CA2117181A1 - Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides - Google Patents

Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides

Info

Publication number
CA2117181A1
CA2117181A1 CA002117181A CA2117181A CA2117181A1 CA 2117181 A1 CA2117181 A1 CA 2117181A1 CA 002117181 A CA002117181 A CA 002117181A CA 2117181 A CA2117181 A CA 2117181A CA 2117181 A1 CA2117181 A1 CA 2117181A1
Authority
CA
Canada
Prior art keywords
lymphocytes
cytomegalovirus
cytolytic
polypeptides
induction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002117181A
Other languages
French (fr)
Other versions
CA2117181C (en
Inventor
Hema Pande
John A. Zaia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
City of Hope
Original Assignee
Hema Pande
John A. Zaia
City Of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP92915562A priority Critical patent/EP0605432B1/en
Priority to AU22972/92A priority patent/AU675204B2/en
Priority to CA002117181A priority patent/CA2117181C/en
Priority to DE69232265T priority patent/DE69232265T2/en
Priority to JP50324394A priority patent/JPH06510799A/en
Application filed by Hema Pande, John A. Zaia, City Of Hope filed Critical Hema Pande
Priority to PCT/US1992/005432 priority patent/WO1994000150A1/en
Priority claimed from PCT/US1992/005432 external-priority patent/WO1994000150A1/en
Publication of CA2117181A1 publication Critical patent/CA2117181A1/en
Application granted granted Critical
Publication of CA2117181C publication Critical patent/CA2117181C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Immunogens for use in human cytomegalovirus vaccines or skin tests which comprise human cytomegalovirus matrix proteins or fractions thereof are disclosed. It is also disclosed that such matrix proteins are target antigens for human cytomegalovirus specific cytotoxic T-lymphocytes.
CA002117181A 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides Expired - Lifetime CA2117181C (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU22972/92A AU675204B2 (en) 1992-06-25 1992-06-25 Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
CA002117181A CA2117181C (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides
DE69232265T DE69232265T2 (en) 1992-06-25 1992-06-25 INDUCTION OF CYTOLYTIC T-LYMPHOCYTEN WITH POLYPEPTIDES OF THE CYTOMEGALIEVIRUS
JP50324394A JPH06510799A (en) 1992-06-25 1992-06-25 Induction of cytolytic T-lymphocytes by cytomegalovirus polypeptides
EP92915562A EP0605432B1 (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides
PCT/US1992/005432 WO1994000150A1 (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002117181A CA2117181C (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides
PCT/US1992/005432 WO1994000150A1 (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides

Publications (2)

Publication Number Publication Date
CA2117181A1 true CA2117181A1 (en) 1994-01-06
CA2117181C CA2117181C (en) 2008-05-27

Family

ID=4153043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002117181A Expired - Lifetime CA2117181C (en) 1992-06-25 1992-06-25 Induction of cytolytic t-lymphocytes with cytomegalovirus polypeptides

Country Status (1)

Country Link
CA (1) CA2117181C (en)

Also Published As

Publication number Publication date
CA2117181C (en) 2008-05-27

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Legal Events

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EEER Examination request
MKEX Expiry