CA2181570A1 - Metalloproteinase inhibitors - Google Patents
Metalloproteinase inhibitorsInfo
- Publication number
- CA2181570A1 CA2181570A1 CA002181570A CA2181570A CA2181570A1 CA 2181570 A1 CA2181570 A1 CA 2181570A1 CA 002181570 A CA002181570 A CA 002181570A CA 2181570 A CA2181570 A CA 2181570A CA 2181570 A1 CA2181570 A1 CA 2181570A1
- Authority
- CA
- Canada
- Prior art keywords
- ring
- metalloproteinase inhibitors
- co2h
- oxidised
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a phenyl or 5- or 6-membered heteroaryl ring wherein any ring nitrogen atom may be oxidised as an N-oxide, which may be optionally fused to a benzene ring or to a 5-, 6- or 7-membered heterocyclic ring, and wherein any of the rings may be optionally substituted.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9401034.5 | 1994-01-20 | ||
| GB9401034A GB9401034D0 (en) | 1994-01-20 | 1994-01-20 | Metalloproteinase inhibitors |
| GB9415619A GB9415619D0 (en) | 1994-08-02 | 1994-08-02 | Metalloprotease inhibitors |
| GB9415619.7 | 1994-08-02 | ||
| PCT/GB1995/000111 WO1995019956A1 (en) | 1994-01-20 | 1995-01-20 | Metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2181570A1 true CA2181570A1 (en) | 1995-07-27 |
| CA2181570C CA2181570C (en) | 2006-04-11 |
Family
ID=36178091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002181570A Expired - Fee Related CA2181570C (en) | 1994-01-20 | 1995-01-20 | Metalloproteinase inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2181570C (en) |
-
1995
- 1995-01-20 CA CA002181570A patent/CA2181570C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2181570C (en) | 2006-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |