CA2123160A1 - Controlled release formulation - Google Patents

Controlled release formulation

Info

Publication number
CA2123160A1
CA2123160A1 CA002123160A CA2123160A CA2123160A1 CA 2123160 A1 CA2123160 A1 CA 2123160A1 CA 002123160 A CA002123160 A CA 002123160A CA 2123160 A CA2123160 A CA 2123160A CA 2123160 A1 CA2123160 A1 CA 2123160A1
Authority
CA
Canada
Prior art keywords
controlled release
release formulation
pharmaceutically acceptable
acceptable salt
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002123160A
Other languages
French (fr)
Other versions
CA2123160C (en
Inventor
Ronald Brown Miller
Stewart Thomas Leslie
Sandra Therese Antoinette Malkowska
Kevin John Smith
Walter Wimmer
Horst Winkler
Udo Hahn
Derek Allan Prater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Ronald Brown Miller
Stewart Thomas Leslie
Sandra Therese Antoinette Malkowska
Kevin John Smith
Walter Wimmer
Horst Winkler
Udo Hahn
Derek Allan Prater
Euroceltique S.A.
Euro-Celtique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to DEP4315525.1 priority Critical
Priority to DE4315525A priority patent/DE4315525B4/en
Priority to GB9324045A priority patent/GB2284760B/en
Priority to GB9324045.5 priority
Priority to GB9404544.0 priority
Priority to GB9404544A priority patent/GB9404544D0/en
Priority to GB9404928.5 priority
Priority to GB9404928A priority patent/GB2287880A/en
Application filed by Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Kevin John Smith, Walter Wimmer, Horst Winkler, Udo Hahn, Derek Allan Prater, Euroceltique S.A., Euro-Celtique, S.A. filed Critical Ronald Brown Miller
Publication of CA2123160A1 publication Critical patent/CA2123160A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27435744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2123160(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application granted granted Critical
Publication of CA2123160C publication Critical patent/CA2123160C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • A61P29/02Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs) without antiinflammatory effect

Abstract

A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
CA002123160A 1993-05-10 1994-05-09 Controlled release formulation Expired - Lifetime CA2123160C (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DEP4315525.1 1993-05-10
DE4315525A DE4315525B4 (en) 1993-05-10 1993-05-10 Pharmaceutical composition
GB9324045A GB2284760B (en) 1993-11-23 1993-11-23 A method of preparing pharmaceutical compositions by melt pelletisation
GB9324045.5 1993-11-23
GB9404544.0 1994-03-09
GB9404544A GB9404544D0 (en) 1994-03-09 1994-03-09 Controlled release formulation
GB9404928.5 1994-03-14
GB9404928A GB2287880A (en) 1994-03-14 1994-03-14 Production of sustained release compositions

Publications (2)

Publication Number Publication Date
CA2123160A1 true CA2123160A1 (en) 1994-11-11
CA2123160C CA2123160C (en) 2003-04-29

Family

ID=27435744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002123160A Expired - Lifetime CA2123160C (en) 1993-05-10 1994-05-09 Controlled release formulation

Country Status (22)

Country Link
US (6) US5591452A (en)
EP (6) EP1468679B1 (en)
JP (3) JP3045924B2 (en)
CN (2) CN1094755C (en)
AT (5) AT303140T (en)
AU (2) AU6196394A (en)
CA (1) CA2123160C (en)
CZ (1) CZ288517B6 (en)
DE (8) DE69435295D1 (en)
DK (4) DK0699436T4 (en)
ES (5) ES2247574T3 (en)
FI (3) FI942092A (en)
GR (2) GR3020084T3 (en)
HU (1) HU228177B1 (en)
ID (1) ID25988A (en)
IL (3) IL119660A (en)
NO (3) NO306446B1 (en)
NZ (1) NZ260408A (en)
PT (3) PT1468679E (en)
SG (1) SG67347A1 (en)
SK (2) SK283143B6 (en)
TW (1) TW496736B (en)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681585A (en) * 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
KR100354702B1 (en) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 Manufacturing method and sustained release composition of pharmaceutical composition
IL119660A (en) 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
DE4329794C2 (en) * 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadol salt-containing drugs with delayed release
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5698210A (en) 1995-03-17 1997-12-16 Lee County Mosquito Control District Controlled delivery compositions and processes for treating organisms in a column of water or on land
US6262115B1 (en) * 1995-05-22 2001-07-17 Alza Coporation Method for the management of incontinence
US5912268A (en) * 1995-05-22 1999-06-15 Alza Corporation Dosage form and method for treating incontinence
GB9519363D0 (en) * 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE69826113T2 (en) * 1997-03-11 2005-01-20 Arakis Ltd., Saffron Walden R AND S-ENANTIOMER SEPARATED DOSAGE FORMS
DE19710008A1 (en) * 1997-03-12 1998-09-17 Basf Ag Solid, at least two-phase formulations of a sustained-release opioid analgesic
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
JP4083818B2 (en) 1997-06-06 2008-04-30 ディポメド,インコーポレイティド Gastric retentive oral drug dosage form for controlled release of highly soluble drugs
ES2263211T3 (en) * 1997-07-02 2006-12-01 Euro-Celtique S.A. FORMULATIONS OF STABILIZED SUSTAINED RELEASE TRAMADOL.
DE19729487A1 (en) * 1997-07-10 1999-01-14 Dresden Arzneimittel Process for the preparation of active ingredient preparations with controlled release from a matrix
CN1234362C (en) 1997-12-22 2006-01-04 欧罗赛铁克股份有限公司 Opioid agonist/antagonist combinations
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
IL136805D0 (en) * 1997-12-22 2001-11-25 Euro Celtique Sa A method of preventing abuse of opioid dosage forms
JP4367722B2 (en) * 1998-04-17 2009-11-18 大正製薬株式会社 Multiple unit type sustained release tablets
CA2328154A1 (en) 1998-04-17 1999-10-28 Taisho Pharmaceutical Co., Ltd. Multiple-unit sustained release tablets
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form
US20060128806A1 (en) * 1998-05-28 2006-06-15 Medical Research Institute Controlled release arginine alpha-ketoglutarate
US6264974B1 (en) 1998-07-07 2001-07-24 Salvagnini Italia Spa Buccal and sublingual administration of physostigmine
DE29818454U1 (en) * 1998-10-15 1999-01-14 Euro Celtique Sa Opioid analgesic
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
AU3469100A (en) * 1999-01-05 2000-07-24 Copley Pharmaceutical Inc. Sustained release formulation with reduced moisture sensitivity
DE19918325A1 (en) 1999-04-22 2000-10-26 Euro Celtique Sa Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives
CA2388560A1 (en) * 1999-08-31 2001-03-08 Grunenthal Gmbh Sustained-release form of administration containing tramadol saccharinate
SK285128B6 (en) 1999-12-28 2006-07-07 Zentiva, A. S. A remedy with controlled release comprising tramadol hydrochloride and method for preparation thereof
ES2540103T3 (en) 2000-02-08 2015-07-08 Euro-Celtique S.A. Oral formulations of opioid agonists resistant to improper manipulations
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20030119916A1 (en) 2000-03-01 2003-06-26 David Fowler Treatment of functional gastrointestinal disorders
AU2001294979B2 (en) * 2000-10-03 2007-03-29 Penwest Pharmaceuticals Company Delivery system for multi-pharmaceutical active materials at various release rates
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
DE10108122A1 (en) 2001-02-21 2002-10-02 Gruenenthal Gmbh Medicines based on tramadol
PT1397126E (en) * 2001-03-16 2006-10-31 Dmi Biosciences Inc USING TRAMADOL FOR DELAYING EJACULATION
US7858118B2 (en) * 2001-04-11 2010-12-28 Galephar Pharmaceutical Research, Inc. Extended release composition containing Tramadol
JP4522652B2 (en) 2001-05-11 2010-08-11 エンドー ファーマシューティカルズ, インコーポレイティド Abuse prevention controlled release opioid dosage form
US7052706B2 (en) * 2001-06-08 2006-05-30 Nostrum Pharmaceuticals, Inc. Control release formulation containing a hydrophobic material as the sustained release agent
US7968119B2 (en) * 2001-06-26 2011-06-28 Farrell John J Tamper-proof narcotic delivery system
MXPA04000584A (en) * 2001-07-18 2004-04-20 Euro Celtique Sa Pharmaceutical combinations of oxycodone and naloxone.
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
EP1414451B1 (en) 2001-08-06 2009-05-20 Euro-Celtique S.A. Opioid agonist formulations with releasable and sequestered antagonist
AU2002324624A1 (en) * 2001-08-06 2003-02-24 Euro-Celtique S.A. Sequestered antagonist formulations
US6479060B1 (en) * 2001-09-04 2002-11-12 Healthpoint, Ltd. Elegant hydrogenated castor oil ointments
JP2005508327A (en) 2001-09-28 2005-03-31 マクニール−ピーピーシー・インコーポレイテッド Modified release dosage form
PE20030527A1 (en) 2001-10-24 2003-07-26 Gruenenthal Chemie DELAYED-RELEASE PHARMACEUTICAL FORMULATION CONTAINING 3- (3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL) PHENOL OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME AND ORAL TABLETS CONTAINING IT
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
DE60210315T2 (en) * 2001-11-07 2006-11-02 Synthon B.V. TAMSULOSIN TABLETS
KR20030060730A (en) * 2002-01-09 2003-07-16 하나제약 주식회사 A sustained release pharmaceutical composition
EP1476138B8 (en) * 2002-02-21 2012-03-07 Valeant International (Barbados) SRL Modified release formulations of at least one form of tramadol
US8128957B1 (en) * 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
MXPA04009256A (en) * 2002-03-22 2005-01-25 Cilag Ag Sustained release formulation of tramadol.
GEP20074022B (en) 2002-04-05 2007-01-10 Euro Celtique Sa Pharmaceutical formulations comprising oxycodone and naloxone
US7125563B2 (en) 2002-04-12 2006-10-24 Dava Pharmaceuticals, Inc. Sustained release pharmaceutical preparations and methods for producing the same
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
WO2004002398A2 (en) * 2002-06-27 2004-01-08 Cilag Ag Spherical pellet containing a water-soluble active ingredient
DK1551372T3 (en) * 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
US20090304793A1 (en) * 2003-09-22 2009-12-10 Alpharma, Inc. Sustained release opioid formulations and methods of use
US20050020613A1 (en) * 2002-09-20 2005-01-27 Alpharma, Inc. Sustained release opioid formulations and method of use
WO2004026262A2 (en) * 2002-09-23 2004-04-01 Verion, Inc. Abuse-resistant pharmaceutical compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
MXPA05004410A (en) * 2002-10-25 2005-11-23 Labopharm Inc Controlled-release compositions.
CN1942175B (en) * 2002-10-25 2010-05-26 莱博法姆公司 Sustained-release tramadol formulations with 24-hour efficacy
AU2003275855B2 (en) * 2002-10-25 2009-04-23 Paladin Labs (Barbados) Inc. Sustained-release tramadol formulations with 24-hour efficacy
US20040086566A1 (en) * 2002-11-04 2004-05-06 Alpharma, Inc. Waxy matrix dosage forms
TW200427448A (en) * 2002-12-13 2004-12-16 Cilag Ag Controlled release preparations comprising tramadol and topiramate
DE10300325A1 (en) 2003-01-09 2004-07-22 Hexal Ag Granules with oily substance, manufacturing process and tablet
CN100500130C (en) * 2003-01-23 2009-06-17 株式会社太平洋 Sustained-release preparations and method for producing the same
EP1905435A3 (en) 2003-03-11 2008-05-14 Euro-Celtique S.A. Titration dosing regimen for controlled release tramadol
US7413749B2 (en) * 2003-03-11 2008-08-19 Purdue Pharma L.P. Titration dosing regimen for controlled release tramadol
US20040202717A1 (en) * 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) * 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
MY141815A (en) 2003-04-30 2010-06-30 Purdue Pharma Lp Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
KR20090029856A (en) * 2005-01-28 2009-03-23 유로-셀띠끄 소시에떼 아노님 Alcohol resistant dosage forms
DE102004020220A1 (en) * 2004-04-22 2005-11-10 Grünenthal GmbH Process for the preparation of a secured against misuse, solid dosage form
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
CA2601716C (en) 2004-06-25 2011-05-31 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
DE102004032051A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Process for the preparation of a secured against misuse, solid dosage form
DE102004032049A1 (en) * 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
US20070224281A1 (en) * 2004-07-22 2007-09-27 Amorepacific Corporation Sustained-Release Preparations Containing Topiramate and the Producing Method Thereof
GB0501638D0 (en) * 2005-01-28 2005-03-02 Euro Celtique Sa Particulates
JPWO2006080481A1 (en) * 2005-01-31 2008-06-19 杏林製薬株式会社 Multiple unit type oral sustained-release preparation and method for producing the same
BG66008B1 (en) * 2005-02-01 2010-10-29 Cooperative Clinical Drug Research And Development Ag Medicamentous preparation of changeable release
DE102005005449A1 (en) * 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
CA2578626C (en) 2005-06-27 2011-07-19 Biovail Laboratories International Srl Modified-release formulations of a bupropion salt
CA2615802C (en) * 2005-07-07 2015-10-06 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
JP5269595B2 (en) 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー Trazodone composition for once daily administration
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
US9125833B2 (en) * 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
WO2007087452A2 (en) * 2006-01-27 2007-08-02 Theraquest Biosciences, Llc Abuse resistant and extended release formulations and method of use thereof
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US8062667B2 (en) 2006-03-16 2011-11-22 Tris Pharma, Inc. Modified release formulations containing drug-ion exchange resin complexes
WO2007114376A1 (en) * 2006-03-30 2007-10-11 Nippon Zoki Pharmaceutical Co., Ltd. Solid pharmaceutical preparation
US20070264335A1 (en) * 2006-05-09 2007-11-15 Sherman Bernard C Modified release tablets comprising tramadol
BRPI0714039A2 (en) 2006-06-19 2014-12-23 Alpharma Inc PHARMACEUTICAL COMPOSITION
US20080069871A1 (en) * 2006-07-21 2008-03-20 Vaughn Jason M Hydrophobic abuse deterrent delivery system
SA2709B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
US20080261991A1 (en) 2007-02-12 2008-10-23 Dmi Biosciences, Inc. Reducing Side Effects of Tramadol
EP2120570B1 (en) 2007-02-12 2012-05-16 DMI Biosciences, Inc. Treatment of comorbid premature ejaculation and erectile dysfunction
EP2144599B1 (en) 2007-03-02 2010-08-04 Farnam Companies, Inc. Sustained release pellets comprising wax-like material
DE102007011485A1 (en) 2007-03-07 2008-09-11 Grünenthal GmbH Dosage form with more difficult abuse
US20080026054A1 (en) * 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
WO2009018169A1 (en) * 2007-07-27 2009-02-05 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
CZ300468B6 (en) * 2007-09-20 2009-05-27 Zentiva, A. S Tramadol-containing, 24 hours controlled release medicamentous formulation and process for preparing thereof
US20090081291A1 (en) * 2007-09-26 2009-03-26 Gin Jerry B Sustained Release Dosage Forms For Delivery of Agents to an Oral Cavity of a User
BRPI0818762B8 (en) * 2007-10-16 2021-05-25 Chimigen Inc bilayer immediate and controlled release pharmaceutical composition containing tramadol and acetaminophen, and use of a composition
RU2010129907A (en) 2007-12-17 2012-01-27 Лабофарм Инк. (CA) MEDICINAL FORM WITH MONITORED RELEASE PREVENTING PREVENTING IMPROPER USE
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
CA2709992A1 (en) * 2007-12-17 2009-07-16 Alpharma Pharmaceuticals, Llc Abuse resistant pharmaceutical compositions of opiod agonists
RU2493830C2 (en) 2008-01-25 2013-09-27 Грюненталь Гмбх Drug form
US20090246276A1 (en) * 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CA2720108C (en) * 2008-03-11 2016-06-07 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
MX2010012039A (en) 2008-05-09 2010-11-30 Gruenenthal Gmbh Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step.
GB0811024D0 (en) * 2008-06-17 2008-07-23 E Therapeutics Plc Sustained release treatment of depression
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
EP2317991B1 (en) * 2008-07-07 2017-05-03 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
BRPI0917206B1 (en) 2008-07-31 2018-04-17 Clarke Mosquito Control Products, Inc. METHOD FOR THE FORMATION OF A DOUBLE RELEASED TABLET, TABLETS AND METHOD FOR THE MANUFACTURE OF AN EXTENDED SOLID MATRIX
US20090176882A1 (en) * 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
EP2367541B1 (en) 2008-12-16 2014-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
EP3045043B1 (en) * 2009-02-26 2020-04-29 Relmada Therapeutics, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
EP2403487A2 (en) * 2009-03-04 2012-01-11 Fdc Limited Oral controlled release dosage forms for water soluble drugs
WO2010103039A1 (en) 2009-03-10 2010-09-16 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
US8811578B2 (en) * 2009-03-23 2014-08-19 Telemanager Technologies, Inc. System and method for providing local interactive voice response services
DE102009019268A1 (en) * 2009-04-28 2010-11-11 Lts Lohmann Therapie-Systeme Ag Perorally administrable solid drug, useful for the controlled release of active agent in gastrointestinal tract, comprises a porous matrix made of a material in which an active component is dissolved, emulsified, suspended or dispersed
TWI473628B (en) 2009-07-22 2015-02-21 Tamper-resistant dosage form for oxidation-sensitive opioids
ES2534908T3 (en) 2009-07-22 2015-04-30 Grünenthal GmbH Hot melt extruded controlled release dosage form
BR112012004525A2 (en) * 2009-08-31 2016-03-22 Depomed Inc gastric-profitable pharmaceutical compositions for immediate or prolonged release of acetaminophen
US20110104272A1 (en) * 2009-11-05 2011-05-05 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of acetaminophen and phenylephrine
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9579285B2 (en) * 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
EP2371356B1 (en) * 2010-03-12 2012-12-19 Phoeme GmbH Multi-particle pharmaceutical formulation for colon absorption
WO2012003968A1 (en) 2010-07-06 2012-01-12 Grünenthal GmbH Novel gastro- retentive dosage forms comprising a gaba analog and an opioid
EP2611426B1 (en) 2010-09-02 2014-06-25 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
AR082862A1 (en) 2010-09-02 2013-01-16 Gruenenthal Gmbh ALTERATION RESISTANT DOSAGE FORM INCLUDING AN ANIONIC POLYMER
US8623409B1 (en) 2010-10-20 2014-01-07 Tris Pharma Inc. Clonidine formulation
US8927010B2 (en) 2011-03-23 2015-01-06 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9283214B2 (en) 2011-03-23 2016-03-15 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US8916588B2 (en) 2011-03-23 2014-12-23 Ironshore Pharmaceuticals & Development, Inc. Methods for treatment of attention deficit hyperactivity disorder
CA2830788C (en) 2011-03-23 2016-05-17 Ironshore Pharmaceuticals & Development, Inc. Methods and compositions for treatment of attention deficit disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8658631B1 (en) 2011-05-17 2014-02-25 Mallinckrodt Llc Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
EP2736497B1 (en) 2011-07-29 2017-08-23 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
JP6117249B2 (en) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Tamper resistant dosage forms comprising a pharmacologically active compound and an anionic polymer
PT2838512T (en) 2012-04-18 2018-11-09 Gruenenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
DE102013009114A1 (en) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmaceutical composition to overcome metabolic problems
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
AR096438A1 (en) 2013-05-29 2015-12-30 Gruenenthal Gmbh DOSAGE FORM RESISTANT TO INDEBITED USE WITH BIMODAL RELEASE PROFILE, PROCESS
WO2014205228A1 (en) * 2013-06-19 2014-12-24 Orbis Biosciences, Inc. Tramadol particle formulations and methods
KR20160031526A (en) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
NZ716267A (en) 2013-07-23 2017-05-26 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
CA2931553C (en) 2013-11-26 2022-01-18 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
JP2017518980A (en) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Anti-modification immediate release capsule formulation containing tapentadol
MX2016015417A (en) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticles safeguarded against ethanolic dose-dumping.
MX2017013637A (en) 2015-04-24 2018-03-08 Gruenenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction.
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
CN106109431B (en) * 2015-12-18 2020-11-10 上海奕利制药有限公司 Sustained and controlled release pellet tablet and preparation method thereof
EP3703724A1 (en) 2017-11-02 2020-09-09 NatureCeuticals Sdn. Bhd. Extract of orthosiphon stamineus, formulations, and uses thereof
US20210308040A1 (en) * 2018-10-26 2021-10-07 Guangzhou Dazhou Biomedicine Ltd. Ketamine oral transmucosal delivery system
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol
US11103452B2 (en) 2019-11-08 2021-08-31 Athena Bioscience, Llc Tramadol hydrochloride solution

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US266331A (en) * 1882-10-24 walmsley
US2738303A (en) 1952-07-18 1956-03-13 Smith Kline French Lab Sympathomimetic preparation
US3065143A (en) 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
FR3618M (en) 1963-04-02 Gruenenthal Chemie New drugs based on basic substituted phenol ethers.
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US3830934A (en) * 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
GB1405088A (en) 1971-06-03 1975-09-03 Mundipharma Ag Slow release formulation
FR2183546B1 (en) 1972-05-10 1975-06-20 Servier Lab
US3965256A (en) 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4076798A (en) * 1975-05-29 1978-02-28 American Cyanamid Company High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition
DE2360796B2 (en) * 1973-12-06 1977-06-02 Edelfettwerke Werner Schlüter, 2000 Hamburg; Glyco Iberica S.A., Gava, Barcelona (Spanien) Vti: Hegel, K.Th., Dr.; Dickel, K., Dipl.-Ing.; Pat.-Anwälte, 2000 Hamburg und 8000 München MEDICINAL PRODUCTS WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE IN THE INTESTINE
US3974157A (en) * 1974-03-04 1976-08-10 Pennwalt Corporation 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
DE2426812A1 (en) * 1974-06-04 1976-01-02 Klinge Co Chem Pharm Fab PROCESS FOR THE MANUFACTURING OF GRANULES
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
US4259314A (en) * 1979-12-10 1981-03-31 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals
IE49324B1 (en) 1979-12-19 1985-09-18 Euro Celtique Sa Controlled release compositions
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
DE3024416C2 (en) 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Process for the production of medicaments with sustained release of active substances
JPS6340131B2 (en) * 1981-04-13 1988-08-09 Sankyo Kk
DE3124983C2 (en) 1981-06-25 1992-03-26 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim, De
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4987136A (en) * 1982-03-16 1991-01-22 The Rockefeller University Method for controlling gastrointestinal dysmotility
US4389393B1 (en) 1982-03-26 1985-10-22
US4421736A (en) * 1982-05-20 1983-12-20 Merrel Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
US4443428A (en) 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4421436A (en) * 1982-07-06 1983-12-20 Texaco Development Corporation Tension leg platform system
ZA836627B (en) 1982-10-08 1984-05-30 Verex Lab Constant release rate solid oral dosage formulation of pharmaceutical compounds having a high degree of water solubility
US4917899A (en) * 1983-12-22 1990-04-17 Elan Corporation Plc Controlled absorption diltiazem formulation
EP0147780A3 (en) * 1984-01-03 1987-03-11 Merck & Co. Inc. Drug delivery device
EP0152379A3 (en) 1984-02-15 1986-10-29 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
GB8405112D0 (en) * 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
US4894234A (en) 1984-10-05 1990-01-16 Sharma Shri C Novel drug delivery system for antiarrhythmics
EP0189861A3 (en) 1985-01-26 1988-02-17 Showa Denko Kabushiki Kaisha Percutaneous absorption accelerator for ionic water-soluble medicine
US4772475A (en) 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
NL8500724A (en) * 1985-03-13 1986-10-01 Univ Groningen DEVICES FOR REGULAR RELEASE OF ACTIVE SUBSTANCES AND METHOD OF MANUFACTURE THEREOF
EP0204951B1 (en) 1985-05-13 1993-01-20 Miles Inc. Use of calcium channel blockers in the production of compositions for withdrawal symptoms
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
JPH0371406B2 (en) * 1985-06-24 1991-11-13 Teisan Seiyaku Kk
FR2585246A1 (en) 1985-07-26 1987-01-30 Cortial PROCESS FOR OBTAINING SOLID PHARMACEUTICAL FORMS WITH PROLONGED RELEASE
GB8521350D0 (en) 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
IT1188212B (en) 1985-12-20 1988-01-07 Paolo Colombo SYSTEM FOR THE RELEASE SPEED OF ACTIVE SUBSTANCES
US4940665A (en) 1985-12-27 1990-07-10 Showa Denko K. K. Method for granulation of enzyme
DE3602370A1 (en) 1986-01-27 1987-08-06 Chrubasik Sigrun Use of analgesics by inhalation
GB2186485B (en) * 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
DE3612212A1 (en) * 1986-04-11 1987-10-15 Basf Ag METHOD FOR PRODUCING SOLID PHARMACEUTICAL FORMS
US4820523A (en) 1986-04-15 1989-04-11 Warner-Lambert Company Pharmaceutical composition
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613689D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
EP0249347B1 (en) * 1986-06-10 1994-06-29 Euroceltique S.A. Controlled release dihydrocodeine composition
DE3623193A1 (en) 1986-07-10 1988-01-14 Gruenenthal Gmbh NEW COMPOUNDS, THIS MEDICINAL PRODUCT AND METHOD FOR THE PRODUCTION THEREOF
JPH0816066B2 (en) 1986-07-18 1996-02-21 エーザイ株式会社 Long-acting drug
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4970075A (en) * 1986-07-18 1990-11-13 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4760094A (en) 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
GB8626098D0 (en) * 1986-10-31 1986-12-03 Euro Celtique Sa Controlled release hydromorphone composition
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
ZA882783B (en) 1987-06-10 1988-10-20 Warner-Lambert Company Process for preparing a pharmaceutical composition
DE3721721C1 (en) 1987-07-01 1988-06-09 Hoechst Ag Process for coating granules
GB8717168D0 (en) 1987-07-21 1987-08-26 Roussel Lab Ltd Controlled-release device
JPH01149717A (en) * 1987-12-04 1989-06-12 Showa Denko Kk Drug composition for rectal infusion
EP0327295A3 (en) 1988-02-01 1989-09-06 F.H. FAULDING & CO. LTD. Tetracycline dosage form
DE3812799A1 (en) 1988-04-16 1989-10-26 Sanol Arznei Schwarz Gmbh ORGANIC PREPARATION FOR THE PURPOSES OF AN ACTUATED ACTIVE INGREDIENTS AND METHOD OF PREPARING THEM
US5472710A (en) 1988-04-16 1995-12-05 Schwarz Pharma Ag Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
JP2681373B2 (en) 1988-07-18 1997-11-26 塩野義製薬株式会社 Method for manufacturing sustained-release preparation
US4925675A (en) * 1988-08-19 1990-05-15 Himedics, Inc. Erythromycin microencapsulated granules
GB8820327D0 (en) 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
DE3830353A1 (en) 1988-09-07 1990-03-15 Basf Ag METHOD FOR THE CONTINUOUS PRODUCTION OF SOLID PHARMACEUTICAL FORMS
AT107854T (en) 1988-09-30 1994-07-15 Rhone Poulenc Rorer Ltd PHARMACEUTICAL GRANULES.
US5178868A (en) 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
AU645003B2 (en) 1988-11-08 1994-01-06 Takeda Chemical Industries Ltd. Sustained release preparations
CA2002492A1 (en) 1988-11-11 1990-05-11 Sandra T. A. Malkowska Pharmaceutical ion exchange resin composition
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
CA2007055A1 (en) 1989-01-06 1990-07-06 Garth Boehm Theophylline dosage form
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5330766A (en) * 1989-01-06 1994-07-19 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5196203A (en) 1989-01-06 1993-03-23 F. H. Faulding & Co. Limited Theophylline dosage form
FR2642420B1 (en) 1989-01-27 1991-09-06 Valpan Sa Labo Pharma NEW FORMAL RELEASE GALENIC FORM CONTAINING A COMBINATION OF FERROUS SALTS, SUCCINIC ACID AND ASCORBIC ACID
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5126145A (en) 1989-04-13 1992-06-30 Upsher Smith Laboratories Inc Controlled release tablet containing water soluble medicament
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
JPH0642655Y2 (en) * 1989-05-12 1994-11-09 トミー株式会社 Orthodontic bracket with hook
DK161743C (en) 1989-07-03 1992-02-17 Niro Atomizer As PROCEDURE AND APPARATUS FOR AGGLOMERATION OF A POWDER-SHAPED MATERIAL
EP0415693A1 (en) 1989-08-28 1991-03-06 Arizona Technology Development Corporation Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence
US5169645A (en) * 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
IL96311A (en) 1989-12-01 1995-05-26 Abbott Lab Sustained-release drug dosage units
JPH04217925A (en) * 1990-03-27 1992-08-07 Nippon Saafuakutanto Kogyo Kk New antipyretic, antiphlogistic and analgesic agent composition
JP3191948B2 (en) 1990-04-12 2001-07-23 塩野義製薬株式会社 Coated preparation and method for producing the same
HU208495B (en) 1990-06-27 1993-11-29 Alkaloida Vegyeszeti Gyar Process for producing retarde pharmaceutical compositions
WO1992001446A1 (en) * 1990-07-20 1992-02-06 Aps Research Limited Sustained-release formulations
FR2665357B1 (en) * 1990-07-31 1995-03-31 Aiache Jean Marc PROCESS FOR THE PREPARATION OF A BIO-ADHESIVE GALENIC FORM AND GALENIC FORM THUS PREPARED.
GB2246514B (en) 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
IE912955A1 (en) 1990-08-24 1992-02-26 Spirig Ag Process for the production of pellets
JP2875611B2 (en) * 1990-08-29 1999-03-31 エーザイ株式会社 Topical formulation containing calcium silicate
DE4031881C2 (en) 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Solvent-free, oral sustained-release pharmaceutical preparation and process for its preparation
SE9003296L (en) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab PROCEDURE SHOULD FORMULATE MEDICINAL PRODUCTS
US5271934A (en) * 1990-10-22 1993-12-21 Revlon Consumer Products Corporation Encapsulated antiperspirant salts and deodorant/antiperspirants
US5603956A (en) 1990-11-27 1997-02-18 Labopharm Inc. Cross-linked enzymatically controlled drug release
CA2041774C (en) 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
US5403593A (en) 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
US5132142A (en) 1991-03-19 1992-07-21 Glatt Gmbh Apparatus and method for producing pellets by layering power onto particles
IT1245891B (en) * 1991-04-12 1994-10-25 Alfa Wassermann Spa CONTROLLED RELEASE PHARMACEUTICAL FORMULATIONS FOR ORAL USE GAS RESISTANT CONTAINING BILE ACIDS AND THEIR SALTS.
IT1251153B (en) 1991-08-06 1995-05-04 Vectorpharma Int SOLID PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION HAVING PROHIBITED GASTRIC RESIDENCE
DK0534628T3 (en) 1991-09-06 1996-12-09 Mcneilab Inc Preparations containing a tramadol material and any one of codeine, oxycodone or hydrocodone, and use thereof
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
GB9121204D0 (en) 1991-10-04 1991-11-20 Euro Celtique Sa Medicament
WO1993007859A1 (en) * 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US5162117A (en) * 1991-11-22 1992-11-10 Schering Corporation Controlled release flutamide composition
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5958459A (en) 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5167964A (en) 1992-02-14 1992-12-01 Warner-Lambert Company Semi-enteric drug delivery systems and methods for preparing same
SE9200858L (en) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Method for producing delayed release pellets
JP2568202Y2 (en) 1992-10-13 1998-04-08 オリエンタル写真工業株式会社 Magazine for roll material
DE4236752A1 (en) 1992-10-30 1994-05-05 Asta Medica Ag Combination preparation of flupirtine and morphine for the treatment of pain and for avoiding morphine addiction
US5321012A (en) 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
US5616343A (en) 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
SE9301057L (en) * 1993-03-30 1994-10-01 Pharmacia Ab Controlled release preparation
KR100354702B1 (en) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 Manufacturing method and sustained release composition of pharmaceutical composition
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
IL119660A (en) 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
IL109944A (en) 1993-07-01 1998-12-06 Euro Celtique Sa Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
DE4329794C2 (en) 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadol salt-containing drugs with delayed release
US5478577A (en) 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
GB2287880A (en) 1994-03-14 1995-10-04 Euro Celtique Sa Production of sustained release compositions
US5395626A (en) * 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
CA2173818A1 (en) 1996-04-10 1997-10-11 Francois Chouinard Time-released pharmaceutical compound containing a cured amylose-based support and hydroxypropylmethylcellulose
ES2263211T3 (en) 1997-07-02 2006-12-01 Euro-Celtique S.A. FORMULATIONS OF STABILIZED SUSTAINED RELEASE TRAMADOL.
IL136805D0 (en) 1997-12-22 2001-11-25 Euro Celtique Sa A method of preventing abuse of opioid dosage forms
US6284273B1 (en) 1998-02-24 2001-09-04 Vincent Lenaerts Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
US6338859B1 (en) 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
US6607748B1 (en) 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Also Published As

Publication number Publication date
NO306446B1 (en) 1999-11-08
US20010036477A1 (en) 2001-11-01
CZ288517B6 (en) 2001-07-11
EP1468679B1 (en) 2005-08-31
IL109460A (en) 1998-03-10
JP2002154954A (en) 2002-05-28
IL109460D0 (en) 1994-07-31
DE69400215T2 (en) 1996-10-31
EP1527775A1 (en) 2005-05-04
DE69427472D1 (en) 2001-07-19
FI122717B (en) 2012-06-15
CN1099262A (en) 1995-03-01
SK279971B6 (en) 1999-06-11
DE69427472T2 (en) 2001-11-08
ID25988A (en) 1994-11-10
FI942092A0 (en) 1994-05-06
US20090117191A1 (en) 2009-05-07
HUT75703A (en) 1997-05-28
EP1468679A3 (en) 2004-11-24
NO941719L (en) 1994-11-11
ES2331046T1 (en) 2009-12-21
EP0624366B1 (en) 1996-05-29
EP0699436A1 (en) 1996-03-06
CN1146410C (en) 2004-04-21
JP3443574B2 (en) 2003-09-02
HU228177B1 (en) 2013-01-28
TW496736B (en) 2002-08-01
HU9401478D0 (en) 1994-08-29
EP2103303B1 (en) 2014-10-08
NO20013566D0 (en) 2001-07-19
FI942092A (en) 1994-11-11
ES2159591T5 (en) 2013-06-11
DK0624366T3 (en) 1996-07-01
US7074430B2 (en) 2006-07-11
AT468850T (en) 2010-06-15
DE09004973T1 (en) 2010-01-14
DE699436T1 (en) 1997-04-10
IL119660D0 (en) 1997-02-18
CN1240132A (en) 2000-01-05
FI20030560A (en) 2003-04-14
DK0699436T3 (en) 2001-07-23
SK54194A3 (en) 1994-12-07
AT201989T (en) 2001-06-15
DE69435295D1 (en) 2010-07-08
DE9422335U1 (en) 2000-04-13
EP0624366A1 (en) 1994-11-17
NZ260408A (en) 1996-05-28
NO993484L (en) 1994-11-11
PT1527775E (en) 2010-07-29
DK0699436T4 (en) 2013-04-08
DE69427472T3 (en) 2013-08-08
EP1527775B1 (en) 2010-05-26
IL119660A (en) 2002-09-12
ES2247574T3 (en) 2006-03-01
DE09004973T8 (en) 2010-10-21
JPH11124327A (en) 1999-05-11
NO331650B1 (en) 2012-02-13
EP0699436B2 (en) 2013-03-20
AT138566T (en) 1996-06-15
AU6196394A (en) 1994-11-17
DK1527775T3 (en) 2010-09-27
JP3045924B2 (en) 2000-05-29
DE729751T1 (en) 1997-03-13
NO20013566L (en) 1994-11-11
SG67347A1 (en) 1999-09-21
ES2159591T3 (en) 2001-10-16
PT699436E (en) 2001-10-30
ES2088312T3 (en) 1996-08-01
NO941719D0 (en) 1994-05-09
PT1468679E (en) 2005-11-30
JPH0753361A (en) 1995-02-28
AT3413U2 (en) 2000-03-27
US6254887B1 (en) 2001-07-03
FI20105856A (en) 2010-08-17
DE69434479T2 (en) 2006-02-23
EP0729751A1 (en) 1996-09-04
NO313124B1 (en) 2002-08-19
EP1468679A2 (en) 2004-10-20
US20060269603A1 (en) 2006-11-30
CA2123160C (en) 2003-04-29
EP0699436B1 (en) 2001-06-13
EP2103303A2 (en) 2009-09-23
DE69434479D1 (en) 2005-10-06
US6326027B1 (en) 2001-12-04
DE69400215D1 (en) 1996-07-04
NO993484D0 (en) 1999-07-15
GR3036565T3 (en) 2001-12-31
CZ109394A3 (en) 1994-11-16
GR3020084T3 (en) 1996-08-31
AU3995797A (en) 1997-12-18
FI121565B (en) 2011-01-14
US5591452A (en) 1997-01-07
EP2103303A3 (en) 2009-12-02
JP3267561B2 (en) 2002-03-18
DK1468679T3 (en) 2005-11-14
AT3413U3 (en) 2000-08-25
ES2346651T3 (en) 2010-10-19
AT303140T (en) 2005-09-15
CN1094755C (en) 2002-11-27
SK283143B6 (en) 2003-03-04

Similar Documents

Publication Publication Date Title
CA2123160A1 (en) Controlled release formulation
WO1997012583A3 (en) Stable compositions containing n-propargyl-1-aminoindan
CA2131350A1 (en) Sustained release drug formulation containing a tramadol salt
CA2213700A1 (en) Pharmaceutical composition for piperidinoalkanol compounds
CA2386690A1 (en) Pharmaceutical tramadol salts
EP1470816A3 (en) Once-a-day metoprolol oral dosage form
CA2163003A1 (en) Solubilizer and external preparations containing the same
AU7305594A (en) Physiologically active substance-prolonged releasing-type pharmaceutical preparation
CA2263404A1 (en) Pharmaceutical composition comprising coenzyme q10
CA2295035A1 (en) Pharmaceutical formulations containing voriconazole
CA2194167A1 (en) Hair-growing agent
HUT61303A (en) Process for producing compounds comprising 1,6-naphthyridine ring system and pharmaceutical compositions comprising same as active ingredient
CA2208230A1 (en) Controlled release formulation (albuterol)
CA2039197A1 (en) Pharmaceutic Formulation for the Treatment of Alcoholism
CA2382919A1 (en) Bicyclic imidazo-3-yl-amine derivatives
CA2326222A1 (en) Medicinal compositions
CA2199679A1 (en) Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical active ingredients
CA2000763A1 (en) Dispersable formulation
AU650484B2 (en) Isoxazole compound, pharmaceutically acceptable salt thereof, and medicinal use thereof
CA2347195A1 (en) Oral pharmaceutical compositions containing buprenorphin
AU692801B2 (en) Pharmaceutical compositions comprising a staurosporine as active ingredient.
CA2340054A1 (en) Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles
EP0522173A4 (en) 4-desoxy-4-epipodophyllotoxin derivative or pharmaceutically acceptable salt thereof
CA2220019A1 (en) Pharmaceutical composition containing tiagabine hydrochloride and the process for its preparation
AU3756797A (en) Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140509