AU7122891A - Oxetanones - Google Patents

Oxetanones

Info

Publication number
AU7122891A
AU7122891A AU71228/91A AU7122891A AU7122891A AU 7122891 A AU7122891 A AU 7122891A AU 71228/91 A AU71228/91 A AU 71228/91A AU 7122891 A AU7122891 A AU 7122891A AU 7122891 A AU7122891 A AU 7122891A
Authority
AU
Australia
Prior art keywords
oxetanones
novel
formula
image
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU71228/91A
Other versions
AU645291B2 (en
Inventor
Romano Derungs
Hans Peter Marki
Henri Stalder
Andre Szente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU7122891A publication Critical patent/AU7122891A/en
Application granted granted Critical
Publication of AU645291B2 publication Critical patent/AU645291B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Novel oxetanones inhibiting pancreatic lipase, of the formula <IMAGE> in which Q, R<1> and R<2> have the meaning given in the description, are disclosed, which are prepared starting from the corresponding beta -hydroxycarboxylic acids.
AU71228/91A 1990-02-26 1991-02-20 Oxetanones Ceased AU645291B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH60490 1990-02-26
CH604/90 1990-02-26
CH400590 1990-12-17
CH4005/90 1990-12-17

Publications (2)

Publication Number Publication Date
AU7122891A true AU7122891A (en) 1991-08-29
AU645291B2 AU645291B2 (en) 1994-01-13

Family

ID=25685091

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71228/91A Ceased AU645291B2 (en) 1990-02-26 1991-02-20 Oxetanones

Country Status (18)

Country Link
EP (1) EP0444482B1 (en)
JP (1) JP2753403B2 (en)
KR (1) KR0183036B1 (en)
AT (1) ATE133167T1 (en)
AU (1) AU645291B2 (en)
CA (1) CA2035967C (en)
DE (1) DE59107262D1 (en)
DK (1) DK0444482T3 (en)
ES (1) ES2082869T3 (en)
FI (1) FI115054B (en)
GR (1) GR3019618T3 (en)
HU (1) HU218272B (en)
IE (1) IE72196B1 (en)
IL (1) IL97148A (en)
MC (1) MC2226A1 (en)
NO (1) NO177055C (en)
NZ (1) NZ237170A (en)
PT (1) PT96887B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644846B2 (en) * 1990-02-23 1993-12-23 F. Hoffmann-La Roche Ag Process for the preparation of oxetanones

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
NL1004559C2 (en) * 1996-11-18 1998-05-19 Unilife Butter.
CA2358921A1 (en) * 1999-10-29 2001-05-10 John Jason Gentry Mullins Oxetanone derivatives
US6342519B2 (en) * 1999-10-29 2002-01-29 2 Pro Chemical Oxetanone derivatives
US6348492B1 (en) * 1999-10-29 2002-02-19 2Pro Chemical Oxetanone derivatives
DE102004009076A1 (en) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamate-substituted β-lactones, processes and intermediates for their preparation, and medicaments containing these compounds
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
US8258321B2 (en) 2007-10-31 2012-09-04 Burnham Institute For Medical Research Beta-lactone compounds
WO2019014434A1 (en) * 2017-07-12 2019-01-17 Mayo Foundation For Medical Education And Research Compounds for the reducing lipotoxic damage

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608117B2 (en) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 New physiologically active substance esterastin and its production method
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
JPH0669130B2 (en) * 1984-08-09 1994-08-31 三菱電機株式会社 Delay line

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644846B2 (en) * 1990-02-23 1993-12-23 F. Hoffmann-La Roche Ag Process for the preparation of oxetanones

Also Published As

Publication number Publication date
IE72196B1 (en) 1997-03-26
FI115054B (en) 2005-02-28
HUT56557A (en) 1991-09-30
ATE133167T1 (en) 1996-02-15
IL97148A0 (en) 1992-05-25
MC2226A1 (en) 1993-02-02
NO177055B (en) 1995-04-03
CA2035967A1 (en) 1991-08-27
NO910729D0 (en) 1991-02-25
DK0444482T3 (en) 1996-05-06
KR910021391A (en) 1991-12-20
GR3019618T3 (en) 1996-07-31
IE910631A1 (en) 1991-08-28
HU218272B (en) 2000-07-28
JP2753403B2 (en) 1998-05-20
FI910925A (en) 1991-08-27
JPH0770099A (en) 1995-03-14
PT96887A (en) 1991-10-31
AU645291B2 (en) 1994-01-13
IL97148A (en) 1996-11-14
PT96887B (en) 1998-09-30
EP0444482A3 (en) 1991-12-04
EP0444482B1 (en) 1996-01-17
EP0444482A2 (en) 1991-09-04
NO177055C (en) 1995-07-12
DE59107262D1 (en) 1996-02-29
CA2035967C (en) 2001-10-16
FI910925A0 (en) 1991-02-26
KR0183036B1 (en) 1999-05-01
NZ237170A (en) 1993-12-23
ES2082869T3 (en) 1996-04-01
NO910729L (en) 1991-08-27

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