CA2100363A1 - Agglutination reaction device utilizing porous absorbent material - Google Patents
Agglutination reaction device utilizing porous absorbent materialInfo
- Publication number
- CA2100363A1 CA2100363A1 CA 2100363 CA2100363A CA2100363A1 CA 2100363 A1 CA2100363 A1 CA 2100363A1 CA 2100363 CA2100363 CA 2100363 CA 2100363 A CA2100363 A CA 2100363A CA 2100363 A1 CA2100363 A1 CA 2100363A1
- Authority
- CA
- Canada
- Prior art keywords
- layer
- chamber
- well
- liquid
- slot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000004520 agglutination Effects 0.000 title claims abstract description 83
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 72
- 239000000463 material Substances 0.000 title claims abstract description 37
- 239000002250 absorbent Substances 0.000 title claims description 29
- 230000002745 absorbent Effects 0.000 title claims description 28
- 239000007788 liquid Substances 0.000 claims abstract description 70
- 238000004891 communication Methods 0.000 claims abstract description 19
- 239000002245 particle Substances 0.000 claims description 30
- 230000001464 adherent effect Effects 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 239000010410 layer Substances 0.000 description 140
- 239000000523 sample Substances 0.000 description 24
- 239000003153 chemical reaction reagent Substances 0.000 description 21
- 239000000123 paper Substances 0.000 description 21
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
- 239000000243 solution Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 238000003556 assay Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000005755 formation reaction Methods 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 239000004677 Nylon Substances 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000000984 immunochemical effect Effects 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 229920006289 polycarbonate film Polymers 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000004816 latex Substances 0.000 description 3
- 229920000126 latex Polymers 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002195 soluble material Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 229920003169 water-soluble polymer Polymers 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- 229920000298 Cellophane Polymers 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000012792 core layer Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011087 paperboard Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- -1 (e.g. Polymers 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000009582 blood typing Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229960000359 chromic chloride Drugs 0.000 description 1
- LJAOOBNHPFKCDR-UHFFFAOYSA-K chromium(3+) trichloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Cl-].[Cr+3] LJAOOBNHPFKCDR-UHFFFAOYSA-K 0.000 description 1
- 239000011636 chromium(III) chloride Substances 0.000 description 1
- 235000007831 chromium(III) chloride Nutrition 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920006284 nylon film Polymers 0.000 description 1
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61489590A | 1990-11-16 | 1990-11-16 | |
| US614,895 | 1990-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2100363A1 true CA2100363A1 (en) | 1992-05-17 |
Family
ID=24463154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2100363 Abandoned CA2100363A1 (en) | 1990-11-16 | 1991-11-15 | Agglutination reaction device utilizing porous absorbent material |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0557447A4 (enrdf_load_stackoverflow) |
| AU (1) | AU658593B2 (enrdf_load_stackoverflow) |
| CA (1) | CA2100363A1 (enrdf_load_stackoverflow) |
| TW (1) | TW201824B (enrdf_load_stackoverflow) |
| WO (1) | WO1992008973A1 (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5518887A (en) * | 1992-03-30 | 1996-05-21 | Abbott Laboratories | Immunoassays empolying generic anti-hapten antibodies and materials for use therein |
| WO2006047831A1 (en) * | 2004-11-03 | 2006-05-11 | Agen Biomedical Limited | Detection device and method |
| DK3400754T3 (da) * | 2016-01-08 | 2021-11-01 | Siemens Healthcare Diagnostics Inc | Varmeelement til sensorarray |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1292176C (en) * | 1985-09-18 | 1991-11-19 | Joel M. Blatt | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
| KR940008752B1 (ko) * | 1985-10-15 | 1994-09-26 | 판 아메리카 보오에끼 가부시끼가이샤 | 약액주입기 |
| US4906439A (en) * | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
| ES2056877T3 (es) * | 1987-12-23 | 1994-10-16 | Abbott Lab | Dispositivo para realizar reacciones de aglutinacion. |
-
1991
- 1991-11-15 WO PCT/US1991/008573 patent/WO1992008973A1/en not_active Application Discontinuation
- 1991-11-15 CA CA 2100363 patent/CA2100363A1/en not_active Abandoned
- 1991-11-15 EP EP19920901199 patent/EP0557447A4/en not_active Withdrawn
- 1991-11-15 AU AU90821/91A patent/AU658593B2/en not_active Ceased
-
1992
- 1992-01-29 TW TW81100682A patent/TW201824B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0557447A1 (en) | 1993-09-01 |
| AU9082191A (en) | 1992-06-11 |
| TW201824B (enrdf_load_stackoverflow) | 1993-03-11 |
| AU658593B2 (en) | 1995-04-27 |
| WO1992008973A1 (en) | 1992-05-29 |
| EP0557447A4 (en) | 1994-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |