CA2090721C - Procede de fecondation en cycle spontane - Google Patents
Procede de fecondation en cycle spontane Download PDFInfo
- Publication number
- CA2090721C CA2090721C CA002090721A CA2090721A CA2090721C CA 2090721 C CA2090721 C CA 2090721C CA 002090721 A CA002090721 A CA 002090721A CA 2090721 A CA2090721 A CA 2090721A CA 2090721 C CA2090721 C CA 2090721C
- Authority
- CA
- Canada
- Prior art keywords
- oocyte
- container
- fertilization
- culture
- embryo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 71
- 230000004720 fertilization Effects 0.000 title claims abstract description 48
- 210000000287 oocyte Anatomy 0.000 claims abstract description 81
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract description 27
- 239000001963 growth medium Substances 0.000 claims abstract description 11
- 230000000638 stimulation Effects 0.000 claims abstract description 9
- 210000004291 uterus Anatomy 0.000 claims abstract description 7
- 230000008569 process Effects 0.000 claims abstract description 6
- 230000035800 maturation Effects 0.000 claims description 18
- 238000000338 in vitro Methods 0.000 claims description 14
- 210000002257 embryonic structure Anatomy 0.000 claims description 12
- 238000012546 transfer Methods 0.000 claims description 12
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 229960005309 estradiol Drugs 0.000 claims description 6
- 229930182833 estradiol Natural products 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 230000036765 blood level Effects 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims description 2
- 238000009630 liquid culture Methods 0.000 claims description 2
- 230000007017 scission Effects 0.000 claims description 2
- 238000011010 flushing procedure Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 abstract description 5
- 238000009534 blood test Methods 0.000 abstract description 4
- 230000005070 ripening Effects 0.000 abstract description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 18
- 208000000509 infertility Diseases 0.000 description 12
- 230000036512 infertility Effects 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 9
- 239000000186 progesterone Substances 0.000 description 9
- 229960003387 progesterone Drugs 0.000 description 9
- 230000002269 spontaneous effect Effects 0.000 description 9
- 208000021267 infertility disease Diseases 0.000 description 8
- 230000035935 pregnancy Effects 0.000 description 8
- 238000002604 ultrasonography Methods 0.000 description 8
- 231100000535 infertility Toxicity 0.000 description 7
- 230000003325 follicular Effects 0.000 description 5
- 230000029849 luteinization Effects 0.000 description 5
- 230000002611 ovarian Effects 0.000 description 5
- 230000009469 supplementation Effects 0.000 description 5
- 230000003054 hormonal effect Effects 0.000 description 4
- 230000009027 insemination Effects 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 201000009273 Endometriosis Diseases 0.000 description 3
- 208000034702 Multiple pregnancies Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000004696 endometrium Anatomy 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000016087 ovulation Effects 0.000 description 3
- 239000010902 straw Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 210000002503 granulosa cell Anatomy 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- PYTMYKVIJXPNBD-OQKDUQJOSA-N 2-[4-[(z)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 PYTMYKVIJXPNBD-OQKDUQJOSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 208000035002 Pregnancy of unknown location Diseases 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 210000001109 blastomere Anatomy 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 229940046989 clomiphene citrate Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 210000001771 cumulus cell Anatomy 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000001733 follicular fluid Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001150 spermicidal effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 210000004340 zona pellucida Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/906—Fertility tests
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Catching Or Destruction (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Fertilizing (AREA)
- Fertilizers (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR91/08177 | 1991-07-01 | ||
| FR9108177A FR2678506B1 (fr) | 1991-07-01 | 1991-07-01 | Procede de fecondation en cycle spontane. |
| PCT/FR1992/000615 WO1993000863A1 (fr) | 1991-07-01 | 1992-07-01 | Procede de fecondation en cycle spontane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2090721A1 CA2090721A1 (fr) | 1993-01-02 |
| CA2090721C true CA2090721C (fr) | 2004-06-29 |
Family
ID=9414546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002090721A Expired - Fee Related CA2090721C (fr) | 1991-07-01 | 1992-07-01 | Procede de fecondation en cycle spontane |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5532155A (de) |
| EP (1) | EP0546155B1 (de) |
| AT (1) | ATE180401T1 (de) |
| AU (1) | AU2278692A (de) |
| CA (1) | CA2090721C (de) |
| DE (1) | DE69229259D1 (de) |
| FR (1) | FR2678506B1 (de) |
| RU (1) | RU2152758C2 (de) |
| WO (1) | WO1993000863A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2276322A (en) * | 1993-03-24 | 1994-09-28 | Rudiger Ulrich Josef Pitroff | Mammalian embryo fertilization and incubation device |
| US6819411B1 (en) | 1997-01-31 | 2004-11-16 | Xy, Inc. | Optical apparatus |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| AU5240899A (en) | 1998-07-30 | 2000-02-21 | Colorado State University Research Foundation | Equine system for non-surgical artificial insemination |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| BR0110731A (pt) | 2000-05-09 | 2004-04-27 | Xy Inc | Populações de espermatózoides contendo cromossomo x e cromossomo y de alta pureza |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| BRPI0115791B1 (pt) * | 2000-11-29 | 2020-05-05 | Colorado State Univ | sistema para fertilização in vitro com espematozóides separados em populações portadoras de cromossoma x e cromossoma y |
| AU2003234947A1 (en) * | 2002-04-17 | 2003-10-27 | Yuriy Vladimirovich Komissarov | "natural selection" method for conceiving a child and device for carrying out said method |
| BRPI0313163B1 (pt) | 2002-08-01 | 2015-11-17 | Univ Colorado State | sistema de separação de células espermáticas a baixa pressão |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
| CA2534394C (en) | 2002-08-15 | 2013-01-08 | Xy, Inc. | High resolution flow cytometer |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| WO2004035766A2 (en) * | 2002-10-15 | 2004-04-29 | Novo Nordisk A/S | In vitro synchronisation of nuclear and cytoplasmatic maturation of oocytes involving addition and removal of phosphodiesterase type 3 inhibitor |
| EP2305171B1 (de) | 2003-03-28 | 2021-12-29 | Inguran, LLC | Vorrichtung und Verfahren zur Bereitstellung von geschlechtssortierten Tierspermien |
| ES2541121T3 (es) | 2003-05-15 | 2015-07-16 | Xy, Llc | Clasificación eficiente de células haploides por sistemas de citometría de flujo |
| NZ550198A (en) | 2004-03-29 | 2009-12-24 | Inguran Llc | Sperm suspensions for use in insemination |
| AU2005245899A1 (en) | 2004-05-17 | 2005-12-01 | The General Hospital Corporation | Methods and compositions for producing germ cells from peripheral blood derived germline stem cells |
| BRPI0513685A (pt) | 2004-07-22 | 2008-05-13 | Monsanto Technology Llc | processo para enriquecimento de uma população de células de esperma |
| AU2012242591B2 (en) | 2011-04-14 | 2014-10-23 | The General Hospital Corporation | Compositions and methods for autologous germline mitochondrial energy transfer |
| CN103827293A (zh) | 2011-06-29 | 2014-05-28 | 通用医疗公司 | 用于增强雌性生殖细胞中生物能状态的组合物和方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4010738A (en) * | 1974-10-30 | 1977-03-08 | The Trustees Of The University Of Pennsylvania | Method of predicting and detecting ovulation |
| IL72088A (en) * | 1983-06-14 | 1990-03-19 | Fertility & Genetics Ass | Uterine catheter for embryo transfer |
| DE3569876D1 (en) * | 1984-02-20 | 1989-06-08 | Olympus Optical Co | Endoscopic ovum picker instruments |
| FR2614626B1 (fr) * | 1987-04-30 | 1989-07-21 | Ranoux Claude | Conteneur pour fecondation des ovocytes et replacement des embryons chez l'homme et l'animal |
| FR2614899B1 (fr) * | 1987-05-07 | 1989-08-11 | Ranoux Claude | Dispositif pour preparation selection et capacitation des spermatozoides humains et animaux par filtration |
-
1991
- 1991-07-01 FR FR9108177A patent/FR2678506B1/fr not_active Expired - Fee Related
-
1992
- 1992-07-01 WO PCT/FR1992/000615 patent/WO1993000863A1/fr active IP Right Grant
- 1992-07-01 AT AT92914635T patent/ATE180401T1/de not_active IP Right Cessation
- 1992-07-01 US US07/977,409 patent/US5532155A/en not_active Expired - Lifetime
- 1992-07-01 AU AU22786/92A patent/AU2278692A/en not_active Abandoned
- 1992-07-01 RU RU93005171/14A patent/RU2152758C2/ru not_active IP Right Cessation
- 1992-07-01 EP EP92914635A patent/EP0546155B1/de not_active Expired - Lifetime
- 1992-07-01 CA CA002090721A patent/CA2090721C/fr not_active Expired - Fee Related
- 1992-07-01 DE DE69229259T patent/DE69229259D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2278692A (en) | 1993-02-11 |
| US5532155A (en) | 1996-07-02 |
| RU2152758C2 (ru) | 2000-07-20 |
| ATE180401T1 (de) | 1999-06-15 |
| FR2678506A1 (fr) | 1993-01-08 |
| DE69229259D1 (de) | 1999-07-01 |
| EP0546155A1 (de) | 1993-06-16 |
| EP0546155B1 (de) | 1999-05-26 |
| WO1993000863A1 (fr) | 1993-01-21 |
| CA2090721A1 (fr) | 1993-01-02 |
| FR2678506B1 (fr) | 2000-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |