CA2143455A1 - A method for producing taxol and taxanes from embryo cultures of taxus species - Google Patents

A method for producing taxol and taxanes from embryo cultures of taxus species

Info

Publication number
CA2143455A1
CA2143455A1 CA2143455A CA2143455A CA2143455A1 CA 2143455 A1 CA2143455 A1 CA 2143455A1 CA 2143455 A CA2143455 A CA 2143455A CA 2143455 A CA2143455 A CA 2143455A CA 2143455 A1 CA2143455 A1 CA 2143455A1
Authority
CA
Canada
Prior art keywords
taxus species
taxanes
taxol
embryo
embryo cultures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2143455A
Other languages
French (fr)
Other versions
CA2143455C (en
Inventor
Bo-Sik Lee
Sung-Ho Son
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forest Genetics Research Institute
Original Assignee
Bo-Sik Lee
Sung-Ho Son
Forest Genetics Research Institute, Forestry Administration In Republic Of Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bo-Sik Lee, Sung-Ho Son, Forest Genetics Research Institute, Forestry Administration In Republic Of Korea filed Critical Bo-Sik Lee
Publication of CA2143455A1 publication Critical patent/CA2143455A1/en
Application granted granted Critical
Publication of CA2143455C publication Critical patent/CA2143455C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein is methods of taxol and taxane production through extraction of tissue of Taxus species and cell culture thereof. The method of production of taxol and its derivatives by extracting tissues and/or culture medium of Taxus species is characterized in that said tissue is zygote embryo. Cell culture of zygote embryo of Taxus species can be carried out by inducing somatic embryo or embryogenic callus.
CA002143455A 1993-07-06 1994-07-06 A method for producing taxol and taxanes from embryo cultures of taxus species Expired - Fee Related CA2143455C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR1993-12641 1993-07-06
KR930012641 1993-07-06
KR1019940013914A KR950005081B1 (en) 1993-07-06 1994-06-20 Method for producing taxol and its derivatives from embryo cultures of taxus species
KR1994-13914 1994-06-20
PCT/KR1994/000088 WO1995002063A1 (en) 1993-07-06 1994-07-06 A method for producing taxol and taxanes from embryo cultures of taxus species

Publications (2)

Publication Number Publication Date
CA2143455A1 true CA2143455A1 (en) 1995-01-19
CA2143455C CA2143455C (en) 1999-09-07

Family

ID=26629770

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002143455A Expired - Fee Related CA2143455C (en) 1993-07-06 1994-07-06 A method for producing taxol and taxanes from embryo cultures of taxus species

Country Status (8)

Country Link
EP (1) EP0662144A1 (en)
JP (1) JP2795542B2 (en)
KR (1) KR950005081B1 (en)
CN (1) CN1047795C (en)
AU (1) AU675147B2 (en)
CA (1) CA2143455C (en)
RU (1) RU2120740C1 (en)
WO (1) WO1995002063A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
BR9709361B1 (en) 1996-05-24 2009-05-05 increased taxane production by taxus species cell cultures.
CN1055120C (en) * 1996-11-27 2000-08-02 天津大学 Method for improving content and release of yew alcohol in Taxus chinensis cell
KR100287465B1 (en) * 1997-06-25 2001-05-02 나까니시 히로유끼 Method for producing taxane type diterpenes
KR100432426B1 (en) * 2001-07-11 2004-05-22 엔프라니 주식회사 Method for preparing Taxus seed extract and Taxus seed oil, and cosmetic composition containing them
KR20030066162A (en) * 2002-02-04 2003-08-09 (주)하나이피에스 Dha jerk fish meat
AU2008202078B2 (en) * 2007-10-10 2012-05-31 Wellkey Holdings Limited Stability of secondary metabolite mass production through synchronized plant cell cultures
KR20100127727A (en) * 2009-05-26 2010-12-06 주식회사 운화 Plant stem cell derived from cambium of family salicaceae and method of isolating and culturing the same
EP2436757A2 (en) * 2009-05-26 2012-04-04 Unhwa Corporation Plant stem cell derived from cambium of family asteraceae and method for the isolated culturing thereof
JP2012527890A (en) * 2009-05-28 2012-11-12 株式会社ウンファ Plant stem cells derived from the formation layer of Ziraceae and method for separating and culturing the same
JP2012217441A (en) * 2011-04-14 2012-11-12 Housetec Inc Method for producing taxanes, and method for inducing callus
CN103923873A (en) * 2014-03-18 2014-07-16 上海交通大学 Method for reducing plant cell browning risk through absorption of quinone substances with silica gel
KR20180080487A (en) * 2017-01-04 2018-07-12 대한민국(산림청 국립산림과학원장) Method of enhancing embryogenic tissue growth by treatment of anti-browning and polyamines in Japanese larch
CN114788496B (en) * 2022-04-07 2023-07-21 江苏省中国科学院植物研究所 Method for inducing efficient embryogenesis of larch through solid-liquid alternate culture
KR102519385B1 (en) * 2022-10-07 2023-04-06 유성근 Manufacturing method of seasoned drying fillet using scallop coat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
JPH05507629A (en) * 1991-02-12 1993-11-04 新日本製鐵株式会社 Production method of taxol by yew tissue culture
US5344775A (en) * 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
CA2131532A1 (en) * 1992-04-01 1993-10-14 Steven R. Wann Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
US5322779A (en) * 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
EP0642586A4 (en) * 1992-05-21 1995-11-29 Penn State Res Found CULTURED -i(TAXUS) TISSUES AS A SOURCE OF TAXOL, RELATED TAXANES AND OTHER NOVEL ANTI-TUMOR/ANTI-VIRAL COMPOUNDS.

Also Published As

Publication number Publication date
EP0662144A1 (en) 1995-07-12
RU95109640A (en) 1997-06-10
CN1047795C (en) 1999-12-29
AU675147B2 (en) 1997-01-23
RU2120740C1 (en) 1998-10-27
KR950002782A (en) 1995-02-16
AU7085994A (en) 1995-02-06
KR950005081B1 (en) 1995-05-18
JP2795542B2 (en) 1998-09-10
CA2143455C (en) 1999-09-07
WO1995002063A1 (en) 1995-01-19
CN1111911A (en) 1995-11-15
JPH08503618A (en) 1996-04-23

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