CA2145169A1 - A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use - Google Patents

A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use

Info

Publication number
CA2145169A1
CA2145169A1 CA002145169A CA2145169A CA2145169A1 CA 2145169 A1 CA2145169 A1 CA 2145169A1 CA 002145169 A CA002145169 A CA 002145169A CA 2145169 A CA2145169 A CA 2145169A CA 2145169 A1 CA2145169 A1 CA 2145169A1
Authority
CA
Canada
Prior art keywords
allergenic
proteins
molecular weight
low
extracts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002145169A
Other languages
French (fr)
Other versions
CA2145169C (en
Inventor
Lubertus Berrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Leti SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP92920684A priority Critical patent/EP0662080B1/en
Priority to DE200512000034 priority patent/DE122005000034I1/en
Application filed by Individual filed Critical Individual
Priority to PCT/NL1992/000160 priority patent/WO1994006821A1/en
Priority to AU26486/92A priority patent/AU675629B2/en
Priority to DE69217395T priority patent/DE69217395T2/en
Priority to AT92920684T priority patent/ATE148708T1/en
Priority to JP50798394A priority patent/JP3397791B2/en
Priority to DE122005000035C priority patent/DE122005000035I2/en
Priority to ES92920684T priority patent/ES2098543T3/en
Priority to CA002145169A priority patent/CA2145169C/en
Priority to US08/403,832 priority patent/US5770698A/en
Publication of CA2145169A1 publication Critical patent/CA2145169A1/en
Application granted granted Critical
Publication of CA2145169C publication Critical patent/CA2145169C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention concerns the removal of various allergologically irrelevant low-molecular weight components from the usual aqueous extracts of allergenically active proteins of plant pollens. Described are the desorption and subsequent elimination, from traditionally prepared allergenic pollen protein extracts, of low-molecular weight pigment and other compounds which are nor-mally retained by strong electrostatic and/or hydrophobic forces. The preparation of such depigmented pollen proteins does not impair their allergenic potency or immunological specificity. The invention enables the production of fully active allergenic poll-en proteins devoid of adhering low-molecular weight substances interfering with their safety, diagnostic accuracy and clinical ef-ficacy. The purified pollen proteins represent improved starting materials for chemical derivatization, i.e., the preparation of at-tenuated vaccines for immunotherapy. The invention also provides suitable products for investigating the molecular structure of allergenic epitopes.
CA002145169A 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use Expired - Lifetime CA2145169C (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE122005000035C DE122005000035I2 (en) 1992-09-21 1992-09-21 PROCESS FOR CLEANING WAESSER EXTRACTS CONTAINING ALLERGENIC PROTEINS, EXTRACTS OBTAINED THEREOF, AND THEIR USE
PCT/NL1992/000160 WO1994006821A1 (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
DE200512000034 DE122005000034I1 (en) 1992-09-21 1992-09-21 Process for the purification of aqueous extracts containing allergenic proteins, extracts thus obtained and their use.
DE69217395T DE69217395T2 (en) 1992-09-21 1992-09-21 METHOD FOR PURIFYING AQUEOUS EXTRACTS CONTAINING ALLERGENIC PROTEINS, EXTRACTS SO OBTAINED, AND THEIR USE
AT92920684T ATE148708T1 (en) 1992-09-21 1992-09-21 METHOD FOR PURIFYING AQUEOUS EXTRACTS CONTAINING ALLERGENIC PROTEINS, EXTRACTS SO OBTAINED AND THEIR USE
CA002145169A CA2145169C (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
EP92920684A EP0662080B1 (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
AU26486/92A AU675629B2 (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
JP50798394A JP3397791B2 (en) 1992-09-21 1992-09-21 Purification method of aqueous extract containing protein active as allergen, extract obtained by this method and use thereof
US08/403,832 US5770698A (en) 1992-09-21 1992-09-21 Process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
ES92920684T ES2098543T3 (en) 1992-09-21 1992-09-21 A PROCESS FOR THE PURIFICATION OF AQUEOUS EXTRACTS CONTAINING ALLERGENICALLY ACTIVE PROTEINS, EXTRACTS OBTAINABLE ACCORDING TO THIS PROCESS, AS WELL AS THEIR USE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/NL1992/000160 WO1994006821A1 (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use
CA002145169A CA2145169C (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use

Publications (2)

Publication Number Publication Date
CA2145169A1 true CA2145169A1 (en) 1994-03-31
CA2145169C CA2145169C (en) 2003-05-27

Family

ID=25677852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002145169A Expired - Lifetime CA2145169C (en) 1992-09-21 1992-09-21 A process for the purification of aqueous extracts containing allergenically active proteins, extracts obtainable according to this process as well as their use

Country Status (3)

Country Link
JP (1) JP3397791B2 (en)
CA (1) CA2145169C (en)
WO (1) WO1994006821A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302352B6 (en) 1997-10-30 2011-03-30 C. B. F. Leti, S. A. Process for preparing extracts providing tolerance against allergenic material and their use
DE502004008649D1 (en) * 2004-09-18 2009-01-22 Protectimmun Gmbh Barn dust extract for protection against allergies
EP1834649A1 (en) * 2006-03-14 2007-09-19 Alk-Abello A/S Method of developing a process for producing an allergen extract
EP1834648B1 (en) * 2006-03-14 2013-07-31 Alk-Abelló A/S Process for producing an allergen extract
EP1872792A1 (en) * 2006-06-29 2008-01-02 Biotech Tools S.A. A method for the production of hydrolyzed allergen
US7887821B2 (en) 2007-12-20 2011-02-15 Alk-Abello A/S Process for producing an allergen extract
US9884111B2 (en) * 2010-02-12 2018-02-06 Laboratorios Leti, S.L. Process for producing an allergen extract
CN110124028A (en) * 2018-03-23 2019-08-16 中国医学科学院北京协和医院 A kind of pollen humuli scandentis allergen extract, immersion liquid and preparation method thereof
AU2019422413A1 (en) * 2019-01-17 2021-08-26 LETI Pharma S.L. Methods of purifying an allergen extract

Also Published As

Publication number Publication date
CA2145169C (en) 2003-05-27
WO1994006821A1 (en) 1994-03-31
JP3397791B2 (en) 2003-04-21
JPH08504187A (en) 1996-05-07

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Effective date: 20120921