CA2030875A1 - Methods and probes for detecting nucleoside transporter and method for producing the probes - Google Patents

Methods and probes for detecting nucleoside transporter and method for producing the probes

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Publication number
CA2030875A1
CA2030875A1 CA 2030875 CA2030875A CA2030875A1 CA 2030875 A1 CA2030875 A1 CA 2030875A1 CA 2030875 CA2030875 CA 2030875 CA 2030875 A CA2030875 A CA 2030875A CA 2030875 A1 CA2030875 A1 CA 2030875A1
Authority
CA
Canada
Prior art keywords
probes
substituted
halogen
methods
nucleoside transporter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2030875
Other languages
French (fr)
Other versions
CA2030875C (en
Inventor
Alan R.P. Paterson
Carol E. Cass
Wendy P. Gati
James D. Craik
Morris J. Robins
James S. Wiley
Gary Jamieson
William H. Sawyer
John K. Buolamwini
David P. Mcadam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
University of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta filed Critical University of Alberta
Priority to CA 2030875 priority Critical patent/CA2030875C/en
Publication of CA2030875A1 publication Critical patent/CA2030875A1/en
Application granted granted Critical
Publication of CA2030875C publication Critical patent/CA2030875C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel probes are provided for determining the es nucleoside transporter sites of animal cells, including human cells. Methods of preparing these probes and methods of using them to determine the es nucleoside transporter are also provided. The probe is preferably comprised of a compound having the general formula:
wherein n is 1 - 12; R7 is H, halogen, NH2, OH, OCH3, O(CH2)n CH3 (where n is 1 - 12), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12); A is NH, S, 0, Se; X is N
or C; Y is N or C; Z is N or C; R2 is C 1 to C20 substituted or unsubstituted alkyl or heteroalkyl; C1 to C20 substituted or unsubstituted aliphatic carbocycle or heterocycle; C1 to C20 substituted or unsubstituted arene or heteroarene, aryl or substituted aryl; C1 to C20 heteroaryl or substituted heteroaryl with the proviso that R2 is not methyl; R3 is H, halogen, NO2 (nitro), N3 (azido), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12) when Y is C and R3 is absent when Y is N;
R4 is H, OH or halogen when n is 1 to 12; R5 is H, OH, halogen, N3 (azido), acetal, or hemiacetal when n is 1 to 12; R6 is H, -CO-NH2 or -C=N when X is C and R6 is absent when X is N and R1 is a reporter moiety or a reporter moiety and a linker moiety.
CA 2030875 1990-11-26 1990-11-26 Methods and probes for detecting nucleoside transporter and method for producing the probes Expired - Fee Related CA2030875C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2030875 CA2030875C (en) 1990-11-26 1990-11-26 Methods and probes for detecting nucleoside transporter and method for producing the probes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2030875 CA2030875C (en) 1990-11-26 1990-11-26 Methods and probes for detecting nucleoside transporter and method for producing the probes

Publications (2)

Publication Number Publication Date
CA2030875A1 true CA2030875A1 (en) 1992-05-27
CA2030875C CA2030875C (en) 2002-07-02

Family

ID=4146531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2030875 Expired - Fee Related CA2030875C (en) 1990-11-26 1990-11-26 Methods and probes for detecting nucleoside transporter and method for producing the probes

Country Status (1)

Country Link
CA (1) CA2030875C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174984B2 (en) 2011-10-24 2015-11-03 Glaxosmithkline Intellectual Property (No.2) Limited Chemical compounds
WO2017216726A1 (en) 2016-06-13 2017-12-21 Glaxosmithkline Intellectual Property Development Limited Substituted pyridines as inhibitors of dnmt1

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174984B2 (en) 2011-10-24 2015-11-03 Glaxosmithkline Intellectual Property (No.2) Limited Chemical compounds
WO2017216726A1 (en) 2016-06-13 2017-12-21 Glaxosmithkline Intellectual Property Development Limited Substituted pyridines as inhibitors of dnmt1
WO2017216727A1 (en) 2016-06-13 2017-12-21 Glaxosmithkline Intellectual Property Development Limited Substituted pyridines as inhibitors of dnmt1

Also Published As

Publication number Publication date
CA2030875C (en) 2002-07-02

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