CA2014486A1 - Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyltrithio group - Google Patents

Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyltrithio group

Info

Publication number
CA2014486A1
CA2014486A1 CA002014486A CA2014486A CA2014486A1 CA 2014486 A1 CA2014486 A1 CA 2014486A1 CA 002014486 A CA002014486 A CA 002014486A CA 2014486 A CA2014486 A CA 2014486A CA 2014486 A1 CA2014486 A1 CA 2014486A1
Authority
CA
Canada
Prior art keywords
antitumor
methyltrithio
group
compounds possessing
derivatives prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002014486A
Other languages
French (fr)
Other versions
CA2014486C (en
Inventor
William J. Mcgahren
Martin L. Sassiver
George A. Ellestad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of CA2014486A1 publication Critical patent/CA2014486A1/en
Application granted granted Critical
Publication of CA2014486C publication Critical patent/CA2014486C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.
CA002014486A 1989-04-14 1990-04-12 Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyltrithio group Expired - Lifetime CA2014486C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33932389A 1989-04-14 1989-04-14
US07/339,323 1989-04-14

Publications (2)

Publication Number Publication Date
CA2014486A1 true CA2014486A1 (en) 1990-10-14
CA2014486C CA2014486C (en) 2002-10-29

Family

ID=23328476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002014486A Expired - Lifetime CA2014486C (en) 1989-04-14 1990-04-12 Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyltrithio group

Country Status (5)

Country Link
KR (1) KR0159767B1 (en)
CA (1) CA2014486C (en)
PH (1) PH30494A (en)
SG (1) SG47848A1 (en)
ZA (1) ZA902840B (en)

Also Published As

Publication number Publication date
KR900016243A (en) 1990-11-13
CA2014486C (en) 2002-10-29
ZA902840B (en) 1991-12-24
KR0159767B1 (en) 1998-11-16
PH30494A (en) 1997-05-28
SG47848A1 (en) 1998-04-17

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