CA2045695A1 - Substituted-acyclic terpene compound - Google Patents
Substituted-acyclic terpene compoundInfo
- Publication number
- CA2045695A1 CA2045695A1 CA 2045695 CA2045695A CA2045695A1 CA 2045695 A1 CA2045695 A1 CA 2045695A1 CA 2045695 CA2045695 CA 2045695 CA 2045695 A CA2045695 A CA 2045695A CA 2045695 A1 CA2045695 A1 CA 2045695A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- compound
- solvent
- mmol
- ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 235000007586 terpenes Nutrition 0.000 title claims abstract description 8
- -1 Acyclic terpene compounds Chemical class 0.000 claims abstract description 52
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 33
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 26
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 16
- 125000005843 halogen group Chemical group 0.000 claims abstract description 14
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims abstract description 9
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims abstract description 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 7
- 125000002252 acyl group Chemical group 0.000 claims abstract description 7
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims abstract description 7
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims abstract description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 6
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 153
- YADVRLOQIWILGX-MIWLTHJTSA-N Sarcophytol A Chemical compound CC(C)C/1=C/C=C(C)/CC\C=C(C)\CC\C=C(C)\C[C@@H]\1O YADVRLOQIWILGX-MIWLTHJTSA-N 0.000 abstract description 39
- YADVRLOQIWILGX-UHFFFAOYSA-N sarcophytol N Natural products CC(C)C1=CC=C(C)CCC=C(C)CCC=C(C)CC1O YADVRLOQIWILGX-UHFFFAOYSA-N 0.000 abstract description 39
- 239000000543 intermediate Substances 0.000 abstract description 9
- 230000003217 anti-cancerogenic effect Effects 0.000 abstract description 4
- 230000000259 anti-tumor effect Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 216
- 239000002904 solvent Substances 0.000 description 131
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 116
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 98
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 87
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 60
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 58
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 54
- 239000000243 solution Substances 0.000 description 54
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 48
- 239000000203 mixture Substances 0.000 description 48
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 34
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 33
- 238000010898 silica gel chromatography Methods 0.000 description 33
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 30
- 229910052987 metal hydride Inorganic materials 0.000 description 28
- 150000004681 metal hydrides Chemical class 0.000 description 28
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 26
- 239000011541 reaction mixture Substances 0.000 description 26
- 238000000034 method Methods 0.000 description 25
- 239000002585 base Substances 0.000 description 24
- 238000003756 stirring Methods 0.000 description 24
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 23
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 22
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 22
- 239000007858 starting material Substances 0.000 description 22
- 101150041968 CDC13 gene Proteins 0.000 description 21
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 21
- 229920006395 saturated elastomer Polymers 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 239000003153 chemical reaction reagent Substances 0.000 description 20
- 229940093499 ethyl acetate Drugs 0.000 description 20
- 235000019439 ethyl acetate Nutrition 0.000 description 20
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 20
- 239000012300 argon atmosphere Substances 0.000 description 19
- 125000006519 CCH3 Chemical group 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
- 239000004215 Carbon black (E152) Substances 0.000 description 17
- 229930195733 hydrocarbon Natural products 0.000 description 17
- 150000002430 hydrocarbons Chemical class 0.000 description 17
- 239000000047 product Substances 0.000 description 17
- 239000002253 acid Substances 0.000 description 15
- 239000012044 organic layer Substances 0.000 description 15
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 14
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 14
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 14
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 14
- 239000007832 Na2SO4 Substances 0.000 description 13
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 13
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 13
- 229910052751 metal Inorganic materials 0.000 description 13
- 239000002184 metal Substances 0.000 description 13
- 229910052938 sodium sulfate Inorganic materials 0.000 description 13
- 235000011152 sodium sulphate Nutrition 0.000 description 13
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 12
- 239000000460 chlorine Substances 0.000 description 12
- 229910052736 halogen Inorganic materials 0.000 description 12
- 150000002367 halogens Chemical class 0.000 description 12
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 description 12
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 11
- 229960001701 chloroform Drugs 0.000 description 11
- SIPUZPBQZHNSDW-UHFFFAOYSA-N diisobutylaluminium hydride Substances CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 description 11
- 235000019341 magnesium sulphate Nutrition 0.000 description 11
- 239000012312 sodium hydride Substances 0.000 description 11
- 229910000104 sodium hydride Inorganic materials 0.000 description 11
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 10
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 10
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 10
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 230000003197 catalytic effect Effects 0.000 description 8
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 8
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 8
- 239000012280 lithium aluminium hydride Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000002798 polar solvent Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 8
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 7
- 238000006546 Horner-Wadsworth-Emmons reaction Methods 0.000 description 7
- 229960001040 ammonium chloride Drugs 0.000 description 7
- 235000019270 ammonium chloride Nutrition 0.000 description 7
- AZWXAPCAJCYGIA-UHFFFAOYSA-N bis(2-methylpropyl)alumane Chemical compound CC(C)C[AlH]CC(C)C AZWXAPCAJCYGIA-UHFFFAOYSA-N 0.000 description 7
- 230000002140 halogenating effect Effects 0.000 description 7
- 235000011167 hydrochloric acid Nutrition 0.000 description 7
- 229960000443 hydrochloric acid Drugs 0.000 description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 6
- WRQNANDWMGAFTP-UHFFFAOYSA-N Methylacetoacetic acid Chemical compound COC(=O)CC(C)=O WRQNANDWMGAFTP-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 239000012043 crude product Substances 0.000 description 6
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 6
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 229940073584 methylene chloride Drugs 0.000 description 6
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 6
- 229910000105 potassium hydride Inorganic materials 0.000 description 6
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 5
- TXMNHLKZJPMSGH-UHFFFAOYSA-N 2-diethoxyphosphoryl-3-methylbutanenitrile Chemical compound CCOP(=O)(OCC)C(C#N)C(C)C TXMNHLKZJPMSGH-UHFFFAOYSA-N 0.000 description 5
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 5
- 150000004703 alkoxides Chemical class 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 150000002576 ketones Chemical class 0.000 description 5
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 4
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 4
- HZIJXISIZGWHAY-NXAIOARDSA-N [(2e,6e)-8-hydroxy-3,7-dimethylocta-2,6-dienyl] acetate Chemical group CC(=O)OC\C=C(/C)CC\C=C(/C)CO HZIJXISIZGWHAY-NXAIOARDSA-N 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- 229950005499 carbon tetrachloride Drugs 0.000 description 4
- 238000006735 epoxidation reaction Methods 0.000 description 4
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 4
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 4
- RMGJCSHZTFKPNO-UHFFFAOYSA-M magnesium;ethene;bromide Chemical compound [Mg+2].[Br-].[CH-]=C RMGJCSHZTFKPNO-UHFFFAOYSA-M 0.000 description 4
- 235000006408 oxalic acid Nutrition 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 239000008096 xylene Substances 0.000 description 4
- GQYWTOZOZBWNBG-UHFFFAOYSA-N (2,6-dimethyl-10-oxoundeca-2,6-dienyl) acetate Chemical compound CC(=O)CCC=C(C)CCC=C(C)COC(C)=O GQYWTOZOZBWNBG-UHFFFAOYSA-N 0.000 description 3
- AHCRIYLDRFPMFP-UHFFFAOYSA-N (2,6-dimethyl-10-oxoundeca-2,6-dienyl) benzoate Chemical compound CC(=O)CCC=C(C)CCC=C(C)COC(=O)C1=CC=CC=C1 AHCRIYLDRFPMFP-UHFFFAOYSA-N 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- NGMZEDNYGLPBRW-UHFFFAOYSA-N 12-hydroxy-7,11-dimethyldodeca-6,10-dien-3-one Chemical compound CCC(=O)CCC=C(C)CCC=C(C)CO NGMZEDNYGLPBRW-UHFFFAOYSA-N 0.000 description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 3
- AQROFDJIBGKDOT-UHFFFAOYSA-N 5,9,13-trimethyl-2-propan-2-yltetradeca-2,4,8,12-tetraenenitrile Chemical compound CC(C)C(C#N)=CC=C(C)CCC=C(C)CCC=C(C)C AQROFDJIBGKDOT-UHFFFAOYSA-N 0.000 description 3
- KBLSZPXECGDEFD-UHFFFAOYSA-N 6,10-dimethyl-11-(oxan-2-yloxy)undeca-5,9-dien-2-one Chemical compound CC(=O)CCC=C(C)CCC=C(C)COC1CCCCO1 KBLSZPXECGDEFD-UHFFFAOYSA-N 0.000 description 3
- XJUZRXYOEPSWMB-UHFFFAOYSA-N Chloromethyl methyl ether Chemical compound COCCl XJUZRXYOEPSWMB-UHFFFAOYSA-N 0.000 description 3
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 3
- 239000012346 acetyl chloride Substances 0.000 description 3
- 150000008065 acid anhydrides Chemical class 0.000 description 3
- 150000001266 acyl halides Chemical class 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 3
- 244000309464 bull Species 0.000 description 3
- 229940061627 chloromethyl methyl ether Drugs 0.000 description 3
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 3
- 230000026030 halogenation Effects 0.000 description 3
- 238000005658 halogenation reaction Methods 0.000 description 3
- 150000004678 hydrides Chemical class 0.000 description 3
- 239000005457 ice water Substances 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- WMWSRIHFAVOHSW-UHFFFAOYSA-N lithium;ethane-1,2-diamine;ethyne Chemical compound [Li+].[C-]#C.NCCN WMWSRIHFAVOHSW-UHFFFAOYSA-N 0.000 description 3
- 229910001507 metal halide Inorganic materials 0.000 description 3
- 150000005309 metal halides Chemical class 0.000 description 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 3
- 239000012046 mixed solvent Substances 0.000 description 3
- 239000012299 nitrogen atmosphere Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 3
- 235000011118 potassium hydroxide Nutrition 0.000 description 3
- 229940093932 potassium hydroxide Drugs 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000008707 rearrangement Effects 0.000 description 3
- 229930195734 saturated hydrocarbon Natural products 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 3
- YHRUHBBTQZKMEX-YFVJMOTDSA-N (2-trans,6-trans)-farnesal Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\C=O YHRUHBBTQZKMEX-YFVJMOTDSA-N 0.000 description 2
- YHRUHBBTQZKMEX-UHFFFAOYSA-N (2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-al Natural products CC(C)=CCCC(C)=CCCC(C)=CC=O YHRUHBBTQZKMEX-UHFFFAOYSA-N 0.000 description 2
- HZIJXISIZGWHAY-UHFFFAOYSA-N (8-hydroxy-3,7-dimethylocta-2,6-dienyl) acetate Chemical compound CC(=O)OCC=C(C)CCC=C(C)CO HZIJXISIZGWHAY-UHFFFAOYSA-N 0.000 description 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 2
- BIAAQBNMRITRDV-UHFFFAOYSA-N 1-(chloromethoxy)-2-methoxyethane Chemical compound COCCOCCl BIAAQBNMRITRDV-UHFFFAOYSA-N 0.000 description 2
- OBMDUZHDOPUPSR-UHFFFAOYSA-N 12-(methoxymethoxy)-3,7,11-trimethyldodeca-2,6,10-trienal Chemical compound COCOCC(C)=CCCC(C)=CCCC(C)=CC=O OBMDUZHDOPUPSR-UHFFFAOYSA-N 0.000 description 2
- UDWHZWNMLSZTOS-UHFFFAOYSA-N 14-hydroxy-5,9,13-trimethyl-2-propan-2-yltetradeca-2,4,8,12-tetraenenitrile Chemical compound CC(C)C(C#N)=CC=C(C)CCC=C(C)CCC=C(C)CO UDWHZWNMLSZTOS-UHFFFAOYSA-N 0.000 description 2
- XEZNGIUYQVAUSS-UHFFFAOYSA-N 18-crown-6 Chemical compound C1COCCOCCOCCOCCOCCO1 XEZNGIUYQVAUSS-UHFFFAOYSA-N 0.000 description 2
- MGCHMIBVAYUNEC-UHFFFAOYSA-N 5,9-dimethyl-2-propan-2-yldeca-2,4,8-trienenitrile Chemical compound CC(C)C(C#N)=CC=C(C)CCC=C(C)C MGCHMIBVAYUNEC-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 2
- 238000005821 Claisen rearrangement reaction Methods 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- YHRUHBBTQZKMEX-FBXUGWQNSA-N E,E-Farnesal Natural products CC(C)=CCC\C(C)=C/CC\C(C)=C/C=O YHRUHBBTQZKMEX-FBXUGWQNSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 241000134874 Geraniales Species 0.000 description 2
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- OJGMBLNIHDZDGS-UHFFFAOYSA-N N-Ethylaniline Chemical compound CCNC1=CC=CC=C1 OJGMBLNIHDZDGS-UHFFFAOYSA-N 0.000 description 2
- 229910007161 Si(CH3)3 Inorganic materials 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- 238000007259 addition reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- 125000000746 allylic group Chemical group 0.000 description 2
- SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 150000004696 coordination complex Chemical class 0.000 description 2
- 238000006114 decarboxylation reaction Methods 0.000 description 2
- 229940043279 diisopropylamine Drugs 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000004210 ether based solvent Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- NTKZUWDMQWHMBP-UHFFFAOYSA-N hydroxy(triphenyl)silane;oxovanadium Chemical compound [V]=O.C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(O)C1=CC=CC=C1.C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(O)C1=CC=CC=C1.C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(O)C1=CC=CC=C1 NTKZUWDMQWHMBP-UHFFFAOYSA-N 0.000 description 2
- QHDRKFYEGYYIIK-UHFFFAOYSA-N isovaleronitrile Chemical compound CC(C)CC#N QHDRKFYEGYYIIK-UHFFFAOYSA-N 0.000 description 2
- AHNJTQYTRPXLLG-UHFFFAOYSA-N lithium;diethylazanide Chemical compound [Li+].CC[N-]CC AHNJTQYTRPXLLG-UHFFFAOYSA-N 0.000 description 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 2
- NEARTNVEKBLUHG-UHFFFAOYSA-N methyl 2-acetyl-5,9-dimethyl-10-(oxan-2-yloxy)deca-4,8-dienoate Chemical compound COC(=O)C(C(C)=O)CC=C(C)CCC=C(C)COC1CCCCO1 NEARTNVEKBLUHG-UHFFFAOYSA-N 0.000 description 2
- 150000002825 nitriles Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 150000004967 organic peroxy acids Chemical class 0.000 description 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000011369 resultant mixture Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 235000009518 sodium iodide Nutrition 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 235000011150 stannous chloride Nutrition 0.000 description 2
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 2
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 2
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 2
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
- LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 2
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 2
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical class C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 1
- MEFKFJOEVLUFAY-UHFFFAOYSA-N (2,2,2-trichloroacetyl) 2,2,2-trichloroacetate Chemical compound ClC(Cl)(Cl)C(=O)OC(=O)C(Cl)(Cl)Cl MEFKFJOEVLUFAY-UHFFFAOYSA-N 0.000 description 1
- AVHRJMXIKKJVHG-QIRCYJPOSA-N (2E,6E,10E)-geranylgeranial Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\C=O AVHRJMXIKKJVHG-QIRCYJPOSA-N 0.000 description 1
- FBSIQBKNYXANLZ-UHFFFAOYSA-N (9-methoxycarbonyl-2,6-dimethyl-10-oxoundeca-2,6-dienyl) benzoate Chemical compound COC(=O)C(C(C)=O)CC=C(C)CCC=C(C)COC(=O)C1=CC=CC=C1 FBSIQBKNYXANLZ-UHFFFAOYSA-N 0.000 description 1
- 125000005918 1,2-dimethylbutyl group Chemical group 0.000 description 1
- LHORCXXUZJAMPU-UHFFFAOYSA-N 1,7,11-trimethyl-4-(propan-2-yl)cyclotetradecane Chemical compound CC(C)C1CCC(C)CCCC(C)CCCC(C)CC1 LHORCXXUZJAMPU-UHFFFAOYSA-N 0.000 description 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 description 1
- MKKBUCAMYKBPNY-UHFFFAOYSA-N 11-(methoxymethoxy)-6,10-dimethylundeca-5,9-dien-2-one Chemical compound COCOCC(C)=CCCC(C)=CCCC(C)=O MKKBUCAMYKBPNY-UHFFFAOYSA-N 0.000 description 1
- LYWWXLJPRGRCSY-UHFFFAOYSA-N 11-[tert-butyl(dimethyl)silyl]oxy-6,10-dimethylundeca-5,9-dien-2-one Chemical compound CC(=O)CCC=C(C)CCC=C(C)CO[Si](C)(C)C(C)(C)C LYWWXLJPRGRCSY-UHFFFAOYSA-N 0.000 description 1
- NRRNZTBQPXHFHY-UHFFFAOYSA-N 12-(methoxymethoxy)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol Chemical compound COCOCC(C)=CCCC(C)=CCCC(C)(O)C=C NRRNZTBQPXHFHY-UHFFFAOYSA-N 0.000 description 1
- BHIGRWQDTIZCGO-UHFFFAOYSA-N 14-chloro-5,9,13-trimethyl-2-propan-2-yltetradeca-2,4,8,12-tetraenenitrile Chemical compound CC(C)C(C#N)=CC=C(C)CCC=C(C)CCC=C(C)CCl BHIGRWQDTIZCGO-UHFFFAOYSA-N 0.000 description 1
- KGRKDUNHYBPZFJ-UHFFFAOYSA-N 15-chloro-6,10,14-trimethyl-3-propan-2-yl-2-trimethylsilyloxypentadeca-3,5,9,13-tetraenenitrile Chemical compound C[Si](C)(C)OC(C#N)C(C(C)C)=CC=C(C)CCC=C(C)CCC=C(C)CCl KGRKDUNHYBPZFJ-UHFFFAOYSA-N 0.000 description 1
- YXIFOKDKHGSQOB-UHFFFAOYSA-N 2,6,10-trimethyldodeca-2,6,11-triene-1,10-diol Chemical compound OCC(C)=CCCC(C)=CCCC(C)(O)C=C YXIFOKDKHGSQOB-UHFFFAOYSA-N 0.000 description 1
- UWCWUCKPEYNDNV-LBPRGKRZSA-N 2,6-dimethyl-n-[[(2s)-pyrrolidin-2-yl]methyl]aniline Chemical compound CC1=CC=CC(C)=C1NC[C@H]1NCCC1 UWCWUCKPEYNDNV-LBPRGKRZSA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- LODHFNUFVRVKTH-ZHACJKMWSA-N 2-hydroxy-n'-[(e)-3-phenylprop-2-enoyl]benzohydrazide Chemical compound OC1=CC=CC=C1C(=O)NNC(=O)\C=C\C1=CC=CC=C1 LODHFNUFVRVKTH-ZHACJKMWSA-N 0.000 description 1
- XWKFPIODWVPXLX-UHFFFAOYSA-N 2-methyl-5-methylpyridine Natural products CC1=CC=C(C)N=C1 XWKFPIODWVPXLX-UHFFFAOYSA-N 0.000 description 1
- HNUKTDKISXPDPA-UHFFFAOYSA-N 2-oxopropyl Chemical compound [CH2]C(C)=O HNUKTDKISXPDPA-UHFFFAOYSA-N 0.000 description 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 1
- IXLSHNRLPYQCKH-UHFFFAOYSA-N 5,9,13-trimethyl-2-propan-2-ylcyclotetradeca-2,4,8,12-tetraen-1-one Chemical compound CC(C)C1=CC=C(C)CCC=C(C)CCC=C(C)CC1=O IXLSHNRLPYQCKH-UHFFFAOYSA-N 0.000 description 1
- WOSIIDYQABNGMZ-UHFFFAOYSA-N 5,9,13-trimethyl-2-propan-2-yltetradeca-2,4,8,12-tetraenal Chemical compound CC(C)C(C=O)=CC=C(C)CCC=C(C)CCC=C(C)C WOSIIDYQABNGMZ-UHFFFAOYSA-N 0.000 description 1
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical compound C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 description 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 description 1
- 229930182820 D-proline Natural products 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- AVHRJMXIKKJVHG-UHFFFAOYSA-N Geranylneral Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=O AVHRJMXIKKJVHG-UHFFFAOYSA-N 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 101000913968 Ipomoea purpurea Chalcone synthase C Proteins 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 1
- 101000907988 Petunia hybrida Chalcone-flavanone isomerase C Proteins 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 238000007239 Wittig reaction Methods 0.000 description 1
- 238000006406 Wittig rearrangement reaction Methods 0.000 description 1
- AQYKCBKBHSCLAC-UHFFFAOYSA-N [3,7-dimethyl-8-(oxan-2-yloxy)octa-2,6-dienyl] acetate Chemical compound CC(=O)OCC=C(C)CCC=C(C)COC1CCCCO1 AQYKCBKBHSCLAC-UHFFFAOYSA-N 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical compound CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000003927 aminopyridines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001448 anilines Chemical class 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229930001594 cembrane Natural products 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical class Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000006345 epimerization reaction Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- IEARPTNIYZTWOZ-UHFFFAOYSA-N ethene Chemical compound [CH-]=C IEARPTNIYZTWOZ-UHFFFAOYSA-N 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- BVSRWCMAJISCTD-UHFFFAOYSA-N ethyl 2-diethoxyphosphorylpropanoate Chemical compound CCOC(=O)C(C)P(=O)(OCC)OCC BVSRWCMAJISCTD-UHFFFAOYSA-N 0.000 description 1
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- IGONHEVHCCPWNE-UHFFFAOYSA-N geranylgeranial Natural products CC(=CCCC(=CCC(=O)C=C(/C)CCC=C(C)C)C)C IGONHEVHCCPWNE-UHFFFAOYSA-N 0.000 description 1
- FVIZARNDLVOMSU-UHFFFAOYSA-N ginsenoside K Natural products C1CC(C2(CCC3C(C)(C)C(O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O FVIZARNDLVOMSU-UHFFFAOYSA-N 0.000 description 1
- 150000003944 halohydrins Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- ARNWQMJQALNBBV-UHFFFAOYSA-N lithium carbide Chemical compound [Li+].[Li+].[C-]#[C-] ARNWQMJQALNBBV-UHFFFAOYSA-N 0.000 description 1
- WGOPGODQLGJZGL-UHFFFAOYSA-N lithium;butane Chemical compound [Li+].CC[CH-]C WGOPGODQLGJZGL-UHFFFAOYSA-N 0.000 description 1
- OVEHNNQXLPJPPL-UHFFFAOYSA-N lithium;n-propan-2-ylpropan-2-amine Chemical compound [Li].CC(C)NC(C)C OVEHNNQXLPJPPL-UHFFFAOYSA-N 0.000 description 1
- LROBJRRFCPYLIT-UHFFFAOYSA-M magnesium;ethyne;bromide Chemical compound [Mg+2].[Br-].[C-]#C LROBJRRFCPYLIT-UHFFFAOYSA-M 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- XTMFSHBVSQXLDP-UHFFFAOYSA-N methyl 2-acetyl-10-(methoxymethoxy)-5,9-dimethyldeca-4,8-dienoate Chemical compound COCOCC(C)=CCCC(C)=CCC(C(C)=O)C(=O)OC XTMFSHBVSQXLDP-UHFFFAOYSA-N 0.000 description 1
- WVQDEZARZRLJRR-UHFFFAOYSA-N methyl 2-acetyl-10-acetyloxy-5,9-dimethyldeca-4,8-dienoate Chemical compound COC(=O)C(C(C)=O)CC=C(C)CCC=C(C)COC(C)=O WVQDEZARZRLJRR-UHFFFAOYSA-N 0.000 description 1
- IAPCVVZLVISVMU-UHFFFAOYSA-N methyl 3-(triphenyl-$l^{5}-phosphanylidene)propanoate Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CCC(=O)OC)C1=CC=CC=C1 IAPCVVZLVISVMU-UHFFFAOYSA-N 0.000 description 1
- 229960002221 methylephedrine Drugs 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229930003658 monoterpene Natural products 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- HVFSJXUIRWUHRG-UHFFFAOYSA-N oic acid Natural products C1CC2C3CC=C4CC(OC5C(C(O)C(O)C(CO)O5)O)CC(O)C4(C)C3CCC2(C)C1C(C)C(O)CC(C)=C(C)C(=O)OC1OC(COC(C)=O)C(O)C(O)C1OC(C(C1O)O)OC(COC(C)=O)C1OC1OC(CO)C(O)C(O)C1O HVFSJXUIRWUHRG-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000006462 rearrangement reaction Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000001119 stannous chloride Chemical class 0.000 description 1
- 239000012257 stirred material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 150000003461 sulfonyl halides Chemical class 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 description 1
- PGOLTJPQCISRTO-UHFFFAOYSA-N vinyllithium Chemical compound [Li]C=C PGOLTJPQCISRTO-UHFFFAOYSA-N 0.000 description 1
Abstract
Abstract of the Disclosure Acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the general formula (I):
(I) [wherein R is a group of formula:
, or (wherein R1 is cyano group or formyl group; R2 is a hydrogen atom or -CO2R3; R3 is C1 - C4 alkyl group; R4 is -C?CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -OR5 or -OSO2R6 (wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, silyl group substituted with C1 - C5 alkyl group or phenyl group; R6 is C1 - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C1 - C4 alkyl group); and n is an integer of 0 to 2 with the proviso that when R is a group of formula:
or X must be -OR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 is 1-ethoxyethyl group, R3 is not a methyl group].
(I) [wherein R is a group of formula:
, or (wherein R1 is cyano group or formyl group; R2 is a hydrogen atom or -CO2R3; R3 is C1 - C4 alkyl group; R4 is -C?CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -OR5 or -OSO2R6 (wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, silyl group substituted with C1 - C5 alkyl group or phenyl group; R6 is C1 - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C1 - C4 alkyl group); and n is an integer of 0 to 2 with the proviso that when R is a group of formula:
or X must be -OR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 is 1-ethoxyethyl group, R3 is not a methyl group].
Description
20~69~
SUBSTITUTED-ACYCLIC TERPENE COMPOUND
FIELD OF THE ART
The present invention relates to novel substitut-ed-acyclic terpene compounds. More particularly, the present invention is directed to substituted-acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity.
BACKGROUND OF THE INVENTION
The sarcophytol A was reported to exhibit anti-carcinogenic promotor activity [Cancer Surveys, 2, 540 (1983); Taisha, Vol. 25, Special Edition, Gan '88,3 (1988)]
and anti-tumor activity [Japanese Patent Publication 20213/1988], whereby it has been regarded as a useful anti-tumor agent. As can be seen from the following structure, sarcophytol A is a cembrane type diterpene-alcohol containing one conjugated double bond and other two double bonds in the 14-membered ring.
OH
Sarcophytol A
The present inventors had been studied with the aim of developing a synthetic method of sarcophytol A and proposed a synthetic route shown by the following synthetic 20~6~5 route 1 [JP Patent Appln. 181710/1989; filing date: July 14, 19~1 ] .
Reaction Route 1 type reaction ~ t-BuOH
(A) (B) halogenation reduction Ho ~\ srulfonYl~ xlJ~! >
CO2R7 esterification CO2R7 (C) (D) trimethyl-silyl-oxidation I I I I nitrile x~,~1 > x~
OH CHO
(E) (F) X' ~ ~ CN
(G) oR8 (H) Iysis ~ re ~ r (J) sarcophytol A
_ 3 _ 2045~9~
wherein R7 is Cl - C4 lower alkyl group or phenyl group; X1 is a halogen atom or a leaving group such as OS02R9 and the like; R8 is a hydrogen atom, or trimethylsilyl group or l-ethoxyethyl group; and R9 is lower alkyl group such as methyl group or ethyl group, substituted alkyl group such as trifluoromethyl group, phenyl group or substituted phenyl group such as toluyl group, mesityl group or the like.
Although the previously proposed method according to the above synthetic route 1 gives the aimed sarcophytol A, it has some problems as follows:
1) it requires as the starting material a valuable compound (A), namely "E,E'-farnesal" of a structure essen-tial for the production of sarcophytol A;
SUBSTITUTED-ACYCLIC TERPENE COMPOUND
FIELD OF THE ART
The present invention relates to novel substitut-ed-acyclic terpene compounds. More particularly, the present invention is directed to substituted-acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity.
BACKGROUND OF THE INVENTION
The sarcophytol A was reported to exhibit anti-carcinogenic promotor activity [Cancer Surveys, 2, 540 (1983); Taisha, Vol. 25, Special Edition, Gan '88,3 (1988)]
and anti-tumor activity [Japanese Patent Publication 20213/1988], whereby it has been regarded as a useful anti-tumor agent. As can be seen from the following structure, sarcophytol A is a cembrane type diterpene-alcohol containing one conjugated double bond and other two double bonds in the 14-membered ring.
OH
Sarcophytol A
The present inventors had been studied with the aim of developing a synthetic method of sarcophytol A and proposed a synthetic route shown by the following synthetic 20~6~5 route 1 [JP Patent Appln. 181710/1989; filing date: July 14, 19~1 ] .
Reaction Route 1 type reaction ~ t-BuOH
(A) (B) halogenation reduction Ho ~\ srulfonYl~ xlJ~! >
CO2R7 esterification CO2R7 (C) (D) trimethyl-silyl-oxidation I I I I nitrile x~,~1 > x~
OH CHO
(E) (F) X' ~ ~ CN
(G) oR8 (H) Iysis ~ re ~ r (J) sarcophytol A
_ 3 _ 2045~9~
wherein R7 is Cl - C4 lower alkyl group or phenyl group; X1 is a halogen atom or a leaving group such as OS02R9 and the like; R8 is a hydrogen atom, or trimethylsilyl group or l-ethoxyethyl group; and R9 is lower alkyl group such as methyl group or ethyl group, substituted alkyl group such as trifluoromethyl group, phenyl group or substituted phenyl group such as toluyl group, mesityl group or the like.
Although the previously proposed method according to the above synthetic route 1 gives the aimed sarcophytol A, it has some problems as follows:
1) it requires as the starting material a valuable compound (A), namely "E,E'-farnesal" of a structure essen-tial for the production of sarcophytol A;
2) the oxidation of the terminal methyl group of compound (B) with selenium dioxide is poor in both the selectivity and yield.
3) the process to prepare the Compound (F) by reducing compound (D) to Compound (E), and oxidizing the latter is complicated and inefficient.
Thus, the process shown by the synthetic route 1, especially that concerned to the production of the interme-diate (F) from the starting compound (A) is not optimal for the industrial production of sarcophytol A and more effi-cient method for preparing the compound (F) has been demand-ed.
Under these circumstances, the present inventors have continuously investigated intimately with the aim of 2~45695 developing more efficient and simple method for producing the intermediate ~F), thereby providiny a process applicable to the industrial production of sarcophytol A, and have now found that certain novel substituted-acyclic terpene com-pounds are useful for the establishment of the purpose of the invention.
DISCLOSURE OF THE INVENTION
The present invention provides acyclic terpene compounds of the general formula (I):
X ~ R
[ wherein R is a group of formula:
Rl R2 0 --CH=CHCHCH(CH3)2 1 --CH2CHCCH3 \ /
or --CH2CH2C CH3 (wherein Rl is cyano group or formyl group; R2 is a hydrogen atom or -C02R3; R3 is Cl - C4 alkyl group; R is -C_CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -oR5 or -OS02R6 (wherein R5 is a hydrogen atom, l-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, _ 5 204~ 6~ ~
silyl group substituted with Cl - C5 alkyl group or phenyl group; R6 is Cl - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C
- C4 alkyl group); and n is an integer of O to 2 with the proviso that when R is a group of formula:
I 11 \/
--CH2CHCCH3 or --CH2CHaCCH3 X must be -oR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 i5 1-ethoxyethyl group, R3 is not a methyl group].
The terms used for the definition of the compound (I) are explained below.
In the definition of R3, examples of "C1 to C4 lower alkyl group" include a straight or branched alkyl groups containing 1 to 4 carbon atoms, for example, methyl group, ethyl group, n-propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group and the like.
In the definition of R5, the term "Cl to C5 lower alkyl group~' refers to the above "Cl to C4 lower alkyl group" and pentyl group, isopentyl group, neopentyl group and 1,2-dimethylbutyl group. Examples of "l-alkoxyalkyl group" include methoxymethyl group, 1-ethoxyethyl group and the like. Examples of "silyl group substituted with C1 - C5 alkyl group or phenyl group" include trimethylsilyl group, 2~69~
t-butyldimethylsilyl group, t-butyldiphenylsilyl group and the like. Examples of llacyl group" include acetyl group, propionyl group, benzoyl group and the like.
In the definition of R6, the term ~'halogen atom~
include fluorine, chlorine, bromine and the like. Examples of "Cl - C4 alkyl group optionally substituted with halogen atom" include methyl group, ethyl group, propyl group, trifluoromethyl group, trichloromethyl group and the like.
Examples of ~phenyl group optionally substituted with C1 -C4 alkyl group" include phenyl group, p-tolyl group and the like.
PREFERRED EMBODIMENT OF THE INVENTION
Typical compounds represented by the general formula (I) are shown below. However, these are given only for the illustrative purpose and never restrict the scope of the invention.
(1) Compound (I) wherein R is R ' --C H = C H C H C H ( C H 3) 2 204~63~
1) R'=CN, n=O
X~
CN
Compound No. X
--H
3 - C ~
Thus, the process shown by the synthetic route 1, especially that concerned to the production of the interme-diate (F) from the starting compound (A) is not optimal for the industrial production of sarcophytol A and more effi-cient method for preparing the compound (F) has been demand-ed.
Under these circumstances, the present inventors have continuously investigated intimately with the aim of 2~45695 developing more efficient and simple method for producing the intermediate ~F), thereby providiny a process applicable to the industrial production of sarcophytol A, and have now found that certain novel substituted-acyclic terpene com-pounds are useful for the establishment of the purpose of the invention.
DISCLOSURE OF THE INVENTION
The present invention provides acyclic terpene compounds of the general formula (I):
X ~ R
[ wherein R is a group of formula:
Rl R2 0 --CH=CHCHCH(CH3)2 1 --CH2CHCCH3 \ /
or --CH2CH2C CH3 (wherein Rl is cyano group or formyl group; R2 is a hydrogen atom or -C02R3; R3 is Cl - C4 alkyl group; R is -C_CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -oR5 or -OS02R6 (wherein R5 is a hydrogen atom, l-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, _ 5 204~ 6~ ~
silyl group substituted with Cl - C5 alkyl group or phenyl group; R6 is Cl - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C
- C4 alkyl group); and n is an integer of O to 2 with the proviso that when R is a group of formula:
I 11 \/
--CH2CHCCH3 or --CH2CHaCCH3 X must be -oR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 i5 1-ethoxyethyl group, R3 is not a methyl group].
The terms used for the definition of the compound (I) are explained below.
In the definition of R3, examples of "C1 to C4 lower alkyl group" include a straight or branched alkyl groups containing 1 to 4 carbon atoms, for example, methyl group, ethyl group, n-propyl group, isopropyl group, butyl group, isobutyl group, sec-butyl group, tert-butyl group and the like.
In the definition of R5, the term "Cl to C5 lower alkyl group~' refers to the above "Cl to C4 lower alkyl group" and pentyl group, isopentyl group, neopentyl group and 1,2-dimethylbutyl group. Examples of "l-alkoxyalkyl group" include methoxymethyl group, 1-ethoxyethyl group and the like. Examples of "silyl group substituted with C1 - C5 alkyl group or phenyl group" include trimethylsilyl group, 2~69~
t-butyldimethylsilyl group, t-butyldiphenylsilyl group and the like. Examples of llacyl group" include acetyl group, propionyl group, benzoyl group and the like.
In the definition of R6, the term ~'halogen atom~
include fluorine, chlorine, bromine and the like. Examples of "Cl - C4 alkyl group optionally substituted with halogen atom" include methyl group, ethyl group, propyl group, trifluoromethyl group, trichloromethyl group and the like.
Examples of ~phenyl group optionally substituted with C1 -C4 alkyl group" include phenyl group, p-tolyl group and the like.
PREFERRED EMBODIMENT OF THE INVENTION
Typical compounds represented by the general formula (I) are shown below. However, these are given only for the illustrative purpose and never restrict the scope of the invention.
(1) Compound (I) wherein R is R ' --C H = C H C H C H ( C H 3) 2 204~63~
1) R'=CN, n=O
X~
CN
Compound No. X
--H
3 - C ~
--0 S 0 2~ C H 3 6 --0 S i ( C H 3 ) 3 -o o 7 \0 8 - 0 C H C H 3 ( 0 ) C 2 H 5 2~4~69~
2) R'=CN, n=l X~ ~
CN
Compound No X
1 1 -C~
1 2 --Br 1 4 -OS02~CH3 1 5 - O C H C H 3 ( O E t) 7 -~
20~569~
g 3 ) R ' - C N, n = 2 X ~
CN
Compound No X
-2 0 - C e 4) Rl= CHO, n= O
X~
CHO
Compound No. X
2 5 -OSi(CH3)2 C4Hs' 2 6 --O C H C H 3 ( O C 2 H s ) -0,~
- lO 204~69~
2) R'=CN, n=l X~ ~
CN
Compound No X
1 1 -C~
1 2 --Br 1 4 -OS02~CH3 1 5 - O C H C H 3 ( O E t) 7 -~
20~569~
g 3 ) R ' - C N, n = 2 X ~
CN
Compound No X
-2 0 - C e 4) Rl= CHO, n= O
X~
CHO
Compound No. X
2 5 -OSi(CH3)2 C4Hs' 2 6 --O C H C H 3 ( O C 2 H s ) -0,~
- lO 204~69~
5) R'= C H O, n= 1 X ~
Compound No. X
3 0 - O C H C H 3(0 C 2H s) -o o 3 2 ~
3 4 -OCO~
Compound No. X
3 0 - O C H C H 3(0 C 2H s) -o o 3 2 ~
3 4 -OCO~
6) R'=CHO. n= 2 X / /~
Compound No. X
. . . _ 3 7 --O C H C H 3 ( O C 2 H 5 ) 11- 20456~
(2) Compound (I) wherein R is R2 o R s o\~
Compound R2 Rs NO.
2 --C 02C H3 ~]
3 - C 02C H3 --Si(C H3)2C4Hs' 4 --CO2C2Hs --Si(CH3)2C4Hg' 7 -CO2CH3 --CO~
O C2Hs O~
H ~
11 H -Si(CH3)2C4Hs' 14 H --CO~) - 12 - 2~5~5 ( 3 ) Compound ( I ) wherein R is \/
Rs~ ~
Compound R 4 R 5 No.
O CaHs 1~ --CH=CH2 CHCH3 16 --C H = C H 2 ~
17 --C H = C H2 --C H2O C H 3 18 -CH= CH2 --Si(CH3)2C4H4t 19 --CH= CH2 --H
--C H = C H2 --C O C H 3 21 --CH=CH2 --CO~
O C2Hs 2~ --C - C H C H C H3 23 - C--C H ~
204~69~
_ 13 ---C--C H --S i ( C H 3 ) 2 C 4 H ~ ' 28 --C--CH --CO~
Although all the compounds of the formula (I) including those illustrated in the above are useful as intermediates for the production of sarcophytol A, there are certain preferable compounds, that is, for example, those wherein n is 0 or 1. Especially preferred compounds can be found among the illustrated ones as follows:
(1): compound Nos. 1, 2, 3, 9, 10, 11, 12, 13, 14, 15, 17, 23, 24, 28, 29, 30, 32 and 33; and (27: compounds Nos. 2, 6, 8, 10, 12, 15, 16, 19, 20, 22 and 23.
Preparaion of the compound (I) of the present invention is described below according to the type of the directed compound.
(1) Compound of general formula (I) wherein R is a group of formula:
R I
--C H = C H C H C H ( C H 3 ) a 1) Compounds wherein Rl is CN and X is H
Among the compounds of this t~pe, those wherein n is 0, 1 or 2 can be prepared from corresponding startin~
materials, that is, those wherein n is O are from geranial, those wherein n is 1 are from farnesal, and those wherein n is 2 are from geranyl geranial, by reacting the each starting material with 1 to 10 mol equivalent of Wittig-Horner reagent in the presence of less than 1 mol equivalent of a base (for the Wittig-Horner reagent) in an appropriate solvent.
The Wittig-Horner reagent which can be used is, for example, 2-tdimethylphosphono)isovaleronitrile~ 2-(diethylphosphono)isovaleronitrile, or the like. Generally 1 to 10 mol equivalent of such a reagent is used for the starting material.
Examples of appropriate solvents include ether solvents such as tetrahydrofuran (THF), diethyl ether and the like, hydrocarbon solvents such as benzene, toluene, n-hexane and the like and aprotic polar solvents such as dimethylformamide (DMF) and the like. Preferred solvents are hydrocarbon solvents such as toluene, n-hexane and the like.
Examples of bases include metal hydrides such as sodium hydride, potassium hydride and the like, organic metals such as n-butyllithium, lithium diisopropylamide, lithium-bis-(trimethylsilyl)amide, potassium bis-(trimethylsilyl)amide and the like, metal alkoxides such as sodium methoxide, potassium t-butoxide and the like.
Generally, less than 1 mol equivalent of such a base is used 2~456~
for the Wittig-Hornar reagent. In this reaction, it is possible to control the steric isomerism at the double bond of the product by selecting the solvent and the base.
The reaction is usually carried out at temperature from -100 to 100C, preferably from -80 to 50C, more preferably -70 to 0C.
Each starting compound, when reacted with anion which generates during the reaction between the compound and a selected base in the presence of a selected Wittig-Horner reagent at temperature within the cited range in a selected solvent, gives the corresponding product. Under these conditions, the reaction usually completes in ~he period from 30 minutes to 12 hours.
2) Compound (I) wherein Rl is CHO and X is H
Compounds of this type can be prepared, for example, by reacting a compound prepared in above 1) with l to 10 mol equivalent of a metal hydride such as diisobutylaluminium hydride at temperature from -100 to 150 C in a hydrocarbon solvent such as toluene, n-hexane, heptane, benzene or the like, which is followed by hydroly-sis .
3) Compounds (I) wherein X is OH
Compounds of this type can be prepared, forexample, by reacting a compound prepared in above l) or 2) with an equivalent amount to 50 mol equivalent of t-butylhydroperoxide in the presence of 0.01 to 0.1 mol equivalent of selenium dioxide at temperature from -20 to 50 204~59~
c over a period of 1 to 100 hours in a solvent such as methylenechloride or the like.
4) Compounds (I) wherein R1 is CN and X is a halogen atom Compounds of this type can be prepared, for example, from an alcohol wherein R1 is CN, obtained in above 3), by halogenating said allylic alcohol without allyl rearrangement. Such a reaction can be carried out by reacting the alcohol with 1.0 to 10 mol equivalent of carbon tetrahalide in the presence of 1.0 to 10 mol equivalent of triphenylphosphine at temperature from room temperature to 100C over a period of 1 to 8 hours in an inert solvent such as ace onitrile or the like. In case of chlorination~ carbon tetrachloride can be used as a solvent. Alternatively, it can be carried out by reacting 1.0 to 10 mol equivalent of methanesulfonyl chloride together with a metal halide and y-collidine at temperature from -40C to room temperature over a period of 1 to 10 hours.
5) Compounds wherein R1 is CN and X is OSO2R6 (R6 is as defined above) Compounds of this type can be prepared, for example, by reacting an alcohol wherein R1 is CN obtained in above 3) with 1.0 to 10 mol equivalent of sulfonyl chloride such as methanesulfonyl chloride, p-toluenesulfonyl chloride or sulfonyl anhydride such as trifluoromethanesulfonic anhydride in the presence of 1.0 to 10 mol equivalent of amine such as triethylamine, pyridine or the like at 2 ~ 5 temperature from -40C to room temperature over a period of 1 to 10 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like or a halogen solvent such as methylenechloride, chloroform or the like, or pyridine in case it is used as a base.
6) Compounds wherein X is oR5 (R5 is as defined above) a) Compounds wherein R5 is substituted silyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 0.5 to 10 mol equiva-lent of a substituted silyl chloride such as trimethylchlorosilane, t-butyldimethylchlorosilane or the like in the presence of 0.5 to 10 mol equivalent of a base such as triethylamine, pyridine, imidazole or the like at temperature from -50 to 50 C in an ether solvent such as ethyl ether, THF or the like, an aprotic polar solvent such as dimethylformamide or the like, a halogen solvent such as dichlorometahne, chloroform or the like.
b) Compounds wherein R5 is l-alkoxyalkyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 0.5 to 10 mol equiva-lent of l-haloalkyl ether such as chloromethylmethyl ether or chloromethyl-(2-methoxyethyl) ether or the like together with 0.5 to 10 mol equivalent of a base such as sodium hydride, potassium hydride, diisopropylamine, triethylamine or the like at temperature from -50 to 50 in a solvent such as THF, DMF or the like or without solvent; or with 1 to 10 - 18 - 204~S9~
mol equivalent of l-alkenylalkyl ether such as vinylethyl ether, dihydropyrane or the like in the presenae of a catalytic amount to equivalent amount of mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic acid such as p-toluenesulfonic acid, camphorsulfonic acid or the like or a salt such as pyridinium salt of p-toluenesulfonic acid or the like at temperature from -20 to 100 C in an ether solvent such as diethyl ether, THF or the like, an ester solvent such as ethyl acetate or the like, or a halogen solvent such as dichloromethane, chloroform or the like.
c3 Compounds wherein R5 is acyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 1 to 10 mol equivalent of acyl halide such as acetyl chloride, benzoyl chloride or the like or acid anhydride such as acetic anhydride, trichloroacetic anhydride or the like in the presence of 1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -20 to 100 C in a halogen solvent such as dichloromethane, chloroform or the like or an ether solvent such as ethyl ether, THF or the like or a hydrocarbon solvent such as benzene, toluene, n-hexane or the like, or without solvent where a base serves as a solvent.
(2) Compound of general formula (I) wherein R is a group of formula: R 2 o 204~95 1) Compounds (I) wherein R5 is l-alkoxyalkyl group , tetrahydrofuranyl group or tetrahydropyranyl group, silyl group substituted with Cl - C5 alkyl group or phenyl group and R2 is C02R3 (wherein R3 is as defined above) Compounds of this type can be prepared by substi-tuting the hydroxyl group at the 8 position of 8-hydroxygeranyl acetate with -oR5 ~R5 is as defined above) according to either of the following methods.
a) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of 1-haloalkyl ether such as chloromethylmethyl ether, chloromethyl-2-methoxyethyl ether or the like in the presence of 0.5 to 10 mol equivalent of a base, for example, a metal hydride such as sodium hydride, potassium hydride or the like, amines such as diisopropylamine, triethylamine or the like, or pyridine or the like at temperature from -20 to +100 over a period of 5 minutes to 24 hours in a halogen solvent such as methylene chloride, chloroform or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl acetate or dimethylformamide or the like, or without solvent.
b) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of vinyl ether such as ethylvinyl ether, dihydropyrane or the like in the presence of a catalytic amount to equivalent amount of mineral acid such as hydro-chloric acid, sulfuric acid or the like, an organic acid such as p-toluenesulfonic acid, camphorsulfonic acid or the like, or a salt of a strong acid such as pyridinium salt of 2~4~9~
p-toluenesulfonic acid or the like at temperature from -20 to +100 C in a halogen solvent such as dichloromethane, chloroform or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl acetate or dimethylformamide or the like, or without solvent.
c) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of trialkylsilyl halide such as trimethyl-silyl chloride, t-butyldimethylsilyl chloride or the like in the presence of 0.1 to 10 mol equivalent of a base such as nitrogen-containing compound such as triethylamine, dimethylaminopyridine, imidazole or the like, or metal hydride such as sodium hydride, potassium hydride or the like at temperature from -20 to +100 C over a period of 5 minutes to 24 hours in a halogen solvent such as methylene chloride, chloroform or the like, a hydrocarbon solvent such as hexane, benzene or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl ace-tate, dimethylformamide, dimethyl sulfoxide or the like.
The resultant compound, when reacted, for example, with an alkali metal salt of acetoacetic ester, gives the desired compound. Thus, the compound is reacted with an alkali metal salt of an acetoacetic ester at temperature from -70 to +100C over a period of 30 minutes to 48 hours in an aprotic polar solvent such as diethyl ether, tetrahydrofuran, dimethylformamide, dimethyl sulfoxide or the like to give the directed compound, where the alkali metal salt of an acetoacetic ester can be prepared by 2 ~ 9 ~
reacting an acetoacetic ester such as ethyl acetoacetate, ethyl acetoacetate or the like with a metal hydride such as sodium hydride or the like, or a strong base such as n-butyllithium, lithium diisopropylamine or the like in the presence of a palladium (o) chelate such as tetrakis(triphenylphosphine) palladium and the like as a catalyst at temperature from -70 to +100C in an aprotic polar solvent such as diethyl ether, tetrahydrofuran, dimethylformamide, dimethyl sulfoxide or the like.
2) Compounds (I) wherein R5 is H and R2 is Co2R3 (R3 is as defined above) Compounds of this type can be prepared by reacting a compound obtained in above 1) with 0.1 to 10 mol equiva-lent of a mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or the like or a salt of a strong acid such as pyridinium salt of p-toluenesulfonic acid or the like in an alcohol solvent such as methanol, ethanol or a the like or water, or a mixed solvent thereof. Alterna-tively, it can be prepared by reacting the compound obtained in 1) with 0.1 to 10 mol equivalent of tetraalkylammonium fluoride such as tetrabutylammonium fluoride or hydrogen fluoride in a protonic polar solvent such as methanol, ethanol, water or the like, an ether solvent a~ diethyl ether, tetrahydrofuran or the like, or a mixed solvent thereof.
2~569~
- 2~ -3) Compounds (I) wherein R5 is acyl group and R
is Co2R3 (R3 is as defined above) Compounds of this type can be prepared by reacting a compound obtained in above 2) with 0.1 to 10 mol equiva-lent of acyl halide such as acetyl chloride, benzoyl chlo-ride or the like or acid anhydride such as acetic anhydride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at tempera-ture from -20 to +100 C in a halogen solvent such as dichloromethane or the like, an ether solvent such as diethyl ether or the like, a hydrocarbon solvent such as benzene, n-hexane or the like, or without solvent where a base serves as a solvent.
4) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuranyl group, tetrahydropyranyl group, silyl group substituted with Cl C5 alkyl group or phenyl group or acyl group and R2 is a hydrogen atom Compounds of this type can be prepared through the decarboxylation or decarboalkoxylation of a compound obtained in above 1), 2) or 3). The decarboxylation can be carried out by reacting said compound with 0.1 to 10 mol equivalent of a metal hydroxide such as sodium hydroxide, potassium hydroxide or the like, metal alkoxide such as sodium methoxide or the like at temperature from 0 to 100C
over a period of 10 minutes to 24 hours for the hydrolysis 2~6~
or ester-exchanging reaction, and heating at temperature from 100 to 250C over a period of 30 minutes to 10 hours.
The decarboalkoxylation which is carried out by reacting a compound with 0.1 to 10 mol equivalent of a metal halide such as sodium chloride, sodium iodide or the like at temperature from 50 to 250C in an aprotic polar solvent such as dimethylformamider dimethylsulfoxide or the like.
(3) Compounds (I) wherein ~ is a group of formula:
\ /
1) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl, tetrahydrofuranyl or tetrahydropyranyl group, or silyl group substituted with C1 - C5 al y g p phenyl group and R is -CH=CH2 Compounds of this type can be preparcd by sub~ect-ing a compound obtained in (2), 4) to an addition reaction, which is conducted by reacting said compound with 0.1 to 10 mol equivalent of a vinyl anion such as vinyl lithium, vinyl magnesium bromide or the like at temperature from -50 to 100 C over a period of 30 minutes to 48 hours in an ether solvent such as diethyl etherr tetrahydrofuran or the like or a hydrocarbon solvent such as n-hexane , benzene or the like.
2) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuranyl group, tetrahydropyranyl group or silyl group substituted with Cl -C5 alkyl group or phenyl and R4 is -C-CH
2~4~S9~
Compounds of this type can be prepared by subject-ing a compound obtained in above (2), 4) to an addition reaction which is conducted by reacting said compound with 0.1 to 10 mol equivalent of a metal acetylide such as lithium acetylide, ethynyl magnesium bromide or the like at temperature from -50 to +100 C over a period of 30 minutes to 48 hours in an ether solvent such as diethyl ether, tetrahydrofuran or the like or a hydrocarbon solvent such as n-hexane, benzene or the like.
3) Compounds (I) wherein R5 is acyl group and R4 is a group of -CH=CH2 or -C-CH
Compounds of this type can be prepared by reacting a compound obtained in above ~3),1) or 2), in which R5 is a hydrogen atom and R4 is -CH=CH2 or -C-CH, with 0.1 to 10 mol equivalent of acyl halide such as acetyl chloride, benzoyl chloride or the like or acid anhydride such as acetic anhydride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -20 to +100 C in a halogen solvent such as dichloromethane or the like, an ether solvent such as diethyl ether or the like, a hydrocarbon solvent such as benzene, n-hexane or the like, or without solvent where a base serves as a solvent.
The above are examples of preferred procedures for the production of the compounds of formula (I) of the invention. As one of skill will appreciate, the present invention is not restricted to the compounds (I) produced - 25 _ 20~5~
by the above methods, but include any compounds of formula (I) prepared by other methods known to the art.
As mentioned above, the present invention makes it possible to obtain Compound (F), the key intermediate in the synthetic route 1 for the production of sarcophytol A, from a monoterpenoid which is cheap and easy to obtain by an improved and efficient process with avoiding the oxidation of alcohol to aldehyde of the previously provided method, reducing the total steps, and in high yield.
Thus, the present invention provides an industri-ally advantageous synthetic route for preparing sarcophytol A.
Typical procedures for the production of the intermediate (F) in the synthetic route 1 from various compounds ~I) of the invention as the starting material, and that for the production of the final product, sarcophytol A, will hereinafter be described.
(1) When the starting material is a compound (I) wherein X is a halogen atom, n is 1 and R is a group of formula: C N
I
_ r ~ - r ~ r T7 ~ TT ~ ~ TT ~
v ~ n ~, n ~ ~, n 3 J 2 Compound (F) in the above synthetic route 1 can be prepared by reacting a compound (I) as defined above with 0.1 to 10 mol equivalent of diisobutylaluminium hydride in a solvent such as toluene, benzene, n-hexane or the like at temperature from -100 to 100 C and hydrolyzing the product.
2~4~6~
(2) When the starting material is Compound (I') which is shown by the formula (I) wherein R5 is l-alkoxyalkyl group and R is a group of formula:
HO C--CH
or Compound (I") which is shown by the formula (I) wherein R2 is l-alkoxyalkyl group and R is a group of formula:
HO C--CH
\/
~ 27 _ 2~4~
Svnthetic Route 2 HO CH=CH2 R50 J ~ ~ oxidation HO C-CH
R50 ~ ~ \/ R50 ~ ~ ~ CHO >
\~\ . ~ , \~/
eplmerlzatlon (I') (A') Rs~ > Rs~ >
CN CHO
(B') (C') HO~ > X ~ >
(E~ ) CHO (F) CHO
a process of JA181710/1989 ~ ~ ~
> ~, ~OH
sarcophytol A
(wherein R5 and X are as defined above).
a) When the starting material is Compound tI') Compound (A') can be prepared by subjecting the Compound (I') to rearrangement reaction in the presence of 0.01 to 1 mol equivalent of silylvanadate such as tris(triphenylsilyl)vanadate, poly{(diphenylsilyl)vanadate~
2~4~9~
or the like at temperature from 100 to 300C over a period of 30 minutes to 24 hours in a hydrocarbon solvent ~uch as undecane, xylene or the like, an ether solvent such as bis[2-(2-methoxyethoxy~-ethyl] ether or a mineral oil.
b) When the starting material is Compound (I") An unsaturated aldehyde (A') can be prepared by reacting the Compound (I") with chromic oxides such as pyridinium chlorochromate or the like at temperature from 0 to 100C over a period of 30 minutes to 24 hours in a halogen solvent such as methylene chlorider chloroform or the like, a hydrocarbon solvent such as n-hexane, banzene or the like, or dimethylformamide or the like.
c) Compound (B') can be prepared by reacting Compound (A') with 0.1 to 10 mol equivalent of Wittig-Horner reagent such as 2-(dimthylphosphono)isovaleronitrile, 2-(diethylphosphono)isovaleronitrile or the like in an ether solvent such as tetrahydrofuran, diethyl ether or the like, a hydrocarbon solvent such as toluene r n-hexane or the like or an aprotic polar solvent such as dimethylformamide, dimethyl sulfoxide or the like at temperature from -100 to +100C, in the presence of less than 1 mol equivalent (for the Wittig-Horner reagent) of a base, for example, metal hydride such as sodium hydride, potassium hydride or the like, organic metal (e.g. n-butyllithium, lithium diisopropylamide) or metal alkoxide such as sodium methoxide, potassium t-butoxide or the like while allowing to react Compound (A') with a generated anion.
2~4~g9~
Aldehyde (C') is prepared by reacting Compound (B') with 0.1 to 10 mol equivalent of a metal hydride complex such as lithium aluminum hydride or the like at temperature from -70 to +100C in an ether solvent such as diethyl ether, tetrahydrofuran or the like or reacting with 0.1 to lO mol equivalent of a metal hydride such as diisobutylaluminium hydride or the like at temperature from -70 to +100C over a period of 5 minutes to 5 hours in a hydrocarbon solvent such as n-hexane, benzene or the like.
~ ldehyde (C') is converted into alcohol (E') when treated with 0.1 to 10 mol equivalent of a mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or a salt of a strong acid such as a pyridinium salt of p-toluenesulfonic acid or the like in a solvent such as aqueous methanol, aqueous ethanol, aqueous tetrahydrofuran, or a mixed solvent thereof.
Compound (F) can be prepared from Compound (E') by halogenating the allylic alcoholic without allyl rearrange-ment. For example, Compound (E') is reacted with 0.1 to 10 mol equivalent of carbon tetrahalide in the presence of 1.0 to 10 mol equivalent of triphenylphosphine in a solvent such as acetonitrile, dichloromethane or the like, in case of chlorination, with carbon tetrachloride without solvent, at temperature from -10 to +100C over a period of 10 minutes to 12 hours. Alternatively, Compound (E') is reacted with 0.1 to 10 mol equivalent of sulfonyl halide such as 20~G95 methanesulfonyl chloride, p-toluenesulfonyl chloride or the like together with a metal halide such as lithium chloride in the presence of an amine such as pyridine, y-collidine, lutidine or the like at temperature from -40 to +30C over a period of 1 to 12 hours.
The final product, sarcophytol A, can be prepared be treating Compound (F) according to the procedure shown by the synthetic route 1 as shown below.
Process of the svnthetic route 1 a) Preparation of Compound (G) Thus, Compound (G) whexein R8 is trimethylsilyl group is prepared, for example, by treating Compound (F~
with 1.0 to 10 mol equivalent of trimethylsilylnitrile in the presence of a catalytic amount of metal cyanide 18-crown-6-ether complex, an ammonium salt such as tetraalkylammonium cyanide or the like at temperature from -20 to 50C over a period of 30 minutes to 5 hours in a solvent such as methylene chloride, chloroform, ethyl acetate or the like, or without solvent. The resultant product can be converted into cyanohydrin wherein R8 is hydrogen by treating with 0.1 - 3N aqueous mineral acid such as hydrochloric acid, sulfuric acid or the like at 0C to room temperature over a period of 5 minutes to 5 hours or by treating with a catalytic amount to 10 mol equivalent of tetraalkylammonium salt such as tetrabutylammonium fluoride or the like at temperature from -20C to room temperature in a solvent such as tetrahydrofuran, dioxane or the like.
- 31 - 2a4~69~
Compound (G) wherein R8 is 1-ethoxyethyl group can be prepared by reacting the above cyanohydrin with 1.0 to 10 mol equivalent of ethyl vinyl ether in the presence of a catalytic amount of mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or the like, or a salt of strong acid such as p-toluenesulfonic acid or the like pyridinium salt at temperature from -20C to room temperature over a period of 30 minutes to 5 hours in a solvent such as ethyl ether, ethyl acetate or the like.
b) Preparation of Compound (H~
Compound (H) wherein R8 is trimethylsilyl or l-ethoxyethyl group can be prepared by reacting Compound (G) wherein R8 is trimethylsilyl group or l-ethoxyethyl group with 1.0 to 10 mol equivalent of a base such as lithium diisopropylamide, lithium bis-(trimethylsilyl) amide, sodium hydride or the like at temperature from -70 to 100C over a period of 5 minutes to 10 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydrocarbon solvent such as n-hexane, n-heptane or the like.
Compound (H) wherein R8 is a hydrogen atom is prepared by treating the compound obtained above with 0.1 -3N aqueous mineral acid such as hydrochloric acid, sulfuric acid or the like at temperature from 0C to room temperature over a period of 5 minutes to 5 hours in a solvent such as 2~69~
tetrahydrofuran, methanol or the like or by treating with a catalytic amount to 10 mol equivalent of tetraalkylammonium salt such as tetrabutylammonium fluoride at temperature from -20C to room temperature in a solvent such as tetrahydro-furan, dioxane or the like.
c) Preparation of a ketone, Compound (J) The ketone (J) can be prepared by treating a solution of Compound (H) wherein R8 is a hydrogen atom in an organic solvent such as ethyl ether, ethyl acetate or the like with aqueous sodium bicarbonate at temperature from 0C
to room temperature over a period of 5 minutes to 5 hours, or by treating Compound H wherein R8 is trimethylsilyl group with a catalytic amount to 10 mol equivalent of an alkylammonium fluoride such as tetrabutylammonium fluoride in a solvent such as aqueous tetrahydrofuran, dioxane or the like.
d) Preparation of sarcophytol A
Sarcophytol A can be prepared by reacting the ketone (J) thus obtained with 1.0 to 10 mol equivalent of a metal hydride such as diisobutylaluminum hydride or the like or a metal complex such as lithium aluminum hydride or the like at temperature from -70 to 50C over a period of 5 minutes to 5 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydro-carbon solvent such as n-hexane, n-heptane or the like.
204~9~
Further, sarcophytol A in native form shown below is prepared by subjecting ketone Compound (J) to asymmetric reduction with an asymmetrically-modified metal hydride or metal hydride complex.
~ ~ OH
~1 Sarcophytol A in native form Examples of asymmetrically-modifying reagents used for preparing asymmetrically-modified metal hydride or metal hydride complex, which are used in the asymmetric reduction, include asymmetric amino alcohols prepared by converting carboxy group of optically-active amino acid such as L- or D-proline, valine or the like into substituted alcohol group or substituted amino group [Bull. Soc.Chim.Belq. 97: 691 (1988); J. Chem. Soc. Perkin I 1673: (1983)]; asymmetric diamines [Bull. Chem. Soc. Japan 51: 1869 (1978);
Tetrahedron 37: 4111 (1981)], asymmetric alkaloids such as L- or D-methylephedrine and the like [Chem.Pharm.Bull. 31:
837 (1983)]; and (S)- or (R)-l,l'-bis-2-naphtol and the like.
Examples of metal hydrides or metal hydride complexes include diisobutylaluminium hydride, lithium aluminium hydride, sodium borohydride and the like. An asymmetric reducing reagent can be prepared by reacting a 2~4~6~
metal hydride or metal hydride complex with 0.1 to S mol equivalent, preferably 0.5 to 1.5 mol equivalent of the above-mentioned asymmetrically-modifying reagent, optionally in the presence of an additive such as alkyl-substituted aniline, substituted aminopyridine, stannous chloride or the like at temperature from -50 to 50C, preferably from -20C
to room temperature over a period of 10 minutes to 5 hours in an appropriate solvent to obtain a coordinated complex of said asymmetrically-modifying reagent and metal hydride or metal hydride complex. Examples of appropriate solvents include ether solvents such as diethyl ether, tetrahydrofuran and the like and hydrocarbon solvents such as benzene, toluene, n-hexane and the like. A halogen solvent such as dichloromethane and chloroform is also available in case metal hydride is used. Illustrative combinations are listed in the Table 1 below.
204~69~
Table 1 _ metal hydride axymmetric or metal modifying additive hydride compl~ x reagent O H
L iA lH 4 Ph ~ HsC 2 N
NMe2 ~
H A l(i- B u)2 A ~ ~
(D I B A L) ~ N ~ S nCl2 . ~
~ B H 9 \;
20~69~
Although the amount of the asymmetric reducing reagent to be reacted with the macrocyclic ketone ~hown by the structure (J) is not critical, it is preferable to u~e 1 to 2 mol equivalent of asymmetric reducing reagent for the ketone considering the recovery of un-reacted starting materials and yield of the product. The reaction is usually conducted at temperature from -150 to 100C, preferably from -100C to room temperature over a period of 10 minutes to 5 hours in the same solvent as that used for ~he preparation -of the asymmetric reducing reagent. No regularity can be found between the absolute configuration of the product ~arcophytol A ( its native form is expressed by IR and non-native form IS as shown below) and that of the asymmet-ric reducing reagent, which i8 attributable to the original compound in L- or D-form. The absolute configuration of the product varies depending on the combination of the asymmet-ric reducing reagent and metal hydride or metal hydride complex.
The by-product of the present method, sarcophytol A in non-native form of formula:
~ ~~
-OH
J (I ~) , when subjected to the conventional epimerization reaction 2 ~ ~ 5 S ~ ~
for hydroxyl group, easily gives the optically-active sarcophytol A (Is) in native form after the inversion.
(3) When the starting material is a compound of formula (I) wherein n is 1 and R i8 a group of formula:
R I
- C H = C H C H C H ( C H 3) 2 wherein R1 is as defined above.
- 38 - 2(~ i6~5 Synthetic Route 3 CHO (K) epoxidation (L) Ae(O-C3H7)3 )~
OH (M) OH
sulfonylesterification (N) OR~
etherification ~ ) J
(O) [2.3]Wittig rearrangement ~
OH
sarcophytol A
20~69~
R : substituted sulfonyl group such as methanesulfonyl group or p-toluenesulfonyl group.
Compound ~K) in the above synthetic route 3 can be prepared by, for example, reacting a compound of formula (I) wherein n is 1, X is a hydrogen atom and R is a group:
- C H = C H C H C H (C H3)2 with either of 1.0 to 10 mol equivalent of metal hydride such as dibutylaluminium hydride or the like, or a metal complex such as lithium aluminium hydride or the like at temperature from -70 to 50 C over a period of 5 minutes to 5 hours in a ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydro-carbon solvent such as n-hexane, n-heptane or the like, or with 0.5 to 10 mol equivalent of metal hydride complex such as sodium borohydride or the like at temperature -70 to 100C in a solvent such as methanol, ethanol or the like.
The resulting Compound (K) is converted into Compound (L) through the epoxidation which is conducted by halogenating the Compound K with 0.1 to 1 mol equivalent of a halogenating agent such as N-bromosuccinimide, N-chlorosuccinimide or the like at temperature from -20 to 100C over a period of 30 minutes to 5 hours in an aqueous solvent of a water-miscible solvent such tetrahydrofuran, dimethoxyethane or the like, followed by treating with an aqueous solution of a base such as sodium hydroxide, 2~Gg~
potassium hydroxide, sodium carbonate or the like, or after the halogenation, isolating halohydrin, and treating it with a base such as sodium carbonate, sodium methoxide or the like in a solvent such as methanol or tetrahydrofuran or the like; or by treating with 0.1 to 1 mol equivalent of organic peracid such as m-chloroperben~oic acid, peracetic acid or the like at temperature from -50 to 50C over a period of 30 minutes to 10 hours.
Compound (M) can be prepared by reacting Compound (L) with 0.1 to 10 mol equivalent of metal alkoxide such as aluminium triisopropoxide or the like at temperature from 50 to 200 C in a solvent such as toluene, xylene or the like;
or with 0.1 to 10 mol equivalent of a metal amide such as lithium diisopropylamide, lithium diethylamide or the like at temperature from -70 to 100 C in a solvent such as diethyl ether, tetrahydrofuran or the like.
Compound (N) can be prepared by the sulfonylesterification of the diallyl alcohol (M). For example, Compound (M) is reacted with 0.1 to 1.5 mol equiva-lent of a substituted sulfonyl chloride such as methanesulfonyl chloride, p-toluenesulfonyl chloride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -70 to 100 C in a halogen solvent such as dichloromethane, chloroform or the like or a ether solvent such as diethyl ether, tetrahydrofuran or the like.
20~69~
Compound (0) can be prepared, for example, by treating Compound (N) with 0.1 to 10 mol equivalent of metal hydride such as sodium hydride, potassium hydride or the like or organic metal such as n-butyllithium, ethyl magnesi-um chloride or the like at temperature from -50 to 150 C in an ether solvent such as diethyl ether, tetrahydrofuran or the like, a hydrocarbon solvent such as benzene, toluene, n-hexane or the like or an aprotonic polar solvent such as dimethylformamide, dimethyl sulfoxide or the like.
The resultan~ Compound (o) can be converted into sarcophytol A by reacting said Compound (o) with 0.1 to 10 mol equivalent of organic metal such as n-butyl lithium, sec-butyl lithium, lithium diisopropyl amide or the like at temperature from -100 to 100 C in an ether solvent such as diethyl ether, tetrahydrofuran or the like, a hydrocarbon solvent such as benzenel toluene, n-hexane or the like, or further adding hexamethylphosphoric triamide or the like to the solvent.
(4) When the starting material is a compound of formula I wherein n is 0 and R is a group of formula:
- C H = C H C H C H (C H 3)2 wherein Rl is as defined above.
204~fi9~
Synthetic route 4 CN CN
(A") epoxidation ~ Claisen Rearrangement > /~/\
OH CN
(B") OHC ~ Wittig Reaction CN
(C") ~ H
(D") HO ~ PPh3, CCe4 CHO
(E") CB ~ a route of JA 181710/1989 CHO
(F) OH
Sarcophytol A
20~6~
Compound (A") in the above synthetic route 4 can be prepared from a compound (I) wherein R1 is -CN, n is 0 and X is a hydrogen atom as mentioned above through epoxidation as follows. Thus, Compound (A") i9 prepared by halogenating a compound (I) with 0.1 to 1 mol equivalent of a halogenating agent such as N-bromosuccinimide, N-chlorosuccinimide or the like at temperature from -50 to 50C over a period of 30 minutes to 5 hours in an aqueous solvent of a water-miscible solvent such tetrahydrofuran, dimethoxyethane or the like, followed by treating with an aqueous solution of a base such as sodium hydroxide, potas-sium hydroxide, sodium carbonate or the like, or after the halogenation, separating halohydrine, and reducing it with a base such as sodium carbonate, sodium methoxide or the like in a solvent such as methanol or tetrahydrofuran or the like; or by treating the compound with 0.1 to 1 mol equiva-lent of organic peracid such as m-chloroperbenzoic acid, peracetic acid or the like at temperature from -50 to 50C
over a period of 30 minutes to 10 hours.
Compound (B") is prepared by treating the above epoxy compound (A") with 0.1 to 10 mol equivalent of metal alkoxide such as aluminium triisopropoxide or the like at temperature from 50 to 200 C in a solvent such as toluene, xylene or the like; or with 0.1 to 10 mol equivalent of a metal amide such as lithium diisopropylamide, lithium diethylamide or the like at temperature from -70 to 100 C
204569~
in a solvent such as diethyl ether, tetrahydrofuran or the like.
~ he aldehyde compound (C") can be prepared by, for example, through the Claisen rearrangement, which is con-ducted by reacting Compound (B") with 1.0 to 100 mol equiva-lent of alkyl vinyl ether such as ethyl vinyl ether or the like in the presence of 0.1 to 5 mol equivalent of a mercury salt such as mercury acetate or the like at temperature from 0 to 100 C to give the vinyl ether of Compound (s") or leading said Compound (B") to 3-alkoxyacrylic acid according to a known method [J. Orq. Chem., 48: 5406 (1983)], ~ollowed by heating at temperature from 100 to 250 C in the presence of a catalytic amount of hydroquinone in each case.
Compound (D") is prepared by reacting the aldehyde (C") with 0.5 to 5 mol equivalent of Wittig reagent such as carbomethoxyethylidene triphenylphosphorane or the like or an anion made from Wittig-Horner reagent such as ethyl 2 -(diethylphosphono)propionate, ethyl 2-(dimethylphos-phono)propionate or the like at temperature from -50 to 100C in a solvent such as diethyl ether, THF, DMF, dichloromethane or the like.
Compound (D"), when treated with 0.5 to 10 mol equivalent of metal hydride complex such as lithium aluminium hydride or the like at temperature from -70 to 100 C in an ether solvent such as diethyl ether, THF or the like or with 0.5 to 10 mol equivalent of metal hydride such as dibutylaluminium hydride or the like at temperature from 204~G9~
-70 to 100 C in a hydrocarbon solvent such as benzene, toluene, n-hexane, n-heptane or the like, gives Compound (E~), which is a compound o~ formula I wherein n is 1, X is hydroxyl group and ~ is a group of formula:
C H O
- C H = C H C H C H(C H 3)2 , which is the same as Compound (E~) in the synthetic route 2.
Compound (F) can be prepared from Compound (E") by halogenating the allylic alcoholic without allyl rearrange-ment as previously described in the synthetic route 2.
Compound (E"), when treated in the same manner as mentioned above, gives sarcophytol A.
As can be seen from the above, sarcophytol A can be prepared effectively from the compound (I) of the inven-tion through various processes using or without using the intermediate F, which demonstrates that the compound (I) is highly useful and important for the attainment of the purpose of the invention.
Following Examples are provided for purposes of illustration only and are not to be construed as limiting the scope of the instant invention in any way.
PreParation 1 HO~ THPOJ~
2~69~
A mixture of 8-acetox~-2,6-dimethyl-2,6-octadien-1-ol (1.81 g, 8.52 mmol) and dihydropyran (1.17 ml, 12.8 mmol) in dichloromethane (6 ml) was stirred, and p-toluenesulfonic acid (40 mg) was added thereto, and the mixture was stirred at room temperature for 30 minutes.
After addition of saturated aqueous sodium bicarbonate (30 ml), the product was extracted with hexane/ether (5:1.2) (30 ml). The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a residue, which was purified with silica gel column chromatography to give l-acetoxy-8-(2-tetrahydropyranyl)oxy-3,7-dimethyl-2,6-octad-iene (2.42 g, 96%~.
Pre~aration 2 HO ~ > H3COH2CO ~
A mixture of 8-acetoxy-2,6-dimethyl-2,6-octadien-l-ol (110 mg, 0.52 mmol) and triethylamine (0.25 ml, 1.83 mmol) and chloromethyl methyl ether (0.069 ml, 0.92 mmol) in acetonitrile (2 ml) was refluxed with stirring for 4 hours. After addition of water (3 ml) to the reaction mixture, the product was extracted several times with ether (5 ml). The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a residue, which was then sub~ected to silica gel column chromatography to give the aimed l-acetoxy-8-(2-methoxymethyl)oxy-3,7-dimethyl-2,6-octadiene (109 mg, 82~).
20~6~5 - ~7 -Preparation 3 HO~OCOCH3 C4H9 '-SiO~V OCOCH3 8-Acetoxy-2,6-dimethyl-2,6 octadien-l-ol in dimethylformamide (4 ml) was stirred on an ice bath. To the solution were added imidazole (338 mg, 4.96 mmol) and chlorodimethyl t-butylsilane (410 mg, 2.73 mmol), and the mixture was stirred at room temperature for one hour. After addition of water ~30 ml) to the reaction mixture, the product was extracted with hexane (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel column chromatography to obtain l-acetoxy-8-(dimethyl t-butylsilyl)oxy-3,7-dimethyl-2,6-octadiene (606 mg, 75%).
Exam~le 1 0~ ~ 0~
OCOCH3 ~/
To a solution of 1-acetoxy-8-(2-tetrahydropyranyl)oxy-3,7-dimethyl-2,6-octadiene (1.08 g, 3.64 mmol) in tetrahydrofuran (6 ml) were added under nitrogen atmosphere triphenylphosphine (105 mg, 0.4 mmol) and tetrakis(triphenylphosphine)paradium (168 mg, 0.15 mmol), and the mixture was stirred at room temperature for 15 minutes. To the mixture were added a sodium salt of 2 0 ~ ~ 6 9 ~
methyl acetoacetate in tetrahydrofuran (25 ml) which has been prepared from sodium hydride (305 mg, 12.7 mmol) and methyl acetoacetate (1.57 ml, 14.6 mmol), and the mixture was refluxed for 5 hours. After addition of ~ater (10 ml) and ether (30 ml), the reaction mixture was stirred well, and the organic layer was separated. The aqueous layer was extracted with ether (5 ml), and the extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-5,9-dimethyl-10-(2-tetrahydropyranyl)oxy-4,8-decad-ienate (1.06 g, 83~).
IR(film)cm 1; 2950, 2870, 1750, 1722, 1440, 1360, 1201, 1150, 1022.
NMR(CDC13, 250MHz)~ppm; 1.45-1.92(m, 6H, C(O)H2-Ca2-CH2-CH2-CHO-), 1.63, 1.65(2s, 6H, 2x-CH3C=CH-), 1.94-2.15(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22(s, 3H, CH3C=O), 3.46(t, J=7.5Hz, lH, -CHCO2-), 3.53(m, lH, -CH2-CHaHb-O-), 3.73(s, 3H, CO2CH3), 3-83, 4-09(2d~ J=11-8Hz~ 2H~
-OCa2C=CH-), 3.82-3.94(m, lH, -CH2-CHaHb-O-), 4.60(t, J=3.4Hz, lH, -OCHO-), 5.04(t, J=7.3Hz, lH, -C=CH-CH2-), 5.38(t, J=6.2Hz, lH, -C=CH-CH2-).
ExamPle 2 o H3COH2CO~ H3COH2CO ~
20~69~
To a solution of l-acetoxy-8-(methoxymethyl)oxy-3,7-dimethyl-2,6-octadiene t600 mg, 2.34 mmol) in tetrahydrofuran (6 ml) were added under nitrogen atmosphere triphenylphosphine (60 mg, 23 mmol) and tetrakis(triphenylphosphine)paradium ~108 mg, 0.09 mmol), and the mixture was stirred at room temperature for 15 minutes. To the mixture were added a sodium salt of methyl acetoacetate in tetrahydrofuran (25 ml) which has been prepared from sodium hydride (225 mg, 9.36 mmol) and methyl acetoacetate (1.26 ml, 11.7 mmol), and the mixture was refluxed for 2 hours. After addition of water (40 ml) and ether (50 ml), the reaction mixture was stirred well, and the organic layer was separated. The aqueous layer was extracted with ether (50 ml), and the extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-5,9-dimethyl-10-(methoxymethyl~oxy-4,8-decadienate (670 mg, 92%).
IR(film)cm 1; 2930, 1745, 1720, 1438, 1355, 1208, 1150, 1100, 1040, 920.
lH NMR(CDC13, 250MHz)~ppm; 1.63, 1.65(2s, 6H, CH3C=CH-x2), 1.93-2.17(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22( 6, 3H, COCH3), 2.56(t, J=7.4Hz, 2H, -C=CH-CH2-CH(CO2CH3)-), 3.38(s, 3H, CH3OCH2O-), 3.46(t, J=7.SHz, lH, CH(CO2CH3)), 3.73(s, 3H, CO2CH3), 3.92(~, 2H, -OCH2C=CH-), 4.61(s, 2H, -OCH2O-), - sn -5.04(t, J=7.3Hz, lH, -C=CH-CH2-), 5.38(t, J-6.7Hz, lH, -C=CH-CH2- ) -ExamPle 3 C4H~ '-SiO I I ~ C4H9 '-SiO ~ ~ ~
C~3\~\ococl99 CH3\~\
CO2Cl13 To a solution of 1-acetoxy-8-(dimethoxy t-butylsilyl) oxy-3,7-dimethyl-2,6-octadiene (600 mg, 1.84 mmol) in tetrahydrofuran (5 ml) were added under nitrogen atmosphere triphenylphosphine (47 mg, 0.18 mmol) and tetrakis(triphenylphosphine)paradium (81 mg, 0.07 mmol), and the mixture was stirred at room temperature for 15 minutes.
To the mixture was added a sodium salt of methyl acetoacetate in tetrahydrofuran (20 ml) which has been prepared from sodium hydride (92 mg, 8.0~mmolj;and methyl acetoacetate (0.99 ml, 9.20 mmol), and the mixture was`
refluxed overnight. After addition o water (10 ml) and ether (30 ml), the reaction mixture was stirred well, and the organic layer was separated. ~he aqueous layer was extracted with ether (5 mlx2), and the extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a re~idue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-10-(dimethyl t-butylsilyl)oxy-5,9-dimethyl-4,8-decadienate (620 mg, 88%).
- 51 - 2~69~
IR(film)cm 1; 2970, 2940, 2910, 2860, 1745, 1722, 1435, 1360, 1250, 1065, 837, 775.
H NMR(CDC13, 250MHz)~ppm; 0.06, (s, 6H, (CH3)2Si), O.90(s, 9H, (CH3)3CSi), 1.59, 1.63(2s, 6H, 2xCH3C=CH-), 1.92-2.15(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22(s, 3H, -CHCH3), 2.55(t, J=7.4Hz, 2H, -C=CH-CH2-CH(C02CH3)), 3.46(t, J=7.4H~, lH, -CH(CO2CH3)), 3.73(s, 3H, -CO2CH3), 3.99(s, 2H, SiOCH2), 5.04(t, J=6.7Hz, lH, -C=CH-CH2-), 5.33(t, J=6.8Hz, lH, -C=CH-CH2-)-ExamPle 4 O . O
To a solution of methyl 2-acetyl-5,9-dimethyl-10-(2-tetrahydropyranyl)oxy-4,8-decadienate (370 mg, 1.05 mmol) in methylsulfoxide (2 ml) were added sodium chloride (180 mg, 3.08 mmol) and water (0.1 ml), and the mixture was stirred at 150C. After four hours, the reaction mixture was allowed to cool to room temperature, and water (15 ml) was added thereto. The product was extracted with ether (20 mlx2). The extract was dried over Na~SO4, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-(2-tetrahydropyranyl)oxy-5,9-undecadien-2-one (70~).
204~9~
~ 52 -IR(film)cm 1; 2950, 2880, 1720, 1442, 1358, 1120, 1078, 1024, 90s, 870, 815.
lH NMR(CDC13, 250MHz)~ppm; 1.45-l.90(m, 6H, -OCH2-cH2-ca2-ca2-cH(o))r 1.62, 1.65(2s, 6H, (Ca3)C=CH-CH2-CH2-(CH3)c=cH-), 1.96-2.20(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.14(s, 3H, COCH3), 2.26(q, J=7.lHz, 2H, -C=CH-CH2-CH2CO-), 2.46(t, J=7.lHz, 2H, -CH2COCH3), 3.45-3.55(m, lH, OCHaHb-CH2-CH2-CH2-CH(0)), 3.84, 4.10(2d, J=11.5Hz, -OCa2C=CH-), 3.80-3.95(m, lH, CHaHb~cH2-cH2-cH2-)~ 4.60(t, J=3.6Hz, lH, CH(O)), 5.08(t, J=7.lHz, -C=Ca-CH2-CH2-C=CH-), 6.9(t, J=6.9Hz, lH, -C=CH-CH2-CH2-C=ca-)-Example 5 O O
H3COH2CO ¦ ¦ ¦¦ H3COH2CO ¦
To a solution of methyl 2-acetyl-5,9-dimethyl-10-(methoxymethyl)oxy-4,8-decadienate (420 mg, 1.37 mmol) in methylsulfoxide (4 ml) were added sodium chloride (160 mg, 2.74 mmol) and water (0.1 ml), and the mixture was stirred at 150C. After five hours, the reaction mixture was allowed to cool to room temperature, and water (10 ml) was added thereto. The product was extracted with ether (20 mlx2). The extract was dried over Na2S04, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-20~695 (methoxymethyl)oxy-S,9-undecadien-2-one (358 mg, 67%).
IR(film)cm 1; 2940, 1720, 1440, 1358, 1150, 1100, 1050, 920.
~ NMR(CDCl3, 250MHz)~ppm; 1.62, 1.66(2s, 6H, 2xCH3C=CH-), 1.94-2.32(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.14(s, 3H, COCH3), 2.46(t, J=7.3Hz, 2H, -CH2COCH3), 3.38(s, 3~, CH30), 3.92(s, 2H, OCH2C=CH-), 4.61(s, 2H, -OCH2C-), 5.08(t, J=6-1Hz~ lH~ -C=Ca-CH2-), 5.40(t, J=6.7Hz, lH, -C=CHCH2-).
ExamPle 6 C4Hg'-Si0 ~ > C4Hg'-Si0 CH3 ~ CH
To a solution of methyl 2-acetyl-10-(dimethyl t-butylsilyl)oxy-5,9-dimethyl-4,8-decadienate (96 mg, 0.25 mmol) in hexamethylphosphoric triamide (0.5 ml) were added sodium iodide (45 mg, 0.30 mmol) and water (0.01 ml), and the mixture was stirred at 150C. After two hours, the reaction mixture was allowed to cool to room temperature, and water (2 ml) was added thereto. The product was ex-tracted with ether (5 mlx2). The extract was dried over Na2SO4, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-(dimethyl t-butylsilyl)oxy-undecadien-2-one (57 mg, 70%).
IR(film)cm 1; 2970, 2950, 2910, 2870, 1725, 1465, 1360, 1255, 1155, 1110, 1070, 837, 775, 662.
H NMR(CDCl3, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(5, 9H, (CH3)3CSi), 1.59, 1.62(2s, 6H, 2x-C=CH-CH2-), 1.92 -2.32(m, 6H, -CH=CH-CH2~CH2-C=CH-CH2-), 2-14(s, 3H, COCH3)~
2.46(t, J=8.7Hz, 2H, CH2COCH3), 4.00(s, 2H, SiOCH2-), 5.08, 5.35(2m, 2H, -C=CH-CH2-x2).
ExamPles 7 and 8 The procedures described in Examples 4-6 were repeated except that methyl 2-acetyl-5,9-dimethyl-10-acetoxy-4,8-decadienate or methyl 2-acetyl-5,9-dimethyl-10-(benzoyl)oxy-4,8-decadienate was employed as a starting material to give 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-one and 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one.
,ExamPle 9 0 ~ > H0 ~
To a solution of 6,10-dimethyl-ll-(2-tetrahydropyranyl) oxy-5,9-undecadien-2-one (362 mg, 1.23 mmol) in a mixture of methanol (5 ml) and water (l ml) was added p toluensulfonic acid (20 mg), and the mixture was stirred at room temperature overnight. After addition of saturated aqueous sodium bicarbonate (20 ml), the product wa~ extracted with ethyl acetate (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel 2~4~69~
column chromatography to provide 2,6-dimethyl-2,6-dodecadien-10-on-1-ol (234 mg, 90%).
IR(film)cm 1; 3430, 2930, 2860, 1715, 1440, 1360, 1160, 1080.
lH NMR(CDCl3+D20, 250MHz)~ppm; 1.62, 1.66(2s, 6H, 2xCH3C=CH-), 1.98-2.34(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.13(s, 3H, COCH3), 2.47(tl J=7.2H~, 2H, -CH2COCH3), 3.98(s, 2H, -CH2OH), 5.06(t, J=7.lHz, lH, -C=CH-CH2-), 5.33(t, J=6.9Hz, lH, -C=CH-CH2-)-Exam~le 10 o C-CH
A solution of 6,10-dimethyl-11-(2-tetrahydropyranyl) oxy-5,9-undecadien-2-one (90 mg, 0.31 mmol) in tetrahydrofuran (5 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (180 mg, 1.95 mmol), and the mixture was warmed to room temperature and stirred for 3 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(2-tetrahydropyranyl)oxy-6,10-dodecadien-1-in-3-ol (75 mg, 75%).
2a~5~9~
IR(film)cm 1; 3440, 3320, 2950, 2880, 2200, 1440, 1450, 13~2, 1360, 1260, 1200, 1180, 1115, 1075, 1020, 905, 865, 810.
H NMR(CDC13, 250MHz)~ppm; 1.50(s, 3H, CH3C(OH)), 1.45 -1 90(m, 8H, OCH2-CH2-CH2-CH2-cH(O)~ CH2C( )~
2xCH3C=CH-), 2.00-2.40(m, 7H, -C=CH-CH2-CH2-C=CH-CH2-, OH), 2.46(s, lH, -C~_C-H), 3.45-3.57(m, lH, -OCHaHb-CH2-), 3.84, 4.10(2d, J=11.5Hz, 2H, OCH2C=CH-), 3.80-3.94(m, lH, -OCHaHb-CH2-), 4.60(t, J=3.4Hz, lH, -OCHO-), 5.19~t, J=6-7Hz~ lH~ -C=CH-CH2-), 5-41(t, J=6.7Hz, lH, -C=CH-CH2_).
Example 11 H3COH2CO ~ > H3COH2CO ~ C-CH
OH
A solution of 6,10-dimethyl-11-(methoxymethyl)oxy-5,9-undecadien-2-one (67 mg, 0.26 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (30 mg, 0.33 mmol), and the mixture was warmed to room temperature and stirred for 3 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(methoxymethyl)oxy-6,10-dodecadien-l-in-2~6~
3-ol (61 mg, 83~).
IR(film)cm l; 3450, 3300, 2940, 1445, 1370, 1148, 1045, 918.
H NMR(CDCl3, 250MHz)~ppm; 1.05(s, 3H, CH3C(O)), 1.55 -1.84(m, 9H, 2xCH3C=CH-, OH), 2.00-2.40(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.46(s, lH, -C--C-H), 3.78(s, 3H, CH30), 3.92(s, 2H, -OCH2C=CH-), 4.61(s, 2H, OCH2O), 5.19(t, ~=6.2Hz, lH, -C=CH-CH2-), 5.41(t, J=6.2Hz, -C=CH-CH2-).
Example 12 C4H9'-SiO ~ C4Hg~-SiO ~ ~
CH3 ~ >CH3\V~ V\~ \C-CH
OH
A solution of 6,10-dimethyl~ (dimethyl t-butylsilyl)oxy-5,9-undecadien-1-one (71 mg, 0.22 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (90 mg, 0.98 mmol), and the mixture was warmed to room temperature and stirred for 4 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(dimethyl t-butylsilyl)oxy-6,10-dodecadien-1-in-3-ol (51 mg, 67~).
- 58 - 20~
IR(film)cm 1; 3450, 3320, 2960, 2940, 2910, 2860, 1460, 1360, 1250, 1110, 1065, 835, 775.
H NMR(C~C13, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(s, 9H~ (CH3)3Si), 1.50(s, 3H, -CH2-C(OH)(CH3)-C-H), 1.59, 1.66(2s, 6H, 2xCH3C=CH-), 1.68-1.76(m, 2H, -CH2C(OH)-), 1.94-2.36(m, 7H, -C=CH-CH2-CH2-C=CH-CH2-, OH), 2.46(s, lH, -C_CH), 4.00(s, 2H, OCH2-C=CH-), 5-19(t~ J=7.1Hz, lH~
-C=CH-CH2-), 5.36(t, J=6.9Hz, lH, -C=CH-CH2-).
Example 13 and 14 The procedure described in Example 11 was repeated except that 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-on or 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one was employed as a starting amterial to give 3,7,11-trimethyl-12-acetoxy-6,10-dodecadien-1-in-3-ol and 3,7,11-trimethyl-12-(benzoyl)ox~-6,10-dodecadien-1-in-3-ol.
Example 15 The procedures described in Examples 10 and 12 were repeated except that 2,6-dimethyl-2,6-dodecadien-10-on-1-ol was employed as a starting material to give 2,6,10-trimethyl-2,6-dodecadien-11-in-1,10-diol.
ExamPle 16 o ~yO~ > ~,J~
A solution of 6,10-dimethyl-11-(2-2 0 ~
tetrahydropyran~l) oxy-5,9-undecadien-2-one (80 mg, 0.27 mmol) in tetrahydro~uran (3 ml) was stirred on an ice bath under argon atmosphere. To the solut.ion was added vinylmagnesium bromide in tetrahydrofuran (O.3 ml, 0.3 mmol, 1.0 M), and the mixture was warmed to room temperature and stirred for 10 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(2-tetrahydropyranyl)oxy-1,6,10-undecatrien-3-ol (61 mg, 70%).
IR(film)cm ; 3460, 2950, 2880, 1200, 1118, 1075, 1022, 905, 865, 810.
lH NMR(CDC13, 250MHz)~ppm; 1.28(s, 3H, C(OH)CH3), 1.65 -1.92(m, 8H, -OCH2-CH2-CH2-cH2-cH(O)-~ CH2-C(OH))~ 1-95 -2.40(m, 7H, C=CH-CH2-CH2-C=CH-CH2-, OH), 3.45-3.55(m, lH, -OCHaHb-CH2-), 3.84, 4.10(2d, J=11.6Hæ, 2H, -OCH2C=CH2-), 3.80-3.95(m, lH, -OCHaHb-CH2-), 4.60(t, J=3.4Hz, lH, OCH(O)), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(m, lH, -C=CH-CH2-), 5.22(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.41(t, J=6.3Hz, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2)-ExamPle 17 H3COH2CO ~ ~ H3COH2CO
OH
2Q4~9~
A solution of 6,10-dimeth~l-11-(methoxymethyl)oxy-5,9-undecadien-2-one (60 mg, 0.24 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added vinylmagnesium bromide in tetrahydrofuran (1.0 ml, 1.0 mmol, 1.0 M), and the mixture was warmed to room temperature and stirred for 4 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over ~a2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(methoxymethyl)oxy-1,6,10-dodecatrien-3-ol (54 mg, 80%).
IR(film)cm 1; 3480, 2940, 1450, 1370, 1210, 1150, 1100, 1045, 920, 845, 685.
lH NMR(CDC13, 250MHz)~ppm; 1.28(s, 3H, CH3C(OH)), 1.60, 1.66(2s, 6H, 2xCH3-CH=C-), 1.52-1.72(m, 2H, -CH2-C(OH)), 1.95-2.20(m, 7H, -C=CH-CH2-Ca2-C=CH-CH2-, OH), 3.38(s, 3H, CH30), 3.92(s, 2H, -OCH2C=CH-), 4.61(s, 2H, -OCH2O-), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(t, J=7.2Hz, lH, -C=CH-CH2-), 5.20(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.41(t, J=6.9Hz, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2-)~
Example 18 C4H9'-SIiO~A C Hg~-~O~
OH
2~4~
A solution of 6,10-dimethyl-11-(dimethyl-t-butylsilyl) oxy-5,9-undecadien-2-one (48 mg, 0.15 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosph~re. To the solution was added vinylmagnesium bromide in tetrahydrofuran (10 ml, 1.0 mmol, l.O M), and the mixture was warmed to room temperature and stirrsd for 4 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(dimethyl-t-butyls~lyl)oxy-1,6,10-dodecatren-1-3-ol t32 mg, 60%).
IR(film)cm 1; 3420, 2970, 2940, 2860, 1462, 1360, 1250, 1150, 1070, 920, 835, 775, 662.
lH NMR(CDCl3, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(s, 9H, ~CH3)3CSi), 1.2~(s, 3H, -C(OH)(CH3)-CH=CH2), 1.60(s, 6H, 2xCH3C=CH-), 1.46-1.73(m, 3H, -CH2C(OH)(CH3))-, 4.00(s, 2H, SiOCH2-), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(m, lH, -C=CH-CH2-), 5.22(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.36(m, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2-)-Example 19 The procedure described in Example 16 was repeated except that 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-one or 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one was employed as a starting material to give 3,7,11-trimethyl-204~S~
12-acetoxy-1,6,10-undecatrien-3-one and 3,7,11-trimethyl-12-~benzoyl)oxy-1,6,10-undecatrien-3-one.
Example 20 The procedures described in Examples 17 and 18 were repeated except that 2,6-dimethyl-2,6-dodecadien 10-on-l-ol was employed as a starting material to give 2,6,10-trimethyl-2,6,11-dodecatrien-1,10-diol.
Exam~le 21 ~ CH0 >
To a solution of 2-(diethylphosphono)isovaleronitrile (6.54 g, 30 mmol) in toluene (55 ml) was added a 0.5 M solution of potassium bis(trimethylsilyl)amide in toluene (56 ml) with stirring on a cooling bath at -70~C. After 30 minutes, geranial t3.80 g, 25 mmol) was added thereto with continuous stirring at the same temperature, and then the reaction mixture was warmed up to room temperature. After addition of water to the mixture, the organic layer was extracted. The organic extract was washed with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride, dried over MgSO4, and filtered. The filtrate was concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=100:1) to give 204~6~
2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitrile (4.87 g, 90%, 2Z:2E=22.4:1).
Spectral data of 2Z compound IR(film)cm 1; 2980, 2940, 2890, 2220, 1640, 1450, 1390, 1375, 1295, 1225, 1105, 1030.
lH NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.8Hz, 6H, CH(CH3)2), 1.61, 1.69(each bs, each 3H, -C=CCH3), 1.83(d, J=1.2Hz, 3H, -C=CCH3)~ 2--12-2(m, 4H, -CH2~H2-), 2.53(hep, J=6.8Hz, lH, CH(CH3)2), 5.08(m, lH, -C=CHCH2-), 6.28, 6.82(each d, J=11.5Hz, each lH, =CH-CH=).
Exam~le 22 /~ ~ ~
To a solution of 2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitril (2Z compound, 217 mg, 1 mmol) in n-hexane (4 ml) was added a 1 M solution of diisobutylaluminium hydride in toluene (2 ml) with stirring under argon atmosphere at -70C. After two-hour-stirring at the same temperature, water (0.8 ml) was added to the mixture followed by removal of the cooling bath and vigorous stirring. The resultant while precipitates were filtered and washed with n-hexane. The filtrate was combined with a 10% aqueous solution of oxalic acid and stirred for 3 hours.
The organic layer was extracted and separated, washed with water, dried over MgSO4, and concentrated.
204~69~
The above manipulation was conducted under argon atmosphere.
The resultant residue was subjected to silica gel column chromatography (~olvent: n-hexane/ethyl acetate=50:1) to obtain the aimed 2-tl-methylethyl)-S,9-dimethyl-2,4,8-decatrienal (198 mg, 90%).
IR(film)cm 1; 2980, 2940, 2880, 1670, 1630, 1455, 1375, 1295, 1235, 1135, 1105, 1075.
NMR(CDC13, 250MHz)~ppm; 1.07(d, J=6.8Hz, 6H, -CH(CH3)2), 1.62, 1.69(each bs, each 3H, -C=CCH3), 1.89(d, J=l.OHz, 3H, -C=CCa3), 2.-12.3(m, 4H, -CH2CH2-), 2.91(hep, J=6.8Hz, lH, -Ca(CH3)2), S.lO(m, lH, =CaCH2-), 6.83, 7.14(each d, J=12.0Hz, each lH, =Ca-CH=), 10.29(s, lH, -CHO~.
Example 23 CHO
CN
~ o a solution of 2-(diethylphosphono)isovaleronitrile (8.72 g, 40 mmol) in toluene (75 ml) was gradually added a 0.5 M solution of potassium bis(trimethylsilyl)amide in toluene (75 ml) with stirring at -70C under argon atmosphere. The cooling bath was removed, and the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was cooled to -70C again, and farnesal (5.88 g, 26.7 mmol) was added thereto with stirring, and the mixture was allowed to warm to room temperature. After addition of water, the organic 204~69~
layer was separated, washed with saturated aqueous sodium bicarbonate and then saturated aqueous sodium chloride, and dried over MgSO4. The organic layer was separated from MgSO4 by filtration and concentrated to give a residue, which was purified with silica gel column chromatography (solvent: n-hexane/ethyl acetate=100:1) to obtain the aimed 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (7.23 g, 96~; 2Z:2E=25.6:1).
SPectral data of 2Z compound IR(film)cm 1; 2980, 2940, 2210, 1640, 1450, 1390, 1290, 1225, 1110, 1030.
NMR(CDC13, 250MHz)~ppm; 1.14(d, J=6.8Hz, 6H, CH~CH3)2), 1.58(bs, 3Hx2, -C=CCH3), 1.65(bs, 3H, -C=CCH3), 1.81(d, J=1.2Hz, 3H, -C=CCH3), 1.9-2.2(m, 8H, -CH2CH2-x2), 2-50(hep~
J=6.8Hz, lH, -CH(CH3)2), 5-06(m, 1~, =CHCH2-), 6-26~ 6-80( each d, J=11.5Hz, each lH, =CH-Ca=~.
ExamPle 24 CN CH~
To a solution of 2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (856 mg, 3.0 mmol) in n-hexane (30 ml) was added a 0.5 M solution of diisobutylaluminium hydride in toluene (6 ml) with stirring at -70C under argon atmosphere. After one hour, water (3 ml) was added, the cooling bath was removed, and the 204~95 reaction mixture was stirred well. Resultant white precipitates were filtered and washed. The filtrate was concentrated to give a residue, which was dissolved in n-hexane (10 ml). The n-hexane so~ution was combined with a 10% aqueou~ solution of oxalic acid (5 ml) and stirred for 3 hours. The organic layer was extracted and separated, washed with water, dried over MgSO4, and concentrated. The resultant residue was subjected to silica gel column chromatography ~solvent: n-hexane/ethyl acetate=10:1) to obtain 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenal (865 mg, 84%).
IR(film)cm 1; 2980, 2940, 2210, 1640, 1450, 1390, 1290, 1225, 1110, 1030.
NMR(CDC13, 250MHz)~ppm; 1.07(d, J=6.8Hz, 6H, -CH(CH3)2), 1.59, 1.61, 1.67(each bs, 3Hx3, -C=CCH3), 1.89(d, J=l.OHz, 3H, -C=CCH3), 2.0-2.2(m, 8H, -CH2CH2-x2), 2.91(hep, J=6.8Hz, lH, -CH(CH3)2), 5.10(m, lH, -C=CCH3), 6.81, 7.16(each d, J=12.0Hz, each lH, =CH-CH=), 10.29(s, lH, -CHO).
ExamPle 25 > HO~
CN CN
To a suspension of selenium dioxide (58 mg) and 2-hydroxybenzoic acid (365 mg) in methylene chloride (10.5 ml) wa~ gradually added an aqueous solution of 80~ t-butyl 204~6~
hydroperoxide (11.6 ml) with stirring on a water bath.
After 30 minutes, 2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (7.56 g, 26.8 mmol)was added to the mixture, which was then allowed to stand at room temperature for 30 hours. Most of the solvent was removed by evaporation in vacuo, and the residue was dissolved in ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried over MgSO4, and concentrated. The resultant residue was subjected to silica gel column chromatography to give the aimed 14-hydroxy-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetr-adecatetraenenitrile (2.53 g, 31%). The starting material was also recovered (3.10 g, 40~) in the column chromatography. The yield of the aimed product based on the consumed starting material was 52%.
IR(film)cm 1; 3450, 2975, 2930, 2880, 2210, 1635, 1445, 1385, 1220, 1020.
NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.7Hz, 6H, CH(CH3)2), 1.62, 1.67(each ~s, each 3H, -C=CCH3), 1.84(d, J=1.2Hz, 3H, -C=CCH3), 2.0-2.2(m, 8H, -CH2CH2-x2), 2.S3(hep, J=6.7Hz, lH, -CH(CH3)2), 3.99(bs, 2H, -CH2OH), 5.11(m, lH, -CHCH2-), 5.39(bt, J=5.5Hz, lH, -CHCH2-), 6.28, 6.83(each d, J=11.5H~, each lH, =CH-CH=).
Exam~le 26 H0 ~ ce~
CN CN
2~6~
To a solution of 14-hydroxy-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (904 mg, 3.0 mmol) in carbon tetrachloride (2 ml) was added triphenylphosphine ~1.02 g, 3.9 mmol), and the mixture was heated under reflux f or one hour. Most of carbon tetra-chloride was removed by evaporation in vacuo, and n-hexane was added to the residue. The resultant mixture was f il-tered and washed and the f iltrate was concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=10:1) to obtain the aimed 14~chloro compound (890 mg, 93~).
IR(film)cm ; 2980, 2940, 2880, 2215, 1635, 1445, 1390, 1265, 1025.
NMR(CDC13, 250MHz~ppm; 1.14(d, J=6.8Hz, 6H, CH(CH3)2), 1.59, 1.64(each bs, each 3H, -C=CCH3), 1.81(d, J=l.OHz, 3H, -C=CCa3), 1.9-2.2(m, 8H, -CH2CH2-x2), 2.50(hep, J=6.8Hz, lH, -CH(CH3)2), 3.96(bs, 2H, -CH20H), 5.08(m, lH, -CHCH2-), 5.36(bt, J=5.5Hz, lH, =CHCH2-), 6.25, 6.80(each d, J=11.5Hz, each lH, =CH-CH=).
The following Reference Examples illustrate a method of preparation of sarcophytol A by the use of the compounds obtained in the foregoing Examples.
Reference ExamPle 1 H3COH2CO ~ H3COH2CO ~ CHO
OH
204~69~
A solution of 3,7,11-trimethyl-12-(methoxymethyl)oxy-6,10-dodecadien-1-in-3-ol (175 mg, 0.62 mmol)/ tris (triphenylsilyl)vanadate (49 mg, 0.062 mmol), and benzoic acid (7.6 mg, 0.062 mmol) in xylene (2 ml) was stirred on an oil bath at 140C. After two-hour-stirring, the solution was allowed to cool to room temperature and concentrated. The resultant residue was subjected to silica gel column chromatography to obtain 12-(methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (88 mg, 50%).
IR(film)cm 1; 2950, 1675, 1450, 1385, 1198, 1157, 1120, 1105, 1050, 925, 850.
lH NMR(CDC13, 250MHz)~ppm; 1.57, 1.62, 2.13(each s, each 3H, CH3C=CH-), 1.93-2.30(m, 8H, 2x-C=CH-CH2-CH2-~, 3.33(s, 3H, CH30), 3.88(s, 2H, -OCH2C=CX-), 4.57(s, 2H, -OCH20-), 5.06, 5.36(each m, each lH, -C=CH-CH2-), 5.84(d, J=8.2Hz, lH, -C=CH-CHO), 9.96(d, J=8.2Hz, lH, -C=CH-CHO).
Reference ExamPle 2 H3COH2CO ~ H3COH2CO ~ CHO
OH
A solution of 3,7,11-trimethyl-12-(methoxymeth~l)oxy-1,6,10-dodecatrien-3-ol (460 mg, 1.6 mmol) in dishloromethane (30 ml) was added pyridinium chlorochromate (690 mg, 3.2 mmol), and the mixture was stirred at room temperature for 8 hours. After addition of a mixture of hexane, ethyl acetate, and ether (3:1:1) (lOO
2~4~9~
ml), the mixture was stirred and insoluble materials were filtered. ~he filtrate was concentrated ln vacuo, and the residue was purified with silica gel column chromatography to give 12-(methoxymethyl~oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (233 mg, 52%). The physico-chemical properties of the product was the same as those described in Reference Example 1.
Reference Exam~le 3 H3COH2CO ¦ I i H3COH2CO
CHO >
CN
To a solution of 2-(diethylphosphono)isovaleronitrile (316 mg, 1.44 mmol) in toluene (1 ml) was dropwise added a 1.0 M solution of lithium bis(trimethylsilyl)amide in hexane (1.3 ml, 1.3 mmol) with stirring at -70C. After 30 minutes, 12-(methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (130 mg, 0.46 mmol) in toluene (2 ml) was added at the same temperature, and the mixture was allowed to warm to room temperature over about 3 hours. An aqueous ammonium chlo-ride (6 ml) was added and the mixture was extracted with hexane. The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography (solvent:
n-hexane/ethyl acetate=20:1) to obtain the aimed 2 204~6~
-(1-methylethyl)-14-(methoxymethyl)oxy-5,9,13-trim0thyl-2,4,8,12-tetraenenitrile (135 mg, 85%).
IR(film)cm ; 2980, 2945, 2900, 2310, 1640, 1150, 1050.
lN NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.8Hz, 6H, (CH3)2CH-), 1.61, 1.67, 1.84(each s, each 3H, CH3C=CH-), 1.96-2.21(m, 8H~ -C=CH-CH2-CH2-C=CH-CH2-CH2-)~ 2.53(hep, J=6.8Hz, lH, -CH(CH3)2), 3.38(s, 3H, CH30-), 3.92(s, 2H, -OCH2O-), 4.62~s, 2H, -Q-CH2-C=CH-), 5.10(brs, lH, -C=CH-), 5.42(brt, J=6.4H~, lH, -C=CH-), 6.28, 6.82(each d, J=11.5Hz, each lH, -C-CH-CH=C(CN)-).
~eference Example 4 H3COHaC0 ~ ~ H0 ~
CN CN
To the product obtained in Reference Example 3 (135 mg, 0.39 mmol) in methanol (5 ml) was added a trace amount of conc. HCl, and the mixture was heated with stirring at 60C for 6 hours. After addition of saturated aqueous sodium bicarbonate (20 ml), the reaction mixture was extracted with ether (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography (solvent: n-hexane/ether=5:1) to obtain the 14-hydroxy compound (96 mg, 82%).
IR(film)cm 1; 3460, 2980, 2930, 2210, 1635, 1450, 1020.
2~4569~
H NMR(CDCl3, 250MHz)~ppm; 1.14(d, J=6.8Hz, 6H, (CH3)2CH-), l.S8(m, 4H, CH3C=CH-, -OH), 1.65(s, 3H, Ca3C=CH-), 1.81(d, J=l.lHz, 3H, CH3C=CH-), 1.92-2.25(m, 8H, -2 CH2 (CH3)C=CH-Ca2-Ca2-), 2.51(hep, J=6.8Hz lH
(CH3)2CH-), 3.97(d, J=5.9Hz, 2H, CH2OH), 5.08(brs, lH, -C=CH-), 5.36(m, lH, -C=CH-), 6.26, 6.80(each d, J=ll.SHz, each lH, -C=CH-CH=C(CN)).
Reference Example 5 H0 ~ > H0 ~
CN , CH0 To the hydroxy compound obtained in Reference Example 4 in toluene (S ml) was dropwise added a 1 M
solution of diisobutylaluminium hydride in toluene (2.0 ml, 2.0 mmol) at -70C under argon atmosphere. After two-hour-stirring at -70C, a 1 M aqueous solution of oxalic acid (4.0 ml) was added, and the mixture was allowed to warm gradually to room temperature with stirring under argon atmosphere. The organic layer was washed with water and saturated aqueous sodium bicarbonate, dried over Na2SO4, and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography (solvent: n-hexane/eth~l acetate=7:1) to obtain the aimed formyl compound.
IR(film)cm 1; 3430, 2960, 2920, 2870, 1670, 1630, 1450, 1390, 1295, 1230, 1130, 1070, 1010.
73 204~695 lH NMR(CDC13, 250MHz)~ppm; 1.04(d, 6H, J=6.8Hz, -CH(CH3)2), 1.59(d, J=0.6Hz, 3H, CH3-C=), 1.63(brs, 3H, CH3-C=), 1.86(d, J=1.2Hz, 3H, CH3-C=), 1.7-2.2(m, 8H, -CH2CH2-), 2.88(hep.J=6.8Hz, lH, -CH(CH3)2), 3.95(brs, 2H~ -CH2OH)~
5.09(m, lH, -CH2CH=), 5.38~brt, J-6.8Hz, lH, -CH2CH=), 6.80(d, J=12.0Hz, lH, =CH-CH=), 7.11(d, J=12.0Hz, lH, =CH-CH=), 10.25(s, lH, -CHO).
7 2~
~eference ExamPle 6 ~0~ > C~
C~0 CH0 ~ solution of dry lithium chloride (64 mg, 1.5 mmol), 2, 6-lutidine (0.23 ml, 2.0 mmol) and hydroxy formyl compound (305 mg, 1.0 mmol) in dimethylformamide (1.0 ml) was chilled on an ice water bath and mixed with methane-sulfonyl chloride (160 mg, 1.4 mmol) with stirring in argon atmosphere. About 8 hours later, the starting material was confirmed to disappear, and the reaction mixture was dis-solved in water and ether. The organic layer was washed with water, dried over magnesium sulfate and concentrated.
The residue was chromatographed on a column of silica gel eluting with n-hexane: ethyl acetate (15:1) as an eluent to give the objective chloroformyl com~ound (281 mg, 87%).
IR (film)cm- ; 2970, 2930, 2880, 1670, 1630, 1445, 1390, 1295, 1265, 1135.
MMR (CDC13, 250MHz)~ppm; 1.04 (d, J = 7.0Hz, 6H, -CH(CH3)2), 1.59, 1.70 (each bs, each 3H, -C = CCH3), 1.87 (d, J = 1.3Hz, 3H, - C = CCH 3), 1.9 - 2.2 (m, 8H, -CH2CH2-), 2.89 (hep, J = 7.0 Hz, lH, - CH(CH3)2), 3.98 (bs, 2H2, - CH2Cl), 5.09 (m, lH, - C = CHC H2-), 5.47 (bt, J =
6.5Hz, lH, - C = CHCH2-), 6.82 (d, J = 12.0Hz, lH, - C = CH
2Q~6~
- CH = C(CHO) -), 7.11 (d, J = 12.0Hz, -C = CH - CH -C~CHO)-), 10.27 ts, lH, - CHO).
Reference Exam~l~ 7 ce~ ~ > c~
To a solution of the nitrile (14-chloro-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraene-nitril)(890 mg, 2.78 mmol) in n-hexane (30 ml) was dropwise added gradually a lM solution (4.2 ml) of diisobutylaluminum hydride in toluene at -70C under argon atmosphere. One hour later, 2 ml of water was added to the mixture, and the bath was removed. The reaction mixture was vigorously stirred, and the resultant solid was filtered and washed with n-hexane. ~he resultant filtrate was stirred still with 10% oxalic acid. The organic layer was washed, dried, filtered and concentrated. The residue was chromatographed on a column of silica gel eluting with n-hexane: ethyl acetate (20 : 1) to give the objective formyl compound (781 mg, 87%).
IR(film)cm 1; 2970, 2930, 2880, 1670, 1630, 1445, 1390, 1295, 1265, 1135.
NMR(CDC13, 250MHz)~ppm; 1.04(d, J=7.0Hz, 6H, -CH(CH3)2), 1.~9, 1.70(each bs, each 3H, -C=CCH3), 1.87(d, J=1.3Hz, 3H, -C=CCH3), 1.9-2.2(m, 8H, -CH2CH2-), 2.89(hep, J=7.OHz, lH, -CH(CH3)2), 3.98(bs, 2H, -CH2Cl), 5.09(m, lH, -C=CHCH2-), 2a4~59~
5.47(bt, J=6.5Hz, lH, -CH=CHCH2-), 6.82(d, J-12.0Hz, lH, -C=CH-CH-C(CHO)-), 7.11(d, J-12.OHz, -C=CH-CH=C(CHO)-), 10.27( 6, lH, -CHO~.
Reference Example 8 C~ ~ ce i CHO CN
OSi(CH3)3 The above formyl compound, 14-chloro-2~
methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenal (640 mg, 2.0 mmol) was dissolved in trimethylsilylnitril (0.35 ml, 2.6 mmol). To the solution on an ice-water bath was added with stirring under argon atmosphere a trace amount of potassium cyanide/18-crown 6-ether complex. Two hours later, disappearance of the starting compound was confirmed. Excessive trimethylsilylnitrile was evaporated off to obtain crude 15-chloro-3-(1-methylethyl)-6,10,14-trimethyl-2-(trimethylsiloxy)-3,5,9,13-pentadecatetraenenitrile (647 mg, quantitative).
IR(film)cm 1; 2960, 2930, 2880, 2320, 1445, 1255, 1080, 875, 845.
NMR(CDC13, 250MHz)~ppm; 1.11, 1.15(each d, J=6.9Hz, each 3H, -CH(CH3)2), 1.60, 1.71, 1.77(each s, each 3H, -C=CCH3), 1-9-2-2(m~ 8H, -CH2CH2-), 2-64(hep, J=6.9Hz, lH, -CH(CH3)2, 3.99( 8 , lH, -CH2Cl), 5.11(m, lH, -C=CHCH2-), 5.33(s, lH, -CHCN), 5.48(bt, J=6.5Hz, lH, -C=CHCH2-), 6.04, 6.25(each d, J=11.3Hz, each lH, -C=CH-CH=C-).
204~fi9~
Reference Example 9 'C~
,/~CN
OSi (CH9) 3 ~ ~ k \~<CN + ~ ~<Cl~
OSi (CH3) 3 ~ / OH
A solution of the crude cyanohydrine trimethyl-5ilyl ether (647 mg, 2.00 mmol if it is 100% pure), which was obtained in Reference Example 8 in tetrahydrofuran (25 ml) was dropwise added with stirring at 50-55C under argon atmosphere over 30 minutes to a solution of lM lithium bis(trimethylsilyl)amide in tetrahydrofuran, which had been diluted with 25 ml of tetrahydrofuran. After completion of the dropwise addition, the tetrahydrofuran was evaporated off in vacuo, and the residue was dissolved in ethyl ether (30 ml), and the solution was washed with cooled lN HCl, water, and then saturated aqueous sodium chloride. The organic layer was dried over MgSO4 and then concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=50:1-5:1) to obtain the aimed cyclized 2-(1-methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraen-1-2Q4~9~
carbonitrile (496 mg, 64%) and desilylated analogue (56 mg, 9%) .
NMR s~ectrum of l-trimethYlsiloxY comPound NMR(CDC13, 250MHz)~ppm; 0.23(s, 9H, -Si(CH3)3), 1.09, 1.15(each d, J=6.7Hz, each 3H, -CH(C ~ )2)' 1.50, 1.62(each bs, each 3H, -C=CCH3), 1.70(d, J=1.3Hz, 3H, -C=CCH3), 2-0-2-2(m, 8H, -CH2CH2-), 2-51(hep, J=6.7Hz, lH, -CH(CH3)2), 2.55, 2.65(each d, J=14.2Hz, each lH, -CHa Hb CN-), 4.94(bt, J=6.lHz, lH, -C=CHCH2-), 5.15(bt, J=5.6Hz, lH, -C=CHCH2-), 6.17, 6.44(each d, J=11.8Hz, each lH, -C=CH-CH=C-).
NMR sPeCtrum of l-hvdroxy comPound NMR(CDC13, 25OMHz)~ppm; 1.15, l.l9(each d, J=6.7Hz, each 3H, CH(CH3)2), 1.55, 1.63, 1.69(each s, each 3H, CH3-C=C-), 1.94-2.35(m, 8H, CH2-C=C-), 2.51(hep, J=6.7Hz, lH, CH(CH3)2), 2.66, 2.73(each d, J=14.1Hz, 2H, CHa Hb CCN), 2.89(brs, lH, OH), 4.93, 5.24(each brt, J=5.3Hz, each lH, -C=CH-CH2-), 6.22, 6.42(each d, J=ll.lHz, each lH, -C=CH-CH=C-).
Reference ExamPle 10 ~ /~
Si(CH3)3 ~ ~
The above cyanohydrine trimethylsilyl ether compound, 2-(1-methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraen-1-2 0 ~
carbonitrile (657 mg, 1.7 mmol) was dissolved in 10% aqueous tetrahydrofuran (10 ml). To the solution on an ice-water bath was added a solution of lM tetra n-butylammonium fluoride in tetrahydrofuran (0.02 ml)~ and the mixture was stirred and then allowed to stand at room temperature for 2 days. Most of the tetrahydrofuran was removed in vacuo and the residue was dissolved in ethyl ether. The ether layer was dried over MgS04, filtered, concentrated, and subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=30:1) to obtain the ketone compound, 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-cyclotetradecatetraen-1-one (411 mg, 85~).
Reference Example ll > ~ OH
To the above ketone compound, 2-(1-methylethyl)-S,9,13-trimethyl-2,4,8,12-cyclotetradecatetraen-l-one (137 mg, 0.48 mmol) in dry toluene (2.5 ml) was dropwise added with stirring on a cooling hath at -70C a solution of lM
diisobutyl aluminium hydride in toluene (0.6 ml). One hour later, disappearance of the starting material was confirmed.
After addition of water (0.25 ml) and removal of the cooling bath, the reaction mixture was stirred, followed by drying over MgS04, filtration, and concentration to give a residue, 2~ 6~
which was subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=12:1) to obtain the aimed sarcophytol A (125 mg, 88%)~
Reference Exam~le 12 Lithium aluminium hydride (80.0 mg, 2.11 mmol) was added to diethyl ether (S ml) under argon atmosphere, and the mixture was stirred. To the suspension was dropwise added at room temperature over 5 minutes a solution of (lR,2S)-(-)-N-methylephedrine (308 mg, 2.12 mmol) in diethyl ether (5 ml). After one hour reflux of the reaction mixture with stirring, N-ethylaniline (0.53 ml, 4.23 mmol) was dropwise added thereto over 5 minutes, and the mixture was refluxed with stirring additional one hour. The mixture was then cooled to -72C, and a solution of the ketone compound (136 mg, 0.475 mmol) obtained in Reference Example 10 in diethyl ether (3 ml) was gradually added thereto, and the mixture was stirred for 6 hours at -72C. After addition of lN HCl (9 ml), the organic layer was separated, washed with 3N HCl (5 mlx2~, and dried over Na2SO4. Removal of the solvent in vacuo gave a residue, which was then subjected to silica gel column chromatography to give optically active ~arcophytol A (81 mg, 60%) and nonreacted ketone compound (51 mg, 37%).
Optical purity of the optically active sarcophytol A was determined to be 87% by means of high pressure liquid chromatography u~ing a separation column for optical isomers, specifically CHIRALCELL OD (commercially available 204~
from Daisel Kagaku Kogyo), said analysis being referred to as "HPLC analysis using CHIRALCELL OD~ hereinafter.
Reference Example 13 A solution of lithium aluminum hydride in diethyl ether (2.26 ml, 1.40 mmol, 0.62M) was stirred under argon atmosphere. To the solution was dropwise added (S)-2-(anilinomethyl)pyrolidine (296 mg, 1.68 mmol) in diethyl ether (3 ml) at room temperature over 10 minutes.
The reaction mixture was stirred at room temperature addi-tional one hour and then cooled to 72C. To the mixture was gradually added the ketone compound (162 mg, 0.56 mmol)in diethyl ether (5 ml), which had been prepared in Reference Example 10. After one hour stirring at -72C, saturated aqueous sodium bicarbonate (1 ml) was added, and the mixture was stirred at room temperature for 10 minutes.
After addition of lN HCl (15 ml) and diethyl ether (20 ml), the organic layer was separated. The aqueous layer was extracted with diethyl ether (20 ml), and the extract was washed with saturated aqueous sodium chloride (20 ml), dried over Na2SO4, and evaporated in vacuo to remove the solvent.
The resultant residue was subjected to silica gel column chromatography to obtain optically active sarcophytol A (126 mg, 78%).
Optical purity of the thus obtained sarcophytol A
was 92% when measured by HPLC analysis using CHIRALCELL OD.
[~] 4D: +209.9 (c=0.372, CHCl3) Reference Example 14 2~4~35 A solution of lithium aluminium hydride in diethyl ether (2.94 ml, 2.0 mmol, 0.68M) was stirred under argon atmosphere, and to the solution was gradually added (S)-2-(2,6-xylidinomethyl)pyrrolidine (490 mg, 2.4 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled to -74C, and to the mixture was dropwise added over 10 minutes a solution of the ketone compound (69 mg, 0.24 mmol) in diethyl ether (3 ml), which had been prepared in Reference Example 10. After one hour stirring at -74C, saturated aqueous sodium sulfonate (1 ml) was added, and the resultant mixture was stirred at room temperature for a while. After addition of diethyl ether (10 ml) and diluted HCl l20 ml), the organic layer was separated, and the aqueous layer was extracted with diethyl ether (20 ml). The extract was washed with saturated aqueous sodium chloride (20 ml), dried over Na2SO4, and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel column chromatography to obtain optically active sarcophytol A (61 mg, 88%).
Optical purity of the optically active sarcophytol A was 93% according to HPLC analysis using CHIRALCELL OD.
~] D: +204.4 (c=0.27, CHCl3) Reference ExamPle 15 A suspension of tin (II) chloride (382 mg, 2.01 mmol) and (R)-1-methyl-2-(piperidinomethyl)pyrrodine (366 mg, 2.01 mmol) in dichloromethane (6 ml) was cooled to -72C
20~95 ~ 83 -under argon atmosphere. To the suspension was added diisobutylaluminum hydride in toluene (1.0 mmol), and the mixture was stirred for ten minutes. To the mixture was gradually added at -72C a solution of the ketone compound ~100 mg, 0.349 mmol) in dichloromethane (3 ml). The reaction mixture was stirred for 4 hours, and the stirring was continued at room temperature for 30 minutes after addition of saturated aqueous sodium chloride (3 ml).
Resultant precipitates were filtered by the use of sellite, and the filtrate was dried over Na2SO4 and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography to give optically active sarcophytol A (79.2 mg, 79%).
Optical purity of the sarcophytol A thus obtained was 42% according to HPLC analysis using CHIRALCELL OD.
[a]25D: +101.9 (c=0.54, CHCl~) Industrial UtilitY
As stated above, the compounds (I) of the present invention are very useful as intermediates for preparing sarcophytol A which possesses an anti-carcinogenic promotor activity and anti-tumor activity. Thus, the present invention pro~ides a method suitable for industrial production of sarcophytol A.
Compound No. X
. . . _ 3 7 --O C H C H 3 ( O C 2 H 5 ) 11- 20456~
(2) Compound (I) wherein R is R2 o R s o\~
Compound R2 Rs NO.
2 --C 02C H3 ~]
3 - C 02C H3 --Si(C H3)2C4Hs' 4 --CO2C2Hs --Si(CH3)2C4Hg' 7 -CO2CH3 --CO~
O C2Hs O~
H ~
11 H -Si(CH3)2C4Hs' 14 H --CO~) - 12 - 2~5~5 ( 3 ) Compound ( I ) wherein R is \/
Rs~ ~
Compound R 4 R 5 No.
O CaHs 1~ --CH=CH2 CHCH3 16 --C H = C H 2 ~
17 --C H = C H2 --C H2O C H 3 18 -CH= CH2 --Si(CH3)2C4H4t 19 --CH= CH2 --H
--C H = C H2 --C O C H 3 21 --CH=CH2 --CO~
O C2Hs 2~ --C - C H C H C H3 23 - C--C H ~
204~69~
_ 13 ---C--C H --S i ( C H 3 ) 2 C 4 H ~ ' 28 --C--CH --CO~
Although all the compounds of the formula (I) including those illustrated in the above are useful as intermediates for the production of sarcophytol A, there are certain preferable compounds, that is, for example, those wherein n is 0 or 1. Especially preferred compounds can be found among the illustrated ones as follows:
(1): compound Nos. 1, 2, 3, 9, 10, 11, 12, 13, 14, 15, 17, 23, 24, 28, 29, 30, 32 and 33; and (27: compounds Nos. 2, 6, 8, 10, 12, 15, 16, 19, 20, 22 and 23.
Preparaion of the compound (I) of the present invention is described below according to the type of the directed compound.
(1) Compound of general formula (I) wherein R is a group of formula:
R I
--C H = C H C H C H ( C H 3 ) a 1) Compounds wherein Rl is CN and X is H
Among the compounds of this t~pe, those wherein n is 0, 1 or 2 can be prepared from corresponding startin~
materials, that is, those wherein n is O are from geranial, those wherein n is 1 are from farnesal, and those wherein n is 2 are from geranyl geranial, by reacting the each starting material with 1 to 10 mol equivalent of Wittig-Horner reagent in the presence of less than 1 mol equivalent of a base (for the Wittig-Horner reagent) in an appropriate solvent.
The Wittig-Horner reagent which can be used is, for example, 2-tdimethylphosphono)isovaleronitrile~ 2-(diethylphosphono)isovaleronitrile, or the like. Generally 1 to 10 mol equivalent of such a reagent is used for the starting material.
Examples of appropriate solvents include ether solvents such as tetrahydrofuran (THF), diethyl ether and the like, hydrocarbon solvents such as benzene, toluene, n-hexane and the like and aprotic polar solvents such as dimethylformamide (DMF) and the like. Preferred solvents are hydrocarbon solvents such as toluene, n-hexane and the like.
Examples of bases include metal hydrides such as sodium hydride, potassium hydride and the like, organic metals such as n-butyllithium, lithium diisopropylamide, lithium-bis-(trimethylsilyl)amide, potassium bis-(trimethylsilyl)amide and the like, metal alkoxides such as sodium methoxide, potassium t-butoxide and the like.
Generally, less than 1 mol equivalent of such a base is used 2~456~
for the Wittig-Hornar reagent. In this reaction, it is possible to control the steric isomerism at the double bond of the product by selecting the solvent and the base.
The reaction is usually carried out at temperature from -100 to 100C, preferably from -80 to 50C, more preferably -70 to 0C.
Each starting compound, when reacted with anion which generates during the reaction between the compound and a selected base in the presence of a selected Wittig-Horner reagent at temperature within the cited range in a selected solvent, gives the corresponding product. Under these conditions, the reaction usually completes in ~he period from 30 minutes to 12 hours.
2) Compound (I) wherein Rl is CHO and X is H
Compounds of this type can be prepared, for example, by reacting a compound prepared in above 1) with l to 10 mol equivalent of a metal hydride such as diisobutylaluminium hydride at temperature from -100 to 150 C in a hydrocarbon solvent such as toluene, n-hexane, heptane, benzene or the like, which is followed by hydroly-sis .
3) Compounds (I) wherein X is OH
Compounds of this type can be prepared, forexample, by reacting a compound prepared in above l) or 2) with an equivalent amount to 50 mol equivalent of t-butylhydroperoxide in the presence of 0.01 to 0.1 mol equivalent of selenium dioxide at temperature from -20 to 50 204~59~
c over a period of 1 to 100 hours in a solvent such as methylenechloride or the like.
4) Compounds (I) wherein R1 is CN and X is a halogen atom Compounds of this type can be prepared, for example, from an alcohol wherein R1 is CN, obtained in above 3), by halogenating said allylic alcohol without allyl rearrangement. Such a reaction can be carried out by reacting the alcohol with 1.0 to 10 mol equivalent of carbon tetrahalide in the presence of 1.0 to 10 mol equivalent of triphenylphosphine at temperature from room temperature to 100C over a period of 1 to 8 hours in an inert solvent such as ace onitrile or the like. In case of chlorination~ carbon tetrachloride can be used as a solvent. Alternatively, it can be carried out by reacting 1.0 to 10 mol equivalent of methanesulfonyl chloride together with a metal halide and y-collidine at temperature from -40C to room temperature over a period of 1 to 10 hours.
5) Compounds wherein R1 is CN and X is OSO2R6 (R6 is as defined above) Compounds of this type can be prepared, for example, by reacting an alcohol wherein R1 is CN obtained in above 3) with 1.0 to 10 mol equivalent of sulfonyl chloride such as methanesulfonyl chloride, p-toluenesulfonyl chloride or sulfonyl anhydride such as trifluoromethanesulfonic anhydride in the presence of 1.0 to 10 mol equivalent of amine such as triethylamine, pyridine or the like at 2 ~ 5 temperature from -40C to room temperature over a period of 1 to 10 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like or a halogen solvent such as methylenechloride, chloroform or the like, or pyridine in case it is used as a base.
6) Compounds wherein X is oR5 (R5 is as defined above) a) Compounds wherein R5 is substituted silyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 0.5 to 10 mol equiva-lent of a substituted silyl chloride such as trimethylchlorosilane, t-butyldimethylchlorosilane or the like in the presence of 0.5 to 10 mol equivalent of a base such as triethylamine, pyridine, imidazole or the like at temperature from -50 to 50 C in an ether solvent such as ethyl ether, THF or the like, an aprotic polar solvent such as dimethylformamide or the like, a halogen solvent such as dichlorometahne, chloroform or the like.
b) Compounds wherein R5 is l-alkoxyalkyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 0.5 to 10 mol equiva-lent of l-haloalkyl ether such as chloromethylmethyl ether or chloromethyl-(2-methoxyethyl) ether or the like together with 0.5 to 10 mol equivalent of a base such as sodium hydride, potassium hydride, diisopropylamine, triethylamine or the like at temperature from -50 to 50 in a solvent such as THF, DMF or the like or without solvent; or with 1 to 10 - 18 - 204~S9~
mol equivalent of l-alkenylalkyl ether such as vinylethyl ether, dihydropyrane or the like in the presenae of a catalytic amount to equivalent amount of mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic acid such as p-toluenesulfonic acid, camphorsulfonic acid or the like or a salt such as pyridinium salt of p-toluenesulfonic acid or the like at temperature from -20 to 100 C in an ether solvent such as diethyl ether, THF or the like, an ester solvent such as ethyl acetate or the like, or a halogen solvent such as dichloromethane, chloroform or the like.
c3 Compounds wherein R5 is acyl group Compounds of this type can be prepared by reacting a compound obtained in above 3) with 1 to 10 mol equivalent of acyl halide such as acetyl chloride, benzoyl chloride or the like or acid anhydride such as acetic anhydride, trichloroacetic anhydride or the like in the presence of 1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -20 to 100 C in a halogen solvent such as dichloromethane, chloroform or the like or an ether solvent such as ethyl ether, THF or the like or a hydrocarbon solvent such as benzene, toluene, n-hexane or the like, or without solvent where a base serves as a solvent.
(2) Compound of general formula (I) wherein R is a group of formula: R 2 o 204~95 1) Compounds (I) wherein R5 is l-alkoxyalkyl group , tetrahydrofuranyl group or tetrahydropyranyl group, silyl group substituted with Cl - C5 alkyl group or phenyl group and R2 is C02R3 (wherein R3 is as defined above) Compounds of this type can be prepared by substi-tuting the hydroxyl group at the 8 position of 8-hydroxygeranyl acetate with -oR5 ~R5 is as defined above) according to either of the following methods.
a) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of 1-haloalkyl ether such as chloromethylmethyl ether, chloromethyl-2-methoxyethyl ether or the like in the presence of 0.5 to 10 mol equivalent of a base, for example, a metal hydride such as sodium hydride, potassium hydride or the like, amines such as diisopropylamine, triethylamine or the like, or pyridine or the like at temperature from -20 to +100 over a period of 5 minutes to 24 hours in a halogen solvent such as methylene chloride, chloroform or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl acetate or dimethylformamide or the like, or without solvent.
b) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of vinyl ether such as ethylvinyl ether, dihydropyrane or the like in the presence of a catalytic amount to equivalent amount of mineral acid such as hydro-chloric acid, sulfuric acid or the like, an organic acid such as p-toluenesulfonic acid, camphorsulfonic acid or the like, or a salt of a strong acid such as pyridinium salt of 2~4~9~
p-toluenesulfonic acid or the like at temperature from -20 to +100 C in a halogen solvent such as dichloromethane, chloroform or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl acetate or dimethylformamide or the like, or without solvent.
c) 8-Hydroxygeranyl acetate is reacted with 0.1 to 10 mol equivalent of trialkylsilyl halide such as trimethyl-silyl chloride, t-butyldimethylsilyl chloride or the like in the presence of 0.1 to 10 mol equivalent of a base such as nitrogen-containing compound such as triethylamine, dimethylaminopyridine, imidazole or the like, or metal hydride such as sodium hydride, potassium hydride or the like at temperature from -20 to +100 C over a period of 5 minutes to 24 hours in a halogen solvent such as methylene chloride, chloroform or the like, a hydrocarbon solvent such as hexane, benzene or the like, an ether solvent such as diethyl ether, tetrahydrofuran or the like, or ethyl ace-tate, dimethylformamide, dimethyl sulfoxide or the like.
The resultant compound, when reacted, for example, with an alkali metal salt of acetoacetic ester, gives the desired compound. Thus, the compound is reacted with an alkali metal salt of an acetoacetic ester at temperature from -70 to +100C over a period of 30 minutes to 48 hours in an aprotic polar solvent such as diethyl ether, tetrahydrofuran, dimethylformamide, dimethyl sulfoxide or the like to give the directed compound, where the alkali metal salt of an acetoacetic ester can be prepared by 2 ~ 9 ~
reacting an acetoacetic ester such as ethyl acetoacetate, ethyl acetoacetate or the like with a metal hydride such as sodium hydride or the like, or a strong base such as n-butyllithium, lithium diisopropylamine or the like in the presence of a palladium (o) chelate such as tetrakis(triphenylphosphine) palladium and the like as a catalyst at temperature from -70 to +100C in an aprotic polar solvent such as diethyl ether, tetrahydrofuran, dimethylformamide, dimethyl sulfoxide or the like.
2) Compounds (I) wherein R5 is H and R2 is Co2R3 (R3 is as defined above) Compounds of this type can be prepared by reacting a compound obtained in above 1) with 0.1 to 10 mol equiva-lent of a mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or the like or a salt of a strong acid such as pyridinium salt of p-toluenesulfonic acid or the like in an alcohol solvent such as methanol, ethanol or a the like or water, or a mixed solvent thereof. Alterna-tively, it can be prepared by reacting the compound obtained in 1) with 0.1 to 10 mol equivalent of tetraalkylammonium fluoride such as tetrabutylammonium fluoride or hydrogen fluoride in a protonic polar solvent such as methanol, ethanol, water or the like, an ether solvent a~ diethyl ether, tetrahydrofuran or the like, or a mixed solvent thereof.
2~569~
- 2~ -3) Compounds (I) wherein R5 is acyl group and R
is Co2R3 (R3 is as defined above) Compounds of this type can be prepared by reacting a compound obtained in above 2) with 0.1 to 10 mol equiva-lent of acyl halide such as acetyl chloride, benzoyl chlo-ride or the like or acid anhydride such as acetic anhydride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at tempera-ture from -20 to +100 C in a halogen solvent such as dichloromethane or the like, an ether solvent such as diethyl ether or the like, a hydrocarbon solvent such as benzene, n-hexane or the like, or without solvent where a base serves as a solvent.
4) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuranyl group, tetrahydropyranyl group, silyl group substituted with Cl C5 alkyl group or phenyl group or acyl group and R2 is a hydrogen atom Compounds of this type can be prepared through the decarboxylation or decarboalkoxylation of a compound obtained in above 1), 2) or 3). The decarboxylation can be carried out by reacting said compound with 0.1 to 10 mol equivalent of a metal hydroxide such as sodium hydroxide, potassium hydroxide or the like, metal alkoxide such as sodium methoxide or the like at temperature from 0 to 100C
over a period of 10 minutes to 24 hours for the hydrolysis 2~6~
or ester-exchanging reaction, and heating at temperature from 100 to 250C over a period of 30 minutes to 10 hours.
The decarboalkoxylation which is carried out by reacting a compound with 0.1 to 10 mol equivalent of a metal halide such as sodium chloride, sodium iodide or the like at temperature from 50 to 250C in an aprotic polar solvent such as dimethylformamider dimethylsulfoxide or the like.
(3) Compounds (I) wherein ~ is a group of formula:
\ /
1) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl, tetrahydrofuranyl or tetrahydropyranyl group, or silyl group substituted with C1 - C5 al y g p phenyl group and R is -CH=CH2 Compounds of this type can be preparcd by sub~ect-ing a compound obtained in (2), 4) to an addition reaction, which is conducted by reacting said compound with 0.1 to 10 mol equivalent of a vinyl anion such as vinyl lithium, vinyl magnesium bromide or the like at temperature from -50 to 100 C over a period of 30 minutes to 48 hours in an ether solvent such as diethyl etherr tetrahydrofuran or the like or a hydrocarbon solvent such as n-hexane , benzene or the like.
2) Compounds (I) wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuranyl group, tetrahydropyranyl group or silyl group substituted with Cl -C5 alkyl group or phenyl and R4 is -C-CH
2~4~S9~
Compounds of this type can be prepared by subject-ing a compound obtained in above (2), 4) to an addition reaction which is conducted by reacting said compound with 0.1 to 10 mol equivalent of a metal acetylide such as lithium acetylide, ethynyl magnesium bromide or the like at temperature from -50 to +100 C over a period of 30 minutes to 48 hours in an ether solvent such as diethyl ether, tetrahydrofuran or the like or a hydrocarbon solvent such as n-hexane, benzene or the like.
3) Compounds (I) wherein R5 is acyl group and R4 is a group of -CH=CH2 or -C-CH
Compounds of this type can be prepared by reacting a compound obtained in above ~3),1) or 2), in which R5 is a hydrogen atom and R4 is -CH=CH2 or -C-CH, with 0.1 to 10 mol equivalent of acyl halide such as acetyl chloride, benzoyl chloride or the like or acid anhydride such as acetic anhydride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -20 to +100 C in a halogen solvent such as dichloromethane or the like, an ether solvent such as diethyl ether or the like, a hydrocarbon solvent such as benzene, n-hexane or the like, or without solvent where a base serves as a solvent.
The above are examples of preferred procedures for the production of the compounds of formula (I) of the invention. As one of skill will appreciate, the present invention is not restricted to the compounds (I) produced - 25 _ 20~5~
by the above methods, but include any compounds of formula (I) prepared by other methods known to the art.
As mentioned above, the present invention makes it possible to obtain Compound (F), the key intermediate in the synthetic route 1 for the production of sarcophytol A, from a monoterpenoid which is cheap and easy to obtain by an improved and efficient process with avoiding the oxidation of alcohol to aldehyde of the previously provided method, reducing the total steps, and in high yield.
Thus, the present invention provides an industri-ally advantageous synthetic route for preparing sarcophytol A.
Typical procedures for the production of the intermediate (F) in the synthetic route 1 from various compounds ~I) of the invention as the starting material, and that for the production of the final product, sarcophytol A, will hereinafter be described.
(1) When the starting material is a compound (I) wherein X is a halogen atom, n is 1 and R is a group of formula: C N
I
_ r ~ - r ~ r T7 ~ TT ~ ~ TT ~
v ~ n ~, n ~ ~, n 3 J 2 Compound (F) in the above synthetic route 1 can be prepared by reacting a compound (I) as defined above with 0.1 to 10 mol equivalent of diisobutylaluminium hydride in a solvent such as toluene, benzene, n-hexane or the like at temperature from -100 to 100 C and hydrolyzing the product.
2~4~6~
(2) When the starting material is Compound (I') which is shown by the formula (I) wherein R5 is l-alkoxyalkyl group and R is a group of formula:
HO C--CH
or Compound (I") which is shown by the formula (I) wherein R2 is l-alkoxyalkyl group and R is a group of formula:
HO C--CH
\/
~ 27 _ 2~4~
Svnthetic Route 2 HO CH=CH2 R50 J ~ ~ oxidation HO C-CH
R50 ~ ~ \/ R50 ~ ~ ~ CHO >
\~\ . ~ , \~/
eplmerlzatlon (I') (A') Rs~ > Rs~ >
CN CHO
(B') (C') HO~ > X ~ >
(E~ ) CHO (F) CHO
a process of JA181710/1989 ~ ~ ~
> ~, ~OH
sarcophytol A
(wherein R5 and X are as defined above).
a) When the starting material is Compound tI') Compound (A') can be prepared by subjecting the Compound (I') to rearrangement reaction in the presence of 0.01 to 1 mol equivalent of silylvanadate such as tris(triphenylsilyl)vanadate, poly{(diphenylsilyl)vanadate~
2~4~9~
or the like at temperature from 100 to 300C over a period of 30 minutes to 24 hours in a hydrocarbon solvent ~uch as undecane, xylene or the like, an ether solvent such as bis[2-(2-methoxyethoxy~-ethyl] ether or a mineral oil.
b) When the starting material is Compound (I") An unsaturated aldehyde (A') can be prepared by reacting the Compound (I") with chromic oxides such as pyridinium chlorochromate or the like at temperature from 0 to 100C over a period of 30 minutes to 24 hours in a halogen solvent such as methylene chlorider chloroform or the like, a hydrocarbon solvent such as n-hexane, banzene or the like, or dimethylformamide or the like.
c) Compound (B') can be prepared by reacting Compound (A') with 0.1 to 10 mol equivalent of Wittig-Horner reagent such as 2-(dimthylphosphono)isovaleronitrile, 2-(diethylphosphono)isovaleronitrile or the like in an ether solvent such as tetrahydrofuran, diethyl ether or the like, a hydrocarbon solvent such as toluene r n-hexane or the like or an aprotic polar solvent such as dimethylformamide, dimethyl sulfoxide or the like at temperature from -100 to +100C, in the presence of less than 1 mol equivalent (for the Wittig-Horner reagent) of a base, for example, metal hydride such as sodium hydride, potassium hydride or the like, organic metal (e.g. n-butyllithium, lithium diisopropylamide) or metal alkoxide such as sodium methoxide, potassium t-butoxide or the like while allowing to react Compound (A') with a generated anion.
2~4~g9~
Aldehyde (C') is prepared by reacting Compound (B') with 0.1 to 10 mol equivalent of a metal hydride complex such as lithium aluminum hydride or the like at temperature from -70 to +100C in an ether solvent such as diethyl ether, tetrahydrofuran or the like or reacting with 0.1 to lO mol equivalent of a metal hydride such as diisobutylaluminium hydride or the like at temperature from -70 to +100C over a period of 5 minutes to 5 hours in a hydrocarbon solvent such as n-hexane, benzene or the like.
~ ldehyde (C') is converted into alcohol (E') when treated with 0.1 to 10 mol equivalent of a mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or a salt of a strong acid such as a pyridinium salt of p-toluenesulfonic acid or the like in a solvent such as aqueous methanol, aqueous ethanol, aqueous tetrahydrofuran, or a mixed solvent thereof.
Compound (F) can be prepared from Compound (E') by halogenating the allylic alcoholic without allyl rearrange-ment. For example, Compound (E') is reacted with 0.1 to 10 mol equivalent of carbon tetrahalide in the presence of 1.0 to 10 mol equivalent of triphenylphosphine in a solvent such as acetonitrile, dichloromethane or the like, in case of chlorination, with carbon tetrachloride without solvent, at temperature from -10 to +100C over a period of 10 minutes to 12 hours. Alternatively, Compound (E') is reacted with 0.1 to 10 mol equivalent of sulfonyl halide such as 20~G95 methanesulfonyl chloride, p-toluenesulfonyl chloride or the like together with a metal halide such as lithium chloride in the presence of an amine such as pyridine, y-collidine, lutidine or the like at temperature from -40 to +30C over a period of 1 to 12 hours.
The final product, sarcophytol A, can be prepared be treating Compound (F) according to the procedure shown by the synthetic route 1 as shown below.
Process of the svnthetic route 1 a) Preparation of Compound (G) Thus, Compound (G) whexein R8 is trimethylsilyl group is prepared, for example, by treating Compound (F~
with 1.0 to 10 mol equivalent of trimethylsilylnitrile in the presence of a catalytic amount of metal cyanide 18-crown-6-ether complex, an ammonium salt such as tetraalkylammonium cyanide or the like at temperature from -20 to 50C over a period of 30 minutes to 5 hours in a solvent such as methylene chloride, chloroform, ethyl acetate or the like, or without solvent. The resultant product can be converted into cyanohydrin wherein R8 is hydrogen by treating with 0.1 - 3N aqueous mineral acid such as hydrochloric acid, sulfuric acid or the like at 0C to room temperature over a period of 5 minutes to 5 hours or by treating with a catalytic amount to 10 mol equivalent of tetraalkylammonium salt such as tetrabutylammonium fluoride or the like at temperature from -20C to room temperature in a solvent such as tetrahydrofuran, dioxane or the like.
- 31 - 2a4~69~
Compound (G) wherein R8 is 1-ethoxyethyl group can be prepared by reacting the above cyanohydrin with 1.0 to 10 mol equivalent of ethyl vinyl ether in the presence of a catalytic amount of mineral acid such as hydrochloric acid, sulfuric acid or the like, an organic strong acid such as p-toluenesulfonic acid or the like, or a salt of strong acid such as p-toluenesulfonic acid or the like pyridinium salt at temperature from -20C to room temperature over a period of 30 minutes to 5 hours in a solvent such as ethyl ether, ethyl acetate or the like.
b) Preparation of Compound (H~
Compound (H) wherein R8 is trimethylsilyl or l-ethoxyethyl group can be prepared by reacting Compound (G) wherein R8 is trimethylsilyl group or l-ethoxyethyl group with 1.0 to 10 mol equivalent of a base such as lithium diisopropylamide, lithium bis-(trimethylsilyl) amide, sodium hydride or the like at temperature from -70 to 100C over a period of 5 minutes to 10 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydrocarbon solvent such as n-hexane, n-heptane or the like.
Compound (H) wherein R8 is a hydrogen atom is prepared by treating the compound obtained above with 0.1 -3N aqueous mineral acid such as hydrochloric acid, sulfuric acid or the like at temperature from 0C to room temperature over a period of 5 minutes to 5 hours in a solvent such as 2~69~
tetrahydrofuran, methanol or the like or by treating with a catalytic amount to 10 mol equivalent of tetraalkylammonium salt such as tetrabutylammonium fluoride at temperature from -20C to room temperature in a solvent such as tetrahydro-furan, dioxane or the like.
c) Preparation of a ketone, Compound (J) The ketone (J) can be prepared by treating a solution of Compound (H) wherein R8 is a hydrogen atom in an organic solvent such as ethyl ether, ethyl acetate or the like with aqueous sodium bicarbonate at temperature from 0C
to room temperature over a period of 5 minutes to 5 hours, or by treating Compound H wherein R8 is trimethylsilyl group with a catalytic amount to 10 mol equivalent of an alkylammonium fluoride such as tetrabutylammonium fluoride in a solvent such as aqueous tetrahydrofuran, dioxane or the like.
d) Preparation of sarcophytol A
Sarcophytol A can be prepared by reacting the ketone (J) thus obtained with 1.0 to 10 mol equivalent of a metal hydride such as diisobutylaluminum hydride or the like or a metal complex such as lithium aluminum hydride or the like at temperature from -70 to 50C over a period of 5 minutes to 5 hours in an ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydro-carbon solvent such as n-hexane, n-heptane or the like.
204~9~
Further, sarcophytol A in native form shown below is prepared by subjecting ketone Compound (J) to asymmetric reduction with an asymmetrically-modified metal hydride or metal hydride complex.
~ ~ OH
~1 Sarcophytol A in native form Examples of asymmetrically-modifying reagents used for preparing asymmetrically-modified metal hydride or metal hydride complex, which are used in the asymmetric reduction, include asymmetric amino alcohols prepared by converting carboxy group of optically-active amino acid such as L- or D-proline, valine or the like into substituted alcohol group or substituted amino group [Bull. Soc.Chim.Belq. 97: 691 (1988); J. Chem. Soc. Perkin I 1673: (1983)]; asymmetric diamines [Bull. Chem. Soc. Japan 51: 1869 (1978);
Tetrahedron 37: 4111 (1981)], asymmetric alkaloids such as L- or D-methylephedrine and the like [Chem.Pharm.Bull. 31:
837 (1983)]; and (S)- or (R)-l,l'-bis-2-naphtol and the like.
Examples of metal hydrides or metal hydride complexes include diisobutylaluminium hydride, lithium aluminium hydride, sodium borohydride and the like. An asymmetric reducing reagent can be prepared by reacting a 2~4~6~
metal hydride or metal hydride complex with 0.1 to S mol equivalent, preferably 0.5 to 1.5 mol equivalent of the above-mentioned asymmetrically-modifying reagent, optionally in the presence of an additive such as alkyl-substituted aniline, substituted aminopyridine, stannous chloride or the like at temperature from -50 to 50C, preferably from -20C
to room temperature over a period of 10 minutes to 5 hours in an appropriate solvent to obtain a coordinated complex of said asymmetrically-modifying reagent and metal hydride or metal hydride complex. Examples of appropriate solvents include ether solvents such as diethyl ether, tetrahydrofuran and the like and hydrocarbon solvents such as benzene, toluene, n-hexane and the like. A halogen solvent such as dichloromethane and chloroform is also available in case metal hydride is used. Illustrative combinations are listed in the Table 1 below.
204~69~
Table 1 _ metal hydride axymmetric or metal modifying additive hydride compl~ x reagent O H
L iA lH 4 Ph ~ HsC 2 N
NMe2 ~
H A l(i- B u)2 A ~ ~
(D I B A L) ~ N ~ S nCl2 . ~
~ B H 9 \;
20~69~
Although the amount of the asymmetric reducing reagent to be reacted with the macrocyclic ketone ~hown by the structure (J) is not critical, it is preferable to u~e 1 to 2 mol equivalent of asymmetric reducing reagent for the ketone considering the recovery of un-reacted starting materials and yield of the product. The reaction is usually conducted at temperature from -150 to 100C, preferably from -100C to room temperature over a period of 10 minutes to 5 hours in the same solvent as that used for ~he preparation -of the asymmetric reducing reagent. No regularity can be found between the absolute configuration of the product ~arcophytol A ( its native form is expressed by IR and non-native form IS as shown below) and that of the asymmet-ric reducing reagent, which i8 attributable to the original compound in L- or D-form. The absolute configuration of the product varies depending on the combination of the asymmet-ric reducing reagent and metal hydride or metal hydride complex.
The by-product of the present method, sarcophytol A in non-native form of formula:
~ ~~
-OH
J (I ~) , when subjected to the conventional epimerization reaction 2 ~ ~ 5 S ~ ~
for hydroxyl group, easily gives the optically-active sarcophytol A (Is) in native form after the inversion.
(3) When the starting material is a compound of formula (I) wherein n is 1 and R i8 a group of formula:
R I
- C H = C H C H C H ( C H 3) 2 wherein R1 is as defined above.
- 38 - 2(~ i6~5 Synthetic Route 3 CHO (K) epoxidation (L) Ae(O-C3H7)3 )~
OH (M) OH
sulfonylesterification (N) OR~
etherification ~ ) J
(O) [2.3]Wittig rearrangement ~
OH
sarcophytol A
20~69~
R : substituted sulfonyl group such as methanesulfonyl group or p-toluenesulfonyl group.
Compound ~K) in the above synthetic route 3 can be prepared by, for example, reacting a compound of formula (I) wherein n is 1, X is a hydrogen atom and R is a group:
- C H = C H C H C H (C H3)2 with either of 1.0 to 10 mol equivalent of metal hydride such as dibutylaluminium hydride or the like, or a metal complex such as lithium aluminium hydride or the like at temperature from -70 to 50 C over a period of 5 minutes to 5 hours in a ether solvent such as ethyl ether, tetrahydrofuran or the like, an aromatic hydrocarbon solvent such as benzene, toluene or the like or a saturated hydro-carbon solvent such as n-hexane, n-heptane or the like, or with 0.5 to 10 mol equivalent of metal hydride complex such as sodium borohydride or the like at temperature -70 to 100C in a solvent such as methanol, ethanol or the like.
The resulting Compound (K) is converted into Compound (L) through the epoxidation which is conducted by halogenating the Compound K with 0.1 to 1 mol equivalent of a halogenating agent such as N-bromosuccinimide, N-chlorosuccinimide or the like at temperature from -20 to 100C over a period of 30 minutes to 5 hours in an aqueous solvent of a water-miscible solvent such tetrahydrofuran, dimethoxyethane or the like, followed by treating with an aqueous solution of a base such as sodium hydroxide, 2~Gg~
potassium hydroxide, sodium carbonate or the like, or after the halogenation, isolating halohydrin, and treating it with a base such as sodium carbonate, sodium methoxide or the like in a solvent such as methanol or tetrahydrofuran or the like; or by treating with 0.1 to 1 mol equivalent of organic peracid such as m-chloroperben~oic acid, peracetic acid or the like at temperature from -50 to 50C over a period of 30 minutes to 10 hours.
Compound (M) can be prepared by reacting Compound (L) with 0.1 to 10 mol equivalent of metal alkoxide such as aluminium triisopropoxide or the like at temperature from 50 to 200 C in a solvent such as toluene, xylene or the like;
or with 0.1 to 10 mol equivalent of a metal amide such as lithium diisopropylamide, lithium diethylamide or the like at temperature from -70 to 100 C in a solvent such as diethyl ether, tetrahydrofuran or the like.
Compound (N) can be prepared by the sulfonylesterification of the diallyl alcohol (M). For example, Compound (M) is reacted with 0.1 to 1.5 mol equiva-lent of a substituted sulfonyl chloride such as methanesulfonyl chloride, p-toluenesulfonyl chloride or the like in the presence of 0.1 to 10 mol equivalent of a base such as triethylamine, pyridine or the like at temperature from -70 to 100 C in a halogen solvent such as dichloromethane, chloroform or the like or a ether solvent such as diethyl ether, tetrahydrofuran or the like.
20~69~
Compound (0) can be prepared, for example, by treating Compound (N) with 0.1 to 10 mol equivalent of metal hydride such as sodium hydride, potassium hydride or the like or organic metal such as n-butyllithium, ethyl magnesi-um chloride or the like at temperature from -50 to 150 C in an ether solvent such as diethyl ether, tetrahydrofuran or the like, a hydrocarbon solvent such as benzene, toluene, n-hexane or the like or an aprotonic polar solvent such as dimethylformamide, dimethyl sulfoxide or the like.
The resultan~ Compound (o) can be converted into sarcophytol A by reacting said Compound (o) with 0.1 to 10 mol equivalent of organic metal such as n-butyl lithium, sec-butyl lithium, lithium diisopropyl amide or the like at temperature from -100 to 100 C in an ether solvent such as diethyl ether, tetrahydrofuran or the like, a hydrocarbon solvent such as benzenel toluene, n-hexane or the like, or further adding hexamethylphosphoric triamide or the like to the solvent.
(4) When the starting material is a compound of formula I wherein n is 0 and R is a group of formula:
- C H = C H C H C H (C H 3)2 wherein Rl is as defined above.
204~fi9~
Synthetic route 4 CN CN
(A") epoxidation ~ Claisen Rearrangement > /~/\
OH CN
(B") OHC ~ Wittig Reaction CN
(C") ~ H
(D") HO ~ PPh3, CCe4 CHO
(E") CB ~ a route of JA 181710/1989 CHO
(F) OH
Sarcophytol A
20~6~
Compound (A") in the above synthetic route 4 can be prepared from a compound (I) wherein R1 is -CN, n is 0 and X is a hydrogen atom as mentioned above through epoxidation as follows. Thus, Compound (A") i9 prepared by halogenating a compound (I) with 0.1 to 1 mol equivalent of a halogenating agent such as N-bromosuccinimide, N-chlorosuccinimide or the like at temperature from -50 to 50C over a period of 30 minutes to 5 hours in an aqueous solvent of a water-miscible solvent such tetrahydrofuran, dimethoxyethane or the like, followed by treating with an aqueous solution of a base such as sodium hydroxide, potas-sium hydroxide, sodium carbonate or the like, or after the halogenation, separating halohydrine, and reducing it with a base such as sodium carbonate, sodium methoxide or the like in a solvent such as methanol or tetrahydrofuran or the like; or by treating the compound with 0.1 to 1 mol equiva-lent of organic peracid such as m-chloroperbenzoic acid, peracetic acid or the like at temperature from -50 to 50C
over a period of 30 minutes to 10 hours.
Compound (B") is prepared by treating the above epoxy compound (A") with 0.1 to 10 mol equivalent of metal alkoxide such as aluminium triisopropoxide or the like at temperature from 50 to 200 C in a solvent such as toluene, xylene or the like; or with 0.1 to 10 mol equivalent of a metal amide such as lithium diisopropylamide, lithium diethylamide or the like at temperature from -70 to 100 C
204569~
in a solvent such as diethyl ether, tetrahydrofuran or the like.
~ he aldehyde compound (C") can be prepared by, for example, through the Claisen rearrangement, which is con-ducted by reacting Compound (B") with 1.0 to 100 mol equiva-lent of alkyl vinyl ether such as ethyl vinyl ether or the like in the presence of 0.1 to 5 mol equivalent of a mercury salt such as mercury acetate or the like at temperature from 0 to 100 C to give the vinyl ether of Compound (s") or leading said Compound (B") to 3-alkoxyacrylic acid according to a known method [J. Orq. Chem., 48: 5406 (1983)], ~ollowed by heating at temperature from 100 to 250 C in the presence of a catalytic amount of hydroquinone in each case.
Compound (D") is prepared by reacting the aldehyde (C") with 0.5 to 5 mol equivalent of Wittig reagent such as carbomethoxyethylidene triphenylphosphorane or the like or an anion made from Wittig-Horner reagent such as ethyl 2 -(diethylphosphono)propionate, ethyl 2-(dimethylphos-phono)propionate or the like at temperature from -50 to 100C in a solvent such as diethyl ether, THF, DMF, dichloromethane or the like.
Compound (D"), when treated with 0.5 to 10 mol equivalent of metal hydride complex such as lithium aluminium hydride or the like at temperature from -70 to 100 C in an ether solvent such as diethyl ether, THF or the like or with 0.5 to 10 mol equivalent of metal hydride such as dibutylaluminium hydride or the like at temperature from 204~G9~
-70 to 100 C in a hydrocarbon solvent such as benzene, toluene, n-hexane, n-heptane or the like, gives Compound (E~), which is a compound o~ formula I wherein n is 1, X is hydroxyl group and ~ is a group of formula:
C H O
- C H = C H C H C H(C H 3)2 , which is the same as Compound (E~) in the synthetic route 2.
Compound (F) can be prepared from Compound (E") by halogenating the allylic alcoholic without allyl rearrange-ment as previously described in the synthetic route 2.
Compound (E"), when treated in the same manner as mentioned above, gives sarcophytol A.
As can be seen from the above, sarcophytol A can be prepared effectively from the compound (I) of the inven-tion through various processes using or without using the intermediate F, which demonstrates that the compound (I) is highly useful and important for the attainment of the purpose of the invention.
Following Examples are provided for purposes of illustration only and are not to be construed as limiting the scope of the instant invention in any way.
PreParation 1 HO~ THPOJ~
2~69~
A mixture of 8-acetox~-2,6-dimethyl-2,6-octadien-1-ol (1.81 g, 8.52 mmol) and dihydropyran (1.17 ml, 12.8 mmol) in dichloromethane (6 ml) was stirred, and p-toluenesulfonic acid (40 mg) was added thereto, and the mixture was stirred at room temperature for 30 minutes.
After addition of saturated aqueous sodium bicarbonate (30 ml), the product was extracted with hexane/ether (5:1.2) (30 ml). The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a residue, which was purified with silica gel column chromatography to give l-acetoxy-8-(2-tetrahydropyranyl)oxy-3,7-dimethyl-2,6-octad-iene (2.42 g, 96%~.
Pre~aration 2 HO ~ > H3COH2CO ~
A mixture of 8-acetoxy-2,6-dimethyl-2,6-octadien-l-ol (110 mg, 0.52 mmol) and triethylamine (0.25 ml, 1.83 mmol) and chloromethyl methyl ether (0.069 ml, 0.92 mmol) in acetonitrile (2 ml) was refluxed with stirring for 4 hours. After addition of water (3 ml) to the reaction mixture, the product was extracted several times with ether (5 ml). The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a residue, which was then sub~ected to silica gel column chromatography to give the aimed l-acetoxy-8-(2-methoxymethyl)oxy-3,7-dimethyl-2,6-octadiene (109 mg, 82~).
20~6~5 - ~7 -Preparation 3 HO~OCOCH3 C4H9 '-SiO~V OCOCH3 8-Acetoxy-2,6-dimethyl-2,6 octadien-l-ol in dimethylformamide (4 ml) was stirred on an ice bath. To the solution were added imidazole (338 mg, 4.96 mmol) and chlorodimethyl t-butylsilane (410 mg, 2.73 mmol), and the mixture was stirred at room temperature for one hour. After addition of water ~30 ml) to the reaction mixture, the product was extracted with hexane (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel column chromatography to obtain l-acetoxy-8-(dimethyl t-butylsilyl)oxy-3,7-dimethyl-2,6-octadiene (606 mg, 75%).
Exam~le 1 0~ ~ 0~
OCOCH3 ~/
To a solution of 1-acetoxy-8-(2-tetrahydropyranyl)oxy-3,7-dimethyl-2,6-octadiene (1.08 g, 3.64 mmol) in tetrahydrofuran (6 ml) were added under nitrogen atmosphere triphenylphosphine (105 mg, 0.4 mmol) and tetrakis(triphenylphosphine)paradium (168 mg, 0.15 mmol), and the mixture was stirred at room temperature for 15 minutes. To the mixture were added a sodium salt of 2 0 ~ ~ 6 9 ~
methyl acetoacetate in tetrahydrofuran (25 ml) which has been prepared from sodium hydride (305 mg, 12.7 mmol) and methyl acetoacetate (1.57 ml, 14.6 mmol), and the mixture was refluxed for 5 hours. After addition of ~ater (10 ml) and ether (30 ml), the reaction mixture was stirred well, and the organic layer was separated. The aqueous layer was extracted with ether (5 ml), and the extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-5,9-dimethyl-10-(2-tetrahydropyranyl)oxy-4,8-decad-ienate (1.06 g, 83~).
IR(film)cm 1; 2950, 2870, 1750, 1722, 1440, 1360, 1201, 1150, 1022.
NMR(CDC13, 250MHz)~ppm; 1.45-1.92(m, 6H, C(O)H2-Ca2-CH2-CH2-CHO-), 1.63, 1.65(2s, 6H, 2x-CH3C=CH-), 1.94-2.15(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22(s, 3H, CH3C=O), 3.46(t, J=7.5Hz, lH, -CHCO2-), 3.53(m, lH, -CH2-CHaHb-O-), 3.73(s, 3H, CO2CH3), 3-83, 4-09(2d~ J=11-8Hz~ 2H~
-OCa2C=CH-), 3.82-3.94(m, lH, -CH2-CHaHb-O-), 4.60(t, J=3.4Hz, lH, -OCHO-), 5.04(t, J=7.3Hz, lH, -C=CH-CH2-), 5.38(t, J=6.2Hz, lH, -C=CH-CH2-).
ExamPle 2 o H3COH2CO~ H3COH2CO ~
20~69~
To a solution of l-acetoxy-8-(methoxymethyl)oxy-3,7-dimethyl-2,6-octadiene t600 mg, 2.34 mmol) in tetrahydrofuran (6 ml) were added under nitrogen atmosphere triphenylphosphine (60 mg, 23 mmol) and tetrakis(triphenylphosphine)paradium ~108 mg, 0.09 mmol), and the mixture was stirred at room temperature for 15 minutes. To the mixture were added a sodium salt of methyl acetoacetate in tetrahydrofuran (25 ml) which has been prepared from sodium hydride (225 mg, 9.36 mmol) and methyl acetoacetate (1.26 ml, 11.7 mmol), and the mixture was refluxed for 2 hours. After addition of water (40 ml) and ether (50 ml), the reaction mixture was stirred well, and the organic layer was separated. The aqueous layer was extracted with ether (50 ml), and the extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-5,9-dimethyl-10-(methoxymethyl~oxy-4,8-decadienate (670 mg, 92%).
IR(film)cm 1; 2930, 1745, 1720, 1438, 1355, 1208, 1150, 1100, 1040, 920.
lH NMR(CDC13, 250MHz)~ppm; 1.63, 1.65(2s, 6H, CH3C=CH-x2), 1.93-2.17(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22( 6, 3H, COCH3), 2.56(t, J=7.4Hz, 2H, -C=CH-CH2-CH(CO2CH3)-), 3.38(s, 3H, CH3OCH2O-), 3.46(t, J=7.SHz, lH, CH(CO2CH3)), 3.73(s, 3H, CO2CH3), 3.92(~, 2H, -OCH2C=CH-), 4.61(s, 2H, -OCH2O-), - sn -5.04(t, J=7.3Hz, lH, -C=CH-CH2-), 5.38(t, J-6.7Hz, lH, -C=CH-CH2- ) -ExamPle 3 C4H~ '-SiO I I ~ C4H9 '-SiO ~ ~ ~
C~3\~\ococl99 CH3\~\
CO2Cl13 To a solution of 1-acetoxy-8-(dimethoxy t-butylsilyl) oxy-3,7-dimethyl-2,6-octadiene (600 mg, 1.84 mmol) in tetrahydrofuran (5 ml) were added under nitrogen atmosphere triphenylphosphine (47 mg, 0.18 mmol) and tetrakis(triphenylphosphine)paradium (81 mg, 0.07 mmol), and the mixture was stirred at room temperature for 15 minutes.
To the mixture was added a sodium salt of methyl acetoacetate in tetrahydrofuran (20 ml) which has been prepared from sodium hydride (92 mg, 8.0~mmolj;and methyl acetoacetate (0.99 ml, 9.20 mmol), and the mixture was`
refluxed overnight. After addition o water (10 ml) and ether (30 ml), the reaction mixture was stirred well, and the organic layer was separated. ~he aqueous layer was extracted with ether (5 mlx2), and the extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a re~idue, which was then subjected to silica gel column chromatography to obtain purified methyl 2-acetyl-10-(dimethyl t-butylsilyl)oxy-5,9-dimethyl-4,8-decadienate (620 mg, 88%).
- 51 - 2~69~
IR(film)cm 1; 2970, 2940, 2910, 2860, 1745, 1722, 1435, 1360, 1250, 1065, 837, 775.
H NMR(CDC13, 250MHz)~ppm; 0.06, (s, 6H, (CH3)2Si), O.90(s, 9H, (CH3)3CSi), 1.59, 1.63(2s, 6H, 2xCH3C=CH-), 1.92-2.15(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.22(s, 3H, -CHCH3), 2.55(t, J=7.4Hz, 2H, -C=CH-CH2-CH(C02CH3)), 3.46(t, J=7.4H~, lH, -CH(CO2CH3)), 3.73(s, 3H, -CO2CH3), 3.99(s, 2H, SiOCH2), 5.04(t, J=6.7Hz, lH, -C=CH-CH2-), 5.33(t, J=6.8Hz, lH, -C=CH-CH2-)-ExamPle 4 O . O
To a solution of methyl 2-acetyl-5,9-dimethyl-10-(2-tetrahydropyranyl)oxy-4,8-decadienate (370 mg, 1.05 mmol) in methylsulfoxide (2 ml) were added sodium chloride (180 mg, 3.08 mmol) and water (0.1 ml), and the mixture was stirred at 150C. After four hours, the reaction mixture was allowed to cool to room temperature, and water (15 ml) was added thereto. The product was extracted with ether (20 mlx2). The extract was dried over Na~SO4, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-(2-tetrahydropyranyl)oxy-5,9-undecadien-2-one (70~).
204~9~
~ 52 -IR(film)cm 1; 2950, 2880, 1720, 1442, 1358, 1120, 1078, 1024, 90s, 870, 815.
lH NMR(CDC13, 250MHz)~ppm; 1.45-l.90(m, 6H, -OCH2-cH2-ca2-ca2-cH(o))r 1.62, 1.65(2s, 6H, (Ca3)C=CH-CH2-CH2-(CH3)c=cH-), 1.96-2.20(m, 4H, -C=CH-CH2-CH2-C=CH-), 2.14(s, 3H, COCH3), 2.26(q, J=7.lHz, 2H, -C=CH-CH2-CH2CO-), 2.46(t, J=7.lHz, 2H, -CH2COCH3), 3.45-3.55(m, lH, OCHaHb-CH2-CH2-CH2-CH(0)), 3.84, 4.10(2d, J=11.5Hz, -OCa2C=CH-), 3.80-3.95(m, lH, CHaHb~cH2-cH2-cH2-)~ 4.60(t, J=3.6Hz, lH, CH(O)), 5.08(t, J=7.lHz, -C=Ca-CH2-CH2-C=CH-), 6.9(t, J=6.9Hz, lH, -C=CH-CH2-CH2-C=ca-)-Example 5 O O
H3COH2CO ¦ ¦ ¦¦ H3COH2CO ¦
To a solution of methyl 2-acetyl-5,9-dimethyl-10-(methoxymethyl)oxy-4,8-decadienate (420 mg, 1.37 mmol) in methylsulfoxide (4 ml) were added sodium chloride (160 mg, 2.74 mmol) and water (0.1 ml), and the mixture was stirred at 150C. After five hours, the reaction mixture was allowed to cool to room temperature, and water (10 ml) was added thereto. The product was extracted with ether (20 mlx2). The extract was dried over Na2S04, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-20~695 (methoxymethyl)oxy-S,9-undecadien-2-one (358 mg, 67%).
IR(film)cm 1; 2940, 1720, 1440, 1358, 1150, 1100, 1050, 920.
~ NMR(CDCl3, 250MHz)~ppm; 1.62, 1.66(2s, 6H, 2xCH3C=CH-), 1.94-2.32(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.14(s, 3H, COCH3), 2.46(t, J=7.3Hz, 2H, -CH2COCH3), 3.38(s, 3~, CH30), 3.92(s, 2H, OCH2C=CH-), 4.61(s, 2H, -OCH2C-), 5.08(t, J=6-1Hz~ lH~ -C=Ca-CH2-), 5.40(t, J=6.7Hz, lH, -C=CHCH2-).
ExamPle 6 C4Hg'-Si0 ~ > C4Hg'-Si0 CH3 ~ CH
To a solution of methyl 2-acetyl-10-(dimethyl t-butylsilyl)oxy-5,9-dimethyl-4,8-decadienate (96 mg, 0.25 mmol) in hexamethylphosphoric triamide (0.5 ml) were added sodium iodide (45 mg, 0.30 mmol) and water (0.01 ml), and the mixture was stirred at 150C. After two hours, the reaction mixture was allowed to cool to room temperature, and water (2 ml) was added thereto. The product was ex-tracted with ether (5 mlx2). The extract was dried over Na2SO4, and concentrated to give a residue, which was then purified with silica gel column chromatography to obtain 6,10-dimethyl-11-(dimethyl t-butylsilyl)oxy-undecadien-2-one (57 mg, 70%).
IR(film)cm 1; 2970, 2950, 2910, 2870, 1725, 1465, 1360, 1255, 1155, 1110, 1070, 837, 775, 662.
H NMR(CDCl3, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(5, 9H, (CH3)3CSi), 1.59, 1.62(2s, 6H, 2x-C=CH-CH2-), 1.92 -2.32(m, 6H, -CH=CH-CH2~CH2-C=CH-CH2-), 2-14(s, 3H, COCH3)~
2.46(t, J=8.7Hz, 2H, CH2COCH3), 4.00(s, 2H, SiOCH2-), 5.08, 5.35(2m, 2H, -C=CH-CH2-x2).
ExamPles 7 and 8 The procedures described in Examples 4-6 were repeated except that methyl 2-acetyl-5,9-dimethyl-10-acetoxy-4,8-decadienate or methyl 2-acetyl-5,9-dimethyl-10-(benzoyl)oxy-4,8-decadienate was employed as a starting material to give 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-one and 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one.
,ExamPle 9 0 ~ > H0 ~
To a solution of 6,10-dimethyl-ll-(2-tetrahydropyranyl) oxy-5,9-undecadien-2-one (362 mg, 1.23 mmol) in a mixture of methanol (5 ml) and water (l ml) was added p toluensulfonic acid (20 mg), and the mixture was stirred at room temperature overnight. After addition of saturated aqueous sodium bicarbonate (20 ml), the product wa~ extracted with ethyl acetate (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel 2~4~69~
column chromatography to provide 2,6-dimethyl-2,6-dodecadien-10-on-1-ol (234 mg, 90%).
IR(film)cm 1; 3430, 2930, 2860, 1715, 1440, 1360, 1160, 1080.
lH NMR(CDCl3+D20, 250MHz)~ppm; 1.62, 1.66(2s, 6H, 2xCH3C=CH-), 1.98-2.34(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.13(s, 3H, COCH3), 2.47(tl J=7.2H~, 2H, -CH2COCH3), 3.98(s, 2H, -CH2OH), 5.06(t, J=7.lHz, lH, -C=CH-CH2-), 5.33(t, J=6.9Hz, lH, -C=CH-CH2-)-Exam~le 10 o C-CH
A solution of 6,10-dimethyl-11-(2-tetrahydropyranyl) oxy-5,9-undecadien-2-one (90 mg, 0.31 mmol) in tetrahydrofuran (5 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (180 mg, 1.95 mmol), and the mixture was warmed to room temperature and stirred for 3 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(2-tetrahydropyranyl)oxy-6,10-dodecadien-1-in-3-ol (75 mg, 75%).
2a~5~9~
IR(film)cm 1; 3440, 3320, 2950, 2880, 2200, 1440, 1450, 13~2, 1360, 1260, 1200, 1180, 1115, 1075, 1020, 905, 865, 810.
H NMR(CDC13, 250MHz)~ppm; 1.50(s, 3H, CH3C(OH)), 1.45 -1 90(m, 8H, OCH2-CH2-CH2-CH2-cH(O)~ CH2C( )~
2xCH3C=CH-), 2.00-2.40(m, 7H, -C=CH-CH2-CH2-C=CH-CH2-, OH), 2.46(s, lH, -C~_C-H), 3.45-3.57(m, lH, -OCHaHb-CH2-), 3.84, 4.10(2d, J=11.5Hz, 2H, OCH2C=CH-), 3.80-3.94(m, lH, -OCHaHb-CH2-), 4.60(t, J=3.4Hz, lH, -OCHO-), 5.19~t, J=6-7Hz~ lH~ -C=CH-CH2-), 5-41(t, J=6.7Hz, lH, -C=CH-CH2_).
Example 11 H3COH2CO ~ > H3COH2CO ~ C-CH
OH
A solution of 6,10-dimethyl-11-(methoxymethyl)oxy-5,9-undecadien-2-one (67 mg, 0.26 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (30 mg, 0.33 mmol), and the mixture was warmed to room temperature and stirred for 3 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over Na2S04 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(methoxymethyl)oxy-6,10-dodecadien-l-in-2~6~
3-ol (61 mg, 83~).
IR(film)cm l; 3450, 3300, 2940, 1445, 1370, 1148, 1045, 918.
H NMR(CDCl3, 250MHz)~ppm; 1.05(s, 3H, CH3C(O)), 1.55 -1.84(m, 9H, 2xCH3C=CH-, OH), 2.00-2.40(m, 6H, -C=CH-CH2-CH2-C=CH-CH2-), 2.46(s, lH, -C--C-H), 3.78(s, 3H, CH30), 3.92(s, 2H, -OCH2C=CH-), 4.61(s, 2H, OCH2O), 5.19(t, ~=6.2Hz, lH, -C=CH-CH2-), 5.41(t, J=6.2Hz, -C=CH-CH2-).
Example 12 C4H9'-SiO ~ C4Hg~-SiO ~ ~
CH3 ~ >CH3\V~ V\~ \C-CH
OH
A solution of 6,10-dimethyl~ (dimethyl t-butylsilyl)oxy-5,9-undecadien-1-one (71 mg, 0.22 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added lithium acetylide ethylenediamine complex (90 mg, 0.98 mmol), and the mixture was warmed to room temperature and stirred for 4 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(dimethyl t-butylsilyl)oxy-6,10-dodecadien-1-in-3-ol (51 mg, 67~).
- 58 - 20~
IR(film)cm 1; 3450, 3320, 2960, 2940, 2910, 2860, 1460, 1360, 1250, 1110, 1065, 835, 775.
H NMR(C~C13, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(s, 9H~ (CH3)3Si), 1.50(s, 3H, -CH2-C(OH)(CH3)-C-H), 1.59, 1.66(2s, 6H, 2xCH3C=CH-), 1.68-1.76(m, 2H, -CH2C(OH)-), 1.94-2.36(m, 7H, -C=CH-CH2-CH2-C=CH-CH2-, OH), 2.46(s, lH, -C_CH), 4.00(s, 2H, OCH2-C=CH-), 5-19(t~ J=7.1Hz, lH~
-C=CH-CH2-), 5.36(t, J=6.9Hz, lH, -C=CH-CH2-).
Example 13 and 14 The procedure described in Example 11 was repeated except that 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-on or 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one was employed as a starting amterial to give 3,7,11-trimethyl-12-acetoxy-6,10-dodecadien-1-in-3-ol and 3,7,11-trimethyl-12-(benzoyl)ox~-6,10-dodecadien-1-in-3-ol.
Example 15 The procedures described in Examples 10 and 12 were repeated except that 2,6-dimethyl-2,6-dodecadien-10-on-1-ol was employed as a starting material to give 2,6,10-trimethyl-2,6-dodecadien-11-in-1,10-diol.
ExamPle 16 o ~yO~ > ~,J~
A solution of 6,10-dimethyl-11-(2-2 0 ~
tetrahydropyran~l) oxy-5,9-undecadien-2-one (80 mg, 0.27 mmol) in tetrahydro~uran (3 ml) was stirred on an ice bath under argon atmosphere. To the solut.ion was added vinylmagnesium bromide in tetrahydrofuran (O.3 ml, 0.3 mmol, 1.0 M), and the mixture was warmed to room temperature and stirred for 10 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(2-tetrahydropyranyl)oxy-1,6,10-undecatrien-3-ol (61 mg, 70%).
IR(film)cm ; 3460, 2950, 2880, 1200, 1118, 1075, 1022, 905, 865, 810.
lH NMR(CDC13, 250MHz)~ppm; 1.28(s, 3H, C(OH)CH3), 1.65 -1.92(m, 8H, -OCH2-CH2-CH2-cH2-cH(O)-~ CH2-C(OH))~ 1-95 -2.40(m, 7H, C=CH-CH2-CH2-C=CH-CH2-, OH), 3.45-3.55(m, lH, -OCHaHb-CH2-), 3.84, 4.10(2d, J=11.6Hæ, 2H, -OCH2C=CH2-), 3.80-3.95(m, lH, -OCHaHb-CH2-), 4.60(t, J=3.4Hz, lH, OCH(O)), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(m, lH, -C=CH-CH2-), 5.22(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.41(t, J=6.3Hz, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2)-ExamPle 17 H3COH2CO ~ ~ H3COH2CO
OH
2Q4~9~
A solution of 6,10-dimeth~l-11-(methoxymethyl)oxy-5,9-undecadien-2-one (60 mg, 0.24 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosphere. To the solution was added vinylmagnesium bromide in tetrahydrofuran (1.0 ml, 1.0 mmol, 1.0 M), and the mixture was warmed to room temperature and stirred for 4 hours. After addition of saturated aqueous ammonium chloride (2 ml), the reaction mixture was extracted with ether. The extract was dried over ~a2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(methoxymethyl)oxy-1,6,10-dodecatrien-3-ol (54 mg, 80%).
IR(film)cm 1; 3480, 2940, 1450, 1370, 1210, 1150, 1100, 1045, 920, 845, 685.
lH NMR(CDC13, 250MHz)~ppm; 1.28(s, 3H, CH3C(OH)), 1.60, 1.66(2s, 6H, 2xCH3-CH=C-), 1.52-1.72(m, 2H, -CH2-C(OH)), 1.95-2.20(m, 7H, -C=CH-CH2-Ca2-C=CH-CH2-, OH), 3.38(s, 3H, CH30), 3.92(s, 2H, -OCH2C=CH-), 4.61(s, 2H, -OCH2O-), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(t, J=7.2Hz, lH, -C=CH-CH2-), 5.20(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.41(t, J=6.9Hz, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2-)~
Example 18 C4H9'-SIiO~A C Hg~-~O~
OH
2~4~
A solution of 6,10-dimethyl-11-(dimethyl-t-butylsilyl) oxy-5,9-undecadien-2-one (48 mg, 0.15 mmol) in tetrahydrofuran (2 ml) was stirred on an ice bath under argon atmosph~re. To the solution was added vinylmagnesium bromide in tetrahydrofuran (10 ml, 1.0 mmol, l.O M), and the mixture was warmed to room temperature and stirrsd for 4 hours. After addition of saturated aqueous ammonium chlo-ride (2 ml), the reaction mixture was extracted with ether.
The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a crude product, which was purified with silica gel column chromatography to obtain 3,7,11-trimethyl-12-(dimethyl-t-butyls~lyl)oxy-1,6,10-dodecatren-1-3-ol t32 mg, 60%).
IR(film)cm 1; 3420, 2970, 2940, 2860, 1462, 1360, 1250, 1150, 1070, 920, 835, 775, 662.
lH NMR(CDCl3, 250MHz)~ppm; 0.06(s, 6H, (CH3)2Si), 0.91(s, 9H, ~CH3)3CSi), 1.2~(s, 3H, -C(OH)(CH3)-CH=CH2), 1.60(s, 6H, 2xCH3C=CH-), 1.46-1.73(m, 3H, -CH2C(OH)(CH3))-, 4.00(s, 2H, SiOCH2-), 5.06(dd, J=1.3, 10.7Hz, lH, -CH=CHaHb), 5.14(m, lH, -C=CH-CH2-), 5.22(dd, J=1.3, 17.4Hz, lH, -CH=CHaHb), 5.36(m, lH, -C=CH-CH2-), 5.92(dd, J=10.7, 17.4Hz, lH, -CH=CH2-)-Example 19 The procedure described in Example 16 was repeated except that 6,10-dimethyl-11-acetoxy-5,9-undecadien-2-one or 6,10-dimethyl-11-(benzoyl)oxy-5,9-undecadien-2-one was employed as a starting material to give 3,7,11-trimethyl-204~S~
12-acetoxy-1,6,10-undecatrien-3-one and 3,7,11-trimethyl-12-~benzoyl)oxy-1,6,10-undecatrien-3-one.
Example 20 The procedures described in Examples 17 and 18 were repeated except that 2,6-dimethyl-2,6-dodecadien 10-on-l-ol was employed as a starting material to give 2,6,10-trimethyl-2,6,11-dodecatrien-1,10-diol.
Exam~le 21 ~ CH0 >
To a solution of 2-(diethylphosphono)isovaleronitrile (6.54 g, 30 mmol) in toluene (55 ml) was added a 0.5 M solution of potassium bis(trimethylsilyl)amide in toluene (56 ml) with stirring on a cooling bath at -70~C. After 30 minutes, geranial t3.80 g, 25 mmol) was added thereto with continuous stirring at the same temperature, and then the reaction mixture was warmed up to room temperature. After addition of water to the mixture, the organic layer was extracted. The organic extract was washed with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride, dried over MgSO4, and filtered. The filtrate was concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=100:1) to give 204~6~
2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitrile (4.87 g, 90%, 2Z:2E=22.4:1).
Spectral data of 2Z compound IR(film)cm 1; 2980, 2940, 2890, 2220, 1640, 1450, 1390, 1375, 1295, 1225, 1105, 1030.
lH NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.8Hz, 6H, CH(CH3)2), 1.61, 1.69(each bs, each 3H, -C=CCH3), 1.83(d, J=1.2Hz, 3H, -C=CCH3)~ 2--12-2(m, 4H, -CH2~H2-), 2.53(hep, J=6.8Hz, lH, CH(CH3)2), 5.08(m, lH, -C=CHCH2-), 6.28, 6.82(each d, J=11.5Hz, each lH, =CH-CH=).
Exam~le 22 /~ ~ ~
To a solution of 2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitril (2Z compound, 217 mg, 1 mmol) in n-hexane (4 ml) was added a 1 M solution of diisobutylaluminium hydride in toluene (2 ml) with stirring under argon atmosphere at -70C. After two-hour-stirring at the same temperature, water (0.8 ml) was added to the mixture followed by removal of the cooling bath and vigorous stirring. The resultant while precipitates were filtered and washed with n-hexane. The filtrate was combined with a 10% aqueous solution of oxalic acid and stirred for 3 hours.
The organic layer was extracted and separated, washed with water, dried over MgSO4, and concentrated.
204~69~
The above manipulation was conducted under argon atmosphere.
The resultant residue was subjected to silica gel column chromatography (~olvent: n-hexane/ethyl acetate=50:1) to obtain the aimed 2-tl-methylethyl)-S,9-dimethyl-2,4,8-decatrienal (198 mg, 90%).
IR(film)cm 1; 2980, 2940, 2880, 1670, 1630, 1455, 1375, 1295, 1235, 1135, 1105, 1075.
NMR(CDC13, 250MHz)~ppm; 1.07(d, J=6.8Hz, 6H, -CH(CH3)2), 1.62, 1.69(each bs, each 3H, -C=CCH3), 1.89(d, J=l.OHz, 3H, -C=CCa3), 2.-12.3(m, 4H, -CH2CH2-), 2.91(hep, J=6.8Hz, lH, -Ca(CH3)2), S.lO(m, lH, =CaCH2-), 6.83, 7.14(each d, J=12.0Hz, each lH, =Ca-CH=), 10.29(s, lH, -CHO~.
Example 23 CHO
CN
~ o a solution of 2-(diethylphosphono)isovaleronitrile (8.72 g, 40 mmol) in toluene (75 ml) was gradually added a 0.5 M solution of potassium bis(trimethylsilyl)amide in toluene (75 ml) with stirring at -70C under argon atmosphere. The cooling bath was removed, and the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was cooled to -70C again, and farnesal (5.88 g, 26.7 mmol) was added thereto with stirring, and the mixture was allowed to warm to room temperature. After addition of water, the organic 204~69~
layer was separated, washed with saturated aqueous sodium bicarbonate and then saturated aqueous sodium chloride, and dried over MgSO4. The organic layer was separated from MgSO4 by filtration and concentrated to give a residue, which was purified with silica gel column chromatography (solvent: n-hexane/ethyl acetate=100:1) to obtain the aimed 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (7.23 g, 96~; 2Z:2E=25.6:1).
SPectral data of 2Z compound IR(film)cm 1; 2980, 2940, 2210, 1640, 1450, 1390, 1290, 1225, 1110, 1030.
NMR(CDC13, 250MHz)~ppm; 1.14(d, J=6.8Hz, 6H, CH~CH3)2), 1.58(bs, 3Hx2, -C=CCH3), 1.65(bs, 3H, -C=CCH3), 1.81(d, J=1.2Hz, 3H, -C=CCH3), 1.9-2.2(m, 8H, -CH2CH2-x2), 2-50(hep~
J=6.8Hz, lH, -CH(CH3)2), 5-06(m, 1~, =CHCH2-), 6-26~ 6-80( each d, J=11.5Hz, each lH, =CH-Ca=~.
ExamPle 24 CN CH~
To a solution of 2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (856 mg, 3.0 mmol) in n-hexane (30 ml) was added a 0.5 M solution of diisobutylaluminium hydride in toluene (6 ml) with stirring at -70C under argon atmosphere. After one hour, water (3 ml) was added, the cooling bath was removed, and the 204~95 reaction mixture was stirred well. Resultant white precipitates were filtered and washed. The filtrate was concentrated to give a residue, which was dissolved in n-hexane (10 ml). The n-hexane so~ution was combined with a 10% aqueou~ solution of oxalic acid (5 ml) and stirred for 3 hours. The organic layer was extracted and separated, washed with water, dried over MgSO4, and concentrated. The resultant residue was subjected to silica gel column chromatography ~solvent: n-hexane/ethyl acetate=10:1) to obtain 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenal (865 mg, 84%).
IR(film)cm 1; 2980, 2940, 2210, 1640, 1450, 1390, 1290, 1225, 1110, 1030.
NMR(CDC13, 250MHz)~ppm; 1.07(d, J=6.8Hz, 6H, -CH(CH3)2), 1.59, 1.61, 1.67(each bs, 3Hx3, -C=CCH3), 1.89(d, J=l.OHz, 3H, -C=CCH3), 2.0-2.2(m, 8H, -CH2CH2-x2), 2.91(hep, J=6.8Hz, lH, -CH(CH3)2), 5.10(m, lH, -C=CCH3), 6.81, 7.16(each d, J=12.0Hz, each lH, =CH-CH=), 10.29(s, lH, -CHO).
ExamPle 25 > HO~
CN CN
To a suspension of selenium dioxide (58 mg) and 2-hydroxybenzoic acid (365 mg) in methylene chloride (10.5 ml) wa~ gradually added an aqueous solution of 80~ t-butyl 204~6~
hydroperoxide (11.6 ml) with stirring on a water bath.
After 30 minutes, 2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (7.56 g, 26.8 mmol)was added to the mixture, which was then allowed to stand at room temperature for 30 hours. Most of the solvent was removed by evaporation in vacuo, and the residue was dissolved in ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried over MgSO4, and concentrated. The resultant residue was subjected to silica gel column chromatography to give the aimed 14-hydroxy-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetr-adecatetraenenitrile (2.53 g, 31%). The starting material was also recovered (3.10 g, 40~) in the column chromatography. The yield of the aimed product based on the consumed starting material was 52%.
IR(film)cm 1; 3450, 2975, 2930, 2880, 2210, 1635, 1445, 1385, 1220, 1020.
NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.7Hz, 6H, CH(CH3)2), 1.62, 1.67(each ~s, each 3H, -C=CCH3), 1.84(d, J=1.2Hz, 3H, -C=CCH3), 2.0-2.2(m, 8H, -CH2CH2-x2), 2.S3(hep, J=6.7Hz, lH, -CH(CH3)2), 3.99(bs, 2H, -CH2OH), 5.11(m, lH, -CHCH2-), 5.39(bt, J=5.5Hz, lH, -CHCH2-), 6.28, 6.83(each d, J=11.5H~, each lH, =CH-CH=).
Exam~le 26 H0 ~ ce~
CN CN
2~6~
To a solution of 14-hydroxy-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenenitrile (904 mg, 3.0 mmol) in carbon tetrachloride (2 ml) was added triphenylphosphine ~1.02 g, 3.9 mmol), and the mixture was heated under reflux f or one hour. Most of carbon tetra-chloride was removed by evaporation in vacuo, and n-hexane was added to the residue. The resultant mixture was f il-tered and washed and the f iltrate was concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=10:1) to obtain the aimed 14~chloro compound (890 mg, 93~).
IR(film)cm ; 2980, 2940, 2880, 2215, 1635, 1445, 1390, 1265, 1025.
NMR(CDC13, 250MHz~ppm; 1.14(d, J=6.8Hz, 6H, CH(CH3)2), 1.59, 1.64(each bs, each 3H, -C=CCH3), 1.81(d, J=l.OHz, 3H, -C=CCa3), 1.9-2.2(m, 8H, -CH2CH2-x2), 2.50(hep, J=6.8Hz, lH, -CH(CH3)2), 3.96(bs, 2H, -CH20H), 5.08(m, lH, -CHCH2-), 5.36(bt, J=5.5Hz, lH, =CHCH2-), 6.25, 6.80(each d, J=11.5Hz, each lH, =CH-CH=).
The following Reference Examples illustrate a method of preparation of sarcophytol A by the use of the compounds obtained in the foregoing Examples.
Reference ExamPle 1 H3COH2CO ~ H3COH2CO ~ CHO
OH
204~69~
A solution of 3,7,11-trimethyl-12-(methoxymethyl)oxy-6,10-dodecadien-1-in-3-ol (175 mg, 0.62 mmol)/ tris (triphenylsilyl)vanadate (49 mg, 0.062 mmol), and benzoic acid (7.6 mg, 0.062 mmol) in xylene (2 ml) was stirred on an oil bath at 140C. After two-hour-stirring, the solution was allowed to cool to room temperature and concentrated. The resultant residue was subjected to silica gel column chromatography to obtain 12-(methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (88 mg, 50%).
IR(film)cm 1; 2950, 1675, 1450, 1385, 1198, 1157, 1120, 1105, 1050, 925, 850.
lH NMR(CDC13, 250MHz)~ppm; 1.57, 1.62, 2.13(each s, each 3H, CH3C=CH-), 1.93-2.30(m, 8H, 2x-C=CH-CH2-CH2-~, 3.33(s, 3H, CH30), 3.88(s, 2H, -OCH2C=CX-), 4.57(s, 2H, -OCH20-), 5.06, 5.36(each m, each lH, -C=CH-CH2-), 5.84(d, J=8.2Hz, lH, -C=CH-CHO), 9.96(d, J=8.2Hz, lH, -C=CH-CHO).
Reference ExamPle 2 H3COH2CO ~ H3COH2CO ~ CHO
OH
A solution of 3,7,11-trimethyl-12-(methoxymeth~l)oxy-1,6,10-dodecatrien-3-ol (460 mg, 1.6 mmol) in dishloromethane (30 ml) was added pyridinium chlorochromate (690 mg, 3.2 mmol), and the mixture was stirred at room temperature for 8 hours. After addition of a mixture of hexane, ethyl acetate, and ether (3:1:1) (lOO
2~4~9~
ml), the mixture was stirred and insoluble materials were filtered. ~he filtrate was concentrated ln vacuo, and the residue was purified with silica gel column chromatography to give 12-(methoxymethyl~oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (233 mg, 52%). The physico-chemical properties of the product was the same as those described in Reference Example 1.
Reference Exam~le 3 H3COH2CO ¦ I i H3COH2CO
CHO >
CN
To a solution of 2-(diethylphosphono)isovaleronitrile (316 mg, 1.44 mmol) in toluene (1 ml) was dropwise added a 1.0 M solution of lithium bis(trimethylsilyl)amide in hexane (1.3 ml, 1.3 mmol) with stirring at -70C. After 30 minutes, 12-(methoxymethyl)oxy-3,7,11-trimethyl-2,6,10-dodecatrienal (130 mg, 0.46 mmol) in toluene (2 ml) was added at the same temperature, and the mixture was allowed to warm to room temperature over about 3 hours. An aqueous ammonium chlo-ride (6 ml) was added and the mixture was extracted with hexane. The extract was dried over Na2SO4 and evaporated in vacuo to remove the solvent to give a residue, which was then subjected to silica gel column chromatography (solvent:
n-hexane/ethyl acetate=20:1) to obtain the aimed 2 204~6~
-(1-methylethyl)-14-(methoxymethyl)oxy-5,9,13-trim0thyl-2,4,8,12-tetraenenitrile (135 mg, 85%).
IR(film)cm ; 2980, 2945, 2900, 2310, 1640, 1150, 1050.
lN NMR(CDC13, 250MHz)~ppm; 1.17(d, J=6.8Hz, 6H, (CH3)2CH-), 1.61, 1.67, 1.84(each s, each 3H, CH3C=CH-), 1.96-2.21(m, 8H~ -C=CH-CH2-CH2-C=CH-CH2-CH2-)~ 2.53(hep, J=6.8Hz, lH, -CH(CH3)2), 3.38(s, 3H, CH30-), 3.92(s, 2H, -OCH2O-), 4.62~s, 2H, -Q-CH2-C=CH-), 5.10(brs, lH, -C=CH-), 5.42(brt, J=6.4H~, lH, -C=CH-), 6.28, 6.82(each d, J=11.5Hz, each lH, -C-CH-CH=C(CN)-).
~eference Example 4 H3COHaC0 ~ ~ H0 ~
CN CN
To the product obtained in Reference Example 3 (135 mg, 0.39 mmol) in methanol (5 ml) was added a trace amount of conc. HCl, and the mixture was heated with stirring at 60C for 6 hours. After addition of saturated aqueous sodium bicarbonate (20 ml), the reaction mixture was extracted with ether (20 mlx2). The extract was dried over MgSO4 and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography (solvent: n-hexane/ether=5:1) to obtain the 14-hydroxy compound (96 mg, 82%).
IR(film)cm 1; 3460, 2980, 2930, 2210, 1635, 1450, 1020.
2~4569~
H NMR(CDCl3, 250MHz)~ppm; 1.14(d, J=6.8Hz, 6H, (CH3)2CH-), l.S8(m, 4H, CH3C=CH-, -OH), 1.65(s, 3H, Ca3C=CH-), 1.81(d, J=l.lHz, 3H, CH3C=CH-), 1.92-2.25(m, 8H, -2 CH2 (CH3)C=CH-Ca2-Ca2-), 2.51(hep, J=6.8Hz lH
(CH3)2CH-), 3.97(d, J=5.9Hz, 2H, CH2OH), 5.08(brs, lH, -C=CH-), 5.36(m, lH, -C=CH-), 6.26, 6.80(each d, J=ll.SHz, each lH, -C=CH-CH=C(CN)).
Reference Example 5 H0 ~ > H0 ~
CN , CH0 To the hydroxy compound obtained in Reference Example 4 in toluene (S ml) was dropwise added a 1 M
solution of diisobutylaluminium hydride in toluene (2.0 ml, 2.0 mmol) at -70C under argon atmosphere. After two-hour-stirring at -70C, a 1 M aqueous solution of oxalic acid (4.0 ml) was added, and the mixture was allowed to warm gradually to room temperature with stirring under argon atmosphere. The organic layer was washed with water and saturated aqueous sodium bicarbonate, dried over Na2SO4, and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography (solvent: n-hexane/eth~l acetate=7:1) to obtain the aimed formyl compound.
IR(film)cm 1; 3430, 2960, 2920, 2870, 1670, 1630, 1450, 1390, 1295, 1230, 1130, 1070, 1010.
73 204~695 lH NMR(CDC13, 250MHz)~ppm; 1.04(d, 6H, J=6.8Hz, -CH(CH3)2), 1.59(d, J=0.6Hz, 3H, CH3-C=), 1.63(brs, 3H, CH3-C=), 1.86(d, J=1.2Hz, 3H, CH3-C=), 1.7-2.2(m, 8H, -CH2CH2-), 2.88(hep.J=6.8Hz, lH, -CH(CH3)2), 3.95(brs, 2H~ -CH2OH)~
5.09(m, lH, -CH2CH=), 5.38~brt, J-6.8Hz, lH, -CH2CH=), 6.80(d, J=12.0Hz, lH, =CH-CH=), 7.11(d, J=12.0Hz, lH, =CH-CH=), 10.25(s, lH, -CHO).
7 2~
~eference ExamPle 6 ~0~ > C~
C~0 CH0 ~ solution of dry lithium chloride (64 mg, 1.5 mmol), 2, 6-lutidine (0.23 ml, 2.0 mmol) and hydroxy formyl compound (305 mg, 1.0 mmol) in dimethylformamide (1.0 ml) was chilled on an ice water bath and mixed with methane-sulfonyl chloride (160 mg, 1.4 mmol) with stirring in argon atmosphere. About 8 hours later, the starting material was confirmed to disappear, and the reaction mixture was dis-solved in water and ether. The organic layer was washed with water, dried over magnesium sulfate and concentrated.
The residue was chromatographed on a column of silica gel eluting with n-hexane: ethyl acetate (15:1) as an eluent to give the objective chloroformyl com~ound (281 mg, 87%).
IR (film)cm- ; 2970, 2930, 2880, 1670, 1630, 1445, 1390, 1295, 1265, 1135.
MMR (CDC13, 250MHz)~ppm; 1.04 (d, J = 7.0Hz, 6H, -CH(CH3)2), 1.59, 1.70 (each bs, each 3H, -C = CCH3), 1.87 (d, J = 1.3Hz, 3H, - C = CCH 3), 1.9 - 2.2 (m, 8H, -CH2CH2-), 2.89 (hep, J = 7.0 Hz, lH, - CH(CH3)2), 3.98 (bs, 2H2, - CH2Cl), 5.09 (m, lH, - C = CHC H2-), 5.47 (bt, J =
6.5Hz, lH, - C = CHCH2-), 6.82 (d, J = 12.0Hz, lH, - C = CH
2Q~6~
- CH = C(CHO) -), 7.11 (d, J = 12.0Hz, -C = CH - CH -C~CHO)-), 10.27 ts, lH, - CHO).
Reference Exam~l~ 7 ce~ ~ > c~
To a solution of the nitrile (14-chloro-2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraene-nitril)(890 mg, 2.78 mmol) in n-hexane (30 ml) was dropwise added gradually a lM solution (4.2 ml) of diisobutylaluminum hydride in toluene at -70C under argon atmosphere. One hour later, 2 ml of water was added to the mixture, and the bath was removed. The reaction mixture was vigorously stirred, and the resultant solid was filtered and washed with n-hexane. ~he resultant filtrate was stirred still with 10% oxalic acid. The organic layer was washed, dried, filtered and concentrated. The residue was chromatographed on a column of silica gel eluting with n-hexane: ethyl acetate (20 : 1) to give the objective formyl compound (781 mg, 87%).
IR(film)cm 1; 2970, 2930, 2880, 1670, 1630, 1445, 1390, 1295, 1265, 1135.
NMR(CDC13, 250MHz)~ppm; 1.04(d, J=7.0Hz, 6H, -CH(CH3)2), 1.~9, 1.70(each bs, each 3H, -C=CCH3), 1.87(d, J=1.3Hz, 3H, -C=CCH3), 1.9-2.2(m, 8H, -CH2CH2-), 2.89(hep, J=7.OHz, lH, -CH(CH3)2), 3.98(bs, 2H, -CH2Cl), 5.09(m, lH, -C=CHCH2-), 2a4~59~
5.47(bt, J=6.5Hz, lH, -CH=CHCH2-), 6.82(d, J-12.0Hz, lH, -C=CH-CH-C(CHO)-), 7.11(d, J-12.OHz, -C=CH-CH=C(CHO)-), 10.27( 6, lH, -CHO~.
Reference Example 8 C~ ~ ce i CHO CN
OSi(CH3)3 The above formyl compound, 14-chloro-2~
methylethyl)-5,9,13-trimethyl-2,4,8,12-tetradecatetraenal (640 mg, 2.0 mmol) was dissolved in trimethylsilylnitril (0.35 ml, 2.6 mmol). To the solution on an ice-water bath was added with stirring under argon atmosphere a trace amount of potassium cyanide/18-crown 6-ether complex. Two hours later, disappearance of the starting compound was confirmed. Excessive trimethylsilylnitrile was evaporated off to obtain crude 15-chloro-3-(1-methylethyl)-6,10,14-trimethyl-2-(trimethylsiloxy)-3,5,9,13-pentadecatetraenenitrile (647 mg, quantitative).
IR(film)cm 1; 2960, 2930, 2880, 2320, 1445, 1255, 1080, 875, 845.
NMR(CDC13, 250MHz)~ppm; 1.11, 1.15(each d, J=6.9Hz, each 3H, -CH(CH3)2), 1.60, 1.71, 1.77(each s, each 3H, -C=CCH3), 1-9-2-2(m~ 8H, -CH2CH2-), 2-64(hep, J=6.9Hz, lH, -CH(CH3)2, 3.99( 8 , lH, -CH2Cl), 5.11(m, lH, -C=CHCH2-), 5.33(s, lH, -CHCN), 5.48(bt, J=6.5Hz, lH, -C=CHCH2-), 6.04, 6.25(each d, J=11.3Hz, each lH, -C=CH-CH=C-).
204~fi9~
Reference Example 9 'C~
,/~CN
OSi (CH9) 3 ~ ~ k \~<CN + ~ ~<Cl~
OSi (CH3) 3 ~ / OH
A solution of the crude cyanohydrine trimethyl-5ilyl ether (647 mg, 2.00 mmol if it is 100% pure), which was obtained in Reference Example 8 in tetrahydrofuran (25 ml) was dropwise added with stirring at 50-55C under argon atmosphere over 30 minutes to a solution of lM lithium bis(trimethylsilyl)amide in tetrahydrofuran, which had been diluted with 25 ml of tetrahydrofuran. After completion of the dropwise addition, the tetrahydrofuran was evaporated off in vacuo, and the residue was dissolved in ethyl ether (30 ml), and the solution was washed with cooled lN HCl, water, and then saturated aqueous sodium chloride. The organic layer was dried over MgSO4 and then concentrated to give a residue, which was then subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=50:1-5:1) to obtain the aimed cyclized 2-(1-methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraen-1-2Q4~9~
carbonitrile (496 mg, 64%) and desilylated analogue (56 mg, 9%) .
NMR s~ectrum of l-trimethYlsiloxY comPound NMR(CDC13, 250MHz)~ppm; 0.23(s, 9H, -Si(CH3)3), 1.09, 1.15(each d, J=6.7Hz, each 3H, -CH(C ~ )2)' 1.50, 1.62(each bs, each 3H, -C=CCH3), 1.70(d, J=1.3Hz, 3H, -C=CCH3), 2-0-2-2(m, 8H, -CH2CH2-), 2-51(hep, J=6.7Hz, lH, -CH(CH3)2), 2.55, 2.65(each d, J=14.2Hz, each lH, -CHa Hb CN-), 4.94(bt, J=6.lHz, lH, -C=CHCH2-), 5.15(bt, J=5.6Hz, lH, -C=CHCH2-), 6.17, 6.44(each d, J=11.8Hz, each lH, -C=CH-CH=C-).
NMR sPeCtrum of l-hvdroxy comPound NMR(CDC13, 25OMHz)~ppm; 1.15, l.l9(each d, J=6.7Hz, each 3H, CH(CH3)2), 1.55, 1.63, 1.69(each s, each 3H, CH3-C=C-), 1.94-2.35(m, 8H, CH2-C=C-), 2.51(hep, J=6.7Hz, lH, CH(CH3)2), 2.66, 2.73(each d, J=14.1Hz, 2H, CHa Hb CCN), 2.89(brs, lH, OH), 4.93, 5.24(each brt, J=5.3Hz, each lH, -C=CH-CH2-), 6.22, 6.42(each d, J=ll.lHz, each lH, -C=CH-CH=C-).
Reference ExamPle 10 ~ /~
Si(CH3)3 ~ ~
The above cyanohydrine trimethylsilyl ether compound, 2-(1-methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraen-1-2 0 ~
carbonitrile (657 mg, 1.7 mmol) was dissolved in 10% aqueous tetrahydrofuran (10 ml). To the solution on an ice-water bath was added a solution of lM tetra n-butylammonium fluoride in tetrahydrofuran (0.02 ml)~ and the mixture was stirred and then allowed to stand at room temperature for 2 days. Most of the tetrahydrofuran was removed in vacuo and the residue was dissolved in ethyl ether. The ether layer was dried over MgS04, filtered, concentrated, and subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=30:1) to obtain the ketone compound, 2 -(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-cyclotetradecatetraen-1-one (411 mg, 85~).
Reference Example ll > ~ OH
To the above ketone compound, 2-(1-methylethyl)-S,9,13-trimethyl-2,4,8,12-cyclotetradecatetraen-l-one (137 mg, 0.48 mmol) in dry toluene (2.5 ml) was dropwise added with stirring on a cooling hath at -70C a solution of lM
diisobutyl aluminium hydride in toluene (0.6 ml). One hour later, disappearance of the starting material was confirmed.
After addition of water (0.25 ml) and removal of the cooling bath, the reaction mixture was stirred, followed by drying over MgS04, filtration, and concentration to give a residue, 2~ 6~
which was subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=12:1) to obtain the aimed sarcophytol A (125 mg, 88%)~
Reference Exam~le 12 Lithium aluminium hydride (80.0 mg, 2.11 mmol) was added to diethyl ether (S ml) under argon atmosphere, and the mixture was stirred. To the suspension was dropwise added at room temperature over 5 minutes a solution of (lR,2S)-(-)-N-methylephedrine (308 mg, 2.12 mmol) in diethyl ether (5 ml). After one hour reflux of the reaction mixture with stirring, N-ethylaniline (0.53 ml, 4.23 mmol) was dropwise added thereto over 5 minutes, and the mixture was refluxed with stirring additional one hour. The mixture was then cooled to -72C, and a solution of the ketone compound (136 mg, 0.475 mmol) obtained in Reference Example 10 in diethyl ether (3 ml) was gradually added thereto, and the mixture was stirred for 6 hours at -72C. After addition of lN HCl (9 ml), the organic layer was separated, washed with 3N HCl (5 mlx2~, and dried over Na2SO4. Removal of the solvent in vacuo gave a residue, which was then subjected to silica gel column chromatography to give optically active ~arcophytol A (81 mg, 60%) and nonreacted ketone compound (51 mg, 37%).
Optical purity of the optically active sarcophytol A was determined to be 87% by means of high pressure liquid chromatography u~ing a separation column for optical isomers, specifically CHIRALCELL OD (commercially available 204~
from Daisel Kagaku Kogyo), said analysis being referred to as "HPLC analysis using CHIRALCELL OD~ hereinafter.
Reference Example 13 A solution of lithium aluminum hydride in diethyl ether (2.26 ml, 1.40 mmol, 0.62M) was stirred under argon atmosphere. To the solution was dropwise added (S)-2-(anilinomethyl)pyrolidine (296 mg, 1.68 mmol) in diethyl ether (3 ml) at room temperature over 10 minutes.
The reaction mixture was stirred at room temperature addi-tional one hour and then cooled to 72C. To the mixture was gradually added the ketone compound (162 mg, 0.56 mmol)in diethyl ether (5 ml), which had been prepared in Reference Example 10. After one hour stirring at -72C, saturated aqueous sodium bicarbonate (1 ml) was added, and the mixture was stirred at room temperature for 10 minutes.
After addition of lN HCl (15 ml) and diethyl ether (20 ml), the organic layer was separated. The aqueous layer was extracted with diethyl ether (20 ml), and the extract was washed with saturated aqueous sodium chloride (20 ml), dried over Na2SO4, and evaporated in vacuo to remove the solvent.
The resultant residue was subjected to silica gel column chromatography to obtain optically active sarcophytol A (126 mg, 78%).
Optical purity of the thus obtained sarcophytol A
was 92% when measured by HPLC analysis using CHIRALCELL OD.
[~] 4D: +209.9 (c=0.372, CHCl3) Reference Example 14 2~4~35 A solution of lithium aluminium hydride in diethyl ether (2.94 ml, 2.0 mmol, 0.68M) was stirred under argon atmosphere, and to the solution was gradually added (S)-2-(2,6-xylidinomethyl)pyrrolidine (490 mg, 2.4 mmol) at room temperature, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled to -74C, and to the mixture was dropwise added over 10 minutes a solution of the ketone compound (69 mg, 0.24 mmol) in diethyl ether (3 ml), which had been prepared in Reference Example 10. After one hour stirring at -74C, saturated aqueous sodium sulfonate (1 ml) was added, and the resultant mixture was stirred at room temperature for a while. After addition of diethyl ether (10 ml) and diluted HCl l20 ml), the organic layer was separated, and the aqueous layer was extracted with diethyl ether (20 ml). The extract was washed with saturated aqueous sodium chloride (20 ml), dried over Na2SO4, and evaporated in vacuo to remove the solvent to give a residue, which was subjected to silica gel column chromatography to obtain optically active sarcophytol A (61 mg, 88%).
Optical purity of the optically active sarcophytol A was 93% according to HPLC analysis using CHIRALCELL OD.
~] D: +204.4 (c=0.27, CHCl3) Reference ExamPle 15 A suspension of tin (II) chloride (382 mg, 2.01 mmol) and (R)-1-methyl-2-(piperidinomethyl)pyrrodine (366 mg, 2.01 mmol) in dichloromethane (6 ml) was cooled to -72C
20~95 ~ 83 -under argon atmosphere. To the suspension was added diisobutylaluminum hydride in toluene (1.0 mmol), and the mixture was stirred for ten minutes. To the mixture was gradually added at -72C a solution of the ketone compound ~100 mg, 0.349 mmol) in dichloromethane (3 ml). The reaction mixture was stirred for 4 hours, and the stirring was continued at room temperature for 30 minutes after addition of saturated aqueous sodium chloride (3 ml).
Resultant precipitates were filtered by the use of sellite, and the filtrate was dried over Na2SO4 and evaporated in vacuo to remove the solvent. The resultant residue was purified with silica gel column chromatography to give optically active sarcophytol A (79.2 mg, 79%).
Optical purity of the sarcophytol A thus obtained was 42% according to HPLC analysis using CHIRALCELL OD.
[a]25D: +101.9 (c=0.54, CHCl~) Industrial UtilitY
As stated above, the compounds (I) of the present invention are very useful as intermediates for preparing sarcophytol A which possesses an anti-carcinogenic promotor activity and anti-tumor activity. Thus, the present invention pro~ides a method suitable for industrial production of sarcophytol A.
Claims
1. Acyclic terpene compounds of the general formula (I):
(I) [wherein R is a group of formula:
, or (wherein R1 is cyano group or formyl group; R2 is a hydrogen atom or -CO2R3; R3 is C1 - C4 alkyl group; R4 is -C?CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -OR5 or -OSO2R6 (wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, silyl group substituted with C1 - C5 alkyl group or phenyl group; R6 is C1 - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C1 - C4 alkyl group); and n is an integer of 0 to 2 with the proviso that when R is a group of formula:
or X must be -OR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 is 1-ethoxyethyl group, R3 is not a methyl group].
(I) [wherein R is a group of formula:
, or (wherein R1 is cyano group or formyl group; R2 is a hydrogen atom or -CO2R3; R3 is C1 - C4 alkyl group; R4 is -C?CH or -CH=CH2 ); X is a hydrogen atom, hydroxyl group, a halogen atom, or a group of formula: -OR5 or -OSO2R6 (wherein R5 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group, silyl group substituted with C1 - C5 alkyl group or phenyl group; R6 is C1 - C4 alkyl group optionally substituted with halogen atom, or phenyl group optionally substituted with C1 - C4 alkyl group); and n is an integer of 0 to 2 with the proviso that when R is a group of formula:
or X must be -OR5 and n must be 0; when R1 is formyl group, X
is not a halogen atom or -OS02R6; when R5 is a hydrogen atom, R6 is not a hydrogen atom; and when R5 is 1-ethoxyethyl group, R3 is not a methyl group].
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP309796/1989 | 1989-11-29 | ||
JP30979689A JPH03170448A (en) | 1989-11-29 | 1989-11-29 | Chain terpene compounds |
JP162439/1990 | 1990-06-20 | ||
JP16243990A JPH0454141A (en) | 1990-06-20 | 1990-06-20 | Chain terpene compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2045695A1 true CA2045695A1 (en) | 1991-05-30 |
Family
ID=26488236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2045695 Abandoned CA2045695A1 (en) | 1989-11-29 | 1990-11-29 | Substituted-acyclic terpene compound |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2045695A1 (en) |
-
1990
- 1990-11-29 CA CA 2045695 patent/CA2045695A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Furuta et al. | Regio-and stereocontrolled synthesis of allenic and acetylenic derivatives. Organotitanium and boron reagents. | |
CN100406451C (en) | Method for preparing prostaglandin derivatives and raw materials thereof | |
Solladié et al. | Enantioselective synthesis of haminol-1, an alarm pheromone of a Mediterranean mollusc | |
EP0021775B1 (en) | Synthesis of 1rs,4sr,5rs-4-(4,8-dimethyl-5-hydroxy-7-nonen-1-yl)-4-methyl-3,8-dioxabicyclo(3.2.1)octane-1-acetic acid and intermediates | |
Ito et al. | Highly stereoselective reformatsky reactions of 3-(2-Bromopropionyl)-2-oxazolidone derivatives with various aldehydes | |
US5324869A (en) | Substituted-acyclic terpene compound | |
CA2045695A1 (en) | Substituted-acyclic terpene compound | |
US5245085A (en) | Substituted-acyclic terpene compound | |
US5354874A (en) | Substituted-acyclic terpene compound | |
EP0455826A1 (en) | Substituted open-chain terpene compound | |
Honda et al. | A novel synthetic method of optically pure α-substituted aldehyde acetals by the use of reductive 1, 2-rearrangement | |
EP0439058B1 (en) | Acyclic terpenes | |
EP0462616A2 (en) | Conjugated diene compounds, process for producing these compounds and use thereof | |
US5399724A (en) | Acyclic terpene compound | |
US4235779A (en) | Bicyclic lactones | |
Hajos et al. | Total synthesis of (1RS, 4SR, 5RS)-4-(5-hydroxy-4, 8-dimethyl-7-nonen-1-yl)-4-methyl-3, 8-dioxabicyclo [3.2. 1] octane-1-acetic acid from geraniol | |
JPS6411620B2 (en) | ||
JPH10101614A (en) | Method for producing α, α-difluoro-β-hydroxyester | |
JPH04283533A (en) | Chain terpenes | |
JPH03170449A (en) | Chain terpenes having conjugated diene | |
JPH03170448A (en) | Chain terpene compounds | |
CN113853378A (en) | Process and intermediates for preparing eldecalcitol | |
JPH0586768B2 (en) | ||
JPH0859607A (en) | Production of prostaglandin e1 compound and synthetic intermediate therefor | |
JPH04305548A (en) | Halogeno allyl alcohol derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |