CA2178504A1 - Immunoassays for prostate specific antigen - Google Patents

Immunoassays for prostate specific antigen

Info

Publication number
CA2178504A1
CA2178504A1 CA002178504A CA2178504A CA2178504A1 CA 2178504 A1 CA2178504 A1 CA 2178504A1 CA 002178504 A CA002178504 A CA 002178504A CA 2178504 A CA2178504 A CA 2178504A CA 2178504 A1 CA2178504 A1 CA 2178504A1
Authority
CA
Canada
Prior art keywords
psa
specific antigen
prostate specific
immunoassays
presented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002178504A
Other languages
French (fr)
Other versions
CA2178504C (en
Inventor
Barry L. Dowell
Carol A. King
Debra B. Alexander
Allan H. Smith
Susan B. O'morchoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/174,964 external-priority patent/US5599677A/en
Application filed by Individual filed Critical Individual
Priority to CA002546529A priority Critical patent/CA2546529A1/en
Publication of CA2178504A1 publication Critical patent/CA2178504A1/en
Application granted granted Critical
Publication of CA2178504C publication Critical patent/CA2178504C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and .alpha.-antichymotrypsin (ACT) that can be used as a calibrator or control in an immunoassay for PSA. Further presented is a method for fractionating polyclonal antibodies, to PSA, into those which bind epitopes that are masked by the binding of PSA to ACT and those which do not bind such epitopes.
CA002178504A 1993-12-29 1994-12-22 Immunoassays for prostate specific antigen Expired - Lifetime CA2178504C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002546529A CA2546529A1 (en) 1993-12-29 1994-12-22 Immunoassays for prostate specific antigen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/174,964 US5599677A (en) 1993-12-29 1993-12-29 Immunoassays for prostate specific antigen
US08/174,964 1993-12-29
PCT/US1994/014902 WO1995018381A1 (en) 1993-12-29 1994-12-22 Immunoassays for prostate specific antigen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002546529A Division CA2546529A1 (en) 1993-12-29 1994-12-22 Immunoassays for prostate specific antigen

Publications (2)

Publication Number Publication Date
CA2178504A1 true CA2178504A1 (en) 1995-07-06
CA2178504C CA2178504C (en) 2006-09-05

Family

ID=36968348

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002178504A Expired - Lifetime CA2178504C (en) 1993-12-29 1994-12-22 Immunoassays for prostate specific antigen

Country Status (1)

Country Link
CA (1) CA2178504C (en)

Also Published As

Publication number Publication date
CA2178504C (en) 2006-09-05

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20141222