CA2173601C - Liposomes contenant des matieres particulaires - Google Patents

Liposomes contenant des matieres particulaires Download PDF

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Publication number
CA2173601C
CA2173601C CA002173601A CA2173601A CA2173601C CA 2173601 C CA2173601 C CA 2173601C CA 002173601 A CA002173601 A CA 002173601A CA 2173601 A CA2173601 A CA 2173601A CA 2173601 C CA2173601 C CA 2173601C
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CA
Canada
Prior art keywords
liposomes
liposome
freeze
particulate material
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002173601A
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English (en)
Other versions
CA2173601A1 (fr
Inventor
Gregory Gregoriadis
Sophia George Antimisiaris
Ihsan Gursel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Defence
Original Assignee
UK Secretary of State for Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939320668A external-priority patent/GB9320668D0/en
Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Publication of CA2173601A1 publication Critical patent/CA2173601A1/fr
Application granted granted Critical
Publication of CA2173601C publication Critical patent/CA2173601C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention se rapporte à un procédé de formation de liposomes, dont le diamètre est compris entre 0,1 µm et 50 µm, présentant une structure monolamellaire ou multilamellaire, et contenant des matières particulaires insolubles ou non dissoutes dans l'eau. Ce procédé consiste (a) à produire des liposomes et à retirer pratiquement la totalité de tout solvant organique utilisé dans leur préparation, (b) à lyophiliser les liposomes ainsi obtenus, puis (c) à les réhydrater en les mélangeant intimement à la matière particulaire. Les matières encapsulées préférées sont des matières particulaires, de préférence des micro-organismes, des cellules végétales ou animales, ou des structures insolubles dans l'eau ayant l'activité biochimique ou immunologique labile des solvants organiques, et n'importe quelle matière particulaire insoluble dans l'eau peut être encapsulée par ce procédé. Par exemple, des catalyseurs ou des médicaments qui sont modérément solubles peuvent également être incorporés de sorte que puisse s'effectuer une libération lente dans le corps d'un patient tout en évitant la libération de détersifs, compris dans les nombreux protocoles de préparation des liposomes.
CA002173601A 1993-10-07 1994-10-07 Liposomes contenant des matieres particulaires Expired - Fee Related CA2173601C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939320668A GB9320668D0 (en) 1993-10-07 1993-10-07 Liposomes containing particulare materials
GB9320668.8 1993-10-07
PCT/GB1994/002191 WO1995009610A1 (fr) 1993-10-07 1994-10-07 Liposomes contenant des matieres particulaires

Publications (2)

Publication Number Publication Date
CA2173601A1 CA2173601A1 (fr) 1995-04-13
CA2173601C true CA2173601C (fr) 2006-04-18

Family

ID=36250868

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002173601A Expired - Fee Related CA2173601C (fr) 1993-10-07 1994-10-07 Liposomes contenant des matieres particulaires

Country Status (1)

Country Link
CA (1) CA2173601C (fr)

Also Published As

Publication number Publication date
CA2173601A1 (fr) 1995-04-13

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