CA2062615A1 - Method and kit for disinfection of contact lenses - Google Patents
Method and kit for disinfection of contact lensesInfo
- Publication number
- CA2062615A1 CA2062615A1 CA 2062615 CA2062615A CA2062615A1 CA 2062615 A1 CA2062615 A1 CA 2062615A1 CA 2062615 CA2062615 CA 2062615 CA 2062615 A CA2062615 A CA 2062615A CA 2062615 A1 CA2062615 A1 CA 2062615A1
- Authority
- CA
- Canada
- Prior art keywords
- chlorine
- parts per
- per million
- contact lenses
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C13/00—Assembling; Repairing; Cleaning
- G02C13/008—Devices specially adapted for cleaning contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Eyeglasses (AREA)
Abstract
METHOD AND KIT FOR DISINFECTION OF CONTACT LENSES
Abstract of the Disclosure A method of disinfecting plastic or rubber contact lenses comprises immersing, for a period of time sufficient to result in disinfection, the contact lenses in a solution containing a chlorine-releasing agent, wherein the amount of chlorine released is from 1 to 500 parts per million, preferably 10 to 20 ppm, and from 1 to 200 parts per million hydrogen peroxide, preferably . The invention further provides a kit for sterilizing soft contact lenses comprising a chlorine-releasing agent, hydrogen peroxide, an apparatus for producing a sterile saline and mixing the sterilizing solution and a holder for washing the lenses.
Abstract of the Disclosure A method of disinfecting plastic or rubber contact lenses comprises immersing, for a period of time sufficient to result in disinfection, the contact lenses in a solution containing a chlorine-releasing agent, wherein the amount of chlorine released is from 1 to 500 parts per million, preferably 10 to 20 ppm, and from 1 to 200 parts per million hydrogen peroxide, preferably . The invention further provides a kit for sterilizing soft contact lenses comprising a chlorine-releasing agent, hydrogen peroxide, an apparatus for producing a sterile saline and mixing the sterilizing solution and a holder for washing the lenses.
Description
~ g i3 METHOD AND RIT FOR DI~INFECTION ~F CONTACT LENSE~
Field of the Invention The present invention relates to methods and apparatus for disinfection of contact lenses, particularly plastic and rubber lenses.
Backqround of the Invention Most contact lenses currently sold and used are hydrophillic or soft contact lenses, as opposed to hydro-phobic or hard lenses, due to the improved comfort of the user of such lenses and reduced irritation of the eye.
However by their nature, it is necessary to maintain such hydrophillic lenses in a sterile condition. Any steri-lizing agent used must kill the bacteria on and in the lens, be harmless to the eye and have no effect on the shape or material of the lens. Improper disinfecting agents can alter the shape of the contact lens which renders them useless. A sterile saline solution is also used to store the lenses when not in use.
Most substances used for sterilization of contact lenses involve either substances which release halogens, in particular chlorine, when dissolved in water, or hydrogen peroxide. For example Canadian Patent No.
1,003,749 issued January 18, 1977 to Hydrophilics Interna-tional, Inc. discloses the use of sodium dichlorocyanurate, chlorinated trisodium phosphate, potassium dich-lorocyanurate and trichloroisocyanuric acid in solution tosterilize soft contact lenses. The present inventor, in co-pending Canadian application no. 2,044,072-4 filed June 7, 1991, discloses the use of a small but effective amount of chloramine-T in concentration effective for disinfection but non-damaging to the eye and to the contact lenses. The use of chlorine alone may cause the lenses to be left with a yellow stain, however. Other methods involve the use of hydrogen peroxide as a sterilizing agent, but large quan-tities of peroxide are required for adequate sterilization.
h ~
Up to now both chlorine and peroxide have not been used in combination for this purpose.
The sterilizing of contact lenses is generally carried out in a sterile saline solution. Currently, users are provided with a collection of bottles of sterile saline to use over a period of time. This method of providing saline is bulky and expensive. The present inventor has disclosed in co-pending Canadian patent application 2,025,-106 filed September 11, l99o and International application lo no. PCT/CAgl/00056 a simple, portable device for storing and dispensing sterile saline. It comprises a resilient hollow container having a first outlet, a housing removably mounted on the container and having a second outlet and a passage communicating between the first and second outlet, a liquid-sterilizing filter mounted in the housing in the passage, and valve means for alternately opening and closing the second outlet, whereby pressure applied to the container forces a liquid stored in the container through said filter and out the second outlet when the valve is in an open position. This device permits sterile saline to be produced readily from tap water. There is a need therefore for a lens cleaning kit which incorporates this improved device to eliminate the previously bulky components of the prior art.
Summary of the Invention The invention provides a method of disinfecting contact lenses comprising immersing, for a period of time sufficient to result in disinfection, the contact lenses in a solution containing a chlorine-releasing agent, wherein the amount of chlorine released is from 1 to 500 parts per million, preferably between 10 and 20 ppm, and from 1 to 1,000 parts per million hydrogen peroxide, preferably 40 to 80 ppm.
The invention further provides a kit for steril-izing soft contact lenses comprising a chlorine-releasing ~;g ~
agent, hydrogen peroxide, an apparatus for producing a sterile saline and a container for immersing the lenses in the sterilizing solution.
Brief Description of_the Drawin~s In a drawing which illustrates a preferred em-bodiment of the invention:
Figure 1 is a schematic diagram illustrating the kit of the invention.
Detailed Description of the Preferred Embodiment According to the invention, a contact lens disinfectant solution is prepared by dissolving a suffi-cient amount of chloramine-T in a sterile saline solution to produce between 1 and 500 parts per million of chlorine in the water (preferably less than 200 ppm and between 10 and 20 ppm is preferred). Hydrogen peroxide in a strength of less than 1000 ppm (40 to 80 ppm is preferred) is added to the saline also. The soft, hydrophillic contact lenses are immersed, for a period of time sufficient to result in disinfection, in the solution, which is effective for disinfection but non-damaging to the eye and to the contact lenses. The further step may be taken of adding buffers such as monosodium phosphate and dibasic sodium phosphate to the solution described in a quantity sufficient to neutralize the solution.
The irvention is used by way of a kit 1 illus-trated schematically in Fig. 1. A suitable amount of a chlorine-releasing agent (e.g. chloramine-T) is provided in a pre-measured powder form in salt capsules or packets 3, which also provide the salt for the saline solution in a pre-measured amount. Hydrogen peroxide is provided in a 1 oz. spray atomizer container 5. A filter unit 7 of the type ~ J
described in Canadian patent application 2,025,106 is provided as is a contact lens washer/holder 9 of the type disclosed in Canadian industrial design registration 67701 issued December 24, l99o. The lens or lenses are placed in holder 9. A spray of peroxide from atomizer 5 is sprayed into lens holder unit 9. Either distilled or tap water is added to filter unit 7 in the appropriate measured amount (use of distilled water results in improved filter life but tap water may also be used). The salt packet with chlorine-releasing agent is dissolved in the water in the filterunit 7 to the appropriate concentrations noted above. The saline solution is then expelled from the filter unit as described in the above-noted application, causing it to be sterilized, into the lens washer/holder unit 9 which is operated in the usual manner to clean and sterilize the lens. Preferably the buffers noted above will be added to the saline, either in unit 7 or in the holder 9, and the lenses will be left overnight for sterilization (at least 4 hours is preferred, although sterilization may be a-chieved in considerably less time). The resulting saline isof ophthalmic quality, non-irritating to the eye and can be used for subsequent storage of the lenses.
The invention provides a number of advantages.
Chlorine alone in concentration tends to cause the lens to ~5 turn yellow due to partial oxidation of proteins. These partially oxidized proteins are retained in the porous lens material. The addition of peroxide apparently completes the oxidation process and de-ionizes the protein. Use of peroxide alone would require a much higher concentration of peroxide. Also the peroxide oxidizes the residual active chlorine which remains after disinfection. The xeaction between H202 (hydrogen peroxide) and HOCl (hydrochlorous acid) produces HCl (hydrochloric acid). The HCl is neutral-ized by the buffering agent. The result is a saline that is non-irritating to the eye while effectively maintaining the lens sterile. The kit thus produces its own sterile saline from water for sterilizing and storage purposes, which saves considerable expense and storage size.
EXAMPLE
By way of example, 106 germs of type staph dermatitis were added to 10 ml of water. Chloramine-T in powdered form was added to the 10 ml. of water to provide 10 parts per million of chlorine in the water. Hydrogen peroxide was added in a concentration of 60 parts per million. After 4 hours the solution was cultured and no growth was reported after 48 hours of incubation. A soft contact lens of class 4 material etasilicon - A (ACUVIEWTM) was tested clinically in the solution for discolouration and no protein binding or yellow discolouration was noted. The amounts of living bacteria on the lens after removal were found to be mini-mal, and there was no detected alteration of the lens shape or material.
As will be apparent to those skilled in the art in the light of the foregoing disclosure, many alterations and modifications are possible in the practice of this invention without departing from the spirit or scope thereof. Accordingly, the scope of the invention is to be construed in accordance with the substance defined by the following claims.
Field of the Invention The present invention relates to methods and apparatus for disinfection of contact lenses, particularly plastic and rubber lenses.
Backqround of the Invention Most contact lenses currently sold and used are hydrophillic or soft contact lenses, as opposed to hydro-phobic or hard lenses, due to the improved comfort of the user of such lenses and reduced irritation of the eye.
However by their nature, it is necessary to maintain such hydrophillic lenses in a sterile condition. Any steri-lizing agent used must kill the bacteria on and in the lens, be harmless to the eye and have no effect on the shape or material of the lens. Improper disinfecting agents can alter the shape of the contact lens which renders them useless. A sterile saline solution is also used to store the lenses when not in use.
Most substances used for sterilization of contact lenses involve either substances which release halogens, in particular chlorine, when dissolved in water, or hydrogen peroxide. For example Canadian Patent No.
1,003,749 issued January 18, 1977 to Hydrophilics Interna-tional, Inc. discloses the use of sodium dichlorocyanurate, chlorinated trisodium phosphate, potassium dich-lorocyanurate and trichloroisocyanuric acid in solution tosterilize soft contact lenses. The present inventor, in co-pending Canadian application no. 2,044,072-4 filed June 7, 1991, discloses the use of a small but effective amount of chloramine-T in concentration effective for disinfection but non-damaging to the eye and to the contact lenses. The use of chlorine alone may cause the lenses to be left with a yellow stain, however. Other methods involve the use of hydrogen peroxide as a sterilizing agent, but large quan-tities of peroxide are required for adequate sterilization.
h ~
Up to now both chlorine and peroxide have not been used in combination for this purpose.
The sterilizing of contact lenses is generally carried out in a sterile saline solution. Currently, users are provided with a collection of bottles of sterile saline to use over a period of time. This method of providing saline is bulky and expensive. The present inventor has disclosed in co-pending Canadian patent application 2,025,-106 filed September 11, l99o and International application lo no. PCT/CAgl/00056 a simple, portable device for storing and dispensing sterile saline. It comprises a resilient hollow container having a first outlet, a housing removably mounted on the container and having a second outlet and a passage communicating between the first and second outlet, a liquid-sterilizing filter mounted in the housing in the passage, and valve means for alternately opening and closing the second outlet, whereby pressure applied to the container forces a liquid stored in the container through said filter and out the second outlet when the valve is in an open position. This device permits sterile saline to be produced readily from tap water. There is a need therefore for a lens cleaning kit which incorporates this improved device to eliminate the previously bulky components of the prior art.
Summary of the Invention The invention provides a method of disinfecting contact lenses comprising immersing, for a period of time sufficient to result in disinfection, the contact lenses in a solution containing a chlorine-releasing agent, wherein the amount of chlorine released is from 1 to 500 parts per million, preferably between 10 and 20 ppm, and from 1 to 1,000 parts per million hydrogen peroxide, preferably 40 to 80 ppm.
The invention further provides a kit for steril-izing soft contact lenses comprising a chlorine-releasing ~;g ~
agent, hydrogen peroxide, an apparatus for producing a sterile saline and a container for immersing the lenses in the sterilizing solution.
Brief Description of_the Drawin~s In a drawing which illustrates a preferred em-bodiment of the invention:
Figure 1 is a schematic diagram illustrating the kit of the invention.
Detailed Description of the Preferred Embodiment According to the invention, a contact lens disinfectant solution is prepared by dissolving a suffi-cient amount of chloramine-T in a sterile saline solution to produce between 1 and 500 parts per million of chlorine in the water (preferably less than 200 ppm and between 10 and 20 ppm is preferred). Hydrogen peroxide in a strength of less than 1000 ppm (40 to 80 ppm is preferred) is added to the saline also. The soft, hydrophillic contact lenses are immersed, for a period of time sufficient to result in disinfection, in the solution, which is effective for disinfection but non-damaging to the eye and to the contact lenses. The further step may be taken of adding buffers such as monosodium phosphate and dibasic sodium phosphate to the solution described in a quantity sufficient to neutralize the solution.
The irvention is used by way of a kit 1 illus-trated schematically in Fig. 1. A suitable amount of a chlorine-releasing agent (e.g. chloramine-T) is provided in a pre-measured powder form in salt capsules or packets 3, which also provide the salt for the saline solution in a pre-measured amount. Hydrogen peroxide is provided in a 1 oz. spray atomizer container 5. A filter unit 7 of the type ~ J
described in Canadian patent application 2,025,106 is provided as is a contact lens washer/holder 9 of the type disclosed in Canadian industrial design registration 67701 issued December 24, l99o. The lens or lenses are placed in holder 9. A spray of peroxide from atomizer 5 is sprayed into lens holder unit 9. Either distilled or tap water is added to filter unit 7 in the appropriate measured amount (use of distilled water results in improved filter life but tap water may also be used). The salt packet with chlorine-releasing agent is dissolved in the water in the filterunit 7 to the appropriate concentrations noted above. The saline solution is then expelled from the filter unit as described in the above-noted application, causing it to be sterilized, into the lens washer/holder unit 9 which is operated in the usual manner to clean and sterilize the lens. Preferably the buffers noted above will be added to the saline, either in unit 7 or in the holder 9, and the lenses will be left overnight for sterilization (at least 4 hours is preferred, although sterilization may be a-chieved in considerably less time). The resulting saline isof ophthalmic quality, non-irritating to the eye and can be used for subsequent storage of the lenses.
The invention provides a number of advantages.
Chlorine alone in concentration tends to cause the lens to ~5 turn yellow due to partial oxidation of proteins. These partially oxidized proteins are retained in the porous lens material. The addition of peroxide apparently completes the oxidation process and de-ionizes the protein. Use of peroxide alone would require a much higher concentration of peroxide. Also the peroxide oxidizes the residual active chlorine which remains after disinfection. The xeaction between H202 (hydrogen peroxide) and HOCl (hydrochlorous acid) produces HCl (hydrochloric acid). The HCl is neutral-ized by the buffering agent. The result is a saline that is non-irritating to the eye while effectively maintaining the lens sterile. The kit thus produces its own sterile saline from water for sterilizing and storage purposes, which saves considerable expense and storage size.
EXAMPLE
By way of example, 106 germs of type staph dermatitis were added to 10 ml of water. Chloramine-T in powdered form was added to the 10 ml. of water to provide 10 parts per million of chlorine in the water. Hydrogen peroxide was added in a concentration of 60 parts per million. After 4 hours the solution was cultured and no growth was reported after 48 hours of incubation. A soft contact lens of class 4 material etasilicon - A (ACUVIEWTM) was tested clinically in the solution for discolouration and no protein binding or yellow discolouration was noted. The amounts of living bacteria on the lens after removal were found to be mini-mal, and there was no detected alteration of the lens shape or material.
As will be apparent to those skilled in the art in the light of the foregoing disclosure, many alterations and modifications are possible in the practice of this invention without departing from the spirit or scope thereof. Accordingly, the scope of the invention is to be construed in accordance with the substance defined by the following claims.
Claims (14)
1. A method of disinfecting contact lenses comprising immersing, for a period of time sufficient to result in disinfection, a contact lens in a sterile saline solution containing from 1 to 500 parts per million chlorine and from 1 to 1000 parts per million peroxide.
2. The method of claim 1 wherein said amount of chlorine is from 1 to 200 parts per million.
3. The method of claim 1 wherein said amount of chlorine is approximately 10 to 20 parts per million.
4. The method of claim 1 wherein said amount of peroxide is approximately 40 to 80 parts per million.
5. The method of claim 3 wherein said period of time is between .1 and 8 hours.
6. The method of claim 1 comprising the further step of adding a buffer to the solution described in claim 1 in A quantity sufficient to neutralize said solution.
7. A kit for sterilizing contact lenses using water, said kit comprising a chlorine-releasing agent, hydrogen peroxide, an apparatus for producing a sterile saline and a container for immersing said lens in a sterilizing sol-ution.
8. The kit of claim 7 further comprising salt.
g. The kit of claim 7 further comprising a buffer.
10. A method of disinfecting contact lenses comprising:
a) providing a kit for sterilizing soft contact lenses comprising a chlorine-releasing agent, hydrogen per-oxide, an apparatus for producing a sterile saline and a container for immersing said lens in a sterilizing solution;
b) adding water and salt to said apparatus and produc-ing said sterile saline;
c) mixing said chlorine-releasing agent and said hydrogen peroxide in said saline to produce a steril-izing solution containing from 1 to 500 parts per million chlorine and from 1 to 1000 parts per million peroxide; and d) immersing, for a period of time sufficient to result in disinfection, a contact lens in said steril-izing solution in said container.
a) providing a kit for sterilizing soft contact lenses comprising a chlorine-releasing agent, hydrogen per-oxide, an apparatus for producing a sterile saline and a container for immersing said lens in a sterilizing solution;
b) adding water and salt to said apparatus and produc-ing said sterile saline;
c) mixing said chlorine-releasing agent and said hydrogen peroxide in said saline to produce a steril-izing solution containing from 1 to 500 parts per million chlorine and from 1 to 1000 parts per million peroxide; and d) immersing, for a period of time sufficient to result in disinfection, a contact lens in said steril-izing solution in said container.
11. The method of claim 1 wherein said amount of chlorine is from 1 to 200 parts per million.
12. The method of claim 1 wherein said amount of chlorine is approximately 10 to 20 parts per million.
13. The method of claim 1 wherein said amount of peroxide is approximately 40 to 80 parts per million.
14. The method of claim 3 wherein said period of time is between .1 and 8 hours.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2062615 CA2062615A1 (en) | 1992-03-10 | 1992-03-10 | Method and kit for disinfection of contact lenses |
| AU38806/93A AU3880693A (en) | 1992-03-10 | 1993-03-10 | Method and kit for disinfection of contact lenses |
| PCT/CA1993/000093 WO1993017720A1 (en) | 1992-03-10 | 1993-03-10 | Method and kit for disinfection of contact lenses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2062615 CA2062615A1 (en) | 1992-03-10 | 1992-03-10 | Method and kit for disinfection of contact lenses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2062615A1 true CA2062615A1 (en) | 1993-09-11 |
Family
ID=4149408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2062615 Abandoned CA2062615A1 (en) | 1992-03-10 | 1992-03-10 | Method and kit for disinfection of contact lenses |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA2062615A1 (en) |
| WO (1) | WO1993017720A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157553A (en) * | 1994-09-09 | 1997-08-20 | 诺沃挪第克公司 | Method for cleaning, disinfecting and preserving contact lenses |
| US5611464A (en) * | 1995-05-30 | 1997-03-18 | Ciba Geigy Corporation | Container for preserving media in the tip of a solution dispenser |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2256767B1 (en) * | 1974-01-07 | 1978-10-06 | Nat Patent Dev Corp | |
| FR2544880B1 (en) * | 1983-04-20 | 1986-08-29 | Pos Lab | PROCESS FOR THE CLEANING AND DECONTAMINATION OF CONTACT LENSES AND COMPOSITION FOR ITS IMPLEMENTATION |
| ZA913506B (en) * | 1990-05-22 | 1992-02-26 | Alcon Lab Inc | Double redox system for disinfecting contact lenses |
-
1992
- 1992-03-10 CA CA 2062615 patent/CA2062615A1/en not_active Abandoned
-
1993
- 1993-03-10 WO PCT/CA1993/000093 patent/WO1993017720A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993017720A1 (en) | 1993-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |