CA2156121A1 - Method of manufacturing the cycloheptimidazole derivatives - Google Patents

Method of manufacturing the cycloheptimidazole derivatives

Info

Publication number
CA2156121A1
CA2156121A1 CA002156121A CA2156121A CA2156121A1 CA 2156121 A1 CA2156121 A1 CA 2156121A1 CA 002156121 A CA002156121 A CA 002156121A CA 2156121 A CA2156121 A CA 2156121A CA 2156121 A1 CA2156121 A1 CA 2156121A1
Authority
CA
Canada
Prior art keywords
hydrogen
lower alkyl
group
cycloheptimidazole
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002156121A
Other languages
French (fr)
Other versions
CA2156121C (en
Inventor
Tsuyoshi Tomiyama
Akira Tomiyama
Takashi Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kotobuki Seiyaku Co Ltd
Original Assignee
Kotobuki Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kotobuki Seiyaku Co Ltd filed Critical Kotobuki Seiyaku Co Ltd
Publication of CA2156121A1 publication Critical patent/CA2156121A1/en
Application granted granted Critical
Publication of CA2156121C publication Critical patent/CA2156121C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disclosed is a method in which a compound of general formula (1) is reacted with a compound of general formula (2), followed by deprotection of protective group Z to give the cycloheptimidazole derivative (4) wherein R1 is hydrogen or isopropyl; R2 is a lower alkyl; A and A1 are each a substituent at the 4- or 8-position, Al is hydrogen or hydroxyl when A is a hydrogen or A and A1 together form an oxo group or =CHCOOR3 (R3 represents a lower alkyl); the dotted line means two double bonds or saturated single bonds; X is halogen atom or trifluoromethanesulfonate group; Y is B(OH)2 or -Sn(R5)3 (R5 represents a lower alkyl group). The cycloheptimidazole derivative (4) is useful as antihypertensive agent.
CA002156121A 1994-09-05 1995-08-15 Method of manufacturing the cycloheptimidazole derivatives Expired - Fee Related CA2156121C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP210867/94 1994-09-05
JP21086794A JP4316686B2 (en) 1994-09-05 1994-09-05 Cycloheptimidazole derivative

Publications (2)

Publication Number Publication Date
CA2156121A1 true CA2156121A1 (en) 1996-03-06
CA2156121C CA2156121C (en) 2006-03-28

Family

ID=16596423

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002156121A Expired - Fee Related CA2156121C (en) 1994-09-05 1995-08-15 Method of manufacturing the cycloheptimidazole derivatives

Country Status (7)

Country Link
JP (1) JP4316686B2 (en)
CN (1) CN1061655C (en)
CA (1) CA2156121C (en)
CH (1) CH689511A5 (en)
HU (1) HU226806B1 (en)
NO (1) NO308358B1 (en)
TW (1) TW408113B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115093372A (en) * 2022-06-16 2022-09-23 安徽工程大学 Synthesis method of imidazole derivative

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2707390B2 (en) * 1992-05-22 1998-01-28 壽製薬株式会社 Cycloheptoimidazole derivative, method for producing the same, and drug containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115093372A (en) * 2022-06-16 2022-09-23 安徽工程大学 Synthesis method of imidazole derivative
CN115093372B (en) * 2022-06-16 2023-05-30 安徽工程大学 Synthesis method of imidazole derivative

Also Published As

Publication number Publication date
NO953459D0 (en) 1995-09-04
NO308358B1 (en) 2000-09-04
HU226806B1 (en) 2009-10-28
CH689511A5 (en) 1999-05-31
CN1061655C (en) 2001-02-07
CA2156121C (en) 2006-03-28
JP4316686B2 (en) 2009-08-19
NO953459L (en) 1996-03-06
CN1127752A (en) 1996-07-31
JPH0873454A (en) 1996-03-19
TW408113B (en) 2000-10-11
HUT73184A (en) 1996-06-28
HU9502172D0 (en) 1995-09-28

Similar Documents

Publication Publication Date Title
CA2147126A1 (en) Piperidine Derivatives and Process for Their Production
CA2183453A1 (en) Antiparasitic Agents
CA2219747A1 (en) Aminothiazole derivative, medicament containing the same, and intermediate for preparation of said compound
CA2475113A1 (en) Isothiazole derivatives useful as anticancer agents
CA2046126A1 (en) 2-thienylglycidic derivative, process for its preparation and its use as synthesis intermediate
GB2145080B (en) Trihalo-trideoxy galactosucrose compounds
EP0394496A4 (en) Glycoside derivatives, polymers containing glycoside derivatives, process for their preparation, and use of said polymers
IE45631L (en) 4-hydroxyphenylalkanolamine derivatives.
IE860838L (en) 4'-demethyl-4-epipodophyllotoxin derivatives
CA2130664A1 (en) Antiparasitic Agents
CA2326815A1 (en) Process for preparation of pyridine derivatives
CA2027351A1 (en) Emulsion of lipid containing a prostaglandin analogue
CA2207307A1 (en) Compounds and methods for monosaccharide analysis
CA1261853A (en) Process for the preparation of 4-phenylpyrrole derivatives
CA2256559A1 (en) N-bis- or n-tris-[(1,2-dicarboxy-ethoxy)-ethyl]-amine derivatives and preparation and use of the same
CA2156121A1 (en) Method of manufacturing the cycloheptimidazole derivatives
CA2281695A1 (en) Process for the preparation of substituted thiazolidinedione
CA2197467A1 (en) Method for the preparation of taxol and its derivatives
CA2067341A1 (en) Method for synthesis of prostaglandin derivatives
AU2278588A (en) Saccharide derivatives
CA2018769A1 (en) Adduct-aldehyde and its use for the preparation of a vitamin-d compound
EP0900785A3 (en) Vitamin A related compounds and process for producing the same
AU4525285A (en) Ellipticine derivative and production process thereof
CA2195975A1 (en) An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
KR960010655A (en) Novel Processes for Sepem Compound

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130815