CA2067244A1 - Anticorps monoclonal specifique pour recepteur d'iga - Google Patents

Anticorps monoclonal specifique pour recepteur d'iga

Info

Publication number
CA2067244A1
CA2067244A1 CA2067244A CA2067244A CA2067244A1 CA 2067244 A1 CA2067244 A1 CA 2067244A1 CA 2067244 A CA2067244 A CA 2067244A CA 2067244 A CA2067244 A CA 2067244A CA 2067244 A1 CA2067244 A1 CA 2067244A1
Authority
CA
Canada
Prior art keywords
effector cells
monoclonal antibody
antibody specific
target
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2067244A
Other languages
English (en)
Other versions
CA2067244C (fr
Inventor
Li Shen
Michael W. Fanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dartmouth College
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2067244A1 publication Critical patent/CA2067244A1/fr
Application granted granted Critical
Publication of CA2067244C publication Critical patent/CA2067244C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coating With Molten Metal (AREA)
  • Heat Treatment Of Sheet Steel (AREA)

Abstract

L'invention concerne des anticorps monoclonaux qui réagissent de manière spécifique au récepteur Fc pour IgA de cellules effectrices humaines. Les anticorps sont utiles pour cibler des cellules effectrices humaines (p. ex. des macrophages) contre une cellule cible (p. ex. une cellule cancéreuse, un agent infectieux, etc). A cet effet des anticorps bifonctionnels ou des hétéroanticorps peuvent être construits, lesquels contiennent la région de liaison dérivée d'un anticorps récepteur anti-Fc-alpha et la région de liaison d'un anticorps spécifique à la cible. Les cellules effectrices ciblées peuvent effectuer la lyse spécifique des cellules cibles.
CA002067244A 1989-10-20 1990-10-19 Anticorps monoclonal specifique pour recepteur d'iga Expired - Fee Related CA2067244C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42488389A 1989-10-20 1989-10-20
US07/424,883 1989-10-20
PCT/US1990/006030 WO1991005805A1 (fr) 1989-10-20 1990-10-19 ANTICORPS MONOCLONAL SPECIFIQUE POUR LEUR RECEPTEUR IgA

Publications (2)

Publication Number Publication Date
CA2067244A1 true CA2067244A1 (fr) 1991-04-21
CA2067244C CA2067244C (fr) 2000-12-19

Family

ID=23684271

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002067244A Expired - Fee Related CA2067244C (fr) 1989-10-20 1990-10-19 Anticorps monoclonal specifique pour recepteur d'iga

Country Status (9)

Country Link
US (1) US5610057A (fr)
EP (1) EP0496818B1 (fr)
JP (1) JPH05504677A (fr)
AT (1) ATE181558T1 (fr)
CA (1) CA2067244C (fr)
DE (1) DE69033181T2 (fr)
DK (1) DK0496818T3 (fr)
ES (1) ES2132072T3 (fr)
WO (1) WO1991005805A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018031A (en) * 1989-10-20 2000-01-25 Trustees Of Dartmouth College Binding agents specific for IgA receptor
US5582996A (en) * 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6111166A (en) * 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
ATE194992T1 (de) * 1995-06-07 2000-08-15 Medarex Inc Bispezifische moleküle gegen allergie
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5922845A (en) * 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
WO2001009186A2 (fr) * 1999-07-30 2001-02-08 Medarex, Inc. Composes therapeutiques constitues d'agents de liaison du recepteur anti fc
US20010051147A1 (en) * 2000-03-27 2001-12-13 Van De Winkel Jan G.J. Methods for immunostimulation using binding agents for the Fc receptor of immunoglobulin A
US7235233B2 (en) 2000-09-26 2007-06-26 Crucell Holland B.V. Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts
CA2437814C (fr) 2001-02-12 2008-05-13 Medarex, Inc. Anticorps monoclonaux humains de l'alphabloquant fc (cd89)
ATE447037T1 (de) 2002-04-25 2009-11-15 Crucell Holland Bv Mittel und verfahren zur herstellung von adenovirusvektoren
US20060165675A1 (en) * 2002-08-02 2006-07-27 Richman-Eisenstat Janice Beth Modulation of mesenchymal cells via iga-receptors
JP2008518947A (ja) * 2004-10-29 2008-06-05 エルシス セラピューティクス， インク． 免疫応答のクリアランス及び誘導におけるｃｒ１結合分子の使用
EP2127666A1 (fr) * 2008-05-28 2009-12-02 Drug Discovery Factory B.V. Procédé pour le traitement ou la prophylaxie de maladies inflammatoires chroniques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes

Also Published As

Publication number Publication date
WO1991005805A1 (fr) 1991-05-02
CA2067244C (fr) 2000-12-19
DE69033181D1 (de) 1999-07-29
DK0496818T3 (da) 1999-11-22
EP0496818B1 (fr) 1999-06-23
ES2132072T3 (es) 1999-08-16
DE69033181T2 (de) 1999-10-21
ATE181558T1 (de) 1999-07-15
US5610057A (en) 1997-03-11
EP0496818A1 (fr) 1992-08-05
JPH05504677A (ja) 1993-07-22

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Legal Events

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