CA2192854A1 - Novel anti-proliferative effects of sodium butyrate - Google Patents
Novel anti-proliferative effects of sodium butyrateInfo
- Publication number
- CA2192854A1 CA2192854A1 CA002192854A CA2192854A CA2192854A1 CA 2192854 A1 CA2192854 A1 CA 2192854A1 CA 002192854 A CA002192854 A CA 002192854A CA 2192854 A CA2192854 A CA 2192854A CA 2192854 A1 CA2192854 A1 CA 2192854A1
- Authority
- CA
- Canada
- Prior art keywords
- pdgf
- sodium butyrate
- smooth muscle
- cells
- induced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 title claims abstract description 110
- 230000001028 anti-proliverative effect Effects 0.000 title description 4
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 26
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- 230000002401 inhibitory effect Effects 0.000 claims abstract description 12
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 9
- 208000026106 cerebrovascular disease Diseases 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 11
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 235000015872 dietary supplement Nutrition 0.000 claims 6
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- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 8
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 6
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 4
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 4
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 4
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- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 3
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
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- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
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- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
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- DILRJUIACXKSQE-UHFFFAOYSA-N n',n'-dimethylethane-1,2-diamine Chemical compound CN(C)CCN DILRJUIACXKSQE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/362,829 US5563173A (en) | 1994-12-22 | 1994-12-22 | Anti-proliferative effects of sodium butyrate |
| US08/362,829 | 1994-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2192854A1 true CA2192854A1 (en) | 1996-06-27 |
Family
ID=23427706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002192854A Abandoned CA2192854A1 (en) | 1994-12-22 | 1995-12-22 | Novel anti-proliferative effects of sodium butyrate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5563173A (enExample) |
| EP (1) | EP0793487A1 (enExample) |
| AU (1) | AU4743096A (enExample) |
| CA (1) | CA2192854A1 (enExample) |
| IL (1) | IL116393A0 (enExample) |
| WO (1) | WO1996019213A1 (enExample) |
| ZA (1) | ZA9510771B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0879600A1 (en) * | 1997-05-20 | 1998-11-25 | Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.) | Fructan containing composition for the prevention and treatment of colon cancer |
| US6498247B2 (en) | 2000-04-13 | 2002-12-24 | Pro-Health, Inc. | Alkali or alkaline earth metal of n-butyric acid for treatment of cognitive and emotional conditions |
| US6613356B1 (en) | 2000-10-10 | 2003-09-02 | Victor Vlahakos | Weight loss medication and method |
| WO2003033678A2 (en) * | 2001-10-18 | 2003-04-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods of using deacetylase inhibitors to promote cell differentiation and regeneration |
| AU2003234567A1 (en) * | 2002-05-15 | 2003-12-02 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
| US20050058611A1 (en) * | 2003-08-22 | 2005-03-17 | L'oreal | Preventing and/or combating collagen fiber degradation induced under conditions of natural exposure to sunlight |
| FR2858932B1 (fr) * | 2003-08-22 | 2009-10-30 | Oreal | Composition destinee a lutter contre la degradation des fibres de collagene induite en condition d'exposition solaire naturelle |
| AU2004291503A1 (en) * | 2003-11-13 | 2005-06-02 | Janssen Pharmaceutica N.V. | Immobilized N-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets |
| CA2619568A1 (en) * | 2005-08-19 | 2007-03-01 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Topical formulations of histone deacetylase inhibitors and methods of using the same |
| WO2017042337A1 (en) * | 2015-09-09 | 2017-03-16 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmhotz-Gemeinschaft | Short-chain fatty acids for use in the treatment of cardiovascular disease |
| CN114732809A (zh) * | 2022-06-09 | 2022-07-12 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 丁酸盐在制备缓解骨骼肌衰老的药物中的应用 |
-
1994
- 1994-12-22 US US08/362,829 patent/US5563173A/en not_active Expired - Fee Related
-
1995
- 1995-12-14 IL IL11639395A patent/IL116393A0/xx unknown
- 1995-12-19 ZA ZA9510771A patent/ZA9510771B/xx unknown
- 1995-12-22 CA CA002192854A patent/CA2192854A1/en not_active Abandoned
- 1995-12-22 EP EP95944669A patent/EP0793487A1/en not_active Withdrawn
- 1995-12-22 AU AU47430/96A patent/AU4743096A/en not_active Abandoned
- 1995-12-22 WO PCT/US1995/016949 patent/WO1996019213A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9510771B (en) | 1997-06-19 |
| WO1996019213A1 (en) | 1996-06-27 |
| EP0793487A1 (en) | 1997-09-10 |
| IL116393A0 (en) | 1996-03-31 |
| AU4743096A (en) | 1996-07-10 |
| US5563173A (en) | 1996-10-08 |
| EP0793487A4 (enExample) | 1997-09-10 |
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