CA2348693A1 - Natural formulation for the treatment and prevention of depression, containing st john's wort and derivatives of dihydro- and tetrahydrofolic acid - Google Patents
Natural formulation for the treatment and prevention of depression, containing st john's wort and derivatives of dihydro- and tetrahydrofolic acid Download PDFInfo
- Publication number
- CA2348693A1 CA2348693A1 CA002348693A CA2348693A CA2348693A1 CA 2348693 A1 CA2348693 A1 CA 2348693A1 CA 002348693 A CA002348693 A CA 002348693A CA 2348693 A CA2348693 A CA 2348693A CA 2348693 A1 CA2348693 A1 CA 2348693A1
- Authority
- CA
- Canada
- Prior art keywords
- wort
- dihydro
- john
- depression
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 title abstract 2
- OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical class N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 244000141009 Hypericum perforatum Species 0.000 abstract 2
- 235000017309 Hypericum perforatum Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to novel compositions containing a combination of the plant St. John's Wort (Hypericum perforatum L.), its extracts of active ingredients and derivatives of dihydro- and tetrahydrofolic acid. This natural formulation is useful for the treatment and prevention of depression with a better effect than the ingredient compounds alone.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10471098P | 1998-10-19 | 1998-10-19 | |
| US60/104,710 | 1998-10-19 | ||
| PCT/EP1999/007556 WO2000023089A1 (en) | 1998-10-19 | 1999-10-08 | Natural formulation for the treatment and prevention of depression, containing st john's wort and derivatives of dihydro- and tetrahydrofolic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2348693A1 true CA2348693A1 (en) | 2000-04-27 |
| CA2348693C CA2348693C (en) | 2008-07-15 |
Family
ID=22301956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002348693A Expired - Fee Related CA2348693C (en) | 1998-10-19 | 1999-10-08 | Natural formulation for the treatment and prevention of depression, containing st john's wort and derivatives of dihydro- and tetrahydrofolic acid |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1121139A1 (en) |
| JP (2) | JP2002527484A (en) |
| CA (1) | CA2348693C (en) |
| WO (1) | WO2000023089A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100814652B1 (en) * | 2000-06-02 | 2008-03-18 | 메르크 파텐트 게엠베하 | Composition for the treatment and/or the prevention of osteoporosis and/or inflammatory joint diseases |
| DE10315022A1 (en) * | 2003-03-03 | 2004-09-23 | Bioplanta Arzneimittel Gmbh | Use of rutin or isorhamnetin, or plant parts or extracts containing them, to treat depression and related conditions, optionally incorporated into foods |
| UY29527A1 (en) * | 2005-05-13 | 2006-12-29 | Schering Ag | PHARMACCUTIC COMPOSITION CONTAINING GESTRGENS AND / OR ESTRNGENS AND 5-METHYL - (6S) - TETRHYDROPHOLATE. |
| JP6333136B2 (en) * | 2014-09-10 | 2018-05-30 | サントリーホールディングス株式会社 | Beverages containing St. John's wort extract |
| CN105687169B (en) * | 2016-03-18 | 2018-06-12 | 西北工业大学 | Application of the hypericin as cystathionine beta-synthase inhibitor |
| WO2022040740A1 (en) * | 2020-08-25 | 2022-03-03 | State of Mind Australasia Pty Ltd | Method of treating depression and/or anxiety, and/or symptoms associated therewith |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1229517B (en) * | 1989-01-31 | 1991-09-03 | Bioresearch Spa | USE OF 5-METHYLTETRAHYDROPHOLIC ACID, OF 5 FORMYLTHETRAHYDROPHOLIC ACID, AND OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE SUITABLE FOR BEING EMPLOYED IN THE TREATMENT OF DISORDERS IN THE TREATMENT OF DISORDERS. |
| FR2643081B1 (en) * | 1989-02-14 | 1991-06-07 | Panmedica Sa | MAGNESIUM FOLATES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS |
| US5820867A (en) * | 1997-04-24 | 1998-10-13 | Bewicke; Calverly M. | General anti-depressant composition for dietary supplement |
| US6096317A (en) * | 1998-01-13 | 2000-08-01 | Rexall Sundown | St. John's Wort and methyl donor composition and uses thereof |
| WO1999037155A1 (en) * | 1998-01-27 | 1999-07-29 | Nutramax Laboratories, Inc. | Combinations of tyrosine, methylating agents, phospholipids, fatty acids, and st. john's wort for the treatment of mental disturbances |
-
1999
- 1999-10-08 EP EP99950676A patent/EP1121139A1/en not_active Ceased
- 1999-10-08 CA CA002348693A patent/CA2348693C/en not_active Expired - Fee Related
- 1999-10-08 WO PCT/EP1999/007556 patent/WO2000023089A1/en not_active Application Discontinuation
- 1999-10-08 JP JP2000576863A patent/JP2002527484A/en active Pending
-
2011
- 2011-02-14 JP JP2011029032A patent/JP2011132250A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2348693C (en) | 2008-07-15 |
| JP2011132250A (en) | 2011-07-07 |
| EP1121139A1 (en) | 2001-08-08 |
| JP2002527484A (en) | 2002-08-27 |
| WO2000023089A1 (en) | 2000-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |