CA2061196A1 - Acetylsalicyloyl l-carnitine and process for its preparation - Google Patents

Acetylsalicyloyl l-carnitine and process for its preparation

Info

Publication number
CA2061196A1
CA2061196A1 CA 2061196 CA2061196A CA2061196A1 CA 2061196 A1 CA2061196 A1 CA 2061196A1 CA 2061196 CA2061196 CA 2061196 CA 2061196 A CA2061196 A CA 2061196A CA 2061196 A1 CA2061196 A1 CA 2061196A1
Authority
CA
Canada
Prior art keywords
carnitine
vis
acetylsalicyloyl
preparation
acetoxybenzoyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2061196
Other languages
French (fr)
Other versions
CA2061196C (en
Inventor
Thomas Meul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Priority to CA 2061196 priority Critical patent/CA2061196C/en
Publication of CA2061196A1 publication Critical patent/CA2061196A1/en
Application granted granted Critical
Publication of CA2061196C publication Critical patent/CA2061196C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 3-(2-acetoxybenzoyloxy)-4-(trimethylammonio)-butyric acid betaine and its pharmaceutically acceptable salts are disclosed. The compounds are distinguished by high water solubility, minimum toxicity and good gastric tolerance vis-a-vis acetylsalicylic acid and can be prepared by acetylating the corresponding salicylic acid ester of the carnitine.
CA 2061196 1992-02-13 1992-02-13 Acetylsalicyloyl l-carnitine and process for its preparation Expired - Fee Related CA2061196C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2061196 CA2061196C (en) 1992-02-13 1992-02-13 Acetylsalicyloyl l-carnitine and process for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2061196 CA2061196C (en) 1992-02-13 1992-02-13 Acetylsalicyloyl l-carnitine and process for its preparation

Publications (2)

Publication Number Publication Date
CA2061196A1 true CA2061196A1 (en) 1993-08-14
CA2061196C CA2061196C (en) 2002-05-14

Family

ID=4149252

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2061196 Expired - Fee Related CA2061196C (en) 1992-02-13 1992-02-13 Acetylsalicyloyl l-carnitine and process for its preparation

Country Status (1)

Country Link
CA (1) CA2061196C (en)

Also Published As

Publication number Publication date
CA2061196C (en) 2002-05-14

Similar Documents

Publication Publication Date Title
CA2083390A1 (en) Polyaspartic acid as a calcium sulfate and a barium sulfate inhibitor
AU7672294A (en) Compositions and methods for the administration of delta-aminolevulinic acid
CA2159058A1 (en) Inhibition of helicobacter
CA2192899A1 (en) Composition containing l-carnitine and hydroxycitric acid
AU2836492A (en) Process for the preparation of polyalkenyl derivatives of unsaturated dicarboxylic acid materials
CA2110693A1 (en) Amino acid derivative anticonvulsant
EP0798285A3 (en) 3,4,4-Trifluoro-3-butenoic acid or its methyl ester
CA2268886A1 (en) Aminothiophenecarboxamides
NZ250762A (en) Five-membered-heterocyclic carboxylic acid derivatives and pharmaceutical compositions
EP0512211A3 (en) Process for the preparation of substituted malonic ester anilides and malonic acid monoanilides
CA2228281A1 (en) Use of l-carnitine and acyl l-carnitines for lowering ceramide levels
CA2108707A1 (en) Esters of l-carnitine and alkanoyl l-carnitines with glycolic acid or esters thereof and pharmaceutical compositions containing same for treating dermatoses
HUT63602A (en) Process for producing carboxylic acid derivatives and compositions comprising same
AU1375992A (en) Fatty acid salt production
CA2084588A1 (en) Stabiliser mixture
EP0647229A1 (en) DIAMINE SALTS OF CLAVULANIC ACID.
NZ248227A (en) 2-phenylacrylic acid ester derivatives, fungicidal compositions thereof
AU649546B2 (en) Dicarboxylic acid derivatives and process for preparation thereof
AU7755294A (en) Epoxysuccinic acid derivatives
CA2061196A1 (en) Acetylsalicyloyl l-carnitine and process for its preparation
AU5686894A (en) High purity fatty acid salt products
AU8918891A (en) Production of fatty acid salts
AU7366794A (en) Synthesis of acid addition salts of hydroxylamines
AU1034695A (en) Inflammatory cytokine production inhibitor containing polyprenyl derivative as active ingredient
IE820310L (en) 2-amino-3-(halobenzoyl)-methylphenylacetic acid and esters

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed