CA2101169A1 - Topical emollient for prevention and treatment of circulatory induced lesions - Google Patents
Topical emollient for prevention and treatment of circulatory induced lesionsInfo
- Publication number
- CA2101169A1 CA2101169A1 CA002101169A CA2101169A CA2101169A1 CA 2101169 A1 CA2101169 A1 CA 2101169A1 CA 002101169 A CA002101169 A CA 002101169A CA 2101169 A CA2101169 A CA 2101169A CA 2101169 A1 CA2101169 A1 CA 2101169A1
- Authority
- CA
- Canada
- Prior art keywords
- skin
- emollient
- lesions
- treatment
- glucose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
2101169 9310795 PCTABS00022 A topical emollient for the treatment of circulation induced lesions comprises a source of glucose and insulin. The topical emollient is utilized in a process wherein the emollient is applied to the affected surface for nourishment thereof and promotion of healing. The emollient also enhances the therapeutic benefits of other medicinal drugs which may be topically applied in conjunction with the insulin and glucose mixture.
Description
2 ~ 9 TOPICAL EMOLLIENT FQR PREVENTION AN:D TREATMENT
OF CIRCULATORY INDU OE D LESIONS
CROSS REFERENCE TO RELATION APPLICATIONS
This application is a continuation in-part of application Serial No. 07/417,239 filed October ~, 1990.
This invention relates generally to the art of medicine and more particularly to the art of treatment of skin lesions, skin ulcers, and other skin maladies, and the treatment of some circulatory disorders, and as a delivery device for transporting topically applied drugs through intact ~kin.
It has been known for many years that patients suffering from diabetes, phlebitis, or other circulatory problems often develop lesions or ulcers which are dif~icult to treat. The affected tissu~ is often poorly nourished or has impaired circulation ana the resulting lesions may heal slowly if at all. Further, many diabetic patients suffer ~rom neuro~athy which predisposes the patients to falls and subsequent injuries which are slow to heal and subject to secondary infectionsO
Infected areas which fail to respond to traditional treatment protocols o~ten become gangrenous and require amputation of the affect2d limb.
.
'~' . ~ '. : '. .': " ' .; :, -: ., . : .
~: .: ,, ;, . : ~ .: .
. . : . ,- ~ . :
. : . . ,:: ; ~ . . , . ~
WO93/1~795 PCT/US91/0 2 ~ 0~1 ~.f3 The treatment for such maladies has involved two gener~
strategies; One, an attempt to increase circulation to affected tissue and secondly, to treat the lesions by the u2 of general antibiotics to prevent infection. For diabet~
patients in particular, insulin packs and insulin/transferr~
packs have been used in the treatment of diabetic gangrene However, all of these methods have had only limited succesc one difficulty in the treatment protocol is that many usef~-medicines to treat skin circulatory disorders require ora~subcutaneous or other delivery systems because the biologica~
active molecules are unable to be effectively absorbed ~r utilized through the skin. To date, transport of m~
medicines is unable to occur through the skin surfa~
Therefore, much room for improvement exists in the art.
SUMMARY OF T~E INVENTION
It is t~us an object of this invention to provide a no~
topical emollient which when applied to circulatory indu~
lesions promotes nourishment of the affected cells, there~
eliminating the source of the lesions.
It is a further object of this invention to provide a no~
process for the treatment of circulatory induced lesions.
~: ' ' - ' , .
: . -~ .: ' -21 ~ 1169 It is a further object of this invention to provide a novel J emollient which facilitates the uptake of biologically active molecules across the skin's surface.
It is a still further object of this invention to provide 5 a process where t~pically applied medications can be more effectively utilizeà by the target tissues.
These as well as other objects are accomplished by a topical emollient comprising of a combination of glucose and insulin.
Tha topical emollient is utili~ed in a process wherein the 10 mixture is applied to the affected surface for nourishment thereof and promotion of healing.
DETAILED DESCRIPTION
In accordance witn this invention it has been surprisingly found that a source of glucose and insulin, applied to a 15 lesion, promoted the healing of the affected surface. This is surprising since it has here-t;o-fore been felt that insulin would not pass through the skin surface. However, -n accordance with this invention, it has been found that when applied with a source of glucose, the insulin mixture provides 20 or stimulates nourishment to the affected area. Further, it has been found that the aqueous glucose and insulin mixture enhances the therapeutic benefits of other topically applied medications.
- , ... . .. ~ .. - . . . . .. . . . .
. .
~ '. . " ' ' . ' , . ' .' '. ,'' ', ' ' 1 .' . ~ ' ' . ,, . . ~ .
.' ' ' ',: ' ;' By way of example, topical applications of hydrocortisone cream, when applied according to the claimed invention, show increased therapeutic benefits consistent with an enhanced uptake or more efficient utilization of the absorbed drug. As such, the claimed invention will enable faster healing and lower concentrations of drugs to be topically applied to affected areas. This will not only lower the cost of treatment but may significantly reduce undesirable drug side effects.
As the effective drug concentration is lowered, dose-responsive side effects will be lessened. In addition, drugs which may not ordinarily be administered through the skin may become candidates for topical administration via the claimed process.
The critical minimum concentrations and ratios of glucose and insulin for effective treatment have not been determined.
An effective insulin concentration, however, is believed to be as low as .06 units/ml in a 2% glucose solution. Effective treatment has been obtained with concentrations of insulin ranging from .06 units/ml to 2.0 units/ml. Similarly, glucose concentrations ranging from 2% to the highly concentrated levels found in strained honey, have all been successfully used.
It is likely that all the effective doses to date contained an excess concentration of both insulin and glucose. Since the insulin/glucose mixture is extremely safe as topically applied , : . . . . .
. .
~W093/10795 2 1 ~ 1 1 6 ~3 PCT/US91/OB840 and relatively inexpensive, the critica:L lower limit of ! activity has not been determined. In addition, the minimum effective concentrations of the clz -sd invention may vary widely depending upon the age, gener~ aall:h, and the surface integrity of the patient's skin.
The insulin/glucose emollient is kept cool and away from strong light. Under these conditions, it has been found that the emollient remains stable and effective for at least several weeks. The emollient is topically applied to the affectecl area by gloved hand on intact skin, keeping the skin moist for at least 10 minutes and using a sterile gauze pad to apply the solution to broken skin areas to keep affected area moist for at least 10 minutes. Following the emollient, other topical medications may be applied to the affected surface. However, if desired, lt would be possible to combine the emollient with other medication for a one-step application process.
The preferred insulin source is a mixture of 70 ~ NPH
insulin and 30 % regular insulin. This ratio provides both long duration insulin (NPH) and a quicker response insulin (regular) though successful results have been obtained when both forms of insulin wer~ used individually.
Having generally set forth the invention the following specific examples are given as an illustration thereof.
.
" '' ' , , :
.
.
,, . , .~ . ~, . .
WO93/10795 PCT/U~91/08840 ~ Q~
., A male diabetic patient 53 years of age had open diabetic lesions on one foot and ankle consist.ing of multiple lesions having an area of one to one and one-half (1-1 1/2l square inches in various stages of skin break down.
The trial was conducted by applying three times a day a topical ointment of 0.6 units/ml of regular insulin in a 5% glucose solution. Within five days improvement of the patients condition had occurred. The patient was discharged from the hospital and instructed to continue the application of the mixture.
An elderly diabetic male patient was homebound because of diabetic neuropathy. The patient had a scalp ulcer approximately one and one-half (1 1/2) inches in diameter. The patient had been treated about two (2) years with very little success. -The scalp ulcer was treated with a mixture of 2.0 units/ml of NPH insulin in a strained honey solution. This mixture was applied once a day and within two (2) weeks the ulcer was healed.
EX~MPLE 3 A 61 year old female patient ~uffering with severe varicose veins and phlebitis was treated with a 0.4 t , . -.
W093/10795 PCT/US91/0884n ,_ units/ml of insulin (a combination of 70% NPH insulin and - 30 % regular insulin) in a 2% glucose solution.
Prior to treatment the patient suffered almost constant pain even early in the morning. This had been a constant problem for thirty (30) years. The mixture was kept cool and away from light and was applied to the legs and feet three (3) times a day at meal time. After five (5) days of treatment the patient was free of pain in the feet cmd legs even at the end of the day. This was the first comfort that the patient had in some thirty (30) years.
After fifteen (15) months there have been no symptoms of phlebitis and there has been a slow but constant reduction in the size of the varicosities.
lS EXAMPLE 4 A 38 year old female patient was suffering from a skin rash on her wrist. One half of the affected rash area was treated with a topical ointment of 0.5%
hydrocortisone cream. The other half of the rash was treated with a mixture of 0.4 units/ml insulin (a combination of 70% NPH insulin and 30% resular insulin) and 2% glucose followed by an applicatio~ of 0.5%
hydrocortisone cream. A marked increase in the healing and recovery of the affected area was noted in the : ' . : . .:
: . . . . : .
,, , .. . , :
~ Q ~ ~r\
portion of the rash treated with the hydrocortisone/insulin/glucose mixture.
It is thus seen that the emollient and process of this invention provide a topical emollient which prevents and promotes healing of lesions and ulcers caused by circulatory problems and increases the effectiveness of other topical medicines applied in conjunction with the claimed invention.
Many variations are apparent to those of skill in the art from a reading of the above description which is exemplary in nature. Such variations are embodied within the spirit and scope of this invention as measured by the following appended claims.
.,;
--
OF CIRCULATORY INDU OE D LESIONS
CROSS REFERENCE TO RELATION APPLICATIONS
This application is a continuation in-part of application Serial No. 07/417,239 filed October ~, 1990.
This invention relates generally to the art of medicine and more particularly to the art of treatment of skin lesions, skin ulcers, and other skin maladies, and the treatment of some circulatory disorders, and as a delivery device for transporting topically applied drugs through intact ~kin.
It has been known for many years that patients suffering from diabetes, phlebitis, or other circulatory problems often develop lesions or ulcers which are dif~icult to treat. The affected tissu~ is often poorly nourished or has impaired circulation ana the resulting lesions may heal slowly if at all. Further, many diabetic patients suffer ~rom neuro~athy which predisposes the patients to falls and subsequent injuries which are slow to heal and subject to secondary infectionsO
Infected areas which fail to respond to traditional treatment protocols o~ten become gangrenous and require amputation of the affect2d limb.
.
'~' . ~ '. : '. .': " ' .; :, -: ., . : .
~: .: ,, ;, . : ~ .: .
. . : . ,- ~ . :
. : . . ,:: ; ~ . . , . ~
WO93/1~795 PCT/US91/0 2 ~ 0~1 ~.f3 The treatment for such maladies has involved two gener~
strategies; One, an attempt to increase circulation to affected tissue and secondly, to treat the lesions by the u2 of general antibiotics to prevent infection. For diabet~
patients in particular, insulin packs and insulin/transferr~
packs have been used in the treatment of diabetic gangrene However, all of these methods have had only limited succesc one difficulty in the treatment protocol is that many usef~-medicines to treat skin circulatory disorders require ora~subcutaneous or other delivery systems because the biologica~
active molecules are unable to be effectively absorbed ~r utilized through the skin. To date, transport of m~
medicines is unable to occur through the skin surfa~
Therefore, much room for improvement exists in the art.
SUMMARY OF T~E INVENTION
It is t~us an object of this invention to provide a no~
topical emollient which when applied to circulatory indu~
lesions promotes nourishment of the affected cells, there~
eliminating the source of the lesions.
It is a further object of this invention to provide a no~
process for the treatment of circulatory induced lesions.
~: ' ' - ' , .
: . -~ .: ' -21 ~ 1169 It is a further object of this invention to provide a novel J emollient which facilitates the uptake of biologically active molecules across the skin's surface.
It is a still further object of this invention to provide 5 a process where t~pically applied medications can be more effectively utilizeà by the target tissues.
These as well as other objects are accomplished by a topical emollient comprising of a combination of glucose and insulin.
Tha topical emollient is utili~ed in a process wherein the 10 mixture is applied to the affected surface for nourishment thereof and promotion of healing.
DETAILED DESCRIPTION
In accordance witn this invention it has been surprisingly found that a source of glucose and insulin, applied to a 15 lesion, promoted the healing of the affected surface. This is surprising since it has here-t;o-fore been felt that insulin would not pass through the skin surface. However, -n accordance with this invention, it has been found that when applied with a source of glucose, the insulin mixture provides 20 or stimulates nourishment to the affected area. Further, it has been found that the aqueous glucose and insulin mixture enhances the therapeutic benefits of other topically applied medications.
