CA2035967A1 - Oxetanones - Google Patents
OxetanonesInfo
- Publication number
- CA2035967A1 CA2035967A1 CA002035967A CA2035967A CA2035967A1 CA 2035967 A1 CA2035967 A1 CA 2035967A1 CA 002035967 A CA002035967 A CA 002035967A CA 2035967 A CA2035967 A CA 2035967A CA 2035967 A1 CA2035967 A1 CA 2035967A1
- Authority
- CA
- Canada
- Prior art keywords
- oxetanones
- formula
- beta
- inhibiting
- description
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Novel pancreas lipase-inhibiting oxetanones of the formula (see formula I) wherein Q, R1 and R2 have the significance given in the description, are manufactured starting from corresponding .beta.-hydroxycarboxylic acids.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH60490 | 1990-02-26 | ||
CH604/90 | 1990-02-26 | ||
CH4005/90 | 1990-12-17 | ||
CH400590 | 1990-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2035967A1 true CA2035967A1 (en) | 1991-08-27 |
CA2035967C CA2035967C (en) | 2001-10-16 |
Family
ID=25685091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002035967A Expired - Fee Related CA2035967C (en) | 1990-02-26 | 1991-02-07 | Oxetanones |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0444482B1 (en) |
JP (1) | JP2753403B2 (en) |
KR (1) | KR0183036B1 (en) |
AT (1) | ATE133167T1 (en) |
AU (1) | AU645291B2 (en) |
CA (1) | CA2035967C (en) |
DE (1) | DE59107262D1 (en) |
DK (1) | DK0444482T3 (en) |
ES (1) | ES2082869T3 (en) |
FI (1) | FI115054B (en) |
GR (1) | GR3019618T3 (en) |
HU (1) | HU218272B (en) |
IE (1) | IE72196B1 (en) |
IL (1) | IL97148A (en) |
MC (1) | MC2226A1 (en) |
NO (1) | NO177055C (en) |
NZ (1) | NZ237170A (en) |
PT (1) | PT96887B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
NL1004559C2 (en) * | 1996-11-18 | 1998-05-19 | Unilife | Butter. |
JP2003524685A (en) * | 1999-10-29 | 2003-08-19 | ムリンズ、ジョーン、ジェイソン、ジェントリー | Oxetanone derivatives |
US6342519B2 (en) * | 1999-10-29 | 2002-01-29 | 2 Pro Chemical | Oxetanone derivatives |
US6348492B1 (en) * | 1999-10-29 | 2002-02-19 | 2Pro Chemical | Oxetanone derivatives |
US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
DE102004009076A1 (en) * | 2004-02-23 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Alkylcarbamate-substituted β-lactones, processes and intermediates for their preparation, and medicaments containing these compounds |
US8258321B2 (en) | 2007-10-31 | 2012-09-04 | Burnham Institute For Medical Research | Beta-lactone compounds |
EP3651784B1 (en) * | 2017-07-12 | 2022-09-28 | Mayo Foundation for Medical Education and Research | Compounds for the reducing lipotoxic damage |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS608117B2 (en) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | New physiologically active substance esterastin and its production method |
GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
JPH0669130B2 (en) * | 1984-08-09 | 1994-08-31 | 三菱電機株式会社 | Delay line |
-
1991
- 1991-02-05 IL IL9714891A patent/IL97148A/en active IP Right Grant
- 1991-02-07 CA CA002035967A patent/CA2035967C/en not_active Expired - Fee Related
- 1991-02-15 DE DE59107262T patent/DE59107262D1/en not_active Expired - Fee Related
- 1991-02-15 ES ES91102151T patent/ES2082869T3/en not_active Expired - Lifetime
- 1991-02-15 DK DK91102151.7T patent/DK0444482T3/en not_active Application Discontinuation
- 1991-02-15 AT AT91102151T patent/ATE133167T1/en not_active IP Right Cessation
- 1991-02-15 EP EP91102151A patent/EP0444482B1/en not_active Expired - Lifetime
- 1991-02-20 AU AU71228/91A patent/AU645291B2/en not_active Ceased
- 1991-02-20 HU HU61/91A patent/HU218272B/en not_active IP Right Cessation
- 1991-02-20 NZ NZ237170A patent/NZ237170A/en unknown
- 1991-02-21 MC MC912172A patent/MC2226A1/en unknown
- 1991-02-22 JP JP3131730A patent/JP2753403B2/en not_active Expired - Fee Related
- 1991-02-25 NO NO910729A patent/NO177055C/en unknown
- 1991-02-25 IE IE63191A patent/IE72196B1/en not_active IP Right Cessation
- 1991-02-26 PT PT96887A patent/PT96887B/en not_active IP Right Cessation
- 1991-02-26 FI FI910925A patent/FI115054B/en not_active IP Right Cessation
- 1991-02-26 KR KR1019910003075A patent/KR0183036B1/en not_active IP Right Cessation
-
1996
- 1996-04-09 GR GR960401013T patent/GR3019618T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2035967C (en) | 2001-10-16 |
NO910729D0 (en) | 1991-02-25 |
FI910925A (en) | 1991-08-27 |
HU218272B (en) | 2000-07-28 |
DK0444482T3 (en) | 1996-05-06 |
JPH0770099A (en) | 1995-03-14 |
IL97148A (en) | 1996-11-14 |
EP0444482A3 (en) | 1991-12-04 |
IE910631A1 (en) | 1991-08-28 |
HUT56557A (en) | 1991-09-30 |
ES2082869T3 (en) | 1996-04-01 |
IE72196B1 (en) | 1997-03-26 |
PT96887B (en) | 1998-09-30 |
PT96887A (en) | 1991-10-31 |
IL97148A0 (en) | 1992-05-25 |
ATE133167T1 (en) | 1996-02-15 |
NO177055C (en) | 1995-07-12 |
FI115054B (en) | 2005-02-28 |
KR910021391A (en) | 1991-12-20 |
NO910729L (en) | 1991-08-27 |
KR0183036B1 (en) | 1999-05-01 |
FI910925A0 (en) | 1991-02-26 |
AU645291B2 (en) | 1994-01-13 |
GR3019618T3 (en) | 1996-07-31 |
NZ237170A (en) | 1993-12-23 |
JP2753403B2 (en) | 1998-05-20 |
MC2226A1 (en) | 1993-02-02 |
EP0444482B1 (en) | 1996-01-17 |
AU7122891A (en) | 1991-08-29 |
NO177055B (en) | 1995-04-03 |
DE59107262D1 (en) | 1996-02-29 |
EP0444482A2 (en) | 1991-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |