CA2115839C - Hla-restricted hepatitis b virus ctl epitopes - Google Patents
Hla-restricted hepatitis b virus ctl epitopes Download PDFInfo
- Publication number
- CA2115839C CA2115839C CA2115839A CA2115839A CA2115839C CA 2115839 C CA2115839 C CA 2115839C CA 2115839 A CA2115839 A CA 2115839A CA 2115839 A CA2115839 A CA 2115839A CA 2115839 C CA2115839 C CA 2115839C
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- Prior art keywords
- peptide
- ctl
- helper
- leu
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74956891A | 1991-08-26 | 1991-08-26 | |
| US82768292A | 1992-01-29 | 1992-01-29 | |
| US827,682 | 1992-01-29 | ||
| US87449192A | 1992-04-27 | 1992-04-27 | |
| US874,491 | 1992-04-27 | ||
| PCT/US1992/007218 WO1993003764A1 (en) | 1991-08-26 | 1992-08-26 | Hla-restricted hepatitis b virus ctl epitopes |
| US749,568 | 1996-11-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2115839A1 CA2115839A1 (en) | 1993-03-04 |
| CA2115839C true CA2115839C (en) | 2010-06-01 |
Family
ID=27419385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2115839A Expired - Lifetime CA2115839C (en) | 1991-08-26 | 1992-08-26 | Hla-restricted hepatitis b virus ctl epitopes |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP0534615B1 (no) |
| JP (2) | JP3738395B2 (no) |
| AU (1) | AU687725B2 (no) |
| BG (1) | BG98523A (no) |
| CA (1) | CA2115839C (no) |
| CZ (1) | CZ42794A3 (no) |
| DE (1) | DE69231621T2 (no) |
| ES (1) | ES2155060T3 (no) |
| FI (1) | FI940918A (no) |
| GR (1) | GR3035575T3 (no) |
| HU (1) | HUT68510A (no) |
| IL (1) | IL102964A0 (no) |
| NO (1) | NO940660L (no) |
| NZ (2) | NZ244103A (no) |
| OA (1) | OA09888A (no) |
| WO (1) | WO1993003764A1 (no) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322789B1 (en) | 1991-08-26 | 2001-11-27 | Epimmune, Inc. | HLA-restricted hepatitis B virus CTL epitopes |
| US5780036A (en) * | 1991-08-26 | 1998-07-14 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus |
| US6607727B1 (en) | 1991-08-26 | 2003-08-19 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus |
| US6419931B1 (en) * | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| US7611713B2 (en) | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
| US6689363B1 (en) | 1992-01-29 | 2004-02-10 | Epimmune Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
| US7252829B1 (en) | 1998-06-17 | 2007-08-07 | Idm Pharma, Inc. | HLA binding peptides and their uses |
| US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
| AU4998993A (en) * | 1992-08-07 | 1994-03-03 | Epimmune, Inc. | Hla binding peptides and their uses |
| US6235288B1 (en) | 1992-08-26 | 2001-05-22 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus |
| US9266930B1 (en) | 1993-03-05 | 2016-02-23 | Epimmune Inc. | Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions |
| ATE221387T1 (de) * | 1993-04-27 | 2002-08-15 | United Biomedical Inc | Immunogene lhrh peptidkonstrukion und synthetische, universale immunstimulatoren als impfstoffe |
| US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| US6413935B1 (en) | 1993-09-14 | 2002-07-02 | Epimmune Inc. | Induction of immune response against desired determinants |
| CN1135181A (zh) * | 1993-09-14 | 1996-11-06 | Cytel有限公司 | 使用泛dr结合肽改变免疫应答 |
| GB9325772D0 (en) * | 1993-12-16 | 1994-02-16 | Smithkline Beecham Biolog | Novel compounds |
| US5686068A (en) * | 1994-03-24 | 1997-11-11 | Ludwig Institute For Cancer Research | Isolated peptides derived from MAGE-2, cytolytic T cells specific to complexes of peptide and HLA-A2 molecules, and uses thereof |
| WO1998029442A1 (en) * | 1996-12-30 | 1998-07-09 | Innogenetics N.V. | ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES |
| ATE352556T1 (de) * | 1997-04-11 | 2007-02-15 | Sangstat Medical Corp | Zytomodulierende lipophile peptide zur modulation der immunsystemaktivität und hemmung von entzündungen |
| US7105164B1 (en) | 1998-04-07 | 2006-09-12 | Sanofi Pasteur Limited | HIV-specific cytotoxic T-cell responses |
| US20010019714A1 (en) * | 1998-04-07 | 2001-09-06 | Charles D. Y. Sia | Hiv-specific cytotoxic t-cell responses |
| CU22871A1 (es) | 1998-12-02 | 2003-10-21 | Ct Ingenieria Genetica Biotech | Formulaciones conteniendo partículas semejantes a virus como inmunopotenciadores por vía mucosal |
| JP4776131B2 (ja) | 1999-11-18 | 2011-09-21 | エピミューン インコーポレイテッド | ヘテロクリティックアナログおよび関連方法 |
| US7026443B1 (en) | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| US7462354B2 (en) | 1999-12-28 | 2008-12-09 | Pharmexa Inc. | Method and system for optimizing minigenes and peptides encoded thereby |
| US7585844B2 (en) * | 2004-04-21 | 2009-09-08 | The University Of Chicago | Myosin light chain kinase inhibitors and methods of use |
| US7943140B2 (en) * | 2006-08-14 | 2011-05-17 | Thymon, Llc | Compositions and methods for the treatment and prophylaxis of multiple strains and subtypes of HIV-1 |
| CN101568550B (zh) | 2006-10-17 | 2012-12-26 | 肿瘤疗法科学股份有限公司 | 用于表达mphosph1或depdc1多肽的癌症的肽疫苗 |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| EP2276495B1 (en) * | 2008-04-17 | 2018-11-21 | PDS Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| EP2391635B1 (en) | 2009-01-28 | 2017-04-26 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
| RU2555346C2 (ru) | 2009-08-07 | 2015-07-10 | Трансген Са | Композиция для лечения инфекции вирусом гепатита в |
| US10076570B2 (en) | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
| TWI575070B (zh) | 2011-07-12 | 2017-03-21 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
| JP5564730B2 (ja) | 2011-08-12 | 2014-08-06 | オンコセラピー・サイエンス株式会社 | Ｍｐｈｏｓｐｈ１ペプチドおよびそれを含むワクチン |
| JP6153526B2 (ja) * | 2011-09-06 | 2017-06-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | ポリペプチドワクチン |
| US20150250872A1 (en) | 2012-09-21 | 2015-09-10 | Frank Bedu-Addo | Vaccine compositions and methods of use |
| US20140220056A1 (en) * | 2013-02-05 | 2014-08-07 | Nitto Denko Corporation | Vaccine composition for transdermal administration |
| EP2762153A3 (en) * | 2013-02-05 | 2015-04-01 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| RU2765574C2 (ru) | 2015-08-12 | 2022-02-01 | Онкотерапи Сайенс, Инк. | Пептид, полученный из depdc1, и содержащая его вакцина |
| EP3347046B1 (en) * | 2015-09-08 | 2022-10-19 | Universität Zürich | Compositions against cat allergy |
| SG10201913531PA (en) | 2015-10-08 | 2020-03-30 | Oncotherapy Science Inc | Mphosph1-derived peptide, and vaccine including same |
| AU2016354590B2 (en) | 2015-11-13 | 2023-11-23 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935235A (en) * | 1979-05-24 | 1990-06-19 | The Regents Of The University Of California | Non-passageable viruses |
| US5017558A (en) * | 1980-01-14 | 1991-05-21 | The Regents Of The University Of California | Synthetic vaccine peptide epitomes of hepatitis B surface antigen |
| JPS60161999A (ja) * | 1984-02-02 | 1985-08-23 | Chemo Sero Therapeut Res Inst | ペプチド |
| US4882145A (en) * | 1986-12-09 | 1989-11-21 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4818527A (en) * | 1986-12-09 | 1989-04-04 | Scripps Clinic And Research Foundation | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| JPH03504975A (ja) * | 1988-06-14 | 1991-10-31 | セル―エスシーアイ コーポレイション | 異種官能性細胞免疫剤、それを含有するワクチン及びその使用方法 |
| IT1238343B (it) * | 1989-10-16 | 1993-07-13 | Cesalpino Andrea Fond | Procedimento per la preparazione di vaccini capaci di generare non solo la risposta immune dei linfociti t helper,ma anche un'efficace risposta di linfociti t citotossici,e vaccini con queste caratteristiche |
| EP0510054A1 (en) * | 1990-01-05 | 1992-10-28 | United Biomedical, Inc. | Hiv-1 core protein fragments |
-
1992
- 1992-08-26 IL IL102964A patent/IL102964A0/xx unknown
- 1992-08-26 CZ CS94427A patent/CZ42794A3/cs unknown
- 1992-08-26 EP EP92307764A patent/EP0534615B1/en not_active Expired - Lifetime
- 1992-08-26 AU AU25487/92A patent/AU687725B2/en not_active Ceased
- 1992-08-26 EP EP00102538A patent/EP1018344A3/en not_active Withdrawn
- 1992-08-26 NZ NZ244103A patent/NZ244103A/en unknown
- 1992-08-26 ES ES92307764T patent/ES2155060T3/es not_active Expired - Lifetime
- 1992-08-26 NZ NZ270605A patent/NZ270605A/en not_active IP Right Cessation
- 1992-08-26 CA CA2115839A patent/CA2115839C/en not_active Expired - Lifetime
- 1992-08-26 JP JP50466493A patent/JP3738395B2/ja not_active Expired - Lifetime
- 1992-08-26 HU HU9400581A patent/HUT68510A/hu unknown
- 1992-08-26 DE DE69231621T patent/DE69231621T2/de not_active Expired - Lifetime
- 1992-08-26 WO PCT/US1992/007218 patent/WO1993003764A1/en not_active Application Discontinuation
-
1994
- 1994-02-22 BG BG98523A patent/BG98523A/xx unknown
- 1994-02-25 FI FI940918A patent/FI940918A/fi not_active Application Discontinuation
- 1994-02-25 OA OA60475A patent/OA09888A/en unknown
- 1994-02-25 NO NO940660A patent/NO940660L/no unknown
-
2001
- 2001-03-14 GR GR20010400422T patent/GR3035575T3/el unknown
-
2003
- 2003-11-20 JP JP2003391442A patent/JP3586278B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO940660L (no) | 1994-04-22 |
| IL102964A0 (en) | 1993-01-31 |
| JP3586278B2 (ja) | 2004-11-10 |
| NZ270605A (en) | 1997-07-27 |
| FI940918A (fi) | 1994-04-08 |
| JP2004075693A (ja) | 2004-03-11 |
| EP0534615A3 (en) | 1994-05-25 |
| NO940660D0 (no) | 1994-02-25 |
| BG98523A (en) | 1995-05-31 |
| HUT68510A (en) | 1995-06-28 |
| FI940918A0 (fi) | 1994-02-25 |
| CZ42794A3 (en) | 1994-11-16 |
| DE69231621T2 (de) | 2001-05-31 |
| AU2548792A (en) | 1993-03-16 |
| WO1993003764A1 (en) | 1993-03-04 |
| JPH06510051A (ja) | 1994-11-10 |
| CA2115839A1 (en) | 1993-03-04 |
| ES2155060T3 (es) | 2001-05-01 |
| DE69231621D1 (de) | 2001-02-08 |
| EP0534615B1 (en) | 2001-01-03 |
| OA09888A (en) | 1994-09-15 |
| EP1018344A3 (en) | 2000-09-20 |
| EP1018344A2 (en) | 2000-07-12 |
| GR3035575T3 (en) | 2001-06-29 |
| JP3738395B2 (ja) | 2006-01-25 |
| HU9400581D0 (en) | 1994-05-30 |
| NZ244103A (en) | 1997-07-27 |
| EP0534615A2 (en) | 1993-03-31 |
| AU687725B2 (en) | 1998-03-05 |
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