CA2114311A1 - Lignee cellulaire monoclonale de lymphocytes b wb - Google Patents
Lignee cellulaire monoclonale de lymphocytes b wbInfo
- Publication number
- CA2114311A1 CA2114311A1 CA2114311A CA2114311A CA2114311A1 CA 2114311 A1 CA2114311 A1 CA 2114311A1 CA 2114311 A CA2114311 A CA 2114311A CA 2114311 A CA2114311 A CA 2114311A CA 2114311 A1 CA2114311 A1 CA 2114311A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- protein
- cell
- cell line
- magnification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 15
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 238000003917 TEM image Methods 0.000 abstract 4
- 210000003935 rough endoplasmic reticulum Anatomy 0.000 abstract 4
- 210000003000 inclusion body Anatomy 0.000 abstract 3
- 210000003470 mitochondria Anatomy 0.000 abstract 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 abstract 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 abstract 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 abstract 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 abstract 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 abstract 2
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 abstract 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 abstract 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 abstract 2
- 102100033467 L-selectin Human genes 0.000 abstract 2
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 abstract 2
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 239000003636 conditioned culture medium Substances 0.000 abstract 2
- 238000001493 electron microscopy Methods 0.000 abstract 2
- 230000001788 irregular Effects 0.000 abstract 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 abstract 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 abstract 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 abstract 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000012980 RPMI-1640 medium Substances 0.000 abstract 1
- 102000040739 Secretory proteins Human genes 0.000 abstract 1
- 108091058545 Secretory proteins Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 230000001338 necrotic effect Effects 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 238000002135 phase contrast microscopy Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
- 210000003934 vacuole Anatomy 0.000 abstract 1
- 230000003442 weekly effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002114311A CA2114311C (fr) | 1991-11-25 | 1991-11-25 | Lignee cellulaire monoclonale de lymphocytes b wb |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002114311A CA2114311C (fr) | 1991-11-25 | 1991-11-25 | Lignee cellulaire monoclonale de lymphocytes b wb |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2114311A1 true CA2114311A1 (fr) | 1993-05-26 |
CA2114311C CA2114311C (fr) | 1996-02-27 |
Family
ID=4152799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002114311A Expired - Fee Related CA2114311C (fr) | 1991-11-25 | 1991-11-25 | Lignee cellulaire monoclonale de lymphocytes b wb |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2114311C (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0792278A1 (fr) * | 1994-11-07 | 1997-09-03 | Human Genome Sciences, Inc. | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
US6599719B2 (en) | 1994-11-07 | 2003-07-29 | Human Genome Sciences, Inc. | Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha |
US6824767B2 (en) | 1994-11-07 | 2004-11-30 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
-
1991
- 1991-11-25 CA CA002114311A patent/CA2114311C/fr not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0792278A1 (fr) * | 1994-11-07 | 1997-09-03 | Human Genome Sciences, Inc. | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
EP0792278A4 (fr) * | 1994-11-07 | 1999-09-22 | Human Genome Sciences Inc | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
US6599719B2 (en) | 1994-11-07 | 2003-07-29 | Human Genome Sciences, Inc. | Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha |
US6824767B2 (en) | 1994-11-07 | 2004-11-30 | Human Genome Sciences, Inc. | Tumor necrosis factor-gamma |
Also Published As
Publication number | Publication date |
---|---|
CA2114311C (fr) | 1996-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |