CA2085462C - Antifungal ointment - Google Patents
Antifungal ointmentInfo
- Publication number
- CA2085462C CA2085462C CA 2085462 CA2085462A CA2085462C CA 2085462 C CA2085462 C CA 2085462C CA 2085462 CA2085462 CA 2085462 CA 2085462 A CA2085462 A CA 2085462A CA 2085462 C CA2085462 C CA 2085462C
- Authority
- CA
- Canada
- Prior art keywords
- ointment
- corn starch
- petroleum jelly
- antifungal agent
- ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 28
- 229940121375 antifungal agent Drugs 0.000 title claims abstract description 11
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229920002261 Corn starch Polymers 0.000 claims abstract description 24
- 239000008120 corn starch Substances 0.000 claims abstract description 24
- 235000019271 petrolatum Nutrition 0.000 claims abstract description 15
- 239000003429 antifungal agent Substances 0.000 claims abstract description 10
- 229960000988 nystatin Drugs 0.000 claims description 7
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 abstract description 8
- 238000001035 drying Methods 0.000 description 5
- 239000003974 emollient agent Substances 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 206010017533 Fungal infection Diseases 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An ointment consisting of the following described ingredients expressed as a percentage of volume. The ingredients being: between 28% and 61% corn starch; between 5% and 30% an antifungal agent compatible with human skin; and between 30% and 60% petroleum jelly.
Description
2~8~62 The present invention relates to an ointment.
R~ ROUND 0~ T~ INVENTIO~
Corn starch iB an odourless byproduct derived from corn with a slight characteristic taste. It is used extensively in food preparation. It can be purcha~ed in either irregular angular white masses or a fine powder form.
Corn starch has long been recognized as having absorben-t and demulcent properties. To take advantage of its properties as an absorbent, it is used in a powder form. To take advantage of its properties as a demulcent, tWQ CUpS of corn starch adde~ to hot bath water i~ reco -n~ed *o reliev~ rashes and other skin irritations which cause itching.
It is ill advised to apply corn starch indescr; r; nAntly to human skin, as it's absorbent proper~ie~ will lead to excess drying of the skin.
S~M~ARY OF T~E l~v~.~ION
What is required is a corn starch preparation which is suited for domestic use.
According to the presenk invention there is provided an ointment which i8 comprised of the following described ingredients expressed as a percentage of volume. The ingredients being: between 28% and 61% corn ~tarch; between 5~ and 30% an antifllngal agent compatible with human skin; and between 30% tc 60% petroleum jelly.
In this composition the corn starch serves it usual function as an absorbent and a demulcent. The petroleum jelly serves as a base for the ointment and also prevents the corn starch from excessively drying the skin. The anti~ungal agent guards againsk yeast infections and the like and lengthens the shelf life of the ointmentO
- , , ~ .. . . ~ : , . . .
. , ., ,. , ,. . , . , . - , , , ~
Although the broad range percentage described will bring beneficial results, it is preferred that the oini --~ have~ -between 50% and 60% corn starch; between 7% and 10% nystatin;
and between 30% and 40% petroleum jelly.
DE~TT-~n DESCRIPTIO~ OF T~E ~ h~ ~BODIMENT
The preferred embodiment, an ointment, will now be described. The ingredients for the ointment which will hereinafter be described are expressed as a percentage of total volume. The primary ingredients of the ointment are corn starch, petroleum jelly, and an antifungal agent~ The use of base substances, othPr than petroleum jelly~ was found to not have beneficial results as the petroleum jelly was the only base capable of preventing the corn starch from unduly drying human skin. The composition without the antifungal agent was found to promote the growth of yeast infections and the like.
:
The operative rarlge of the ingredient corn starch is between 28% and 61%. When the ointment contains less than 28%
corn starch, the beneficial absor~ent and demulcent qualities of the ointment are lost. When the ointment contains morP than 61~ corn starch, the corn starch has been found to ex~essively dry the skin. It is preferred that the corn starch represerlt between 50% and 60~ of the ointment. The best ~'all purpo~e"
ointment cont~ins approximately 56~ corn starch. In tha lower effective ranges of corn starch, ie. 28% to 38% the drying ef~ect of the corn starch is not as effectiYe for such skin conditions as acne or athlete's foot.
The operative range of the antifungal agent compatible with human skin is between 5% and 30%. Successful resul-ts have been obtained through the use of the antifungal agent knc)wn by th~ generic name of "Nystatin". When the oinl - t contains less than 5% the antifungal agent i5 ineffective. When the ointment contains more 30%, excess antifungal agent is taking the place of other ingredients to the detximent of the effectiveness of the ointment. It is preferred that the 2 ~ 6 2 ~:
, ointment have between 7% and 10% nystatin. The best "all purpose" ointment contains approximately 9% nystatin.
The operative range of petroleum jelly is between 30~ and ~0~. When-the ointment contains less than 30% petroleum jelly, the relative strength of the corn starch and nystatin is excessive/ resulting in excess drying of the skin. In addition the ointment becomes "pasty" and difficult to apply. When the ointment contains more 60%, excess petroleum jelly is taking the place of corn starch to the detriment of the effectiveness o~ the ointment. It is preferred that the ointment have bekween 30% and 40% petroleum jelly. The best "all purpose"
ointment contains approximately 35% petroleum jelly.
It will be apparent to one skilled in the art that modifications may be made to the preferred "all purpose"
ointment without departing from the spirit and scope of the invention as defined by the claims.
R~ ROUND 0~ T~ INVENTIO~
Corn starch iB an odourless byproduct derived from corn with a slight characteristic taste. It is used extensively in food preparation. It can be purcha~ed in either irregular angular white masses or a fine powder form.
Corn starch has long been recognized as having absorben-t and demulcent properties. To take advantage of its properties as an absorbent, it is used in a powder form. To take advantage of its properties as a demulcent, tWQ CUpS of corn starch adde~ to hot bath water i~ reco -n~ed *o reliev~ rashes and other skin irritations which cause itching.
It is ill advised to apply corn starch indescr; r; nAntly to human skin, as it's absorbent proper~ie~ will lead to excess drying of the skin.
S~M~ARY OF T~E l~v~.~ION
What is required is a corn starch preparation which is suited for domestic use.
According to the presenk invention there is provided an ointment which i8 comprised of the following described ingredients expressed as a percentage of volume. The ingredients being: between 28% and 61% corn ~tarch; between 5~ and 30% an antifllngal agent compatible with human skin; and between 30% tc 60% petroleum jelly.
In this composition the corn starch serves it usual function as an absorbent and a demulcent. The petroleum jelly serves as a base for the ointment and also prevents the corn starch from excessively drying the skin. The anti~ungal agent guards againsk yeast infections and the like and lengthens the shelf life of the ointmentO
- , , ~ .. . . ~ : , . . .
. , ., ,. , ,. . , . , . - , , , ~
Although the broad range percentage described will bring beneficial results, it is preferred that the oini --~ have~ -between 50% and 60% corn starch; between 7% and 10% nystatin;
and between 30% and 40% petroleum jelly.
DE~TT-~n DESCRIPTIO~ OF T~E ~ h~ ~BODIMENT
The preferred embodiment, an ointment, will now be described. The ingredients for the ointment which will hereinafter be described are expressed as a percentage of total volume. The primary ingredients of the ointment are corn starch, petroleum jelly, and an antifungal agent~ The use of base substances, othPr than petroleum jelly~ was found to not have beneficial results as the petroleum jelly was the only base capable of preventing the corn starch from unduly drying human skin. The composition without the antifungal agent was found to promote the growth of yeast infections and the like.
:
The operative rarlge of the ingredient corn starch is between 28% and 61%. When the ointment contains less than 28%
corn starch, the beneficial absor~ent and demulcent qualities of the ointment are lost. When the ointment contains morP than 61~ corn starch, the corn starch has been found to ex~essively dry the skin. It is preferred that the corn starch represerlt between 50% and 60~ of the ointment. The best ~'all purpo~e"
ointment cont~ins approximately 56~ corn starch. In tha lower effective ranges of corn starch, ie. 28% to 38% the drying ef~ect of the corn starch is not as effectiYe for such skin conditions as acne or athlete's foot.
The operative range of the antifungal agent compatible with human skin is between 5% and 30%. Successful resul-ts have been obtained through the use of the antifungal agent knc)wn by th~ generic name of "Nystatin". When the oinl - t contains less than 5% the antifungal agent i5 ineffective. When the ointment contains more 30%, excess antifungal agent is taking the place of other ingredients to the detximent of the effectiveness of the ointment. It is preferred that the 2 ~ 6 2 ~:
, ointment have between 7% and 10% nystatin. The best "all purpose" ointment contains approximately 9% nystatin.
The operative range of petroleum jelly is between 30~ and ~0~. When-the ointment contains less than 30% petroleum jelly, the relative strength of the corn starch and nystatin is excessive/ resulting in excess drying of the skin. In addition the ointment becomes "pasty" and difficult to apply. When the ointment contains more 60%, excess petroleum jelly is taking the place of corn starch to the detriment of the effectiveness o~ the ointment. It is preferred that the ointment have bekween 30% and 40% petroleum jelly. The best "all purpose"
ointment contains approximately 35% petroleum jelly.
It will be apparent to one skilled in the art that modifications may be made to the preferred "all purpose"
ointment without departing from the spirit and scope of the invention as defined by the claims.
Claims (4)
1. An ointment, comprising:
a. between 28% and 61% corn starch;
b. between 5% and 30% an antifungal agent compatible with human skin; and c. between 30% and 60% petroleum jelly.
a. between 28% and 61% corn starch;
b. between 5% and 30% an antifungal agent compatible with human skin; and c. between 30% and 60% petroleum jelly.
2. An ointment, comprising:
a. between 50% and 60% corn starch;
b. between 7% and 10% an antifungal agent compatible with human skin; and c. between 30% and 40% petroleum jelly.
a. between 50% and 60% corn starch;
b. between 7% and 10% an antifungal agent compatible with human skin; and c. between 30% and 40% petroleum jelly.
3. An ointment as defined in Claim 1 or Claim 2, the antifungal agent being nystatin.
4. An ointment, comprising:
a. 56% corn starch;
b. 9% nystatin; and c. 35% petroleum jelly.
a. 56% corn starch;
b. 9% nystatin; and c. 35% petroleum jelly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2085462 CA2085462C (en) | 1992-12-15 | 1992-12-15 | Antifungal ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2085462 CA2085462C (en) | 1992-12-15 | 1992-12-15 | Antifungal ointment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2085462A1 CA2085462A1 (en) | 1994-06-16 |
| CA2085462C true CA2085462C (en) | 1998-08-11 |
Family
ID=4150853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2085462 Expired - Fee Related CA2085462C (en) | 1992-12-15 | 1992-12-15 | Antifungal ointment |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2085462C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5898034A (en) * | 1998-05-23 | 1999-04-27 | Kessler; Kenneth D. | Psoriasis medication and application for remission and/or cure of plaque psoriasis |
-
1992
- 1992-12-15 CA CA 2085462 patent/CA2085462C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2085462A1 (en) | 1994-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |