CA2028048C - Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol - Google Patents
Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol Download PDFInfo
- Publication number
- CA2028048C CA2028048C CA002028048A CA2028048A CA2028048C CA 2028048 C CA2028048 C CA 2028048C CA 002028048 A CA002028048 A CA 002028048A CA 2028048 A CA2028048 A CA 2028048A CA 2028048 C CA2028048 C CA 2028048C
- Authority
- CA
- Canada
- Prior art keywords
- mannitol
- imino
- dideoxy
- give
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US424,628 | 1989-10-20 | ||
US07/424,628 US5023340A (en) | 1989-10-20 | 1989-10-20 | Pyrrolizioines and synthesis thereof |
US461,859 | 1990-01-08 | ||
US07/461,859 US4996329A (en) | 1989-10-20 | 1990-01-08 | Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2028048A1 CA2028048A1 (en) | 1991-04-21 |
CA2028048C true CA2028048C (en) | 2001-06-19 |
Family
ID=27026400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002028048A Expired - Fee Related CA2028048C (en) | 1989-10-20 | 1990-10-19 | Derivatives of 1,4-dideoxy-1,4-imino-d-mannitol |
Country Status (9)
Country | Link |
---|---|
US (1) | US4996329A (es) |
EP (1) | EP0424350B1 (es) |
JP (1) | JP2975665B2 (es) |
AT (1) | ATE117992T1 (es) |
CA (1) | CA2028048C (es) |
DE (1) | DE69016571T2 (es) |
DK (1) | DK0424350T3 (es) |
ES (1) | ES2069060T3 (es) |
GR (1) | GR3015238T3 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100797A (en) * | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
US5773239A (en) * | 1993-10-19 | 1998-06-30 | Mount Sinai Hospital Corporation. | Mannosidase inhibitors, process for their preparation and their use as therapeutic agents |
US5650413A (en) * | 1995-06-07 | 1997-07-22 | Glycodesign Inc. | Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents |
CA2267412A1 (en) * | 1996-10-01 | 1998-04-09 | Glycodesign Inc. | Novel 3, 5, and/or 6 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents |
US5952363A (en) * | 1997-03-04 | 1999-09-14 | Novo Nordisk A/S | Pyrrolidine compounds useful in the treatment of diabetes |
JP2001514632A (ja) * | 1997-03-07 | 2001-09-11 | ノボ ノルディスク アクティーゼルスカブ | 新規ヘテロサイクリック化合物 |
CA2286766A1 (en) | 1997-04-15 | 1998-10-22 | Glycodesign Inc. | Alkaloid halide salts of swainsonine and methods of use |
CA2307595A1 (en) * | 1997-10-24 | 1999-05-06 | Glycodesign Inc. | Synthesis of swainsonine salts |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
EP1210082B1 (en) * | 1999-08-10 | 2008-01-02 | The Chancellor, Masters And Scholars Of The University Of Oxford | Long chain n-alkyl compounds and oxa-derivatives thereof and use as antiviral compositions |
WO2008088581A2 (en) * | 2006-08-02 | 2008-07-24 | United Therapeutics Corporation | Liposome treatment of viral infections |
WO2008063727A2 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
JP2012521981A (ja) * | 2009-03-27 | 2012-09-20 | ザ チャンセラー,マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード | コレステロールレベル低下リポソーム |
-
1990
- 1990-01-08 US US07/461,859 patent/US4996329A/en not_active Expired - Lifetime
- 1990-10-15 AT AT90870187T patent/ATE117992T1/de not_active IP Right Cessation
- 1990-10-15 ES ES90870187T patent/ES2069060T3/es not_active Expired - Lifetime
- 1990-10-15 EP EP90870187A patent/EP0424350B1/en not_active Expired - Lifetime
- 1990-10-15 DE DE69016571T patent/DE69016571T2/de not_active Expired - Fee Related
- 1990-10-15 DK DK90870187.3T patent/DK0424350T3/da active
- 1990-10-19 JP JP2281740A patent/JP2975665B2/ja not_active Expired - Fee Related
- 1990-10-19 CA CA002028048A patent/CA2028048C/en not_active Expired - Fee Related
-
1995
- 1995-03-01 GR GR950400448T patent/GR3015238T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE117992T1 (de) | 1995-02-15 |
GR3015238T3 (en) | 1995-06-30 |
DE69016571D1 (de) | 1995-03-16 |
DK0424350T3 (da) | 1995-04-10 |
JPH03151359A (ja) | 1991-06-27 |
CA2028048A1 (en) | 1991-04-21 |
EP0424350A1 (en) | 1991-04-24 |
DE69016571T2 (de) | 1995-09-07 |
EP0424350B1 (en) | 1995-02-01 |
JP2975665B2 (ja) | 1999-11-10 |
ES2069060T3 (es) | 1995-05-01 |
US4996329A (en) | 1991-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKLA | Lapsed |
Effective date: 20071019 |