- , ... . .. ~ .. - . . . . .. . . . .
. .
~ '. . " ' ' . ' , . ' .' '. ,'' ', ' ' 1 .' . ~ ' ' . ,, . . ~ .
.' ' ' ',: ' ;' By way of example, topical applications of hydrocortisone cream, when applied according to the claimed invention, show increased therapeutic benefits consistent with an enhanced uptake or more efficient utilization of the absorbed drug. As such, the claimed invention will enable faster healing and lower concentrations of drugs to be topically applied to affected areas. This will not only lower the cost of treatment but may significantly reduce undesirable drug side effects.
As the effective drug concentration is lowered, dose-responsive side effects will be lessened. In addition, drugs which may not ordinarily be administered through the skin may become candidates for topical administration via the claimed process.
The critical minimum concentrations and ratios of glucose and insulin for effective treatment have not been determined.
An effective insulin concentration, however, is believed to be as low as .06 units/ml in a 2% glucose solution. Effective treatment has been obtained with concentrations of insulin ranging from .06 units/ml to 2.0 units/ml. Similarly, glucose concentrations ranging from 2% to the highly concentrated levels found in strained honey, have all been successfully used.
It is likely that all the effective doses to date contained an excess concentration of both insulin and glucose. Since the insulin/glucose mixture is extremely safe as topically applied , : . . . . .
. .
~W093/10795 2 1 ~ 1 1 6 ~3 PCT/US91/OB840 and relatively inexpensive, the critica:L lower limit of ! activity has not been determined. In addition, the minimum effective concentrations of the clz -sd invention may vary widely depending upon the age, gener~ aall:h, and the surface integrity of the patient's skin.
The insulin/glucose emollient is kept cool and away from strong light. Under these conditions, it has been found that the emollient remains stable and effective for at least several weeks. The emollient is topically applied to the affectecl area by gloved hand on intact skin, keeping the skin moist for at least 10 minutes and using a sterile gauze pad to apply the solution to broken skin areas to keep affected area moist for at least 10 minutes. Following the emollient, other topical medications may be applied to the affected surface. However, if desired, lt would be possible to combine the emollient with other medication for a one-step application process.
The preferred insulin source is a mixture of 70 ~ NPH
insulin and 30 % regular insulin. This ratio provides both long duration insulin (NPH) and a quicker response insulin (regular) though successful results have been obtained when both forms of insulin wer~ used individually.
Having generally set forth the invention the following specific examples are given as an illustration thereof.
.
" '' ' , , :
.
.
,, . , .~ . ~, . .
WO93/10795 PCT/U~91/08840 ~ Q~
., A male diabetic patient 53 years of age had open diabetic lesions on one foot and ankle consist.ing of multiple lesions having an area of one to one and one-half (1-1 1/2l square inches in various stages of skin break down.
The trial was conducted by applying three times a day a topical ointment of 0.6 units/ml of regular insulin in a 5% glucose solution. Within five days improvement of the patients condition had occurred. The patient was discharged from the hospital and instructed to continue the application of the mixture.
An elderly diabetic male patient was homebound because of diabetic neuropathy. The patient had a scalp ulcer approximately one and one-half (1 1/2) inches in diameter. The patient had been treated about two (2) years with very little success. -The scalp ulcer was treated with a mixture of 2.0 units/ml of NPH insulin in a strained honey solution. This mixture was applied once a day and within two (2) weeks the ulcer was healed.
EX~MPLE 3 A 61 year old female patient ~uffering with severe varicose veins and phlebitis was treated with a 0.4 t , . -.
W093/10795 PCT/US91/0884n ,_ units/ml of insulin (a combination of 70% NPH insulin and - 30 % regular insulin) in a 2% glucose solution.
Prior to treatment the patient suffered almost constant pain even early in the morning. This had been a constant problem for thirty (30) years. The mixture was kept cool and away from light and was applied to the legs and feet three (3) times a day at meal time. After five (5) days of treatment the patient was free of pain in the feet cmd legs even at the end of the day. This was the first comfort that the patient had in some thirty (30) years.
After fifteen (15) months there have been no symptoms of phlebitis and there has been a slow but constant reduction in the size of the varicosities.
lS EXAMPLE 4 A 38 year old female patient was suffering from a skin rash on her wrist. One half of the affected rash area was treated with a topical ointment of 0.5%
hydrocortisone cream. The other half of the rash was treated with a mixture of 0.4 units/ml insulin (a combination of 70% NPH insulin and 30% resular insulin) and 2% glucose followed by an applicatio~ of 0.5%
hydrocortisone cream. A marked increase in the healing and recovery of the affected area was noted in the : ' . : . .:
: . . . . : .
,, , .. . , :
~ Q ~ ~r\
portion of the rash treated with the hydrocortisone/insulin/glucose mixture.
It is thus seen that the emollient and process of this invention provide a topical emollient which prevents and promotes healing of lesions and ulcers caused by circulatory problems and increases the effectiveness of other topical medicines applied in conjunction with the claimed invention.
Many variations are apparent to those of skill in the art from a reading of the above description which is exemplary in nature. Such variations are embodied within the spirit and scope of this invention as measured by the following appended claims.
.,;
--
Claims (8)
[received by the International Bureau on 22 April 1992 (22.04.92);
original claims 1-5 replaced by amended claims 1-5 (1 page)]
1. A process for treating circulatory induced lesions comprising the steps of:
applying to one of said lesions a mixture consisting essentially of a glucose solution containing insulin sufficient for treatment of said one of lesions.
applying to one of said lesions a mixture consisting essentially of a glucose solution containing insulin sufficient for treatment of said one of lesions.
2. A process for introducing a biologically active molecule across a surface of a patient's skin comprising the steps of:
applying to said surface of said patient's skin a mixture containing a solution consisting essentially of glucose solution containing an effective amount of insulin, and a source of said biologically active drug.
applying to said surface of said patient's skin a mixture containing a solution consisting essentially of glucose solution containing an effective amount of insulin, and a source of said biologically active drug.
3. A process for enhancing the therapeutic benefits of a biologically active compound comprising the steps of:
applying said compound to a surface of a patient's skin, said compound being carried with a solution consisting essentially of a glucose solution containing insulin sufficient to enhance said therapeutic benefits.
applying said compound to a surface of a patient's skin, said compound being carried with a solution consisting essentially of a glucose solution containing insulin sufficient to enhance said therapeutic benefits.
4. A topical emollient for the treatment of skin lesions and disorders consisting essentially of:
a mixture of an effective amount of a glucose solution containing insulin sufficient to treat skin disorders.
a mixture of an effective amount of a glucose solution containing insulin sufficient to treat skin disorders.
5. The emollient according to claim 4 wherein said source of glucose is honey.
6. The use of a topical emollient for the treatment of skin lesions and disorders consisting essentially of a mixture of an effective amount of a glucose solution containing insulin sufficient to treat skin disorders wherein the emollient is applied to a lesion on the surface of a patient's skin.
7. The use of a mixture of an effective amount of a glucose solution containing insulin sufficient to treat skin disorders as a topical emollient for application to skin lesions.
8. The use as claimed in claim 6 or 7 wherein the source of glucose is honey.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1991/008840 WO1993010795A1 (en) | 1991-11-27 | 1991-11-27 | Topical emollient for prevention and treatment of circulatory induced lesions |
CA002101169A CA2101169A1 (en) | 1991-11-27 | 1991-11-27 | Topical emollient for prevention and treatment of circulatory induced lesions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1991/008840 WO1993010795A1 (en) | 1991-11-27 | 1991-11-27 | Topical emollient for prevention and treatment of circulatory induced lesions |
CA002101169A CA2101169A1 (en) | 1991-11-27 | 1991-11-27 | Topical emollient for prevention and treatment of circulatory induced lesions |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2101169A1 true CA2101169A1 (en) | 1993-05-28 |
Family
ID=4151977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002101169A Abandoned CA2101169A1 (en) | 1991-11-27 | 1991-11-27 | Topical emollient for prevention and treatment of circulatory induced lesions |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2101169A1 (en) |
-
1991
- 1991-11-27 CA CA002101169A patent/CA2101169A1/en not_active Abandoned
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Legal Events
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EEER | Examination request | ||
FZDE | Dead |