WO1992000119A1 - Method and device for treating epilepsy - Google Patents

Method and device for treating epilepsy Download PDF

Info

Publication number
WO1992000119A1
WO1992000119A1 PCT/BE1991/000043 BE9100043W WO9200119A1 WO 1992000119 A1 WO1992000119 A1 WO 1992000119A1 BE 9100043 W BE9100043 W BE 9100043W WO 9200119 A1 WO9200119 A1 WO 9200119A1
Authority
WO
WIPO (PCT)
Prior art keywords
characterized
apparatus according
pulses
electrodes
ms
Prior art date
Application number
PCT/BE1991/000043
Other languages
French (fr)
Inventor
Jean-Marie Verhoeven
Original Assignee
Verhoeven Jean Marie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE9000660 priority Critical
Priority to BE9000660 priority
Priority to BE9100054 priority
Priority to BE9100054 priority
Application filed by Verhoeven Jean Marie filed Critical Verhoeven Jean Marie
Publication of WO1992000119A1 publication Critical patent/WO1992000119A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/36167Timing, e.g. stimulation onset
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064Epilepsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36146Control systems specified by the stimulation parameters
    • A61N1/3615Intensity
    • A61N1/36153Voltage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A therapeutical apparatus for treating epilepsy or related diseases includes a positive electrical impulse generator using electrodes to apply impulses to the head of a patient, with said impulses having a frequency of 1.5-28 Hz, a peak voltage of 1-190 volts and a length of 0.025-2.5 ms.

Description

I

i

Proced and device for the treatment of epilepsy.

The present invention relates to a method and a device for the treatment of epilepsy by use of electrodes generating electrical pulses applied to the patient's head.

10

It is known that electrical impulses can be used in some cases to treat patients with epilepsy, especially with implanted electrodes. of the order of MHz frequencies are also used in various other 15 therapeutic title.

It has now been found that superior and unexpected effectiveness can be achieved using a method and device characterized in that pulses

20 frequencies ranging from 1.5 to 28Hz are issued by means of electrodes simply applied to the patient's head. The pulses can be positive or negative. In a particular implementation of the invention, the pulses will be positive preference.

The pulses 25 may also be multiple pulses constituéls different fréquances, used either sequentially or alternately, or by using a carrier frequency or a frequency modulated by a different frequency.

According to a particular embodiment of the invention, a rectangular negative essential wave is superimposed on a generally positive pulse, so that the energy of the negative portion is substantially equivalent to the energy of the positive part. While electrolysis phenomenon perhaps mastered.

According to the invention is applied to the electrodes producing the low-frequency electric pulses between the above values ​​and power that can vary from 1 to 170 V (peak voltage).

The duration of a pulse can vary from 2.5 ms to 0,025 ms, preferably of 0.2 to 0.30 ms. Is advantageously applied a value of 0.25 ms (+/- 0.1).

Use will preferably be three electrodes, or for example a front élecrrode positive and negative electrodes 2 to the base of the neck. One can also use more than three electrodes. Typically, patients are treated in two successive phases of about 10 minutes, the frequency is 1.5 Hz or 1.5 Hz for the first phase lasting 10 minutes and 28 Hz or about 28 Hz for the second phase of the same duration. Powers should be adapted to each individual case and may vary from 1-170 volts.

In epileptic subjects were treated a decrease in the number of attacks and in most of them where neo-controls brainwave (EEG computer) were executed, there was an improvement in brain electrical activity. Some patients have responded favorably to this method when other treatments had been ineffective.

The generator used for the implementation of the invention can be readily designed by the skilled artisan.

The apparatus for implementing the invention can operate on a single battery of 6 volts protected. This battery is rechargeable from the mains, with protection preventing use mains. According to a particular embodiment, the apparatus comprises two Jack mono inputs, two faders one of which is provided with an -4-

switch off / on, various digital displays. There is thus advantageously provided with a display frequency, a power display, a main display and a voltage display. The unit can be fitted with a light load. It switches off when the battery voltage drops to 4.5 volts, in order to avoid premature deterioration thereof.

The voltmeter and ammeter indicate: the peak values. The oh be indicates the result of dividing the voltage by the current (R = U / I). This last indication is therefore significant for U values ​​and I enough.

The device is compact and transportable preference.

Figure 1 illustrates the shape of the pulse at empty and loaded.

The block diagram of FIG 2 illustrates the invention of illustrative manner. The references in FIG relate to:

1 network 220 V charger 2

3 control

4 -o- accumulator

5 relays

6 power

7 frequency adjustment

September 8 frequency oscillator

10 formatting

11 setting

12 buffer

13 output connectors to electrodes 14 U buffer

15 buffer I

17 memo I

18 control divider 19 U / I

20 ohmmeter

21 voltmeter

22 ammeter

Many other equivalent schemes can be adopted without departing from the scope of the invention.

Claims

Figure imgf000008_0001
-6-
claims
: 5 1) An apparatus for therapeutic purposes, characterized in that it comprises an electrical pulse generator and electrodes for applying to the head of a subject the said pulses, the latter having a repetition frequency between 1.5 and 28 Hz, a peak voltage of from 1 to 190 10 volts and a duration of between 0.025 and 2.5 ms.
2) Apparatus according to claim 1 characterized in that the pulses are positive.
15 3) Apparatus according to claims 1 and 2 for the treatment of epilepsy or related disease.
4) Apparatus according to claims 1 to 3 characterized in that the pulses are multiple pulses formed 2 0 of different frequencies used either sequentially or alternately, or by using a carrier frequency or a frequency modulated by a different frequency.
5) Apparatus according to claims 1 to 4 characterized in that 25 the duration of the pulses is between 0.20 and 0.30 ms. 6) Apparatus according to claim 5 characterized in that the pulse duration is 0.25 ms.
7) Apparatus according to claims 1 to 6 characterized in that it comprises at least three electrodes for application to the patient's head.
8) Apparatus according to claim 7 characterized in that two electrodes are negative and a positive electrode.
9) Apparatus according to any one of claims 1 to 8, characterized in that it comprises electronic circuits of FIG. lb. or equivalent circuits.
10) Apparatus according to claim 1 characterized in that it is superimposed on the electrical pulses, generally positive, a negative wave.
11) Apparatus according to claim 9 characterized in that the wave is a negative rectangular wave fundamental.
12) Apparatus according to claims 9 or 10 characterized in that the wave corresponds to a substantially équvalente energy to the energy of the positive part. 13) Uti.li.sati.on a apparei.l according to claims l to
12 for the treatment of epilepsy or related diseases.
14) Method of treatment of the human body characterized in that at least two electrodes applied to the head of an epileptic patient, and that said electrodes emit positive electrical pulses of duration ranging from 0.025 to 25 ms, voltage ranging from 1 at 170 volts and frequency ranging from 1 to 100 Hz, preferably from 1.5 to 28Hz.
5
PCT/BE1991/000043 1990-06-28 1991-06-27 Method and device for treating epilepsy WO1992000119A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BE9000660 1990-06-28
BE9000660 1990-06-28
BE9100054 1991-01-23
BE9100054 1991-01-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO920780A NO920780D0 (en) 1990-06-28 1992-02-27 Method and device for the treatment of epilepsy

Publications (1)

Publication Number Publication Date
WO1992000119A1 true WO1992000119A1 (en) 1992-01-09

Family

ID=25662538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE1991/000043 WO1992000119A1 (en) 1990-06-28 1991-06-27 Method and device for treating epilepsy

Country Status (10)

Country Link
EP (1) EP0489879A1 (en)
JP (1) JPH05502608A (en)
AU (1) AU8095491A (en)
CA (1) CA2065388A1 (en)
IE (1) IE912227A1 (en)
IL (1) IL98656D0 (en)
MX (1) MX9100005A (en)
NO (1) NO920780D0 (en)
PT (1) PT98122A (en)
WO (1) WO1992000119A1 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5752979A (en) * 1996-11-01 1998-05-19 Medtronic, Inc. Method of controlling epilepsy by brain stimulation
WO2004060481A1 (en) * 2003-01-03 2004-07-22 Groenemeyer Dietrich H W Electric trainer
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9421373B2 (en) 1998-08-05 2016-08-23 Cyberonics, Inc. Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9622675B2 (en) 2007-01-25 2017-04-18 Cyberonics, Inc. Communication error alerting in an epilepsy monitoring system
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3918461A (en) * 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
WO1985001213A1 (en) * 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
WO1987000063A1 (en) * 1984-06-29 1987-01-15 Zion Educational Foundation Method of treatment with transcranially applied electrical signals
WO1987007511A2 (en) * 1986-06-16 1987-12-17 Zion Educational Foundation Method and apparatus for delivering a prescriptive electrical signal
WO1990009811A1 (en) * 1989-03-04 1990-09-07 Tony Matthews Electro-therapy apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3918461A (en) * 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
WO1985001213A1 (en) * 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
WO1987000063A1 (en) * 1984-06-29 1987-01-15 Zion Educational Foundation Method of treatment with transcranially applied electrical signals
WO1987007511A2 (en) * 1986-06-16 1987-12-17 Zion Educational Foundation Method and apparatus for delivering a prescriptive electrical signal
WO1990009811A1 (en) * 1989-03-04 1990-09-07 Tony Matthews Electro-therapy apparatus

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5752979A (en) * 1996-11-01 1998-05-19 Medtronic, Inc. Method of controlling epilepsy by brain stimulation
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9113801B2 (en) 1998-08-05 2015-08-25 Cyberonics, Inc. Methods and systems for continuous EEG monitoring
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US7930035B2 (en) 1998-08-05 2011-04-19 Neurovista Corporation Providing output indicative of subject's disease state
US9421373B2 (en) 1998-08-05 2016-08-23 Cyberonics, Inc. Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US8781597B2 (en) 1998-08-05 2014-07-15 Cyberonics, Inc. Systems for monitoring a patient's neurological disease state
US9320900B2 (en) 1998-08-05 2016-04-26 Cyberonics, Inc. Methods and systems for determining subject-specific parameters for a neuromodulation therapy
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
WO2004060481A1 (en) * 2003-01-03 2004-07-22 Groenemeyer Dietrich H W Electric trainer
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US9592004B2 (en) 2005-12-28 2017-03-14 Cyberonics, Inc. Methods and systems for managing epilepsy and other neurological disorders
US9044188B2 (en) 2005-12-28 2015-06-02 Cyberonics, Inc. Methods and systems for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7676263B2 (en) 2006-06-23 2010-03-09 Neurovista Corporation Minimally invasive system for selecting patient-specific therapy parameters
US9480845B2 (en) 2006-06-23 2016-11-01 Cyberonics, Inc. Nerve stimulation device with a wearable loop antenna
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9622675B2 (en) 2007-01-25 2017-04-18 Cyberonics, Inc. Communication error alerting in an epilepsy monitoring system
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
US8543199B2 (en) 2007-03-21 2013-09-24 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts

Also Published As

Publication number Publication date
NO920780D0 (en) 1992-02-27
IL98656D0 (en) 1992-07-15
IE912227A1 (en) 1992-01-01
PT98122A (en) 1993-09-30
AU8095491A (en) 1992-01-23
MX9100005A (en) 1992-02-03
NO920780L (en) 1992-02-27
JPH05502608A (en) 1993-05-13
CA2065388A1 (en) 1991-12-29
EP0489879A1 (en) 1992-06-17

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