CA2115346A1 - Anticorps chimerique anti-cea - Google Patents

Anticorps chimerique anti-cea

Info

Publication number
CA2115346A1
CA2115346A1 CA002115346A CA2115346A CA2115346A1 CA 2115346 A1 CA2115346 A1 CA 2115346A1 CA 002115346 A CA002115346 A CA 002115346A CA 2115346 A CA2115346 A CA 2115346A CA 2115346 A1 CA2115346 A1 CA 2115346A1
Authority
CA
Canada
Prior art keywords
sequence
seq
human
ser
none
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002115346A
Other languages
English (en)
Inventor
John E. Shively
Rainer Fischer
Anna Wu
Raymond Paxton
Y. H. Joy Yang (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
City of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by City of Hope filed Critical City of Hope
Publication of CA2115346A1 publication Critical patent/CA2115346A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002115346A 1992-06-15 1993-06-15 Anticorps chimerique anti-cea Abandoned CA2115346A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90407492A 1992-06-15 1992-06-15
US07/904,074 1992-06-15
PCT/US1993/005709 WO1993025237A1 (fr) 1992-06-15 1993-06-15 Anticorps chimerique anti antigene carcino-embryonnaire

Publications (1)

Publication Number Publication Date
CA2115346A1 true CA2115346A1 (fr) 1993-12-23

Family

ID=25418496

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002115346A Abandoned CA2115346A1 (fr) 1992-06-15 1993-06-15 Anticorps chimerique anti-cea

Country Status (5)

Country Link
EP (1) EP0606430A1 (fr)
JP (1) JPH06509947A (fr)
AU (1) AU4536693A (fr)
CA (1) CA2115346A1 (fr)
WO (1) WO1993025237A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
GB9712512D0 (en) 1997-06-16 1997-08-20 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921690A (en) * 1986-12-29 1990-05-01 City Of Hope Method of enhancing the biodistribution of antibody for localization in lesions
US5081235A (en) * 1989-07-26 1992-01-14 City Of Hope Chimeric anti-cea antibody

Also Published As

Publication number Publication date
JPH06509947A (ja) 1994-11-10
EP0606430A1 (fr) 1994-07-20
AU4536693A (en) 1994-01-04
WO1993025237A1 (fr) 1993-12-23

Similar Documents

Publication Publication Date Title
CA2070659C (fr) Preparation d'anticorps
US5968509A (en) Antibodies with binding affinity for the CD3 antigen
Neumaier et al. Cloning of the genes for T84. 66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chimeric human/mouse T84. 66 genes in myeloma and Chinese hamster ovary cells
AU606320B2 (en) Modular assembly of antibody genes, antibodies prepared thereby and use
US5877293A (en) CDR grafted anti-CEA antibodies and their production
Fell et al. Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting.
AU629401B2 (en) Chimeric anti-cea antibody
AU626254B2 (en) Chimeric antibody with specificity to human tumor antigen
CA2155934A1 (fr) Nouvelle famille d'anticorps chimeriques diriges contre les antigenes carcinoembryonnaires
HU215383B (hu) Humanizált antitest és eljárás előállítására
ZA200100478B (en) Hybrid human/rodent igg antibody to cd3, and methods of its construction.
GB2276169A (en) Antibodies specific for carcinoembryonic antigen
CA2115346A1 (fr) Anticorps chimerique anti-cea
US5075431A (en) Chimeric anti-CEA antibody
US6232123B1 (en) Monoclonal antibodies against leucocyte-specific G protein-coupled receptors
AU652923B2 (en) Specific binding agents
US5674994A (en) Polynucleotides encoding the anti-PEM antibody BW835 variable domains and expression vectors

Legal Events

Date Code Title Description
FZDE Discontinued