CA2108670A1 - Inhibitors of kynureninase - Google Patents

Inhibitors of kynureninase

Info

Publication number
CA2108670A1
CA2108670A1 CA002108670A CA2108670A CA2108670A1 CA 2108670 A1 CA2108670 A1 CA 2108670A1 CA 002108670 A CA002108670 A CA 002108670A CA 2108670 A CA2108670 A CA 2108670A CA 2108670 A1 CA2108670 A1 CA 2108670A1
Authority
CA
Canada
Prior art keywords
gamma
alpha
kynureninase
inhibitor
cysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002108670A
Other languages
English (en)
French (fr)
Inventor
Robert S. Phillips
Rajesh K. Dua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia Research Foundation Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/689,705 external-priority patent/US5254725A/en
Application filed by Individual filed Critical Individual
Publication of CA2108670A1 publication Critical patent/CA2108670A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002108670A 1991-04-18 1992-04-17 Inhibitors of kynureninase Abandoned CA2108670A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/689,705 1991-04-18
US07/689,705 US5254725A (en) 1991-04-18 1991-04-18 Inhibitors of kynureninase
US84040892A 1992-02-24 1992-02-24
US07/840,408 1992-02-24

Publications (1)

Publication Number Publication Date
CA2108670A1 true CA2108670A1 (en) 1992-10-19

Family

ID=27104468

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108670A Abandoned CA2108670A1 (en) 1991-04-18 1992-04-17 Inhibitors of kynureninase

Country Status (7)

Country Link
US (2) US5516936A (enExample)
EP (1) EP0581907A1 (enExample)
JP (1) JPH06510023A (enExample)
AU (1) AU668508B2 (enExample)
CA (1) CA2108670A1 (enExample)
NO (1) NO933726L (enExample)
WO (1) WO1992018003A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
US5786508A (en) * 1994-07-15 1998-07-28 Pharmacia & Upjohn S.P.A. Substituted kynurenines and process for their preparation
EP0897911B9 (en) * 1997-01-14 2004-12-01 Kaneka Corporation Process for producing cysteine derivatives
US6028354A (en) 1997-10-14 2000-02-22 Amkor Technology, Inc. Microelectronic device package having a heat sink structure for increasing the thermal conductivity of the package
US6583299B1 (en) * 1999-05-20 2003-06-24 G.D. Searle & Co. α-amino-β-sulfonyl hydroxamic acid compounds
WO2016027757A1 (ja) * 2014-08-18 2016-02-25 国立大学法人大阪大学 新規２－アミノベンゾイル誘導体
WO2018231462A1 (en) 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293569A (en) * 1978-05-12 1981-10-06 E. R. Squibb & Sons, Inc. Substituted phenylguanindines and method
US4332813A (en) * 1979-08-15 1982-06-01 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
DE3400514A1 (de) * 1984-01-10 1985-07-18 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeure-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
US5254725A (en) * 1991-04-18 1993-10-19 University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase

Also Published As

Publication number Publication date
AU668508B2 (en) 1996-05-09
NO933726D0 (no) 1993-10-15
US5442104A (en) 1995-08-15
EP0581907A4 (enExample) 1994-04-06
US5516936A (en) 1996-05-14
WO1992018003A1 (en) 1992-10-29
EP0581907A1 (en) 1994-02-09
AU1872392A (en) 1992-11-17
NO933726L (no) 1993-12-15
JPH06510023A (ja) 1994-11-10

Similar Documents

Publication Publication Date Title
Gebler et al. Dimethylallyltryptophan synthase. An enzyme-catalyzed electrophilic aromatic substitution
Dixon et al. D-Amino acid oxidase II. Specificity, competitive inhibition and reaction sequence
Dua et al. S-Aryl-L-cysteine S, S-dioxides: design, synthesis, and evaluation of a new class of inhibitors of kynureninase
Poppe et al. Friedel–crafts‐type mechanism for the enzymatic elimination of ammonia from histidine and phenylalanine
Uttamsingh et al. Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines
JPH04226913A (ja) オキザリルアミノ酸誘導体およびそれを含有する医薬
BÜRGER et al. Positional-and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes
US5516936A (en) Inhibitors of kynureninase
AU680672B2 (en) Substituted kynurenines, a process for their preparation, and use as medicaments
Jeon et al. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase
FALEEV et al. Tyrosine phenol‐lyase from Citrobacter intermedius: Factors controlling substrate specificity
Daffe et al. Enantiomeric enrichment in the hydrolysis of oxazolones catalyzed by cyclodextrins or proteolytic enzymes
US5495044A (en) Inhibitors of kynureninase
Abe et al. Discovery of amide (peptide) bond synthetic activity in acyl-CoA synthetase
Do et al. Inhibition of Escherichia coli tryptophan indole-lyase by tryptophan homologues
US6555528B2 (en) Derivatized biotin compounds and methods of use
Rodríguez-Alonso et al. Rational re-design of the “double-racemase hydantoinase process” for optically pure production of natural and non-natural l-amino acids
Danzin et al. Polyamine inhibition in vivo and in organ growth and repair
US5254725A (en) Inhibitors of kynureninase
Nakano Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria
Heiss et al. Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens
Han et al. Synthesis and evaluation of alternative substrates for arginasease
US6127420A (en) L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
Nishimura et al. Inactivation of monoamine oxidase B by analogs of the anticonvulsant agent milacemide [2-(n-pentylamino) acetamide]
Yamada et al. Synthesis of l-cystathionine by the γ-replacement reaction of cystathionine γ-lyase from Streptomyces phaeochromogenes

Legal Events

Date Code Title Description
FZDE Dead