CA2095060A1 - Enzymatic reactions and apparatus for carrying them out - Google Patents
Enzymatic reactions and apparatus for carrying them outInfo
- Publication number
- CA2095060A1 CA2095060A1 CA002095060A CA2095060A CA2095060A1 CA 2095060 A1 CA2095060 A1 CA 2095060A1 CA 002095060 A CA002095060 A CA 002095060A CA 2095060 A CA2095060 A CA 2095060A CA 2095060 A1 CA2095060 A1 CA 2095060A1
- Authority
- CA
- Canada
- Prior art keywords
- enzyme
- substrate
- reaction
- water
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000006911 enzymatic reaction Methods 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 102000004190 Enzymes Human genes 0.000 claims abstract description 26
- 108090000790 Enzymes Proteins 0.000 claims abstract description 26
- 239000000758 substrate Substances 0.000 claims abstract description 23
- 239000007787 solid Substances 0.000 claims abstract description 14
- 239000007790 solid phase Substances 0.000 claims abstract description 12
- 238000002604 ultrasonography Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 239000012071 phase Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 238000010647 peptide synthesis reaction Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 4
- 239000011734 sodium Substances 0.000 description 3
- 241001302210 Sida <water flea> Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- RRONHWAVOYADJL-HNNXBMFYSA-N (2s)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 RRONHWAVOYADJL-HNNXBMFYSA-N 0.000 description 1
- YDIKCZBMBPOGFT-DIONPBRTSA-N (2s,3r,4s,5s,6r)-2-[5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;chloride Chemical compound [Cl-].COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 YDIKCZBMBPOGFT-DIONPBRTSA-N 0.000 description 1
- 101150034533 ATIC gene Proteins 0.000 description 1
- 241001233887 Ania Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000736839 Chara Species 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 241000283014 Dama Species 0.000 description 1
- 101150039033 Eci2 gene Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 101150071986 LRAT gene Proteins 0.000 description 1
- 101100536883 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) thi5 gene Proteins 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 101100348848 Mus musculus Notch4 gene Proteins 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N Ropinirole hydrochloride Chemical compound Cl.CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 XDXHAEQXIBQUEZ-UHFFFAOYSA-N 0.000 description 1
- 101100240664 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nmt1 gene Proteins 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- UCUJUFDOQOJLBE-UHFFFAOYSA-N [Cl].[Ca] Chemical compound [Cl].[Ca] UCUJUFDOQOJLBE-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000015115 caffè latte Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- GPUADMRJQVPIAS-QCVDVZFFSA-M cerivastatin sodium Chemical compound [Na+].COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 GPUADMRJQVPIAS-QCVDVZFFSA-M 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- JNSGIVNNHKGGRU-JYRVWZFOSA-N diethoxyphosphinothioyl (2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetate Chemical compound CCOP(=S)(OCC)OC(=O)C(=N/OC)\C1=CSC(N)=N1 JNSGIVNNHKGGRU-JYRVWZFOSA-N 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000004687 hexahydrates Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- POFWRMVFWIJXHP-UHFFFAOYSA-N n-benzyl-9-(oxan-2-yl)purin-6-amine Chemical compound C=1C=CC=CC=1CNC(C=1N=C2)=NC=NC=1N2C1CCCCO1 POFWRMVFWIJXHP-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4214157.5 | 1992-04-29 | ||
| DE4214157A DE4214157C1 (enExample) | 1992-04-29 | 1992-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2095060A1 true CA2095060A1 (en) | 1993-10-30 |
Family
ID=6457769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002095060A Abandoned CA2095060A1 (en) | 1992-04-29 | 1993-04-28 | Enzymatic reactions and apparatus for carrying them out |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5670332A (enExample) |
| EP (1) | EP0567887A3 (enExample) |
| JP (1) | JPH0622767A (enExample) |
| CA (1) | CA2095060A1 (enExample) |
| DE (1) | DE4214157C1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4214157C1 (enExample) * | 1992-04-29 | 1993-08-05 | Degussa Ag, 6000 Frankfurt, De | |
| DE19607100C2 (de) * | 1995-07-11 | 2000-04-27 | Degussa | Verfahren zur Herstellung von Peptiden und N-Carbamoyl-geschützten Peptiden |
| EP0839153B1 (de) * | 1995-07-11 | 2001-08-16 | Degussa AG | Verfahren zur herstellung von peptiden und n-carbamoyl-geschützten peptiden |
| DE19529099C2 (de) * | 1995-08-08 | 1997-12-04 | Forschungszentrum Juelich Gmbh | Vorrichtung zur Serien-Kultivierung von Mikroorganismen bzw. Zellen in begasten Flüssigkeitssäulen |
| ES2187220B2 (es) * | 1999-07-13 | 2003-12-01 | Univ Alicante | Metodo y equipo para la determinacion del equilibrio liquido-liquido-vapor isobarico en sistemas heterogeneos. |
| US6939693B2 (en) * | 1999-10-29 | 2005-09-06 | Novus International, Inc. | Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids |
| WO2001032906A2 (en) | 1999-10-29 | 2001-05-10 | Novus International, Inc. | Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids |
| DE19953137A1 (de) * | 1999-11-04 | 2001-05-10 | Biotechnologie Ges Mittelhesse | Durchmischbares Gefäß zur Durchführung von Reaktionen oder biologischen Prozessen in flüssiger Phase und Verfahren zu deren Durchführung unter Benutzung des durchmischbaren Gefäßes |
| CN103173354B (zh) * | 2003-10-08 | 2017-07-14 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
| JP5366820B2 (ja) * | 2006-12-07 | 2013-12-11 | ウィルソン ウォルフ マニュファクチャリング コーポレイション | 細胞培養に効果的な装置および方法 |
| US8518692B2 (en) * | 2008-07-08 | 2013-08-27 | Wilson Wolf Manufacturing Corporation | Gas permeable cell culture device and method of use |
| GB2506880A (en) | 2012-10-10 | 2014-04-16 | Michael David Fothergill | Method of enzyme conversion using an immobilised composition consisting of at least two enzymes and a co-factor |
| CN106391292A (zh) * | 2016-10-31 | 2017-02-15 | 中国矿业大学 | 液固流化床分选机及使用其进行分选物料的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB137688A (en) * | 1919-03-27 | 1920-01-22 | Percy John Goodman | Improvements relating to the steering heads of motor cycles |
| DD106146A1 (enExample) * | 1973-08-20 | 1974-06-05 | ||
| DE3237896A1 (de) * | 1982-10-13 | 1984-04-19 | Chemische Werke Hüls AG, 4370 Marl | Verfahren zur biologischen herstellung von mikrobiellen metaboliten und enzymen |
| GB8323358D0 (en) * | 1983-08-31 | 1983-10-05 | Ici Plc | Microbial transformations |
| CS271584B1 (en) * | 1988-03-03 | 1990-10-12 | Krchnak Viktor | Method of solid phase peptide preparation |
| DE4214157C1 (enExample) * | 1992-04-29 | 1993-08-05 | Degussa Ag, 6000 Frankfurt, De |
-
1992
- 1992-04-29 DE DE4214157A patent/DE4214157C1/de not_active Expired - Fee Related
-
1993
- 1993-04-20 EP EP93106333A patent/EP0567887A3/de not_active Withdrawn
- 1993-04-28 JP JP5102515A patent/JPH0622767A/ja active Pending
- 1993-04-28 CA CA002095060A patent/CA2095060A1/en not_active Abandoned
-
1994
- 1994-09-28 US US08/312,674 patent/US5670332A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0622767A (ja) | 1994-02-01 |
| DE4214157C1 (enExample) | 1993-08-05 |
| EP0567887A2 (de) | 1993-11-03 |
| EP0567887A3 (de) | 1994-12-21 |
| US5670332A (en) | 1997-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |