CA2137910A1 - Use of microcapsules as contrasting agents in colour doppler sonography - Google Patents

Use of microcapsules as contrasting agents in colour doppler sonography

Info

Publication number
CA2137910A1
CA2137910A1 CA002137910A CA2137910A CA2137910A1 CA 2137910 A1 CA2137910 A1 CA 2137910A1 CA 002137910 A CA002137910 A CA 002137910A CA 2137910 A CA2137910 A CA 2137910A CA 2137910 A1 CA2137910 A1 CA 2137910A1
Authority
CA
Canada
Prior art keywords
microcapsules
contrasting agents
doppler sonography
colour doppler
colour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002137910A
Other languages
French (fr)
Other versions
CA2137910C (en
Inventor
Michael Reinhardt
Thomas Fritzsch
Dieter Heldmann
Joachim Siegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2137910A1 publication Critical patent/CA2137910A1/en
Application granted granted Critical
Publication of CA2137910C publication Critical patent/CA2137910C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/8979—Combined Doppler and pulse-echo imaging systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • Remote Sensing (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Cosmetics (AREA)
  • Ink Jet (AREA)

Abstract

The invention concerns the use of gas-filled or liquid-filled microcapsules as ultrasonic contrasting agents to contrast regions of the body in which substantially no microcapsule movement is observed, the examination being carried out using colour Doppler sonography.
CA002137910A 1992-06-13 1993-04-24 Use of microcapsules as contrasting agents in colour doppler sonography Expired - Fee Related CA2137910C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4219724A DE4219724A1 (en) 1992-06-13 1992-06-13 Use of microcapsules as a contrast medium for color Doppler sonography
DEP4219724.4 1992-06-13
PCT/EP1993/000991 WO1993025241A1 (en) 1992-06-13 1993-04-24 Use of microcapsules as contrasting agents in colour doppler sonography

Publications (2)

Publication Number Publication Date
CA2137910A1 true CA2137910A1 (en) 1993-12-23
CA2137910C CA2137910C (en) 2003-06-03

Family

ID=6461145

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002137910A Expired - Fee Related CA2137910C (en) 1992-06-13 1993-04-24 Use of microcapsules as contrasting agents in colour doppler sonography

Country Status (10)

Country Link
EP (1) EP0644776B1 (en)
JP (1) JPH07507778A (en)
AT (1) ATE173937T1 (en)
CA (1) CA2137910C (en)
DE (2) DE4219724A1 (en)
DK (1) DK0644776T3 (en)
ES (1) ES2127277T3 (en)
GR (1) GR3029494T3 (en)
NO (1) NO308510B1 (en)
WO (1) WO1993025241A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
IL116328A (en) † 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
DE19510690A1 (en) * 1995-03-14 1996-09-19 Schering Ag Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy
GB9701274D0 (en) 1997-01-22 1997-03-12 Andaris Ltd Ultrasound contrast imaging
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
DE19925311B4 (en) 1999-05-27 2004-06-09 Schering Ag Multi-stage process for the production of gas-filled microcapsules
DE10013850A1 (en) * 2000-03-15 2001-09-20 Schering Ag Gas-filled microcapsules, useful for ultrasonic diagnosis, are prepared from functionalized poly(alkyl cyanoacrylate), allowing attachment of e.g. specific-binding agents
EP2286843A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
US6558399B1 (en) 2000-06-30 2003-05-06 Abbott Laboratories Devices and method for handling a plurality of suture elements during a suturing procedure
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
JP3991086B2 (en) 2000-12-23 2007-10-17 ダイアックス、コープ Fibrin binding moiety useful as a contrast agent
US9370353B2 (en) 2010-09-01 2016-06-21 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US8858573B2 (en) 2012-04-10 2014-10-14 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US9241707B2 (en) 2012-05-31 2016-01-26 Abbott Cardiovascular Systems, Inc. Systems, methods, and devices for closing holes in body lumens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586875A1 (en) * 1988-02-05 1994-03-16 Schering Aktiengesellschaft Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
GB9009423D0 (en) * 1990-04-26 1990-06-20 Williams Alun R Assessment of vascular perfusion by the display of harmonic echoes from ultrasonically excited gas bubbles
JPH0793927B2 (en) * 1990-11-02 1995-10-11 富士通株式会社 Ultrasonic color Doppler diagnostic device

Also Published As

Publication number Publication date
JPH07507778A (en) 1995-08-31
GR3029494T3 (en) 1999-05-28
NO944806L (en) 1994-12-12
EP0644776B1 (en) 1998-12-02
DE4219724A1 (en) 1993-12-16
ES2127277T3 (en) 1999-04-16
EP0644776A1 (en) 1995-03-29
ATE173937T1 (en) 1998-12-15
NO308510B1 (en) 2000-09-25
DE59309189D1 (en) 1999-01-14
WO1993025241A1 (en) 1993-12-23
NO944806D0 (en) 1994-12-12
DK0644776T3 (en) 1999-08-16
CA2137910C (en) 2003-06-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed