CA2093508A1 - Analytical device - Google Patents
Analytical deviceInfo
- Publication number
- CA2093508A1 CA2093508A1 CA002093508A CA2093508A CA2093508A1 CA 2093508 A1 CA2093508 A1 CA 2093508A1 CA 002093508 A CA002093508 A CA 002093508A CA 2093508 A CA2093508 A CA 2093508A CA 2093508 A1 CA2093508 A1 CA 2093508A1
- Authority
- CA
- Canada
- Prior art keywords
- cuvettes
- rotor
- processing
- cuvette
- samples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0406—Individual bottles or tubes
- G01N2035/041—Individual bottles or tubes lifting items out of a rack for access
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6445—Measuring fluorescence polarisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Abstract The analytical device comprises a conveyor for conveying cuvettes to one or more stations for processing samples for analysis in the cuvettes. The processing stations comprise means for removing individual cuvettes from the conveyor, transferring the cuvettes to a processing position and returning the cuvettes to the conveyor after processing.
Fig. 1.
Fig. 1.
Description
{~
~L ~LQ~
The invention relates to a device for chemical and s biochemical analysis, comprising a conveyor for conveying cuvettes and one or more stations for processing the samples for analysis in the cuvettes.
Automatic analytical devices usually operate on the 0 following principle: samples for analysis or parts of samples are placed in containers and then subjected to a series of processing steps such as adding (pipetting) reagents~ mixing, incubation etc~, and measurements of the reactions which have taken place are made a number of times durin~ processing and/or once at the end ls of processing. The usual procedure is as follows: the containers holding the samples for analysis are placed in a fixed sequence on a conveyor and travel through various processing stations, or in ~he case of "batch processing", as is usual in the case of "centrifugal analysers", all sample containers are placed on a 20 carrier (rotor) and subjected practically simultaneously to the processing steps and measurements. Analytical systems operating on these principles give good service in la~ge clinics and analytical centres where large numbers of samples have to be processed.
In view, however, of the variety of possible analyses today and the medical requirements, particularly in clinical chemistry, it has been found that Ithe automatic analysers collventionaliy used hitherto for throughput of large quanti~ies of samples are not sufficiently flexible to provide analytical profiles (full random 30 access) specifically adapted to individual patients or medical conditions, while still being able to handle a large number of samples from patients.
The aim of the invention therefore is to provide an 35 analytical system which meets these requirements in that a large number of analytical samples can be processed with very great flexibility with regard to the analytical profile obtained from the individual sample.
Ve / 12.03.93 2 ~ 0 ~ J
This is ach;eved according to the invention by providing means for removing individual cuvettes from the conveyor, for transferring the cuvettes to a position for processing and for 5 returning the cuvettes to the conveyor after processing.
An embodiment of the inventiorl will now be described with reference to the accompanying drawings, in which:
Fig. I is an axonometric overall view of an analytical device and Fig. 2 is a plan view of the device in the direction of arrow I
in Fig. 1.
As shown in Fig. 1, the device 1 comprises a closed substructure 10 having a top surface on which a number of functional devices are disposed. The substructure contains all the devices which are only indirectly connected with the actual 20 analytical processes, e.g. electricity supply, electronics, cuvette supply and disposal means, refrigerating devices etc.
On the top surface, there is a first region 18 in which all reagents are kept available for pipetting, a second region 13 for 25 disposing the containers from which the samples are pipetted into the measuring cuvettes, and a third region which is the actual analytical region.
Conveyor means 16, 17 each being apt to convey one or 30 preferably two pipetting needles of a pipet~ing device to desired pipetting positions are arranged for displacements above the first region 18 in order to enable pipetting of predetermined amounts of the reagents disposed in that region.
Conveyor means 12, 14 each being apt to convey one or preferably two pipetting needles of a pipetting device to desired pipetting positions are arranged for displacements above the second region 13 in order to enable pipetting of predetermined 3 ~ 3 amounts of the samples from the sample containers disposed in that region.
The second region 13 can include a rack lS for receiving ~-~
S components necessary for special assays, e.g. assays making use of a so called ion selective electrode.
A washing position 19, where washing of the pipetting needles is carried out, is positioned adjacent to each the first 0 region 18 and the second region 13 respectively.
The analytical region contains a cuvette transfer device 2 and a number of stations for processing the samples in the cuvettes. This analytical region is shown in plan view in Fig. 2. It lS comprises the components described hereinafter:
The cuvette conveying device 2 is a circular rotor~ which can be rotated by a drive (not shown) through exact angular steps in both directions of rotation. The measuring cuvettes are held on 20 the outer edge 3 of the rotor, i.e. they have a flange on their upper surface which rests on a flat annular surface at right angles to the rotor axis, they have a w~ll surface which simultaneously abuts the substantially cylindrical outer surface of the rotor, and also the cuvettes are held by spring tongues which are associated with 25 each cuvette position and project radially over the cuvettes, wbich for this purpose have a projec~ion (not shown) on their underside for engaging in a recess in the cuvette flange. The resilien~ holder holds the cuvet~es sufficiently firmly tv prevent them from falling out by themselves, even when the rotor rotates. On the other 30 hand the resilient holder enables the cuYettes to be easily wi~hdrawn or inserted manually or by a mechanical gripping mechanism.
A detailed description of the motor 2 and its operation is 3s given in the simultaneously filed European Patent Application No.
92.105902. Reference is made to this description herewith.
~L ~LQ~
The invention relates to a device for chemical and s biochemical analysis, comprising a conveyor for conveying cuvettes and one or more stations for processing the samples for analysis in the cuvettes.
Automatic analytical devices usually operate on the 0 following principle: samples for analysis or parts of samples are placed in containers and then subjected to a series of processing steps such as adding (pipetting) reagents~ mixing, incubation etc~, and measurements of the reactions which have taken place are made a number of times durin~ processing and/or once at the end ls of processing. The usual procedure is as follows: the containers holding the samples for analysis are placed in a fixed sequence on a conveyor and travel through various processing stations, or in ~he case of "batch processing", as is usual in the case of "centrifugal analysers", all sample containers are placed on a 20 carrier (rotor) and subjected practically simultaneously to the processing steps and measurements. Analytical systems operating on these principles give good service in la~ge clinics and analytical centres where large numbers of samples have to be processed.
In view, however, of the variety of possible analyses today and the medical requirements, particularly in clinical chemistry, it has been found that Ithe automatic analysers collventionaliy used hitherto for throughput of large quanti~ies of samples are not sufficiently flexible to provide analytical profiles (full random 30 access) specifically adapted to individual patients or medical conditions, while still being able to handle a large number of samples from patients.
The aim of the invention therefore is to provide an 35 analytical system which meets these requirements in that a large number of analytical samples can be processed with very great flexibility with regard to the analytical profile obtained from the individual sample.
Ve / 12.03.93 2 ~ 0 ~ J
This is ach;eved according to the invention by providing means for removing individual cuvettes from the conveyor, for transferring the cuvettes to a position for processing and for 5 returning the cuvettes to the conveyor after processing.
An embodiment of the inventiorl will now be described with reference to the accompanying drawings, in which:
Fig. I is an axonometric overall view of an analytical device and Fig. 2 is a plan view of the device in the direction of arrow I
in Fig. 1.
As shown in Fig. 1, the device 1 comprises a closed substructure 10 having a top surface on which a number of functional devices are disposed. The substructure contains all the devices which are only indirectly connected with the actual 20 analytical processes, e.g. electricity supply, electronics, cuvette supply and disposal means, refrigerating devices etc.
On the top surface, there is a first region 18 in which all reagents are kept available for pipetting, a second region 13 for 25 disposing the containers from which the samples are pipetted into the measuring cuvettes, and a third region which is the actual analytical region.
Conveyor means 16, 17 each being apt to convey one or 30 preferably two pipetting needles of a pipet~ing device to desired pipetting positions are arranged for displacements above the first region 18 in order to enable pipetting of predetermined amounts of the reagents disposed in that region.
Conveyor means 12, 14 each being apt to convey one or preferably two pipetting needles of a pipetting device to desired pipetting positions are arranged for displacements above the second region 13 in order to enable pipetting of predetermined 3 ~ 3 amounts of the samples from the sample containers disposed in that region.
The second region 13 can include a rack lS for receiving ~-~
S components necessary for special assays, e.g. assays making use of a so called ion selective electrode.
A washing position 19, where washing of the pipetting needles is carried out, is positioned adjacent to each the first 0 region 18 and the second region 13 respectively.
The analytical region contains a cuvette transfer device 2 and a number of stations for processing the samples in the cuvettes. This analytical region is shown in plan view in Fig. 2. It lS comprises the components described hereinafter:
The cuvette conveying device 2 is a circular rotor~ which can be rotated by a drive (not shown) through exact angular steps in both directions of rotation. The measuring cuvettes are held on 20 the outer edge 3 of the rotor, i.e. they have a flange on their upper surface which rests on a flat annular surface at right angles to the rotor axis, they have a w~ll surface which simultaneously abuts the substantially cylindrical outer surface of the rotor, and also the cuvettes are held by spring tongues which are associated with 25 each cuvette position and project radially over the cuvettes, wbich for this purpose have a projec~ion (not shown) on their underside for engaging in a recess in the cuvette flange. The resilien~ holder holds the cuvet~es sufficiently firmly tv prevent them from falling out by themselves, even when the rotor rotates. On the other 30 hand the resilient holder enables the cuYettes to be easily wi~hdrawn or inserted manually or by a mechanical gripping mechanism.
A detailed description of the motor 2 and its operation is 3s given in the simultaneously filed European Patent Application No.
92.105902. Reference is made to this description herewith.
4 ~3~
The rotor conveys the cuvettes to a photometer 9 for making absorption measurements. The cuvettes travel through the ligh~ beam of the photometer.
s Processing stations are disposed in exactly defined positions relative to the rotor. The processing stations are equipped with means for removing cuvettes from the rotor and/or for inserting cuvettes on the rotor when the rotor is not moving. The functions of the processing stations will be described in detail hereinafter.
10 A detailed description of the processing stations for adding samples or reagents is given in the simultaneously published European Patent Application No. 92,105901. Reference is made to this description herewith.
One processing station 4 is for insertion of new cuvettes and removal of used cuvettes at the end of analysis. The cuvettes removed from the rotor are placed in a waste container.
One processing station 8 is for metering of reagents. One of 20 the cuvettes o~a the rotor is taken of~ ~nd moved to a processing position in the station. One or more reagents are pipetted into the cuve~te. Simultaneously, the reagents are mixed by suitably moving the cuvette, after which the cuve~te and reagents are returned to the rotor.
2s A processing station 6 is for preliminary dilution of the sample. An empty cuvette is taken off the rotor and brought to a processing position in the station. A preset amount of sample and dilution liquid is pipetted in to the cuvette. At the same time, the 30 dilute sample is mixed by suitably moving the cuvette, after which the cuvette is pu~ back on the rotor.
A processing station 5 is for metering of samples. One of the cuvettes on the rotor is taken off and brought into a processing 3s position in the station. A preset quantity of the dilute sample is pipetted into the cuvette. At the same time, the reagents are mixed by suitably moving the cuvette. The cuvette containing the mixture of samples and reagents is then returned to the rotor.
4~ 3 ~ ~ ~
A processing station 7 is for adding a starting reagent to start the reaction by the sample. A cuvette is taken off the rotor and brought to a processing position in the station. A preset s amount of starting reagent is pipetted into the cuvette. At the same time the mixture of samples ansl reagents is mixed by suitably moving the cuvctte The cuvette is then put baek on the rotor.
I O A processing station 11 is for fluorescence polarimetric (~P) measurement. A sample containing a mixture of samples and reagents is taken off the rotor and brought to a rneasuring chamber in the station. At the end of the measurement, the cuvette is returned to the rotor.
Using measurement of absorption as an example, a determination program proceeds as follows:
To malce the required determination, a processing station 4 20 places a cuvette on the rotor. Firstly, an air ~est measurement is made on the cuvette on the rotor.
Thirty seconds later, the processing station 8 takes the cuvette off the rotor and moves it into a pipetting position in the 25 processing station, where one or more reagents are pipe~ted into the cuvette. When there are a number of reagents, they are mixed during and after pipetting. The cuvette is then returned to the rotor.
Seventy two seconds later, the cuvette is taken off the rotor by the processing station 6 and brought to the pipetting position, where the sample and diluent are metered by the sample transfer means. At the same time and/or afterwards, the substances are mixed and, after the pre-dilute sample has been used, the cuvette 3S is put back Oll the rotor.
Six seconds later, the processing station 5 takes the cuvette from the rotor and moves it into the pipetting posit;on, where the 6 ~OL~3~3~8 sample is metered by the transfer means and then mixed and the cuvette is returned to the rotor. A To measurement is then made on the rotor.
s One hundred and sixty two seconds later, the processing station 7 ~akes the cuvette off the rotor and brings it to the pipettin~ position, where a measured amount of starting reagent is added and mixed in and the cuvette is returned to the rotor.
o Three hundred and twenty-four seconds later, the processing station 4 takes the cuvette off the rotor and dumps it.
While the cuvettes are on the rotor, an absorption measurement is made every six seconds.
In addition to this sequence, there are two treatment phases for fluorescence polarometric (FP) measurements.
When the cuvette is returned to the rotor after adding the ~o sample, it is removed 132 seconds later by the processing sta~ion 11 and an FP blank measurement (parallel and at right angles) is made .
Accordingly, 90 seconds after the cuvette and the measured 2s amount of starting reagent have been put back on the rotor, the cuvette is again removed by the processing station 11 and measured and then returned to the rotor.
During the pipetting time in the processing stations, the 30 rotor makes a complete revolution for the absorption measure-ment. The photometer irradiates the cuvettes with white light, which is then divided into twelve wavelengths. Any two values of these twelve wavelengths are stored for further processing. This resuits in a measuring point at two wavelengths for each cuvette 3s every six seconds.
The rotor conveys the cuvettes to a photometer 9 for making absorption measurements. The cuvettes travel through the ligh~ beam of the photometer.
s Processing stations are disposed in exactly defined positions relative to the rotor. The processing stations are equipped with means for removing cuvettes from the rotor and/or for inserting cuvettes on the rotor when the rotor is not moving. The functions of the processing stations will be described in detail hereinafter.
10 A detailed description of the processing stations for adding samples or reagents is given in the simultaneously published European Patent Application No. 92,105901. Reference is made to this description herewith.
One processing station 4 is for insertion of new cuvettes and removal of used cuvettes at the end of analysis. The cuvettes removed from the rotor are placed in a waste container.
One processing station 8 is for metering of reagents. One of 20 the cuvettes o~a the rotor is taken of~ ~nd moved to a processing position in the station. One or more reagents are pipetted into the cuve~te. Simultaneously, the reagents are mixed by suitably moving the cuvette, after which the cuve~te and reagents are returned to the rotor.
2s A processing station 6 is for preliminary dilution of the sample. An empty cuvette is taken off the rotor and brought to a processing position in the station. A preset amount of sample and dilution liquid is pipetted in to the cuvette. At the same time, the 30 dilute sample is mixed by suitably moving the cuvette, after which the cuvette is pu~ back on the rotor.
A processing station 5 is for metering of samples. One of the cuvettes on the rotor is taken off and brought into a processing 3s position in the station. A preset quantity of the dilute sample is pipetted into the cuvette. At the same time, the reagents are mixed by suitably moving the cuvette. The cuvette containing the mixture of samples and reagents is then returned to the rotor.
4~ 3 ~ ~ ~
A processing station 7 is for adding a starting reagent to start the reaction by the sample. A cuvette is taken off the rotor and brought to a processing position in the station. A preset s amount of starting reagent is pipetted into the cuvette. At the same time the mixture of samples ansl reagents is mixed by suitably moving the cuvctte The cuvette is then put baek on the rotor.
I O A processing station 11 is for fluorescence polarimetric (~P) measurement. A sample containing a mixture of samples and reagents is taken off the rotor and brought to a rneasuring chamber in the station. At the end of the measurement, the cuvette is returned to the rotor.
Using measurement of absorption as an example, a determination program proceeds as follows:
To malce the required determination, a processing station 4 20 places a cuvette on the rotor. Firstly, an air ~est measurement is made on the cuvette on the rotor.
Thirty seconds later, the processing station 8 takes the cuvette off the rotor and moves it into a pipetting position in the 25 processing station, where one or more reagents are pipe~ted into the cuvette. When there are a number of reagents, they are mixed during and after pipetting. The cuvette is then returned to the rotor.
Seventy two seconds later, the cuvette is taken off the rotor by the processing station 6 and brought to the pipetting position, where the sample and diluent are metered by the sample transfer means. At the same time and/or afterwards, the substances are mixed and, after the pre-dilute sample has been used, the cuvette 3S is put back Oll the rotor.
Six seconds later, the processing station 5 takes the cuvette from the rotor and moves it into the pipetting posit;on, where the 6 ~OL~3~3~8 sample is metered by the transfer means and then mixed and the cuvette is returned to the rotor. A To measurement is then made on the rotor.
s One hundred and sixty two seconds later, the processing station 7 ~akes the cuvette off the rotor and brings it to the pipettin~ position, where a measured amount of starting reagent is added and mixed in and the cuvette is returned to the rotor.
o Three hundred and twenty-four seconds later, the processing station 4 takes the cuvette off the rotor and dumps it.
While the cuvettes are on the rotor, an absorption measurement is made every six seconds.
In addition to this sequence, there are two treatment phases for fluorescence polarometric (FP) measurements.
When the cuvette is returned to the rotor after adding the ~o sample, it is removed 132 seconds later by the processing sta~ion 11 and an FP blank measurement (parallel and at right angles) is made .
Accordingly, 90 seconds after the cuvette and the measured 2s amount of starting reagent have been put back on the rotor, the cuvette is again removed by the processing station 11 and measured and then returned to the rotor.
During the pipetting time in the processing stations, the 30 rotor makes a complete revolution for the absorption measure-ment. The photometer irradiates the cuvettes with white light, which is then divided into twelve wavelengths. Any two values of these twelve wavelengths are stored for further processing. This resuits in a measuring point at two wavelengths for each cuvette 3s every six seconds.
Claims (3)
1. A device for chemical and biochemical analysis, comprising a conveyor for conveying cuvettes and one or more stations for processing the samples for analysis in the cuvettes, characterized by means for removing individual cuvettes from the conveyor, for transferring the cuvettes to a position for processing and for returning the cuvettes to the conveyor after processing.
2. A device according to claim 1, characterized in that the means are parts of a processing station.
3. A device according to claim 2, characterized in that the means comprises a change-over and positioning device, and a control device is provided for controlling the motions of the change-over and positioning device and for simultaneously controlling a mixing operation during processing.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92105903 | 1992-04-06 | ||
| EP92105903.6 | 1992-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2093508A1 true CA2093508A1 (en) | 1993-10-07 |
Family
ID=8209512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002093508A Abandoned CA2093508A1 (en) | 1992-04-06 | 1993-04-06 | Analytical device |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5762872A (en) |
| EP (1) | EP0564907B1 (en) |
| JP (1) | JP3131068B2 (en) |
| CA (1) | CA2093508A1 (en) |
| DE (1) | DE59306558D1 (en) |
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| US5772962A (en) * | 1995-05-29 | 1998-06-30 | Hitachi, Ltd. | Analyzing apparatus using disposable reaction vessels |
| ATE426456T1 (en) * | 1998-05-01 | 2009-04-15 | Gen Probe Inc | AUTOMATIC DIAGNOSTIC ANALYZER |
| US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
| US6919044B1 (en) * | 1999-06-17 | 2005-07-19 | Beckman Coulter, Inc. | Sample loading and handling interface to multiple chemistry analyzers |
| US8398656B2 (en) | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
| JP3972012B2 (en) | 2003-03-19 | 2007-09-05 | 株式会社日立ハイテクノロジーズ | Sample dispensing mechanism and automatic analyzer equipped with the same |
| EP1615037A1 (en) * | 2004-07-06 | 2006-01-11 | Boehringer Mannheim Gmbh | An apparatus for liquid handling with multiple transfer tools |
| EP2333561A3 (en) | 2005-03-10 | 2014-06-11 | Gen-Probe Incorporated | System for performing multi-formatted assays |
| US8313497B2 (en) | 2005-07-01 | 2012-11-20 | Abbott Laboratories | Clip applier and methods of use |
| ITMI20061502A1 (en) * | 2006-07-28 | 2008-01-29 | Barilla Flli G & R Spa | PROCEDURE AND EQUIPMENT FOR THE QUICK DETERMINATION OF DEOSSINIVALENOL IN A CEREAL-BASED MATRIX. |
| US7641855B2 (en) * | 2006-08-25 | 2010-01-05 | Siemens Healthcare Diagnostics Inc. | System for automatically storing and reprocessing patient samples in an automatic clinical analyzer |
| US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
| JP5286120B2 (en) * | 2009-03-18 | 2013-09-11 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
| AU2012222178B2 (en) | 2011-02-24 | 2014-12-18 | Gen-Probe Incorporated | Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector |
| US8556932B2 (en) | 2011-05-19 | 2013-10-15 | Abbott Cardiovascular Systems, Inc. | Collapsible plug for tissue closure |
| US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
| EP4109106A1 (en) | 2013-03-15 | 2022-12-28 | Abbott Laboratories | Automated diagnostic analyzers having vertically arranged carousels and related methods |
| US10001497B2 (en) | 2013-03-15 | 2018-06-19 | Abbott Laboratories | Diagnostic analyzers with pretreatment carousels and related methods |
| EP2972404B1 (en) | 2013-03-15 | 2021-11-24 | Abbott Laboratories | Automated diagnostic analyzers having rear accessible track systems and related methods |
| FR3048510B1 (en) | 2016-03-01 | 2020-01-31 | Arteion | AUTOMATIC ANALYSIS SYSTEM FOR IN VITRO DIAGNOSIS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3115966A (en) * | 1959-05-04 | 1963-12-31 | Leiter Harry | Sample testing machine |
| US3322958A (en) * | 1964-05-07 | 1967-05-30 | American Instr Co Inc | Photometer automatic sample changer |
| US3432049A (en) * | 1967-02-20 | 1969-03-11 | Elliotts Liverpool Ltd | Apparatus for automatically feeding articles from a store or batch |
| US3644095A (en) | 1967-12-20 | 1972-02-22 | Eppendorf Geractebau Netheler | Apparatus for performing chemical analyses |
| US4582990A (en) * | 1980-10-27 | 1986-04-15 | Randam Electronics, Inc. | Analytical instrument with two moving trains of sample holder-carrying trays under microprocessor control |
| US4518264A (en) * | 1982-07-13 | 1985-05-21 | Mitsubishi Kasei Kogyo Kabushiki Kaisha | Stirring apparatus |
| JPS60174866U (en) * | 1984-04-27 | 1985-11-19 | 三共株式会社 | Reaction liquid stirring and mixing device in automatic measurement equipment |
| JPS61274268A (en) * | 1985-05-30 | 1986-12-04 | Toshiba Corp | Automatic chemical analyzer |
| JPH0786509B2 (en) * | 1985-06-18 | 1995-09-20 | 株式会社東芝 | Automatic chemical analyzer |
| JP2510152B2 (en) | 1985-11-19 | 1996-06-26 | オリンパス光学工業株式会社 | Automatic analyzer |
| CN1014551B (en) * | 1986-09-16 | 1991-10-30 | 尼泰库株式会社 | Automatic analyser |
| US4861553A (en) * | 1987-06-11 | 1989-08-29 | Technicon Instruments Corporation | Automatic sampling system |
| US5066135A (en) * | 1988-08-09 | 1991-11-19 | Beckman Instruments, Inc. | Rotatable vortexing turntable |
| GB9020352D0 (en) * | 1990-09-18 | 1990-10-31 | Anagen Ltd | Assay or reaction apparatus |
| CA2092025A1 (en) * | 1992-04-06 | 1993-10-07 | Bruno Koch | Conveyor for an analytical device |
| CA2092026A1 (en) * | 1992-04-06 | 1993-10-07 | Burkard Rosenberg | Processing station for an analytical device |
-
1993
- 1993-03-24 DE DE59306558T patent/DE59306558D1/en not_active Expired - Lifetime
- 1993-03-24 EP EP93104847A patent/EP0564907B1/en not_active Expired - Lifetime
- 1993-04-05 JP JP05077310A patent/JP3131068B2/en not_active Expired - Fee Related
- 1993-04-06 CA CA002093508A patent/CA2093508A1/en not_active Abandoned
-
1997
- 1997-07-23 US US08/899,461 patent/US5762872A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0564907A1 (en) | 1993-10-13 |
| EP0564907B1 (en) | 1997-05-28 |
| US5762872A (en) | 1998-06-09 |
| DE59306558D1 (en) | 1997-07-03 |
| JPH0618533A (en) | 1994-01-25 |
| JP3131068B2 (en) | 2001-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |