CA2076159A1 - DNA Encoding Precursor Interleukin 1BETA Converting Enzyme - Google Patents
DNA Encoding Precursor Interleukin 1BETA Converting EnzymeInfo
- Publication number
- CA2076159A1 CA2076159A1 CA2076159A CA2076159A CA2076159A1 CA 2076159 A1 CA2076159 A1 CA 2076159A1 CA 2076159 A CA2076159 A CA 2076159A CA 2076159 A CA2076159 A CA 2076159A CA 2076159 A1 CA2076159 A1 CA 2076159A1
- Authority
- CA
- Canada
- Prior art keywords
- ice
- beta
- converting enzyme
- kda
- dna encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002243 precursor Substances 0.000 title abstract 2
- 108090000426 Caspase-1 Proteins 0.000 title 1
- 108020004635 Complementary DNA Proteins 0.000 abstract 5
- 102000000589 Interleukin-1 Human genes 0.000 abstract 5
- 108010002352 Interleukin-1 Proteins 0.000 abstract 5
- 238000010804 cDNA synthesis Methods 0.000 abstract 4
- 239000002299 complementary DNA Substances 0.000 abstract 4
- 108700026244 Open Reading Frames Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Complementary DNA (cDNA) encoding the precursor interleukin-1.beta. (pre-IL-1.beta.) converting enzyme (ICE) is isolated from a cDNA library. A
cDNA, encoding the full-length open reading frame (ORF) for the nascent ICE, as well as individual cDNAs encoding the 20 kDa subunit and the 10 kDa subunit of ICE are identified and sequenced. ICE is useful in the conversion of pre-IL-1.beta. into mature IL-1.beta.. The recombinantly produced ICE, including the individual 20 kDa and 10 kDa subunits is useful in the diagnosis of inflammatory diseases, in the production of recombinant IL-1.beta., and to identify inhibitors of ICE activity.
cDNA, encoding the full-length open reading frame (ORF) for the nascent ICE, as well as individual cDNAs encoding the 20 kDa subunit and the 10 kDa subunit of ICE are identified and sequenced. ICE is useful in the conversion of pre-IL-1.beta. into mature IL-1.beta.. The recombinantly produced ICE, including the individual 20 kDa and 10 kDa subunits is useful in the diagnosis of inflammatory diseases, in the production of recombinant IL-1.beta., and to identify inhibitors of ICE activity.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74645491A | 1991-08-16 | 1991-08-16 | |
US746,454 | 1991-08-16 | ||
US90639292A | 1992-06-24 | 1992-06-24 | |
US906,392 | 1992-06-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2076159A1 true CA2076159A1 (en) | 1993-02-17 |
CA2076159C CA2076159C (en) | 2000-12-05 |
Family
ID=27114606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002076159A Expired - Fee Related CA2076159C (en) | 1991-08-16 | 1992-08-14 | Dna encoding precursor interleukin 1beta converting enzyme |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2076159C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856169A (en) * | 1995-02-21 | 1999-01-05 | Thomas Jefferson University | Isoforms of human interleukin-1β converting enzyme and methods of using the same |
-
1992
- 1992-08-14 CA CA002076159A patent/CA2076159C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856169A (en) * | 1995-02-21 | 1999-01-05 | Thomas Jefferson University | Isoforms of human interleukin-1β converting enzyme and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
CA2076159C (en) | 2000-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |