CA2057049A1 - Membres negatifs dominants de la superfamille de recepteurs steroide/thyroide - Google Patents

Membres negatifs dominants de la superfamille de recepteurs steroide/thyroide

Info

Publication number
CA2057049A1
CA2057049A1 CA002057049A CA2057049A CA2057049A1 CA 2057049 A1 CA2057049 A1 CA 2057049A1 CA 002057049 A CA002057049 A CA 002057049A CA 2057049 A CA2057049 A CA 2057049A CA 2057049 A1 CA2057049 A1 CA 2057049A1
Authority
CA
Canada
Prior art keywords
receptor
wild type
carboxy
analog
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002057049A
Other languages
English (en)
Inventor
Ronald M. Evans
Stanley M. Hollenberg
Anthony E. Oro
Klaus Damm
Richard A. Heyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2057049A1 publication Critical patent/CA2057049A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CA002057049A 1989-05-26 1990-05-25 Membres negatifs dominants de la superfamille de recepteurs steroide/thyroide Abandoned CA2057049A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35869689A 1989-05-26 1989-05-26
US358,696 1989-05-26

Publications (1)

Publication Number Publication Date
CA2057049A1 true CA2057049A1 (fr) 1990-11-27

Family

ID=23410672

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002057049A Abandoned CA2057049A1 (fr) 1989-05-26 1990-05-25 Membres negatifs dominants de la superfamille de recepteurs steroide/thyroide

Country Status (5)

Country Link
EP (1) EP0473716A4 (fr)
JP (1) JPH04506073A (fr)
AU (1) AU639699B2 (fr)
CA (1) CA2057049A1 (fr)
WO (1) WO1990014356A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184256B1 (en) 1997-04-24 2001-02-06 INSTITUT NATIONAL DE LA SANTé DE LA RECHERCHE MéDICALE Methods and compositions for use in modulating expression of matrix metalloproteinase genes

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04504654A (ja) * 1988-12-23 1992-08-20 ザ　ソーク　インスティテュート　フォア　バイオロジカル　スタディーズ レセプターの転写抑制活性組成物および方法
DE69227589T2 (de) * 1991-08-08 1999-04-08 Genentech Inc Ecdysteroid-abhängige gen regulierung in säugetier-zellen
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
CA2135644C (fr) * 1992-05-14 2009-01-27 Elisabetta Vegeto Recepteurs steroidiens mutants, modes d'utilisation et declencheur moleculaire servant a la therapie genique
US6416998B1 (en) * 1992-09-02 2002-07-09 Baylor College Of Medicine Plasmid encoding a modified steroid hormone
AU685412B2 (en) * 1992-10-30 1998-01-22 General Hospital Corporation, The Nuclear hormone receptor-interacting polypeptides and related molecules and methods
EP0935657B1 (fr) * 1996-10-29 2007-08-29 Baylor College Of Medicine Recepteurs d'hormones steroidiennes modifies
DE19855013C2 (de) 1998-11-20 2001-09-13 Schering Ag Androgen- und Progesteron-Rezeptor bindendes Hormon Response Element
EP1326969B1 (fr) 2000-09-25 2009-04-15 Genetronics, Inc. Ameliorations apportees a un systeme de regulation d'une expression transgenique
GB201413293D0 (en) 2014-07-28 2014-09-10 Black & Decker Inc Mode change knob assembly

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
JPH04504654A (ja) * 1988-12-23 1992-08-20 ザ　ソーク　インスティテュート　フォア　バイオロジカル　スタディーズ レセプターの転写抑制活性組成物および方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184256B1 (en) 1997-04-24 2001-02-06 INSTITUT NATIONAL DE LA SANTé DE LA RECHERCHE MéDICALE Methods and compositions for use in modulating expression of matrix metalloproteinase genes

Also Published As

Publication number Publication date
JPH04506073A (ja) 1992-10-22
WO1990014356A1 (fr) 1990-11-29
AU5824890A (en) 1990-12-18
AU639699B2 (en) 1993-08-05
EP0473716A1 (fr) 1992-03-11
EP0473716A4 (en) 1992-09-09

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Legal Events

Date Code Title Description
FZDE Dead