CA2079815A1 - Derives de carbonucleosides - Google Patents

Derives de carbonucleosides

Info

Publication number
CA2079815A1
CA2079815A1 CA002079815A CA2079815A CA2079815A1 CA 2079815 A1 CA2079815 A1 CA 2079815A1 CA 002079815 A CA002079815 A CA 002079815A CA 2079815 A CA2079815 A CA 2079815A CA 2079815 A1 CA2079815 A1 CA 2079815A1
Authority
CA
Canada
Prior art keywords
group
alkyl
pct
derivative
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002079815A
Other languages
English (en)
Inventor
Jo Klaveness
Kjell Undheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLIVE FROUD TO NYCOMED AS
CLIVE FROUD
GE Healthcare AS
Original Assignee
Nycomed AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed AS filed Critical Nycomed AS
Publication of CA2079815A1 publication Critical patent/CA2079815A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002079815A 1990-04-04 1991-04-04 Derives de carbonucleosides Abandoned CA2079815A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9007569.8 1990-04-04
GB909007569A GB9007569D0 (en) 1990-04-04 1990-04-04 Carbo-nucleoside derivatives
PCT/EP1991/000655 WO1991015488A1 (fr) 1990-04-04 1991-04-04 Derives de carbo-nucleoside

Publications (1)

Publication Number Publication Date
CA2079815A1 true CA2079815A1 (fr) 1991-10-05

Family

ID=10673843

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079815A Abandoned CA2079815A1 (fr) 1990-04-04 1991-04-04 Derives de carbonucleosides

Country Status (7)

Country Link
EP (1) EP0523160A1 (fr)
JP (1) JPH05507267A (fr)
AU (1) AU7695991A (fr)
CA (1) CA2079815A1 (fr)
GB (1) GB9007569D0 (fr)
OA (1) OA09670A (fr)
WO (1) WO1991015488A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0630897A3 (fr) * 1993-06-25 1995-03-01 Bristol Myers Squibb Co 3-Hydroxy-4-hydroxyméthyl-2-methylène-cyclopentyl purines et pyrimidines.
AU2787199A (en) * 1998-02-25 1999-09-15 Emory University 2'-fluoronucleosides
AU7653300A (en) * 1999-09-10 2001-04-10 Stichting Rega Vzw Carbocyclic nucleosides and process for obtaining such
ATE491459T1 (de) 2000-10-18 2011-01-15 Pharmasset Inc Modifizierte nukleoside zur behandlung von virusinfektionen und abnormaler zellulärer proliferation
CA2463719A1 (fr) 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Analogues de nucleotides possedant des cycles a six chainons
CN101835374B (zh) 2007-07-09 2014-08-27 东弗吉尼亚医学院 具有抗病毒和抗微生物性质的取代的核苷衍生物
JP5732453B2 (ja) 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
EP3761983A1 (fr) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Stratégie de dosage d'aripiprazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ197458A (en) * 1980-06-23 1983-11-30 Univ Minnesota O-alkoxyalkanoyl derivatives of adenine nucleosides
US4396623A (en) * 1981-08-26 1983-08-02 Southern Research Institute Carbocyclic analogs of uracil nucleosides as antiviral agents
US4719214A (en) * 1985-07-25 1988-01-12 Southern Research Institute Carbocyclic analogues of thymine nucleosides
DE3850571T2 (de) * 1987-03-24 1994-10-27 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
US5015739A (en) * 1988-04-22 1991-05-14 Schering Corporation Processes for preparation of cyclopentyl purine derivatives

Also Published As

Publication number Publication date
WO1991015488A1 (fr) 1991-10-17
JPH05507267A (ja) 1993-10-21
EP0523160A1 (fr) 1993-01-20
GB9007569D0 (en) 1990-05-30
AU7695991A (en) 1991-10-30
OA09670A (en) 1993-05-15

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Legal Events

Date Code Title Description
FZDE Dead