CA2047978A1 - Process for preparing heparin calcium - Google Patents
Process for preparing heparin calciumInfo
- Publication number
- CA2047978A1 CA2047978A1 CA002047978A CA2047978A CA2047978A1 CA 2047978 A1 CA2047978 A1 CA 2047978A1 CA 002047978 A CA002047978 A CA 002047978A CA 2047978 A CA2047978 A CA 2047978A CA 2047978 A1 CA2047978 A1 CA 2047978A1
- Authority
- CA
- Canada
- Prior art keywords
- heparin
- heparin calcium
- calcium salt
- preparing heparin
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940095529 heparin calcium Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920000669 heparin Polymers 0.000 abstract 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 229960002897 heparin Drugs 0.000 abstract 3
- 159000000007 calcium salts Chemical class 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000005684 electric field Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 abstract 1
- 229960001008 heparin sodium Drugs 0.000 abstract 1
- 239000003014 ion exchange membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Materials For Medical Uses (AREA)
- Seasonings (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The preparation of the calcium salt of heparin or of products derived from heparin such as the fractions of low molecular weight obtained by extraction or by partial depolymerisation is disclosed. The process according to the invention is characterised in that the calcium salt of heparin or of its derivatives is prepared by means of ion exchange membranes which, when subjected to an electric field, make it possible to carry out in a single step an exchange of cations on heparin sodium.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9009653 | 1990-07-27 | ||
| FR9009653A FR2665163B1 (en) | 1990-07-27 | 1990-07-27 | PROCESS FOR THE PREPARATION OF CALCIUM HEPARINS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2047978A1 true CA2047978A1 (en) | 1992-01-28 |
| CA2047978C CA2047978C (en) | 2001-02-27 |
Family
ID=9399192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002047978A Expired - Lifetime CA2047978C (en) | 1990-07-27 | 1991-07-26 | Process for preparing heparin calcium |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0469965B1 (en) |
| JP (1) | JP3025346B2 (en) |
| AT (1) | ATE90691T1 (en) |
| CA (1) | CA2047978C (en) |
| CZ (1) | CZ280167B6 (en) |
| DE (1) | DE69100130D1 (en) |
| ES (1) | ES2057812T3 (en) |
| FI (1) | FI101383B (en) |
| FR (1) | FR2665163B1 (en) |
| HU (1) | HU214027B (en) |
| IE (1) | IE66120B1 (en) |
| PL (1) | PL166250B1 (en) |
| PT (1) | PT98430B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408676A (en) * | 2013-07-15 | 2013-11-27 | 河北常山生化药业股份有限公司 | Nadroparin calcium preparation technology |
| CN103601820A (en) * | 2013-10-31 | 2014-02-26 | 安徽工贸职业技术学院 | Preparation method of heparin lithium |
| CN104072637B (en) * | 2014-07-07 | 2017-02-08 | 兆科药业（合肥）有限公司 | Preparation method for low-molecular-weight heparin calcium |
| CN104072638B (en) * | 2014-07-07 | 2016-08-31 | 兆科药业（合肥）有限公司 | A kind of preparation method of nadroparin calcium |
| CN107286271A (en) * | 2017-08-10 | 2017-10-24 | 盐城盛大肠衣食品有限公司 | A kind of resin adsorption extracts liquaemin device |
| CN110894246A (en) * | 2019-12-31 | 2020-03-20 | 湖北亿诺瑞生物制药有限公司 | Method for increasing calcium content in low molecular weight heparin calcium |
| CN113960246A (en) * | 2021-09-08 | 2022-01-21 | 南京南大药业有限责任公司 | Method and equipment for producing low molecular weight heparin sodium without organic solvent residue |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH586059A5 (en) * | 1974-11-29 | 1977-03-31 | Yeda Res & Dev | |
| US4009088A (en) * | 1975-03-10 | 1977-02-22 | Rauma-Repola Oy | Process for producing aqueous solutions of sodium, ammonium and magnesium sulphite |
| IT1141263B (en) * | 1980-02-29 | 1986-10-01 | Italfarmaco Spa | METHOD FOR THE PREPARATION OF CALCIUM HEPARINATE |
| JPS6480408A (en) * | 1987-09-24 | 1989-03-27 | Tosoh Corp | Separation of metal ion by electrodialysis |
-
1990
- 1990-07-27 FR FR9009653A patent/FR2665163B1/en not_active Expired - Fee Related
-
1991
- 1991-07-12 HU HU912352A patent/HU214027B/en unknown
- 1991-07-16 IE IE248791A patent/IE66120B1/en not_active IP Right Cessation
- 1991-07-23 CZ CS912306A patent/CZ280167B6/en not_active IP Right Cessation
- 1991-07-24 AT AT91402067T patent/ATE90691T1/en active
- 1991-07-24 ES ES91402067T patent/ES2057812T3/en not_active Expired - Lifetime
- 1991-07-24 EP EP91402067A patent/EP0469965B1/en not_active Expired - Lifetime
- 1991-07-24 PT PT98430A patent/PT98430B/en not_active IP Right Cessation
- 1991-07-24 DE DE9191402067T patent/DE69100130D1/en not_active Expired - Lifetime
- 1991-07-25 PL PL91291244A patent/PL166250B1/en unknown
- 1991-07-26 JP JP3187309A patent/JP3025346B2/en not_active Expired - Lifetime
- 1991-07-26 FI FI913596A patent/FI101383B/en not_active IP Right Cessation
- 1991-07-26 CA CA002047978A patent/CA2047978C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69100130D1 (en) | 1993-07-22 |
| IE66120B1 (en) | 1995-12-13 |
| IE912487A1 (en) | 1992-01-29 |
| HUT58769A (en) | 1992-03-30 |
| EP0469965A3 (en) | 1992-04-08 |
| PL291244A1 (en) | 1992-04-06 |
| HU214027B (en) | 1997-12-29 |
| ATE90691T1 (en) | 1993-07-15 |
| FI101383B1 (en) | 1998-06-15 |
| EP0469965B1 (en) | 1993-06-16 |
| FR2665163A1 (en) | 1992-01-31 |
| FI913596A (en) | 1992-01-28 |
| CA2047978C (en) | 2001-02-27 |
| CS230691A3 (en) | 1992-02-19 |
| PT98430A (en) | 1992-05-29 |
| FI913596A0 (en) | 1991-07-26 |
| JP3025346B2 (en) | 2000-03-27 |
| ES2057812T3 (en) | 1994-10-16 |
| JPH04233902A (en) | 1992-08-21 |
| FI101383B (en) | 1998-06-15 |
| FR2665163B1 (en) | 1992-10-16 |
| PT98430B (en) | 1999-01-29 |
| PL166250B1 (en) | 1995-04-28 |
| CZ280167B6 (en) | 1995-11-15 |
| EP0469965A2 (en) | 1992-02-05 |
| HU912352D0 (en) | 1991-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |