CA2192073A1 - Novel oligosaccharide derivatives, preparation method therefor and uses thereof - Google Patents
Novel oligosaccharide derivatives, preparation method therefor and uses thereofInfo
- Publication number
- CA2192073A1 CA2192073A1 CA002192073A CA2192073A CA2192073A1 CA 2192073 A1 CA2192073 A1 CA 2192073A1 CA 002192073 A CA002192073 A CA 002192073A CA 2192073 A CA2192073 A CA 2192073A CA 2192073 A1 CA2192073 A1 CA 2192073A1
- Authority
- CA
- Canada
- Prior art keywords
- molecule
- preparation
- method therefor
- oligosaccharide derivatives
- novel oligosaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001542 oligosaccharide Polymers 0.000 title abstract 3
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title 1
- 125000000524 functional group Chemical group 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Compounds including one or more oligosaccharides each of which is covalently bonded to one or more, particularly one, two or three, molecules, matrices or particles, by means of an intermediate molecule having a nitrogen atom on an .alpha. carbon of a C=O group and one or more, particularly one, two or three, functional groups, the covalent bond between said intermediate molecule and the oligosaccharide being via said nitrogen atom, and the covalent bond between said intermediate molecule and said molecule(s), matrix(-ces) or particle(s) being via said functional group(s) of said intermediate molecule and suitable functional groups on said molecule(s), matrix(-ces) or particle(s).Compounds including one or more oligosaccharides each of which is covalently bonded to one or more, particularly one, two or three, molecules, matrices or particles, by means of an intermediate molecule having a nitrogen atom on an .alpha. carbon of a C = O group and one or more, particularly one, two or three, functional groups, the covalent bond between said intermediate molecule and the oligosaccharide being via said nitrogen atom, and the covalent bond between said intermediate molecule and said molecule ( s), matrix (-ces) or particle (s) being via said functional group (s) of said intermediate molecule and suitable functional groups on said molecule (s), matrix (-ces) or particle (s).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9407738A FR2721612B1 (en) | 1994-06-23 | 1994-06-23 | New oligoside derivatives, their preparation process and their applications. |
FR94/07738 | 1994-06-23 | ||
PCT/FR1995/000790 WO1996000229A1 (en) | 1994-06-23 | 1995-06-15 | Novel oligosaccharide derivatives, preparation method therefor and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2192073A1 true CA2192073A1 (en) | 1996-01-04 |
CA2192073C CA2192073C (en) | 2006-08-01 |
Family
ID=36764261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002192073A Expired - Fee Related CA2192073C (en) | 1994-06-23 | 1995-06-15 | Novel oligosaccharide derivatives, preparation method therefor and uses thereof |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2192073C (en) |
-
1995
- 1995-06-15 CA CA002192073A patent/CA2192073C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2192073C (en) | 2006-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |