CA2144189A1 - Prevention of stenosis - Google Patents
Prevention of stenosisInfo
- Publication number
- CA2144189A1 CA2144189A1 CA002144189A CA2144189A CA2144189A1 CA 2144189 A1 CA2144189 A1 CA 2144189A1 CA 002144189 A CA002144189 A CA 002144189A CA 2144189 A CA2144189 A CA 2144189A CA 2144189 A1 CA2144189 A1 CA 2144189A1
- Authority
- CA
- Canada
- Prior art keywords
- mycophenolate mofetil
- pharmaceutically acceptable
- acceptable salt
- mycophenolic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000031481 Pathologic Constriction Diseases 0.000 title claims abstract description 13
- 208000037804 stenosis Diseases 0.000 title claims abstract description 13
- 230000036262 stenosis Effects 0.000 title claims abstract description 13
- 230000002265 prevention Effects 0.000 title description 2
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- 229960004866 mycophenolate mofetil Drugs 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 28
- 238000002399 angioplasty Methods 0.000 claims abstract description 7
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- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229940014456 mycophenolate Drugs 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HJHVQCXHVMGZNC-JCJNLNMISA-M sodium;(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate Chemical compound [Na+].O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C([O-])=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C HJHVQCXHVMGZNC-JCJNLNMISA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI952479A FI952479L (fi) | 1992-11-24 | 1992-11-24 | Stenoosin ehkäisy |
| AU31782/93A AU3178293A (en) | 1992-11-24 | 1992-11-24 | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| HU9501067A HUT72753A (en) | 1992-11-24 | 1992-11-24 | Pharmaceutical compositions containing mycophenolic acid derivatives for inhibiting stenosis |
| JP6513067A JPH08503487A (ja) | 1992-11-24 | 1992-11-24 | 狭窄症を抑止するためのミコフェノール酸、ミコフェノール酸モフェチルまたはそれらの誘導体の使用 |
| EP93900534A EP0670724A1 (en) | 1992-11-24 | 1992-11-24 | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| CA002144189A CA2144189A1 (en) | 1992-11-24 | 1992-11-24 | Prevention of stenosis |
| PCT/US1992/009932 WO1994012184A1 (en) | 1992-11-24 | 1992-11-24 | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
| NO951966A NO951966L (enrdf_load_stackoverflow) | 1992-11-24 | 1995-05-18 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98083892A | 1992-11-24 | 1992-11-24 | |
| CA002144189A CA2144189A1 (en) | 1992-11-24 | 1992-11-24 | Prevention of stenosis |
| PCT/US1992/009932 WO1994012184A1 (en) | 1992-11-24 | 1992-11-24 | Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2144189A1 true CA2144189A1 (en) | 1994-06-09 |
Family
ID=27169974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002144189A Abandoned CA2144189A1 (en) | 1992-11-24 | 1992-11-24 | Prevention of stenosis |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA2144189A1 (enrdf_load_stackoverflow) |
| NO (1) | NO951966L (enrdf_load_stackoverflow) |
-
1992
- 1992-11-24 CA CA002144189A patent/CA2144189A1/en not_active Abandoned
-
1995
- 1995-05-18 NO NO951966A patent/NO951966L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO951966D0 (enrdf_load_stackoverflow) | 1995-05-18 |
| NO951966L (enrdf_load_stackoverflow) | 1995-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |