CA2030875A1 - Methods and probes for detecting nucleoside transporter and method for producing the probes - Google Patents
Methods and probes for detecting nucleoside transporter and method for producing the probesInfo
- Publication number
- CA2030875A1 CA2030875A1 CA 2030875 CA2030875A CA2030875A1 CA 2030875 A1 CA2030875 A1 CA 2030875A1 CA 2030875 CA2030875 CA 2030875 CA 2030875 A CA2030875 A CA 2030875A CA 2030875 A1 CA2030875 A1 CA 2030875A1
- Authority
- CA
- Canada
- Prior art keywords
- probes
- substituted
- halogen
- methods
- nucleoside transporter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Novel probes are provided for determining the es nucleoside transporter sites of animal cells, including human cells. Methods of preparing these probes and methods of using them to determine the es nucleoside transporter are also provided. The probe is preferably comprised of a compound having the general formula:
wherein n is 1 - 12; R7 is H, halogen, NH2, OH, OCH3, O(CH2)n CH3 (where n is 1 - 12), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12); A is NH, S, 0, Se; X is N
or C; Y is N or C; Z is N or C; R2 is C 1 to C20 substituted or unsubstituted alkyl or heteroalkyl; C1 to C20 substituted or unsubstituted aliphatic carbocycle or heterocycle; C1 to C20 substituted or unsubstituted arene or heteroarene, aryl or substituted aryl; C1 to C20 heteroaryl or substituted heteroaryl with the proviso that R2 is not methyl; R3 is H, halogen, NO2 (nitro), N3 (azido), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12) when Y is C and R3 is absent when Y is N;
R4 is H, OH or halogen when n is 1 to 12; R5 is H, OH, halogen, N3 (azido), acetal, or hemiacetal when n is 1 to 12; R6 is H, -CO-NH2 or -C=N when X is C and R6 is absent when X is N and R1 is a reporter moiety or a reporter moiety and a linker moiety.
wherein n is 1 - 12; R7 is H, halogen, NH2, OH, OCH3, O(CH2)n CH3 (where n is 1 - 12), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12); A is NH, S, 0, Se; X is N
or C; Y is N or C; Z is N or C; R2 is C 1 to C20 substituted or unsubstituted alkyl or heteroalkyl; C1 to C20 substituted or unsubstituted aliphatic carbocycle or heterocycle; C1 to C20 substituted or unsubstituted arene or heteroarene, aryl or substituted aryl; C1 to C20 heteroaryl or substituted heteroaryl with the proviso that R2 is not methyl; R3 is H, halogen, NO2 (nitro), N3 (azido), SH, SR (where R is CH3 or (CH2)n CH3 and n is 1 to 12) when Y is C and R3 is absent when Y is N;
R4 is H, OH or halogen when n is 1 to 12; R5 is H, OH, halogen, N3 (azido), acetal, or hemiacetal when n is 1 to 12; R6 is H, -CO-NH2 or -C=N when X is C and R6 is absent when X is N and R1 is a reporter moiety or a reporter moiety and a linker moiety.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2030875 CA2030875C (en) | 1990-11-26 | 1990-11-26 | Methods and probes for detecting nucleoside transporter and method for producing the probes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2030875 CA2030875C (en) | 1990-11-26 | 1990-11-26 | Methods and probes for detecting nucleoside transporter and method for producing the probes |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2030875A1 true CA2030875A1 (en) | 1992-05-27 |
CA2030875C CA2030875C (en) | 2002-07-02 |
Family
ID=4146531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2030875 Expired - Fee Related CA2030875C (en) | 1990-11-26 | 1990-11-26 | Methods and probes for detecting nucleoside transporter and method for producing the probes |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2030875C (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9174984B2 (en) | 2011-10-24 | 2015-11-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Chemical compounds |
WO2017216726A1 (en) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyridines as inhibitors of dnmt1 |
-
1990
- 1990-11-26 CA CA 2030875 patent/CA2030875C/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9174984B2 (en) | 2011-10-24 | 2015-11-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Chemical compounds |
WO2017216726A1 (en) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyridines as inhibitors of dnmt1 |
WO2017216727A1 (en) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyridines as inhibitors of dnmt1 |
Also Published As
Publication number | Publication date |
---|---|
CA2030875C (en) | 2002-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |