CA2076159A1 - DNA Encoding Precursor Interleukin 1BETA Converting Enzyme - Google Patents

DNA Encoding Precursor Interleukin 1BETA Converting Enzyme

Info

Publication number
CA2076159A1
CA2076159A1 CA2076159A CA2076159A CA2076159A1 CA 2076159 A1 CA2076159 A1 CA 2076159A1 CA 2076159 A CA2076159 A CA 2076159A CA 2076159 A CA2076159 A CA 2076159A CA 2076159 A1 CA2076159 A1 CA 2076159A1
Authority
CA
Canada
Prior art keywords
ice
beta
converting enzyme
kda
dna encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2076159A
Other languages
French (fr)
Other versions
CA2076159C (en
Inventor
Andrew D. Howard
Susan M. Molineaux
Michael J. Tocci
Jimmy R. Calaycay
Douglas K. Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2076159A1 publication Critical patent/CA2076159A1/en
Application granted granted Critical
Publication of CA2076159C publication Critical patent/CA2076159C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Complementary DNA (cDNA) encoding the precursor interleukin-1.beta. (pre-IL-1.beta.) converting enzyme (ICE) is isolated from a cDNA library. A
cDNA, encoding the full-length open reading frame (ORF) for the nascent ICE, as well as individual cDNAs encoding the 20 kDa subunit and the 10 kDa subunit of ICE are identified and sequenced. ICE is useful in the conversion of pre-IL-1.beta. into mature IL-1.beta.. The recombinantly produced ICE, including the individual 20 kDa and 10 kDa subunits is useful in the diagnosis of inflammatory diseases, in the production of recombinant IL-1.beta., and to identify inhibitors of ICE activity.
CA002076159A 1991-08-16 1992-08-14 Dna encoding precursor interleukin 1beta converting enzyme Expired - Fee Related CA2076159C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74645491A 1991-08-16 1991-08-16
US746,454 1991-08-16
US90639292A 1992-06-24 1992-06-24
US906,392 1992-06-24

Publications (2)

Publication Number Publication Date
CA2076159A1 true CA2076159A1 (en) 1993-02-17
CA2076159C CA2076159C (en) 2000-12-05

Family

ID=27114606

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002076159A Expired - Fee Related CA2076159C (en) 1991-08-16 1992-08-14 Dna encoding precursor interleukin 1beta converting enzyme

Country Status (1)

Country Link
CA (1) CA2076159C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856169A (en) * 1995-02-21 1999-01-05 Thomas Jefferson University Isoforms of human interleukin-1β converting enzyme and methods of using the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856169A (en) * 1995-02-21 1999-01-05 Thomas Jefferson University Isoforms of human interleukin-1β converting enzyme and methods of using the same

Also Published As

Publication number Publication date
CA2076159C (en) 2000-12-05

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed