Apprûpriate acids c~mpn~e, for example, inolga,~ic acids such as hydluhalic acids, e.g. hy~lluchlOrlr or hydlvblulllic acid; sulfuric; nitric; ~Jho~h-.. ic and the like acids; or 35 organic acids such as, for example, acetic, ~lupd~OiC, hy~l u,~ydCCliC, lactic, lJylll~ic, oxalic, m~lnni~ cn;n;r~ maleic, rull.~lc, malic,tartaric, citric, .~lhAnp~ nic~
ell.AI-e~ ~lfonic~ be n~f ne~lfonic~ p-toluenes~llfonic~ cyclamic, salicylic, p-~ s~licylic, wo 96/01652 2 1 (~ 4 5 6 4 PCT/~9s~2Gl5 pamoic and the like acids. The term ~ ;cm salt as used hereinabove also comprises the solvates which riCpP~ridnnç as well as the salts thereof, are able to form. Such solvates are for c~ le hy~hates, ~l~ohrll~tes and the like.
5 The sslutinns accol~ing to the present invendon have a pH from 2 to 6, preferably from 3 to 5. Oral sslntinnc most preferably have a pH value from 3 to 4, p~ ,.t~"~l soll1tinnc from 5 to 6. The pH of the co",l)osilions is m~ ;n~ by a buffer system. Buffer c~mprice Illi~lu~s of ~p~ul"ia~ ~ of an acid such as phû3phûlic, ~cc;ni~ tartaric, lactic, or citric acid, and a base, in particular sodium L~rdlu~ide or 10 dic-o lillm hydrogen lJhG~h~t~ Ideally, the buffer has sulr;cienl cd,~ ily to remain in the intPn-led pH range upon rlill1tinn with a neutral, a slighdy acidic or a slightly basic beverage.
The desired pH range is most adv~nt~gPoucly obtained using a tartaric acid / sodium 15 hydroxide buffer, pardcularly in view of dle fact that ricpPridnnP tart~ate is the salt form that pl~,se,~lly would appear to have the best solll!Qility in ~qUpollc- media, in particular upon ~lilut1on Thus, the sQlllhility of . ;~. ;don~ tar~e is about 80 mglml, or about 4 times that of ricpPri~1nne l~ucl~k~n~P, (19.6 mg/ml) at room ~ r 20 The ~molmt (w/v) of AspeAdone in dhe present co~ ~S;l;~nc ranges from 0.01% to 1%, preferably from 0.02% to 0.5%, most preferably from 0.05% to 0.25%, and in particular is 0.1% (1 mg/ml) in the oral snluti~nc and about 0.2% (2 mg/ml) in the p~ t~lal sslutinnc 25 In o~der to prevent the growth of micrû organisms such ~ bacteria, yeasts and fungi in the oral co~ l;on~ which are likely to be used l~ Al~" a preservative agent may be added. Sllit~blc pl~sel~aL,~s should be ~J}I~ r~h ~;r~lly stable and crr~ in the pH
range ...c .I;Ol~ above. They comrrice benzoic acid, sorbic acid, .I.~,lI..y~ 7ben, ~u~ylp~ben, imid~nl~ nyl urea k (~çnm~ll 115t~) and di~7nlirlinyl urea (= ('~rm~ll 30 II~), ph~nny~t~l, benzyl ~lrohol, ~lu~ cc.~ 'U~ c~ e.g. benzyl~lknnil-m chl~nde, and the like. Some ~.~s~ s, such as benzoic acid, sorbic acid, Germall 115~9, ( ;~.rm~ and benzyl ~lcohnl~ have the advantage that they yieldclear, tr~ncp~nt sollltionc which do not show any clou~ling upon storage. The con~e~ ion of the pl~,s~ a~,~c,s may range from 0.05% tû 1%, particularly from 0.1% to 0.5%, and most 35 par~cularly is about 0.2%. The most ~.~,f~ d lJl.,~.~rali-c is benzoic acid used at about 2 mg/ml.
Pa~ o_~l sollltinnc do not ~quire the ~ sence of any pl~,selvali~_s. The l,~n~,~l solution is st~ili7~ following art-known ~roc~lules, e.g. it can be filtered ~Q-~l;rAlly through a st~inless-steel filter holder e~lui~ with a 0.2 ~m polyvinylidene ~ o~ ;flP
filter into a suitable sterile glass flask, filled into ampoules (e.g. 2 ml), and then stenli7 by auloclavil~g during 30 .~ ,s at 121 ~C (Flo, 121 2 15 min).
The oral co~ )o~ c optionally may include s~ l;l;ni~l in~dienls known in the art of form~ tion such as ~tç~ g agents, flavou,illg subsl .n~es solubility çnh~ncl,r.cviscosity re~ ting agents and the like ill~cdicl ~. For eY~mrl~, the aqueous solubility 10 of the active il.~l~&enl may be &nh~-~A by the ~ lition to the sol~l;on of a pha~n~reutic~lly ~rcept~bl- co-solvent, a l;~n.to~ in or a d,livali~,_ thereof.
The bitter taste of risperidone and the buffer, and the unpleasant taste ~C-soçi~tç~ with the pH of some formulas optionally may be m~Q~ 3 by one or more intense ~ g 15 agents such as c~rçh~ sodium or~ol~ .. orc~lrillm sacch~hl, aceslllf~me .. or sodium cycl~n~q-t~. The cnnre.~ l;nn of the ~.. ~t,~ .;ng agent may range from 0.04% to 0.15% and in particular is about Ql%. Given the ;ncc~ pql;~bility of riQ~.rifl-)ne with so~bitol, it is believed that the s~?lvti~n should not co...l~ ;s~ polyhydnc ~lcohols such as .~ , fructose, sucrose, m~lt~se and the like ~..~t~ .~;ng agents.
20 The p~l~t~kility of the subject solvtionc op~inn~lly may be o ~ ..; fA further by the ~ltlitinn of one or more flavoulinE, sub ~ res Sllh~ble flavouring ~ul~sl~nces are f~uit flavours such as cherry, la..~b~,ll.y~ black currant or ~llav~ll.y flavour, or stronger flavours, such as Caramel ChocQl~t~ flavour, Mint Cool flavour, ra,~s~ flavour and the like. Combin~ti~n~ of flavours are advantageously used A coml-inAI;fJl~ of two cherry flavours was found to yield very good taste m~i~ results in the present cc --.l~ n~, The total con~ nl.~lion of the n~ouling ~ub~t~ ~cY,s may range from 0.01% to 0.5%, preferably f~m 0.03% to 0.2% and most preferably from 0.05% to 0.1%.
The burr .~id snl~l;snc acc~di,lg to the present il,~e.ltiol- are well suited to rlilutisn with water and beverages or ~rin~ing liquids such as coffee, tea, soft drinks and the like. In general this in.;lcases the p~l~t~bility of the c~al sohltinn and, hence, patient compliance to the m~lir~tinn A particular oral COIll~O~iliOll aCCCildi~lg to the present i~ nlion col;~s (a) 0.02% to 0.5% ri~peridone (b) 0.1% to 0.5% ~ selvati~.es, (c) a suitable amount of buffer to adjust the pH in the range from 2 to 6; and (d) water.
wo96/01652 2 1 94564 PCT/~l55J~615 The most lJlef~ d oral cc....~:~;c n acc~l~hl~ to the present invention con~;n~
(a) 0.1% (1 mg/ml) risperillonr;
(b) 0.2% (2 mg/ml) benzoic acid;
(c) 0.75% (7.5 mg/ml) tartaric acid and snffirient sodium hydroxide 1 N to adjust the pH in the range from 2 to 6 (approx. 1 mg/ml); and (d) water q.s. ad 100% (1 ml).
PalGnt~ l coll~os;l;nn~ according to the present i"~,_"~n preferably compn~e one or 10 more i~o~o;~;g agents, in particular sodium r~lrride~ in amount snffirient to render the final sol~ltinn iSotonir with the body fluid of the subject to be treated. The most pl.,~.lGd pal~,nt~ l colll~o~;l;on accol.ling to the present in~,.l~ion conli~;n~
(a) 0.2% (2 mg/ml) ri~pr,ridQn~;
(b) 0.5% (5 mg/ml) sodium cllloride;
(c) 0.75% (7.5 mg/ml) taTtaric acid and sllfflrient sodium hydroxide 1 N to adjust the pH in the range from 2 to 6 (approx. 3.5 mg/ml); and (d) water q.s. ad 100% (1 ml).
In a further aspect, the present invention relates to a process of ~ ing sc~lutir~n~ of ri~perir1cme as ~le~r~ h~ " cl--- q~ .;,~1 by dissol~i"g the active in~i~nl risp~ridone., either the ~l~s~l ~ali~_ or the iso~o~ agent, and the acid and base co...pol-enl~ of the buffer in water.
In particular, the process comrrices the following steps: (a) adding the acid coll-pol W~l 25 of the buffer and the active in~ ,n~ ;done to an amount of water which is preferably above room temperature (b) st~ring the Illi~ until complete d;~lu~;m~ and cooling the so1llti~m to room t~m~l~lul~, (c) adjusting the pH with the base co~.pon~ nl of the buffer and (d) further ~liluti~ the so~ .. with water to the l~uil~,d end-volume.
In the ~l~z.;.~ n of oral so~ nc~ step (a) may be pl~d by the steps of dissolving 30 the pl~ sel ~àli~, in an amount of heated water and (b) ~lihlting the soltltion with about an equal amount of water. Optionally, one or more ~.cet n;ng agents and na~oulu~g s.lb~-nces may be added during any of the process steps. In the pl~-~i.l;ol- of ~ ,llt~ l sollltir~n~ step (d) may be pl~iceded ;n~...~;3t~,1y by the step of l~nd~,illg the 5~1ul;on iCût~n c by the addition of an a~lul,liaL amount of an i~ton;~;ng agent, and 35 followed by au~claving.
WO 96/01652 2 1 9 4 5 6 4 ~ 55~6l5 The following eY~mrlf-s are int~ n~C'~ to il~ Tat~ the scope of the present i~ ~ion in all its aspects but not to limit it thereto.
Fs~mrle 1 Fl: oral solu~ion (pH = 3+1) ~n~,dienl Ouantity. m~/ml oral solution ri~ploridone 2 tartaric acid 7.5 benzoic acid 2 Cherr,y flavour 1 0.25 Cherry flavour 2 0.5 sodium 5~c~ ;n sodium hy~ udf ' ca. I (q.s. ad pH = 3+1) purified water q.s. ad 1 ml (1) 2 mg benzoic acid was dissolved in 0.5 ml water upon stirring at 80-90~C. 0.4 ml water was added to the solutiQn and 7.5 mg tartaric acid and 2 mg . ;~ one were dissolved in the res~ltin~ upon sti~nngl (2) 1 mg sodium s~cl-A. ;n was dissolved in 0.05 ml water upon stir,ring.
(3) r.~l;on~ (1) and (2) were mixed upon stilTing and the sohll;on was cooled to room (4) 0.25 mg Cherry flavour 1 and 0.5 mg Cher~y flavour 2 were added to fraction (3) upon stirring.
(S) 1 mg sodium hydroxide was added to fraction (4) to adjust the pH to about 3.(6) Lac~n (5) was further diluted with water to 1 ml.
In a similar way there were ~ &~:
F2: oral solunon (pH = 4_1) T.,~ie,ll Ouantity. m~/ml oral scll"~
n~f 0-5 ~ic acid 7.5 benzoic acid 2 Che~y flavour 1 0.25 Cherry flavour 2 0.5 sodium ~ I, ;"
sodium hyd.~Aide q.s. ad pH = 4_1 ... ;1;~ water q.s. ad 1 ml F3: oral solunon (pH = 3) Tr,~lie"l Ouantity. mglml oral sohlticn r. 0.5 tar~ric acid 7.5 sodium chlnri~lP 5 sodium s~cc~
sodium hy~lluAide q.s. ad pH = 3 purified water q.s. ad 1 ml F4: oral solu~ion (pH = 5) In~die.~ Quantity. mg/ml oral solll~iQn ri~pend~!nP 0.5 tartaric acid 7.5 sodium rhlrnde 5 sodium s~rch~. ;n sodium hydroxide q.s. ad pH = 5 p~ified water q.s. ad 1 ml FS: oral solunon (pH = 3) Tn~ielll Ouantity~ m~/ml oral so~ ;ol-n~pendonP~ 1 tartaric acid 7.5 benzoic acid 2 sodium hydroxide ca.1 (q.s. ad pH = 3) l,.. ;r.. ~ water q.s. ad 1 ml F6~r~nt~al solu~ion (pH = 5) Tr,~;~enl Ouantity. m~/ml olal sQlu~iQn 1;~ ;do~-~ 2 tartaric acid 7.5 sodium chlnri~lP 5 sodium hydroxide ca.3.75 (q.s. ad pH = 5) water for injc~, l;on q.s. ad 1 ml 2 1 94~64 ~ 5/02615 wo 96/01652 J
Example 2 The tables hereinbelow ~ the ~ )f ~;dO~f CQ-~C'f~ ' alions IIIG&S~U~d afteraparticular storage time of the co~ n at a palli~;uld~ ~Ill~lalu~ s~ as the S ~l.,~inlageoftheini~ ol-~cc,l-ce.ll.~ion.
Table 1 Fl F2 4~C 12 months 98.2 25~C 1 month 100.4 101.1 3months 102.1 99.1 6 months 100.9 9 months 99.5 12 months 98.7 30~C 3 months 102.1 98.8 6 months 100.3 12 months 98.9 40~C 1 month 102.1 101.1 3 months 100.9 99.4 6 months 100.5 12 months 98.3 60~C 1 month 100.1 100.3 wo 96/016s2 2 1 9 4 5 6 4 PCTIEP95/02615 -g Table 2 80~C S days 97.9 99.0 17 days 96.7 96.6 4 weeks 86.2 87.6 The data in the tables ;~ 'Qtf. that co...l.os;~iQnc Fl-F4 satisfy the criteria as set fo~th 5 hereinbefore to qualify as a "ph~ orl~.f .~ lly stable" c~..nph~;i;ol~
-
5 The present invention is conc~ - ..ed with pl~ och. .. ir~lly stable S~ f~OUC solutinnC of ricp~.ri~on~. for oral and IJa~ lt~ liOll.
EP-0,196,132 (1984) rliscloses an unbuffered oral solutis~n contAil.;..g a 1,2-bc.i,;co~-azol-3-yl delivali~e as an anli~ycholic in~lient, ~ ,lhyl~ ben, ~ ben, 10 tartaric acid (ca. 1.37 eq of the active ingl~ienl), sodium s~cl-~ -, las~bell~ and goosebelly eScence~ the polyhydric ~ ohnlc sorbitol and glycerol (1,2,3-pl(~ ;ol) and a relatively small amount water (< 30~o V/V). It further ~licrlnses oral drops cnnt~ining 10 mg/ml of a 1,2-b~n7icoY~7~1-3-yl d,.ivativt;, lactic acid (5.5 eq.), sodium s~cc~ n, cocoa flavour and a very minor amount of water (5% v/v) in pol~el~lylene 15 glycol. Also .licclose~l iS an unbuffered nq~leo~c inje~t~lc snl.~ co~ g 4 mg/ml of a 1,2-ben~;co~ 1-3-yl de.iva~ ,lLyl~ ben, plu~l~ ben, lactic acid and propylene glycol. The aque(,us ri idol~e rO~ l;onc of the present invention differ from these prior art forrn~ tionc in that they are burr~.~l and do not contain sorbitol.
Moreover, the present formnlflti~nc co~r~ ... more readily to current regnl~t~-y20 requirements.
12ogulAtnry le~lui~ nls for pkA. "~Ac~ Jalalions over the years have becomemore stnng~nt For eYAmplo, the use of pl~. vdli~es such as the parabens is no~adbeing dicco~ gbrl Also stability l~u l~.llent~ during storage, when cQ~-cidb."blo 25 ~ ChAr~C. S may occur which may affect the integ~ity of the pharmaceutical product, have become more 1~lU~ in the re~ Ty a~-u~al phase, h~l)os;ug new chAlkonges to be faced, and solved, during the development of present day phArmAce~ltic~l products. Yet another c~ l~ .. uttered by the A~lho~ s relates to the fact th~t the bioavailability of l-hA- . . .~ l ;rAl p.~xlu.,~ should be ~ ble and 30 ~~l, ollu~;h'~ ForeYAmplo,this l~uil~ enl impliesthatthe~l,c~l,-l;m~behaviou. ofthe p~udu~ upon o~ ~;,I;ol-, as well as upon inj~1;C'~ should be pl~;- 1dhle and l~luduc-;bl~o.
lhe present i.l~,ntion relates to the finding that an l~tl~eOuc burr~, ~d SQllltinn ~h~.~in the 35 ben7icoYA7~le d~ivalive is ~ , idc~ub has s~ti~r~V;~ oral bioavailability, can be l,les~ ,d without or with very little preser~atives, and can easily be diluted. It relates in particular to the fact that oral solutionc were found to have an u~C~t;~r - t ~- y physico-wo 96/01652 PcT/~;l 55~615 21~4564 chrmir~l stability when sorbitol was comrnce~ in the formula. Une~l~t~ Aly, sorbitolwas found to cause ~leco- . ,pO~;I ;OI- of ricperidone upon storage of the solvtirJn at elevated t~ ulcs, i.e. under conditionc which imitate those of a long storage time. A similar observation lccenlly made with the polyhydric alcohol rn~ltitl?l s~gf stc that ri~
may well be ;nro~ ;hle with other poly}lydlic ~lr,Qhc lc A ph~ico-ch~ -..ic~lly stable oral risperidone sQh-tion was obtained after s)mitting the sorbitol co~ nt *om the collll~os;l;nn The advantages over the prior art colllposilions thus are col-r~, I.PA with ease of dihltion in other ~ eo~c systems and with illl~o.cd ph~icorl-. ..,ir~l stability.
10 The present ill~cnlion concerns an a~lueuus sQllltirn for oral and ~ ,llt~ lminictration cc....p. ;cing water, ricperiflnne or a ~ha,..~%re..l;r~lly acceptable acid ~d~lition salt thereof, cl-A. i~ct~ . i~d in that said solntinn co. ~ 'l" ;~es a buffer to m~int~in the pH in the range of 2 to 6 and is e ssc ~.t;~lly free of sorbitol.
1~ The subject co...l~o,;l;r,nC are cl.%~ t~ by their illl~ .edphys~ - ~.,ir~l stability when cc,lll~alcd to the art cc....pQ~ n~ The term ''phycirocl~f .~ic~lly stable" as herein defined refers to a solutif n wh~,.cin, after storage for a period up to 4 weeks at a t~ alulc of 80~C c)r below, the residual amount of ri~,ridone is 80f~o or more of the initial ric~.ridc nf, cm~r~ u~ lio~ Several co~ ;l;nnc of the subject invention are 20 char~cteri7~dbyanImchqngf~co.~ .l;onofric~riclc~neunderevenmore ~h;~
contlitionc, in particular an e.~ n-l~d storage time at an elevated ~IIl~.alulc.
II~e;ll~lf~r, the ~...n~...l~ of each of the i~ diel~t~ in the collll~oc;l;onc are eAyl~;.sed as pe.~- -k1~es by weight based on the total volume of the fonnl~lqtiQn (w/v), or as volume 2~ or weight per ml of final sollltiQn Ratios are ;n~ ~ to define weight-by-weight rados.
Risperidone is generic to 3-[2-[~(6-fluf~1,2-~ ~ l-3-yl)-1-pi~itlinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]~,ylinlidi,l 1 one. The ~ nl;on and ph~rrn~cnlQ~ir~l activity thereof are ~esrrihe~ in EP-0,196,132. The term ri~;peridone as 30 used herein co..~ es the free base form and the pk~ tul;~lly acceptable acid itlf~n salts thereof. The solu~ility of .;~ nne is incl~,ascd upon the ff~ l;nn of such salt forms, which can be obtailled by reaction of the base form with an applul~liàlc acid. Apprûpriate acids c~mpn~e, for example, inolga,~ic acids such as hydluhalic acids, e.g. hy~lluchlOrlr or hydlvblulllic acid; sulfuric; nitric; ~Jho~h-.. ic and the like acids; or 35 organic acids such as, for example, acetic, ~lupd~OiC, hy~l u,~ydCCliC, lactic, lJylll~ic, oxalic, m~lnni~ cn;n;r~ maleic, rull.~lc, malic,tartaric, citric, .~lhAnp~ nic~
ell.AI-e~ ~lfonic~ be n~f ne~lfonic~ p-toluenes~llfonic~ cyclamic, salicylic, p-~ s~licylic, wo 96/01652 2 1 (~ 4 5 6 4 PCT/~9s~2Gl5 pamoic and the like acids. The term ~ ;cm salt as used hereinabove also comprises the solvates which riCpP~ridnnç as well as the salts thereof, are able to form. Such solvates are for c~ le hy~hates, ~l~ohrll~tes and the like.
5 The sslutinns accol~ing to the present invendon have a pH from 2 to 6, preferably from 3 to 5. Oral sslntinnc most preferably have a pH value from 3 to 4, p~ ,.t~"~l soll1tinnc from 5 to 6. The pH of the co",l)osilions is m~ ;n~ by a buffer system. Buffer c~mprice Illi~lu~s of ~p~ul"ia~ ~ of an acid such as phû3phûlic, ~cc;ni~ tartaric, lactic, or citric acid, and a base, in particular sodium L~rdlu~ide or 10 dic-o lillm hydrogen lJhG~h~t~ Ideally, the buffer has sulr;cienl cd,~ ily to remain in the intPn-led pH range upon rlill1tinn with a neutral, a slighdy acidic or a slightly basic beverage.
The desired pH range is most adv~nt~gPoucly obtained using a tartaric acid / sodium 15 hydroxide buffer, pardcularly in view of dle fact that ricpPridnnP tart~ate is the salt form that pl~,se,~lly would appear to have the best solll!Qility in ~qUpollc- media, in particular upon ~lilut1on Thus, the sQlllhility of . ;~. ;don~ tar~e is about 80 mglml, or about 4 times that of ricpPri~1nne l~ucl~k~n~P, (19.6 mg/ml) at room ~ r 20 The ~molmt (w/v) of AspeAdone in dhe present co~ ~S;l;~nc ranges from 0.01% to 1%, preferably from 0.02% to 0.5%, most preferably from 0.05% to 0.25%, and in particular is 0.1% (1 mg/ml) in the oral snluti~nc and about 0.2% (2 mg/ml) in the p~ t~lal sslutinnc 25 In o~der to prevent the growth of micrû organisms such ~ bacteria, yeasts and fungi in the oral co~ l;on~ which are likely to be used l~ Al~" a preservative agent may be added. Sllit~blc pl~sel~aL,~s should be ~J}I~ r~h ~;r~lly stable and crr~ in the pH
range ...c .I;Ol~ above. They comrrice benzoic acid, sorbic acid, .I.~,lI..y~ 7ben, ~u~ylp~ben, imid~nl~ nyl urea k (~çnm~ll 115t~) and di~7nlirlinyl urea (= ('~rm~ll 30 II~), ph~nny~t~l, benzyl ~lrohol, ~lu~ cc.~ 'U~ c~ e.g. benzyl~lknnil-m chl~nde, and the like. Some ~.~s~ s, such as benzoic acid, sorbic acid, Germall 115~9, ( ;~.rm~ and benzyl ~lcohnl~ have the advantage that they yieldclear, tr~ncp~nt sollltionc which do not show any clou~ling upon storage. The con~e~ ion of the pl~,s~ a~,~c,s may range from 0.05% tû 1%, particularly from 0.1% to 0.5%, and most 35 par~cularly is about 0.2%. The most ~.~,f~ d lJl.,~.~rali-c is benzoic acid used at about 2 mg/ml.
Pa~ o_~l sollltinnc do not ~quire the ~ sence of any pl~,selvali~_s. The l,~n~,~l solution is st~ili7~ following art-known ~roc~lules, e.g. it can be filtered ~Q-~l;rAlly through a st~inless-steel filter holder e~lui~ with a 0.2 ~m polyvinylidene ~ o~ ;flP
filter into a suitable sterile glass flask, filled into ampoules (e.g. 2 ml), and then stenli7 by auloclavil~g during 30 .~ ,s at 121 ~C (Flo, 121 2 15 min).
The oral co~ )o~ c optionally may include s~ l;l;ni~l in~dienls known in the art of form~ tion such as ~tç~ g agents, flavou,illg subsl .n~es solubility çnh~ncl,r.cviscosity re~ ting agents and the like ill~cdicl ~. For eY~mrl~, the aqueous solubility 10 of the active il.~l~&enl may be &nh~-~A by the ~ lition to the sol~l;on of a pha~n~reutic~lly ~rcept~bl- co-solvent, a l;~n.to~ in or a d,livali~,_ thereof.
The bitter taste of risperidone and the buffer, and the unpleasant taste ~C-soçi~tç~ with the pH of some formulas optionally may be m~Q~ 3 by one or more intense ~ g 15 agents such as c~rçh~ sodium or~ol~ .. orc~lrillm sacch~hl, aceslllf~me .. or sodium cycl~n~q-t~. The cnnre.~ l;nn of the ~.. ~t,~ .;ng agent may range from 0.04% to 0.15% and in particular is about Ql%. Given the ;ncc~ pql;~bility of riQ~.rifl-)ne with so~bitol, it is believed that the s~?lvti~n should not co...l~ ;s~ polyhydnc ~lcohols such as .~ , fructose, sucrose, m~lt~se and the like ~..~t~ .~;ng agents.
20 The p~l~t~kility of the subject solvtionc op~inn~lly may be o ~ ..; fA further by the ~ltlitinn of one or more flavoulinE, sub ~ res Sllh~ble flavouring ~ul~sl~nces are f~uit flavours such as cherry, la..~b~,ll.y~ black currant or ~llav~ll.y flavour, or stronger flavours, such as Caramel ChocQl~t~ flavour, Mint Cool flavour, ra,~s~ flavour and the like. Combin~ti~n~ of flavours are advantageously used A coml-inAI;fJl~ of two cherry flavours was found to yield very good taste m~i~ results in the present cc --.l~ n~, The total con~ nl.~lion of the n~ouling ~ub~t~ ~cY,s may range from 0.01% to 0.5%, preferably f~m 0.03% to 0.2% and most preferably from 0.05% to 0.1%.
The burr .~id snl~l;snc acc~di,lg to the present il,~e.ltiol- are well suited to rlilutisn with water and beverages or ~rin~ing liquids such as coffee, tea, soft drinks and the like. In general this in.;lcases the p~l~t~bility of the c~al sohltinn and, hence, patient compliance to the m~lir~tinn A particular oral COIll~O~iliOll aCCCildi~lg to the present i~ nlion col;~s (a) 0.02% to 0.5% ri~peridone (b) 0.1% to 0.5% ~ selvati~.es, (c) a suitable amount of buffer to adjust the pH in the range from 2 to 6; and (d) water.
wo96/01652 2 1 94564 PCT/~l55J~615 The most lJlef~ d oral cc....~:~;c n acc~l~hl~ to the present invention con~;n~
(a) 0.1% (1 mg/ml) risperillonr;
(b) 0.2% (2 mg/ml) benzoic acid;
(c) 0.75% (7.5 mg/ml) tartaric acid and snffirient sodium hydroxide 1 N to adjust the pH in the range from 2 to 6 (approx. 1 mg/ml); and (d) water q.s. ad 100% (1 ml).
PalGnt~ l coll~os;l;nn~ according to the present i"~,_"~n preferably compn~e one or 10 more i~o~o;~;g agents, in particular sodium r~lrride~ in amount snffirient to render the final sol~ltinn iSotonir with the body fluid of the subject to be treated. The most pl.,~.lGd pal~,nt~ l colll~o~;l;on accol.ling to the present in~,.l~ion conli~;n~
(a) 0.2% (2 mg/ml) ri~pr,ridQn~;
(b) 0.5% (5 mg/ml) sodium cllloride;
(c) 0.75% (7.5 mg/ml) taTtaric acid and sllfflrient sodium hydroxide 1 N to adjust the pH in the range from 2 to 6 (approx. 3.5 mg/ml); and (d) water q.s. ad 100% (1 ml).
In a further aspect, the present invention relates to a process of ~ ing sc~lutir~n~ of ri~perir1cme as ~le~r~ h~ " cl--- q~ .;,~1 by dissol~i"g the active in~i~nl risp~ridone., either the ~l~s~l ~ali~_ or the iso~o~ agent, and the acid and base co...pol-enl~ of the buffer in water.
In particular, the process comrrices the following steps: (a) adding the acid coll-pol W~l 25 of the buffer and the active in~ ,n~ ;done to an amount of water which is preferably above room temperature (b) st~ring the Illi~ until complete d;~lu~;m~ and cooling the so1llti~m to room t~m~l~lul~, (c) adjusting the pH with the base co~.pon~ nl of the buffer and (d) further ~liluti~ the so~ .. with water to the l~uil~,d end-volume.
In the ~l~z.;.~ n of oral so~ nc~ step (a) may be pl~d by the steps of dissolving 30 the pl~ sel ~àli~, in an amount of heated water and (b) ~lihlting the soltltion with about an equal amount of water. Optionally, one or more ~.cet n;ng agents and na~oulu~g s.lb~-nces may be added during any of the process steps. In the pl~-~i.l;ol- of ~ ,llt~ l sollltir~n~ step (d) may be pl~iceded ;n~...~;3t~,1y by the step of l~nd~,illg the 5~1ul;on iCût~n c by the addition of an a~lul,liaL amount of an i~ton;~;ng agent, and 35 followed by au~claving.
WO 96/01652 2 1 9 4 5 6 4 ~ 55~6l5 The following eY~mrlf-s are int~ n~C'~ to il~ Tat~ the scope of the present i~ ~ion in all its aspects but not to limit it thereto.
Fs~mrle 1 Fl: oral solu~ion (pH = 3+1) ~n~,dienl Ouantity. m~/ml oral solution ri~ploridone 2 tartaric acid 7.5 benzoic acid 2 Cherr,y flavour 1 0.25 Cherry flavour 2 0.5 sodium 5~c~ ;n sodium hy~ udf ' ca. I (q.s. ad pH = 3+1) purified water q.s. ad 1 ml (1) 2 mg benzoic acid was dissolved in 0.5 ml water upon stirring at 80-90~C. 0.4 ml water was added to the solutiQn and 7.5 mg tartaric acid and 2 mg . ;~ one were dissolved in the res~ltin~ upon sti~nngl (2) 1 mg sodium s~cl-A. ;n was dissolved in 0.05 ml water upon stir,ring.
(3) r.~l;on~ (1) and (2) were mixed upon stilTing and the sohll;on was cooled to room (4) 0.25 mg Cherry flavour 1 and 0.5 mg Cher~y flavour 2 were added to fraction (3) upon stirring.
(S) 1 mg sodium hydroxide was added to fraction (4) to adjust the pH to about 3.(6) Lac~n (5) was further diluted with water to 1 ml.
In a similar way there were ~ &~:
F2: oral solunon (pH = 4_1) T.,~ie,ll Ouantity. m~/ml oral scll"~
n~f 0-5 ~ic acid 7.5 benzoic acid 2 Che~y flavour 1 0.25 Cherry flavour 2 0.5 sodium ~ I, ;"
sodium hyd.~Aide q.s. ad pH = 4_1 ... ;1;~ water q.s. ad 1 ml F3: oral solunon (pH = 3) Tr,~lie"l Ouantity. mglml oral sohlticn r. 0.5 tar~ric acid 7.5 sodium chlnri~lP 5 sodium s~cc~
sodium hy~lluAide q.s. ad pH = 3 purified water q.s. ad 1 ml F4: oral solu~ion (pH = 5) In~die.~ Quantity. mg/ml oral solll~iQn ri~pend~!nP 0.5 tartaric acid 7.5 sodium rhlrnde 5 sodium s~rch~. ;n sodium hydroxide q.s. ad pH = 5 p~ified water q.s. ad 1 ml FS: oral solunon (pH = 3) Tn~ielll Ouantity~ m~/ml oral so~ ;ol-n~pendonP~ 1 tartaric acid 7.5 benzoic acid 2 sodium hydroxide ca.1 (q.s. ad pH = 3) l,.. ;r.. ~ water q.s. ad 1 ml F6~r~nt~al solu~ion (pH = 5) Tr,~;~enl Ouantity. m~/ml olal sQlu~iQn 1;~ ;do~-~ 2 tartaric acid 7.5 sodium chlnri~lP 5 sodium hydroxide ca.3.75 (q.s. ad pH = 5) water for injc~, l;on q.s. ad 1 ml 2 1 94~64 ~ 5/02615 wo 96/01652 J
Example 2 The tables hereinbelow ~ the ~ )f ~;dO~f CQ-~C'f~ ' alions IIIG&S~U~d afteraparticular storage time of the co~ n at a palli~;uld~ ~Ill~lalu~ s~ as the S ~l.,~inlageoftheini~ ol-~cc,l-ce.ll.~ion.
Table 1 Fl F2 4~C 12 months 98.2 25~C 1 month 100.4 101.1 3months 102.1 99.1 6 months 100.9 9 months 99.5 12 months 98.7 30~C 3 months 102.1 98.8 6 months 100.3 12 months 98.9 40~C 1 month 102.1 101.1 3 months 100.9 99.4 6 months 100.5 12 months 98.3 60~C 1 month 100.1 100.3 wo 96/016s2 2 1 9 4 5 6 4 PCTIEP95/02615 -g Table 2 80~C S days 97.9 99.0 17 days 96.7 96.6 4 weeks 86.2 87.6 The data in the tables ;~ 'Qtf. that co...l.os;~iQnc Fl-F4 satisfy the criteria as set fo~th 5 hereinbefore to qualify as a "ph~ orl~.f .~ lly stable" c~..nph~;i;ol~
-
Claims (13)
1. An aqueous solution suitable for oral and parental administration comprising water, risperidone or a pharmaceutically acceptable acid addition salt thereof, characterized in that said solution comprises a buffer to maintain the pH in the range of 2 to 6 and is essentially free of sorbitol.
2. A solution according to claim 1 wherein said pH range is obtained with a tartaric acid / sodium hydroxide buffer.
3. A solution according to claim 1 wherein the amount of risperidone ranges from0.01% to 1% by weight based on the total volume of the solution.
4. A solution according to claim 1 having a pH ranging from 3 to 4 which is suitable for oral administration.
5. A solution according to claim 4 further comprising benzoic acid as a preservative.
6. A solution according to claim 5 containing (a) 1 mg/ml risperidone;
(b) 2 mg/ml benzoic acid;
(c) 7.5 mg/ml tartaric acid and sufficient sodium hydroxide to adjust the pH in the range from 3 to 4; and (d) water q.s. ad 1 ml.
(b) 2 mg/ml benzoic acid;
(c) 7.5 mg/ml tartaric acid and sufficient sodium hydroxide to adjust the pH in the range from 3 to 4; and (d) water q.s. ad 1 ml.
7. A solution according to claim 6 further comprising one or more sweetening agents and/or flavouring substances.
8. A solution according to claim 1 having a pH ranging from 5 to 6 which is suitable for parental administration.
9. A solution according to claim 4 further comprising sodium chloride as an isotonizing agent.
10. A solution according to claim 9 containing (a) 1 mg/ml risperidone;
(b) 5 mg/ml sodium chloride;
(c) 7.5 mg/ml tartaric acid and sufficient sodium hydroxide to adjust the pH in the range from 5 to 6; and (d) water q.s. ad 1 ml.
(b) 5 mg/ml sodium chloride;
(c) 7.5 mg/ml tartaric acid and sufficient sodium hydroxide to adjust the pH in the range from 5 to 6; and (d) water q.s. ad 1 ml.
11. A process of preparing a solution according to claim 1 comprising the steps of (a) adding the acid component of the buffer and the active ingredient risperidone to an amount of water, (b) stirring the mixture until complete dissolution and cooling the solution to room temperature, (c) adjusting the pH with the base component of the buffer, and (d) further diluting the solution with water to the required end-volume.
12. A process according to claim 11 for preparing an oral solution as defined in claim 5 wherein step (a) is preceded by the steps of:
(a) dissolving the preservative in an amount of heated water, and (b) diluting the solution with about an equal amount of water.
(a) dissolving the preservative in an amount of heated water, and (b) diluting the solution with about an equal amount of water.
13. A process according to claim 11 for preparing an parenteral solution as defined in claim 9 wherein step (d) is preceded immediately by the step of rendering the solution about isotonic by the addition of an appropriate amount of isotonizing agent, and is followed by autoclaving.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/272,462 | 1994-07-11 | ||
| US08/272,462 US5453425A (en) | 1994-07-11 | 1994-07-11 | Risperidone oral formulation |
| US08/429,435 US5616587A (en) | 1994-07-11 | 1995-04-26 | Aqueous risperidone formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2194564A1 CA2194564A1 (en) | 1996-01-25 |
| CA2194564C true CA2194564C (en) | 1997-12-16 |
Family
ID=26955530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002194564A Expired - Lifetime CA2194564C (en) | 1994-07-11 | 1995-07-04 | Aqueous risperidone formulations |
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| US (3) | US5453425A (en) |
| EP (1) | EP0769965B1 (en) |
| JP (1) | JP2872412B2 (en) |
| KR (1) | KR100212942B1 (en) |
| CN (1) | CN1148226C (en) |
| AP (1) | AP774A (en) |
| AT (1) | ATE206931T1 (en) |
| AU (1) | AU684193B2 (en) |
| BG (1) | BG63070B1 (en) |
| BR (1) | BR9508253A (en) |
| CA (1) | CA2194564C (en) |
| CY (1) | CY2268B1 (en) |
| CZ (1) | CZ285204B6 (en) |
| DE (1) | DE69523313T2 (en) |
| DK (1) | DK0769965T3 (en) |
| EE (1) | EE03426B1 (en) |
| ES (1) | ES2165918T3 (en) |
| FI (1) | FI116510B (en) |
| HK (1) | HK1010691A1 (en) |
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| NZ (1) | NZ289432A (en) |
| PH (1) | PH31626A (en) |
| PL (1) | PL179972B1 (en) |
| PT (1) | PT769965E (en) |
| RO (1) | RO116778B1 (en) |
| RU (1) | RU2161965C2 (en) |
| SI (1) | SI9500220B (en) |
| SK (1) | SK282159B6 (en) |
| TR (1) | TR199500778A1 (en) |
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| ATE288270T1 (en) * | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | MICRO-ENCAPSULED 1,2-BENZAZOLE |
| US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
| UA72189C2 (en) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Aqueous suspensions of 9-hydroxy-risperidone fatty acid esters provided in submicron form |
| US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| AU2003250472A1 (en) * | 2002-08-23 | 2004-03-11 | Ranbaxy Laboratories Limited | Stable aqueous solutions of risperidone and methods for their preparation |
| EP1615924A1 (en) * | 2003-04-22 | 2006-01-18 | Synthon B.V. | Water soluble salts of risperidone |
| PE20050285A1 (en) | 2003-06-24 | 2005-06-09 | Novartis Ag | PHARMACEUTICAL COMPOSITION INCLUDING CYCLIC ANALOGS OF SOMATOSTATIN |
| US20050036977A1 (en) * | 2003-08-11 | 2005-02-17 | Dilip Gole | Taste-masked resinate and preparation thereof |
| ES2245252B1 (en) * | 2004-06-15 | 2007-03-01 | Farmalider, S.A. | RISPERIDONE WATER SOLUTION FOR ORAL ADMINISTRATION. |
| ES2245891B1 (en) * | 2004-07-09 | 2006-11-16 | Clinmet S.L. | "METHOD FOR OBTAINING A UNIVERSAL EXCIPIENT FOR ORAL ADMINISTRATION OF PHARMACEUTICAL ACTIVE PRINCIPLES AND COMPOSITIONS OF EXCIPIENTS RESULTING FROM THE METHOD". |
| WO2006129160A2 (en) * | 2005-06-01 | 2006-12-07 | Aurobindo Pharma Limited | Stable aqueous oral solution of risperidone |
| ATE424399T1 (en) * | 2005-06-29 | 2009-03-15 | Verisfield Uk Ltd | PHARMACEUTICAL COMPOSITIONS OF RISPERIDONE IN AQUEOUS SOLUTION |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
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| US4337261A (en) * | 1980-07-28 | 1982-06-29 | Hoechst-Roussel Pharmaceuticals Inc. | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics |
| IL88233A (en) * | 1987-11-03 | 1993-08-18 | Genentech Inc | Gamma interferon formulation |
| FR2641278B1 (en) * | 1989-01-05 | 1991-03-22 | Lipha | PIPERIDINES, METHODS OF PREPARATION AND MEDICAMENTS CONTAINING THEM |
| DK203990D0 (en) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | piperazinyl |
| TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
| US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
| FR2796273B1 (en) * | 1999-07-15 | 2003-09-12 | Oreal | COMPOSITION WITH A LIQUID FATTY PHASE GELIFIED BY A POLYAMIDE WITH TERMINAL ESTER GROUPS |
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