CA2049799A1 - Optically active triazole derivatives and compositions - Google Patents

Optically active triazole derivatives and compositions

Info

Publication number
CA2049799A1
CA2049799A1 CA002049799A CA2049799A CA2049799A1 CA 2049799 A1 CA2049799 A1 CA 2049799A1 CA 002049799 A CA002049799 A CA 002049799A CA 2049799 A CA2049799 A CA 2049799A CA 2049799 A1 CA2049799 A1 CA 2049799A1
Authority
CA
Canada
Prior art keywords
difluorophenyl
triazol
formula
optically active
vii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002049799A
Other languages
English (en)
French (fr)
Inventor
Kimihiro Murakami
Hidenori Mochizuki
Francis Thomas Boyle
James Michael Wardleworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Mochida Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2049799A1 publication Critical patent/CA2049799A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/19—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic hydroperoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002049799A 1990-08-24 1991-08-23 Optically active triazole derivatives and compositions Abandoned CA2049799A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP223894/90 1990-08-24
JP22389490 1990-08-24

Publications (1)

Publication Number Publication Date
CA2049799A1 true CA2049799A1 (en) 1992-02-25

Family

ID=16805374

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002049799A Abandoned CA2049799A1 (en) 1990-08-24 1991-08-23 Optically active triazole derivatives and compositions

Country Status (8)

Country Link
EP (1) EP0472392A3 (enExample)
KR (1) KR920004382A (enExample)
AU (2) AU637519B2 (enExample)
CA (1) CA2049799A1 (enExample)
HU (1) HU211515A9 (enExample)
SG (1) SG46197A1 (enExample)
TW (1) TW211006B (enExample)
ZA (1) ZA916517B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062941B1 (es) * 1993-03-15 1995-10-01 Uriach & Cia Sa J Nuevos derivados de azol activos por via oral.
GB9307924D0 (en) * 1993-04-16 1993-06-02 Zeneca Ltd Chrial synthesis
US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE4408083C1 (de) * 1994-03-10 1995-01-26 Hoechst Ag Verfahren zur Herstellung von 4-Fluoralkoxyzimtsäurenitrilen
CN1126987A (zh) * 1994-04-19 1996-07-17 钟渊化学工业株式会社 三唑衍生物的制造方法
WO1996002664A1 (en) * 1994-07-18 1996-02-01 Daicel Chemical Industries, Ltd. Process for producing optically active triazole compound and method of racemizing optically active triazole compound
GB9415544D0 (en) * 1994-08-02 1994-09-21 Zeneca Ltd Chemical process and intermediates
GB9415617D0 (en) * 1994-08-02 1994-09-21 Zeneca Ltd Pharmaceutical compound
DE4439836C1 (de) * 1994-11-08 1996-06-05 Hoechst Ag cis-4-(2,2,3,3-Tetrafluorpropoxy)-zimtsäurenitril und trans-4-(2,2,3,3-Tetrafluorpropoxy)- zimtsäurenitril und ein Verfahren zu ihrer Herstellung
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US9181269B2 (en) 2011-03-15 2015-11-10 Fdc Limited Enantiomers of fluconazole analogues containing thieno-[2,-3-D]pyrimidin-4(3H)-one moiety as antifungal agents
CN108473443A (zh) * 2015-11-17 2018-08-31 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈以及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
KR927003494A (ko) * 1989-09-01 1992-12-18 제임스 알. 넬슨 항진균 화합물을 제조하기 위한 비대칭 화학합성법 및 중간체

Also Published As

Publication number Publication date
HU211515A9 (en) 1995-11-28
AU8253191A (en) 1992-02-27
EP0472392A2 (en) 1992-02-26
AU3833293A (en) 1993-07-29
AU656853B2 (en) 1995-02-16
SG46197A1 (en) 1998-02-20
EP0472392A3 (en) 1992-08-05
TW211006B (enExample) 1993-08-11
KR920004382A (ko) 1992-03-27
AU637519B2 (en) 1993-05-27
ZA916517B (en) 1992-05-27

Similar Documents

Publication Publication Date Title
US5773443A (en) Triazole antifungal agents
CA2049799A1 (en) Optically active triazole derivatives and compositions
SK48894A3 (en) Fungicidal trisubstituted tetrahydrofurans
US5545652A (en) Triazole and imidazole compounds and their use as antifungal therapeutic agents
US5278175A (en) Triazole antifungal agents
IE48880B1 (en) New hydroxypropyl-triazole compounds,their production and their medicinal use
WO2005014583A1 (en) Antifungal azole derivatives having a fluorovinyl moiety and process for the preparation thereof
US6362206B1 (en) Azole compounds, their production and use
EP0107392A1 (en) Triazole antifungal agents
EP0115400B1 (en) Triazole antifungal agents
JP2630877B2 (ja) 光学活性なトリアゾール誘導体および組成物
US4239765A (en) Fluorenyl-azolylmethyl-carbinol compounds and their medicinal use
US6376526B1 (en) Triazole antifungal agents
NZ196294A (en) Heterocyclic substituted phenoxyamino propanol derivatives:intermediates and pharmaceutical compositions
US4783538A (en) Process for the preparation of optically active azolyl-carbinol derivatives, optically active 2-(4chloro-phenoxymethyl)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol, prepared by this process and its use as an antimycotic
KR19990087363A (ko) 사람 또는 수의학용 항진균 활성을 갖는 아졸 화합물
NZ506818A (en) 3-[[2-[4-(4-Cyano-2-fluorophenyl)-1,3-butadienyl]-1,3-dioxan-5-yl]thio]-2-(substituted phenyl)-1-(1H-1,2,4-triazolyl)-2-butanol derivatives useful as antifungal agents
IE58516B1 (en) A 1,2,4-triazole derivative, its preparation and use as an anti-fungal

Legal Events

Date Code Title Description
FZDE Dead