CA2065388A1 - Method and device for treating epilepsy_ - Google Patents

Method and device for treating epilepsy_

Info

Publication number
CA2065388A1
CA2065388A1 CA002065388A CA2065388A CA2065388A1 CA 2065388 A1 CA2065388 A1 CA 2065388A1 CA 002065388 A CA002065388 A CA 002065388A CA 2065388 A CA2065388 A CA 2065388A CA 2065388 A1 CA2065388 A1 CA 2065388A1
Authority
CA
Canada
Prior art keywords
electrodes
pulses
positive
duration
frequency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002065388A
Other languages
French (fr)
Inventor
Jean-Marie Verhoeven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VERHOEVEN JEAN MARIE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2065388A1 publication Critical patent/CA2065388A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

A therapeutical apparatus for treating epilepsy or related diseases includes a positive electrical impulse generator using electrodes to apply impulses to the head of a patient, with said impulses having a frequency of 1.5-28 Hz, a peak voltage of 1-190 volts and a length of 0.025-2.5 ms.

Description

wo 92/00119 2 a 6 5 3 8 8 PCTtBE91/~W~3 Procede et dispositif pour le traltement de l'épilepsie.
~,.`''' La présente invention concerne un procedé et un disposi_if pour le traitement de l~epilepsie par utilisation d'électrodes produisant des impulsions elect. ques appli~uees ~ la têt~ du patient.
' Il est connu ~ue des impulsions electriques peu~ent ser~i~
dans certains cas à traiter des malades atteints d'epilepsie, notamment à 1'aide d'electrodes implantees. Des frequences de 1'ordre du MHz sont par ailleurs utilisees à
divers autres titres thérapeutiques.

Il a maintenant ete trou~e qu'une efficacite supexieure et inattendue peut êtse atteinte en utilisant un procede et dispositif caract~rise en ce que des impulsions de ~réquences variant de l,5 a 28 Hz sont emises au moyen d'~lectrodes appli~uées simplement sur la tete du patient.
Les impulsions peuvent être positives ou negatives. Selon un mode particulier de mise en oeuvre de l'invention, les impulsions seront de pré~erence positives.

: ;

W092/00119 PCT/BE91/0~3 wo 92/00119 2 a 6 5 3 8 8 PCTtBE91 / ~ W ~ 3 Method and device for the treatment of epilepsy.
~, .` ''' The present invention relates to a method and a device for the treatment of epilepsy by use of electrodes producing elect pulses. what app ~ uees ~ the head ~ of the patient.
'' It is known ~ ue little electrical impulses ~ ent ser ~ i ~
in some cases to treat affected patients epilepsy, in particular using implanted electrodes. Of frequencies of the order of MHz are also used at various other therapeutic titles.

It has now been found that greater efficiency and unexpected can be achieved using a process and device characterized in that pulses of ~ frequencies ranging from 1.5 to 28 Hz are transmitted using of ~ electrodes applied simply on the patient's head.
The impulses can be positive or negative. According to a particular mode of implementing the invention, the impulses will be positive.

:;

W092 / 00119 PCT / BE91 / 0 ~ 3

2 U ~5 3 88 -2-Les impulsions peuvent aussi être des i~pulsions multiples constituels de ~ifferentes fréquancPs, utilisées soit séquentiellement, soit en alternance, ou encore en utilisant une fréquence porteuse ou une frequence modulée par une 5 autre fré~uence. ~

': .`
Selon un mode particulier de 1'invention, une onde essentielle rec~angulaire, négative est superposée a une impulsion généralement positive, de sorte que 1'énergie de la partie négative est essentiellement é~uivalente à
l'énergie de la partie positive. Tout phénomène d'électrolyse peu~être maîtrisé. `~

Selon l'invention on applique des electrodes produisant des impulsions electri~ues de basse fré~uence comprises entre les valeurs susmentionnées et de puissance pouvant varier de 1 à 170 V (voltage de crête).

La durée d'une impulsion pe~t varier de 2,5 ms à 0,025 ms, ~ , . .
de preference de 0,2 à 0,30 ms. On a avantageusement .. .... ... . .
appliqué une valeur de 0,25 ms (+/- 0,1).

On utilisera de préference trois ~lectrodes, soit par exemple une élec-~ode positi~e frontale et 2 élect-odes négatives a la base de la nuque. On peut egalement u',liser plus de trois eleclrodes.

2~65388 WO 92/OOllg PCl'~BEg1/00043 ' 2 U ~ 5 3 88 -2-The pulses can also be multiple i ~ pulses constituents of ~ different frequencies, used either sequentially, either alternately, or using a carrier frequency or a frequency modulated by a 5 other fre ~ uence. ~

': .`
According to a particular embodiment of the invention, a wave essential rec ~ angular, negative is superimposed on a generally positive impulse, so that the energy of the negative part is essentially equivalent to the energy of the positive part. Any phenomenon little electrolysis ~ be controlled. `~

According to the invention, electrodes are applied which produce pulses electri ~ ues low fr ~ uence between the aforementioned and power values may vary from 1 to 170 V (peak voltage).

The duration of a pulse pe ~ t vary from 2.5 ms to 0.025 ms, ~,. .
preferably 0.2 to 0.30 ms. We have advantageously .. .... .... .
applied a value of 0.25 ms (+/- 0.1).

We will preferably use three ~ electrodes, either by example a front electro ~ positi ~ e and 2 electrodes negative at the base of the neck. We can also read more than three eleclrodes.

2 ~ 65388 WO 92 / OOllg PCl '~ BEg1 / 00043'

-3- ~

''~;,~' De manière caracteristi~ue, les malades sont traites en deux phases successives d'env~rcn 10 minutes, les frequences etant de 1,5 Hz ou d~environ 1,5 Hz pour la première phase pouvant durer 10 minutes t de 28 Hz ou d'environ 28 Hz pour la seconde phase de même duree. Les puissances doivent être adaptees à chaque cas par~iculiers et peu~ent varier de 1 à
170 Volts.

Chez les sujets épileptiques traites on a constaté une diminution du nombre de crises et chez la plupart d'entre eux o~ des contrôles néo-encéphalographiques (électroencephalogr~phie par ordinateur) ont eté exécutés, on a note une amélioration de l'ac~ivité électrique cérébrale. Certains malades ont répon~u favorablement à
- cette méthode alors que d'autres traitements s'étaient révelés inefficaces.

Le genérateur utilisé pour la mise en oeu~re de l'in~ention peut être facilement conçu par l'homme de l'art.

L'appareil pour la mise en oeuvre de l'invention peut fonctionner sur une batterie unique de 6 volts protegee.

Cette batterie es' rechar~eable sur secteur, avec protection empêchant toute utilisation sur secteur. Selon un mode de realisation particulier, l'appareil comprend deux entrees Jac~ mono, 2 potentiomètres dont un est muni d'un WO92/00119 PCT/BE91~00043 ;~
201~5388 -a- -. .~,..

interrupteur off/on, divers affichages digitaux. Il es.
ainsi avantageusemen. muni d'un affichage de frequence, un . `
affichage de puissance, un affichage de résistance et un -`
affichage de tension. L'appareil peut être muni d'un voyant 5 de charge. Il se met hors circuit lorsque la tension de la ~
batterie descend à 4,5 volts, afin d'eviter tou~e -déterioration prematurée de celle-ci.

Le ~oltm~tre et l'ampèremètre indiquent les valeurs de 10 crête. L'ohmètre indi~ue le résul~at de la division de la tension par le courant (R=U/I). Cette der~ière indication n'est donc significative que pour de valeurs de U et de I
suffi ant~s. `

15 L'appareil est de préference compact et transportable.

La figure 1 illustre la forme de 1'impulsion à vide et en charge.

20 Le schema-blocs de la fig 2 illustre l'invention de manière -~

exemplative. Les réf~rences de la figure se rapportent aux eléments sui~ants :

1 reseau 220 V

25 2 chargeur 3 controle -3- ~

''~;, ~ ' Characteristically, the patients are treated in two successive phases of approx ~ rcn 10 minutes, the frequencies being 1.5 Hz or ~ 1.5 Hz for the first phase which can last 10 minutes t of 28 Hz or about 28 Hz for the second phase of the same duration. The powers must be adapted to each case by ~ individual and little ~ ent vary from 1 to 170 Volts.

In treated epileptic subjects, a decrease in the number of seizures and in most of them o ~ neoencephalographic checks (computer electroencephalography) were performed, there has been an improvement in electrical activity cerebral. Some patients responded favorably to - this method while other treatments were found to be ineffective.

The generator used to implement the in ~ ention can be easily designed by those skilled in the art.

The apparatus for implementing the invention can operate on a single protected 6-volt battery.

This battery is rechargeable on mains, with protection preventing any use on sector. According to a mode of particular realization, the device includes two inputs Jac ~ mono, 2 potentiometers, one of which has a WO92 / 00119 PCT / BE91 ~ 00043; ~
201 ~ 5388 -at- -. . ~, ..

off / on switch, various digital displays. He is.
thus advantageously. provided with a frequency display, a. ``
power display, resistance display and a -`
voltage display. The device can be fitted with an indicator 5 charge. It turns off when the voltage of the ~
battery drops to 4.5 volts, to avoid tou ~ e -premature deterioration thereof.

The ~ oltm ~ tre and the ammeter indicate the values of 10 peak. The ohmmeter indicates the result of the division of the voltage by current (R = U / I). This last indication is therefore only significant for values of U and I
enough ant ~ s. ``

15 The device is preferably compact and transportable.

Figure 1 illustrates the shape of the vacuum pulse and charge.

20 The block diagram of FIG 2 illustrates the invention in a way - ~

illustrative. The references in the figure relate to following elements:

1 network 220 V

25 2 charger 3 control

4 accumulateur W092/00119 2 0 6 5 3 8 8 PCT/BE9l/0~43 4 accumulator W092 / 00119 2 0 6 5 3 8 8 PCT / BE9l / 0 ~ 43

5 relais 5 relays

6 alimentation 6 feeding

7 reglage de fre~uence 7 setting of fre ~ uence

8 oscillateur ~:
5 9 frequencemètre -~
10 mise en ~orme ~
11 reglage ~-12 buffer -13 connecteurs de sortie vers électrodes 10 14 buffer U .
15 buffer I ;~
16 memo U ;~:
17 memo I
18 contrôle 15 19 diviseur U/I
20 ohmètre-21 voltmètre 22 ampéremètre .

20 De nombreux autres schemas équivalents peuvent être adoptes sans sortir du cadre de`l'invention. 8 oscillator ~:
5 9 frequency counter - ~
10 setting ~ elm ~
11 setting ~ -12 buffer -13 output connectors to electrodes 10 14 buffer U.
15 buffer I; ~
16 memo U; ~:
17 memo I
18 control 15 19 U / I divider 20 ohm-21 voltmeter 22 ammeter.

20 Many other equivalent schemes can be adopted without departing from the scope of the invention.

Claims (14)

Revendications Claims 1) Appareil à but thérapeutique , caractérisé en ce qu'il comprend un générateur d'impulsions électriques et des électrodes pour appliquer sur la tête d'un sujet les dites impulsions , celles-ci ayant une fréquence de répétition comprise entre 1,5 et 28 Hz ,un voltage de crête de 1 à 190 volts et une durée comprise entre 0,025 et 2,5 ms. 1) Apparatus for therapeutic purposes, characterized in that it includes an electrical pulse generator and electrodes for applying to a subject's head the said pulses, these having a repetition rate between 1.5 and 28 Hz, a peak voltage of 1 to 190 volts and a duration between 0.025 and 2.5 ms. 2) Appareil selon la revendication 1 caractérise en ce que les impulsions sont positives. 2) Apparatus according to claim 1 characterized in that the impulses are positive. 3) Appareil selon les revendications 1 et 2 pour le traitement de l'épilepsie ou de maladie connexe. 3) Apparatus according to claims 1 and 2 for the treatment of epilepsy or related disease. 4) Appareil selon les revendications 1 à 3 caractérisé en ce que les impulsions sont des impulsions multiples constituées de différentes fréquences, utilisées soit séquentiellement, soit en alternance, ou encore en utilisant une fréquence porteuse ou une fréquence modulée par une autre fréquence. 4) Apparatus according to claims 1 to 3 characterized in that that the pulses are multiple pulses consisting of different frequencies, used either sequentially, either alternately, or even using a frequency carrier or a frequency modulated by another frequency. 5) Appareil selon les revendications 1 à 4 caractérisé en ce que la durée des impulsions est comprise entre 0,20 et 0,30 ms. 5) Apparatus according to claims 1 to 4 characterized in that that the duration of the pulses is between 0.20 and 0.30 ms. 6) Appareil selon la revendication 5 caractérisé en ce que la durée des impulsions est de 0,25 ms. 6) Apparatus according to claim 5 characterized in that the duration of the pulses is 0.25 ms. 7) Appareil selon les revendications 1 à 6 caractérisé en ce qu'il comprend au minimum de trois électrodes à appliquer sur la tête du patient. 7) Apparatus according to claims 1 to 6 characterized in that that it comprises at least three electrodes to be applied on the patient's head. 8) Appareil selon la revendication 7 caractérisé en ce que deux électrodes sont négatives et une électrode est positive. 8) Apparatus according to claim 7 characterized in that two electrodes are negative and one electrode is positive. 9) Appareil selon n'importe laquelle des revendications 1 à
8 caractérisé en ce qu'il comprend les circuits électroniques de la fig. lb. ou des circuits équivalents. 9) Apparatus according to any of claims 1 to 8 characterized in that it comprises the circuits electronics of fig. lbs. or equivalent circuits. 10) Appareil selon la revendication 1 caractérisé en ce qu'il est superpose aux impulsions électriques, généralement positives, une onde négative. 10) Apparatus according to claim 1 characterized in that that it is superimposed on electrical impulses, usually positive, a negative wave. 11) Appareil selon la revendication 9 caractérisé en ce que l'onde est une onde esseniielle rectangulaire négative. 11) Apparatus according to claim 9 characterized in that the wave is a negative rectangular wave. 12) Appareil selon les revendications 9 ou 10 caractérisé en ce que l'onde correspond à une énergie essentiellement équvalente à l'énergie de la partie positive. 12) Apparatus according to claims 9 or 10 characterized in what the wave corresponds to an energy essentially equivalent to the energy of the positive part. 13) Utilisation d'un appareil selon les revendications 1 à
12 pour le traitement de l'épilepsie ou de maladies connexes. 13) Use of an apparatus according to claims 1 to 12 for the treatment of epilepsy or diseases related. 14) Méthode de traitement du corps humain caractérisé en ce qu'on applique au moins deux électrodes à la tête d'un patient épileptique et que lesdites électrodes émettent des impulsions électriques positives de durée variant de 0,025 à
ms, de voltage variant de 1 à 170 Volts et de fréquence variant de 1 à 100 Hz, de préférence de 1,5 à 28 Hz. 14) Method for treating the human body characterized in that that at least two electrodes are applied to the head of a epileptic patient and that said electrodes emit positive electrical impulses of duration varying from 0.025 to ms, of voltage varying from 1 to 170 Volts and of frequency varying from 1 to 100 Hz, preferably from 1.5 to 28 Hz.
CA002065388A 1990-06-28 1991-06-27 Method and device for treating epilepsy_ Abandoned CA2065388A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BE9000660 1990-06-28
BE9000660 1990-06-28
BE9100054 1991-01-23
BE9100054 1991-01-23

Publications (1)

Publication Number Publication Date
CA2065388A1 true CA2065388A1 (en) 1991-12-29

Family

ID=25662538

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002065388A Abandoned CA2065388A1 (en) 1990-06-28 1991-06-27 Method and device for treating epilepsy_

Country Status (10)

Country Link
EP (1) EP0489879A1 (en)
JP (1) JPH05502608A (en)
AU (1) AU8095491A (en)
CA (1) CA2065388A1 (en)
IE (1) IE912227A1 (en)
IL (1) IL98656A0 (en)
MX (1) MX9100005A (en)
NO (1) NO920780D0 (en)
PT (1) PT98122A (en)
WO (1) WO1992000119A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5752979A (en) * 1996-11-01 1998-05-19 Medtronic, Inc. Method of controlling epilepsy by brain stimulation
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9113801B2 (en) 1998-08-05 2015-08-25 Cyberonics, Inc. Methods and systems for continuous EEG monitoring
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
DE10300069A1 (en) * 2003-01-03 2004-07-22 Grönemeyer, Dietrich H. W., Prof. Dr.med. EP trainer
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US20080183097A1 (en) 2007-01-25 2008-07-31 Leyde Kent W Methods and Systems for Measuring a Subject's Susceptibility to a Seizure
WO2008092119A2 (en) 2007-01-25 2008-07-31 Neurovista Corporation Systems and methods for identifying a contra-ictal condition in a subject
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3918461A (en) * 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
EP0156854B1 (en) * 1983-09-14 1990-09-05 ZABARA, Jacob Neurocybernetic prosthesis
US4646744A (en) * 1984-06-29 1987-03-03 Zion Foundation Method and treatment with transcranially applied electrical signals
EP0272318A1 (en) * 1986-06-16 1988-06-29 Elefant, Mordecai Method and apparatus for delivering a prescriptive electrical signal
GB8904998D0 (en) * 1989-03-04 1989-04-19 Matthews Tony Anaesthetising apparatus

Also Published As

Publication number Publication date
IL98656A0 (en) 1992-07-15
AU8095491A (en) 1992-01-23
NO920780L (en) 1992-02-27
WO1992000119A1 (en) 1992-01-09
JPH05502608A (en) 1993-05-13
PT98122A (en) 1993-09-30
MX9100005A (en) 1992-02-03
EP0489879A1 (en) 1992-06-17
NO920780D0 (en) 1992-02-27
IE912227A1 (en) 1992-01-01

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Legal Events

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FZDE Discontinued