CA2150234C - Combination of atovaquone with proguanil for the treatment of protozoal infections - Google Patents
Combination of atovaquone with proguanil for the treatment of protozoal infections Download PDFInfo
- Publication number
- CA2150234C CA2150234C CA002150234A CA2150234A CA2150234C CA 2150234 C CA2150234 C CA 2150234C CA 002150234 A CA002150234 A CA 002150234A CA 2150234 A CA2150234 A CA 2150234A CA 2150234 C CA2150234 C CA 2150234C
- Authority
- CA
- Canada
- Prior art keywords
- proguanil
- atovaquone
- treatment
- combination
- infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections, such as protozoal parasitic infections, e.g. malaria and toxoplasmosis, and infections caused by P.carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and proguanil are administered in a potentiating ratio so that they act in synergy.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9224739.4 | 1992-11-26 | ||
GB929224739A GB9224739D0 (en) | 1992-11-26 | 1992-11-26 | Medicaments |
PCT/GB1993/002425 WO1994012164A1 (en) | 1992-11-26 | 1993-11-25 | Combination of atovaquone with proguanil for the treatment of protozoal infections |
Publications (3)
Publication Number | Publication Date |
---|---|
CA2150234A1 CA2150234A1 (en) | 1994-06-09 |
CA2150234C true CA2150234C (en) | 2001-01-16 |
CA2150234E CA2150234E (en) | 2005-03-22 |
Family
ID=10725687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002150234A Expired - Lifetime CA2150234E (en) | 1992-11-26 | 1993-11-25 | Combination of atovaquone with proguanil for the treatment of protozoal infections |
Country Status (38)
Country | Link |
---|---|
US (3) | US5998449A (en) |
EP (1) | EP0670719B1 (en) |
JP (1) | JP3768231B2 (en) |
KR (1) | KR100294802B1 (en) |
CN (1) | CN1087935C (en) |
AP (1) | AP517A (en) |
AT (1) | ATE191340T1 (en) |
AU (1) | AU685408B2 (en) |
BG (1) | BG62595B1 (en) |
CA (1) | CA2150234E (en) |
CY (1) | CY2193B1 (en) |
CZ (2) | CZ289171B6 (en) |
DE (1) | DE69328307T2 (en) |
DK (1) | DK0670719T3 (en) |
ES (1) | ES2145114T3 (en) |
GB (1) | GB9224739D0 (en) |
GR (1) | GR3033745T3 (en) |
HK (1) | HK1004468A1 (en) |
HU (1) | HU225918B1 (en) |
IL (1) | IL107755A (en) |
MX (1) | MX9307402A (en) |
MY (1) | MY114241A (en) |
NO (1) | NO313225B1 (en) |
NZ (1) | NZ257901A (en) |
OA (1) | OA10352A (en) |
PE (1) | PE55694A1 (en) |
PL (1) | PL174323B1 (en) |
PT (1) | PT670719E (en) |
RO (1) | RO119280B1 (en) |
RU (1) | RU2108092C1 (en) |
SA (1) | SA93140434B1 (en) |
SG (1) | SG45387A1 (en) |
SI (1) | SI9300614A (en) |
SK (1) | SK281559B6 (en) |
TW (1) | TW253835B (en) |
UA (1) | UA45948C2 (en) |
WO (1) | WO1994012164A1 (en) |
ZA (1) | ZA938832B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
GB9424013D0 (en) * | 1994-11-29 | 1995-01-18 | Wellcome Found | Medicaments |
DE19737463A1 (en) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the treatment of diseases caused by protozoa |
GB9822681D0 (en) * | 1998-10-16 | 1998-12-09 | Vitabiotics Ltd | Method of treatment |
CZ294903B6 (en) * | 1999-04-09 | 2005-04-13 | Glaxo Group Limited | Combination preparation for treating malaria |
US7104076B2 (en) * | 2004-06-24 | 2006-09-12 | Carrier Corporation | Lubricant return schemes for use in refrigerant cycle |
ITMI20070941A1 (en) * | 2007-05-09 | 2008-11-10 | Chimico Internazi0Nale S P A L | PROCEDURE FOR THE PREPARATION OF TRANS2.3-DISPOSITED NAFTOCHINONES |
ES2517366T3 (en) * | 2009-08-20 | 2014-11-03 | Ipca Laboratories Limited | New complex for the treatment and / or prophylaxis of parasitic infections |
US20180055835A1 (en) | 2016-08-25 | 2018-03-01 | Immune Therapeutics Inc. | Method for Treating And Preventing Protozoal Infections |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2533648A (en) * | 1949-03-05 | 1950-12-12 | Joseph H Warburg | Circular saw making |
NL6411993A (en) * | 1963-10-18 | 1965-04-20 | ||
US3347830A (en) * | 1964-07-30 | 1967-10-17 | Grace W R & Co | Process of polymerizing formaldehyde |
GB1141735A (en) * | 1966-11-23 | 1969-01-29 | Pfizer & Co C | Pharmaceutical anti-tumor composition |
NL6817526A (en) * | 1968-01-24 | 1969-07-28 | ||
US3655699A (en) * | 1970-03-02 | 1972-04-11 | Pfizer | Analogues of lapachol as antitumor agents |
DE2601458A1 (en) * | 1975-01-20 | 1976-07-22 | Ciba Geigy Ag | SOLUBLE POLYAMIDES DERIVED FROM PHENYLINDANEDIAMINES |
JPS5492945A (en) * | 1977-11-22 | 1979-07-23 | Wellcome Found | Naphthoquinone derivative |
US4485117A (en) * | 1981-10-16 | 1984-11-27 | Hudson Alan T | Antiprotozoal compounds |
US4485116A (en) * | 1981-10-16 | 1984-11-27 | Hudson Alan T | Antiprotozoal compounds |
GB8310141D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Naphthoquinone derivatives |
GB8310140D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Antiprotozoal agents |
US5053432A (en) * | 1983-04-14 | 1991-10-01 | Burroughs Wellcome Co. | Naphthoquinone derivatives |
JPS59196467A (en) * | 1983-04-23 | 1984-11-07 | Nissan Motor Co Ltd | Detection of wheel speed and/or wheel acceleration/deceleration |
US5225184A (en) * | 1988-08-16 | 1993-07-06 | Burroughs Wellcome Co. | Medicaments |
GB8819477D0 (en) * | 1988-08-16 | 1988-09-21 | Wellcome Found | Medicaments |
US5206268A (en) * | 1988-08-16 | 1993-04-27 | Burroughs Wellcome Co. | Medicaments |
JP2804302B2 (en) * | 1988-08-16 | 1998-09-24 | ザ ウエルカム フアウンデーション リミテッド | Therapeutic agent |
GB8921516D0 (en) * | 1989-09-22 | 1989-11-08 | Wellcome Found | Medicaments |
GB8923254D0 (en) * | 1989-10-16 | 1989-12-06 | Wellcome Found | Medicaments |
US5014737A (en) * | 1989-11-13 | 1991-05-14 | Allan Berman | Quartz integrated trough/sump recirculating filtered high-purity chemical bath |
GB9121316D0 (en) * | 1991-10-09 | 1991-11-20 | Wellcome Found | Heterocyclic compounds |
GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
GB9226905D0 (en) * | 1992-12-24 | 1993-02-17 | Wellcome Found | Pharmaceutical preparation |
ES2095772T3 (en) * | 1993-05-05 | 1997-02-16 | Palo Alto Medical Found | USE OF RIFAMYCIN DERIVATIVES TO PRODUCE A MEDICINE INTENDED FOR THE TREATMENT OF TOXOPLASMOSIS. |
US5529994A (en) * | 1993-05-05 | 1996-06-25 | Palo Alto Medical Foundation | Treatment for toxoplasmosis |
US5733932A (en) * | 1995-01-06 | 1998-03-31 | The Picower Institute For Medical Research | Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions |
US5744168A (en) * | 1995-12-07 | 1998-04-28 | The Procter & Gamble Company | Methods and compositions for the prevention and treatment of gastrointestinal disorders |
US5827543A (en) * | 1995-12-07 | 1998-10-27 | The Procter & Gamble Company | Methods and compositions for the prevention and treatment of urogenital disorders |
US5747476A (en) * | 1996-07-17 | 1998-05-05 | Mortar & Pestle Veterinary Pharmacy, Inc. | Treatment of equine protozoal myeloencephalitis |
ZA983331B (en) * | 1997-05-01 | 1998-10-27 | Allegheny University Of The He | Method for treating protozoal infections |
AUPO821097A0 (en) * | 1997-07-25 | 1997-08-14 | Cultor Ltd. | A prophylactic |
DE19737463A1 (en) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the treatment of diseases caused by protozoa |
CZ294903B6 (en) * | 1999-04-09 | 2005-04-13 | Glaxo Group Limited | Combination preparation for treating malaria |
-
1992
- 1992-11-26 GB GB929224739A patent/GB9224739D0/en active Pending
-
1993
- 1993-11-25 SK SK570-95A patent/SK281559B6/en not_active IP Right Cessation
- 1993-11-25 CZ CZ19951192A patent/CZ289171B6/en not_active IP Right Cessation
- 1993-11-25 UA UA95058430A patent/UA45948C2/en unknown
- 1993-11-25 NZ NZ257901A patent/NZ257901A/en not_active IP Right Cessation
- 1993-11-25 RU RU95113501A patent/RU2108092C1/en active
- 1993-11-25 WO PCT/GB1993/002425 patent/WO1994012164A1/en active IP Right Grant
- 1993-11-25 SG SG1996005505A patent/SG45387A1/en unknown
- 1993-11-25 DK DK94900254T patent/DK0670719T3/en active
- 1993-11-25 HU HU9501537A patent/HU225918B1/en unknown
- 1993-11-25 EP EP94900254A patent/EP0670719B1/en not_active Expired - Lifetime
- 1993-11-25 TW TW082109940A patent/TW253835B/zh not_active IP Right Cessation
- 1993-11-25 RO RO95-00963A patent/RO119280B1/en unknown
- 1993-11-25 KR KR1019950702071A patent/KR100294802B1/en not_active IP Right Cessation
- 1993-11-25 SI SI9300614A patent/SI9300614A/en unknown
- 1993-11-25 PE PE1993231837A patent/PE55694A1/en not_active IP Right Cessation
- 1993-11-25 PL PL93309222A patent/PL174323B1/en unknown
- 1993-11-25 AU AU55322/94A patent/AU685408B2/en not_active Expired
- 1993-11-25 IL IL10775593A patent/IL107755A/en not_active IP Right Cessation
- 1993-11-25 DE DE69328307T patent/DE69328307T2/en not_active Expired - Lifetime
- 1993-11-25 MX MX9307402A patent/MX9307402A/en unknown
- 1993-11-25 CA CA002150234A patent/CA2150234E/en not_active Expired - Lifetime
- 1993-11-25 MY MYPI93002479A patent/MY114241A/en unknown
- 1993-11-25 AT AT94900254T patent/ATE191340T1/en active
- 1993-11-25 ZA ZA938832A patent/ZA938832B/en unknown
- 1993-11-25 CN CN93114723A patent/CN1087935C/en not_active Expired - Lifetime
- 1993-11-25 PT PT94900254T patent/PT670719E/en unknown
- 1993-11-25 ES ES94900254T patent/ES2145114T3/en not_active Expired - Lifetime
- 1993-11-25 JP JP51291494A patent/JP3768231B2/en not_active Expired - Lifetime
- 1993-11-25 AP APAP/P/1993/000592A patent/AP517A/en active
- 1993-12-22 SA SA93140434A patent/SA93140434B1/en unknown
-
1995
- 1995-05-19 NO NO19951995A patent/NO313225B1/en not_active IP Right Cessation
- 1995-05-22 BG BG99656A patent/BG62595B1/en unknown
- 1995-05-26 OA OA60668A patent/OA10352A/en unknown
-
1997
- 1997-10-31 US US08/962,273 patent/US5998449A/en not_active Expired - Lifetime
-
1998
- 1998-04-23 HK HK98103412A patent/HK1004468A1/en not_active IP Right Cessation
-
1999
- 1999-03-09 CZ CZ1999805A patent/CZ289692B6/en not_active IP Right Cessation
- 1999-10-01 US US09/409,871 patent/US6166046A/en not_active Expired - Lifetime
-
2000
- 2000-06-22 GR GR20000401440T patent/GR3033745T3/en unknown
- 2000-08-29 CY CY0000044A patent/CY2193B1/en unknown
- 2000-10-04 US US09/678,485 patent/US6291488B1/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
NARE | Reissued | ||
MKEX | Expiry |
Effective date: 20131125 |