CA1324317C - Stable radiodiagnostic products, and the preparation thereof - Google Patents

Stable radiodiagnostic products, and the preparation thereof

Info

Publication number
CA1324317C
CA1324317C CA000569727A CA569727A CA1324317C CA 1324317 C CA1324317 C CA 1324317C CA 000569727 A CA000569727 A CA 000569727A CA 569727 A CA569727 A CA 569727A CA 1324317 C CA1324317 C CA 1324317C
Authority
CA
Canada
Prior art keywords
stable product
acid
product according
carrier
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000569727A
Other languages
English (en)
French (fr)
Inventor
Han-Lie Chia
Horia Popescu
Gabrielle Boehmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sorin Biomedica SpA
Original Assignee
Sorin Biomedica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP87810624A priority Critical patent/EP0313712B1/de
Priority to DE87810624T priority patent/DE3780820D1/de
Priority to US07/125,608 priority patent/US4857299A/en
Application filed by Sorin Biomedica SpA filed Critical Sorin Biomedica SpA
Priority to CA000569727A priority patent/CA1324317C/en
Priority to US07/305,103 priority patent/US4873074A/en
Application granted granted Critical
Publication of CA1324317C publication Critical patent/CA1324317C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA000569727A 1986-07-04 1988-06-17 Stable radiodiagnostic products, and the preparation thereof Expired - Fee Related CA1324317C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP87810624A EP0313712B1 (de) 1987-10-30 1987-10-30 Stabile radiodiagnostische Präparate und ihre Herstellung
DE87810624T DE3780820D1 (enExample) 1987-10-30 1987-10-30
US07/125,608 US4857299A (en) 1987-10-30 1987-11-25 Stable radiodiagnostic product
CA000569727A CA1324317C (en) 1987-10-30 1988-06-17 Stable radiodiagnostic products, and the preparation thereof
US07/305,103 US4873074A (en) 1986-07-04 1989-01-31 Process for the preparation of stable radiodiagnostic products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87810624A EP0313712B1 (de) 1987-10-30 1987-10-30 Stabile radiodiagnostische Präparate und ihre Herstellung
CA000569727A CA1324317C (en) 1987-10-30 1988-06-17 Stable radiodiagnostic products, and the preparation thereof

Publications (1)

Publication Number Publication Date
CA1324317C true CA1324317C (en) 1993-11-16

Family

ID=25671944

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000569727A Expired - Fee Related CA1324317C (en) 1986-07-04 1988-06-17 Stable radiodiagnostic products, and the preparation thereof

Country Status (4)

Country Link
US (2) US4857299A (enExample)
EP (1) EP0313712B1 (enExample)
CA (1) CA1324317C (enExample)
DE (1) DE3780820D1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61103841A (ja) * 1984-10-26 1986-05-22 Nippon Mejifuijitsukusu Kk 放射性テクネチウム標識に供する安定な塩化第一スズ組成物
US5262175A (en) * 1989-05-10 1993-11-16 Solanki Kishor K Stabilization of radiopharmaceutical compositions
DE69231469T2 (de) * 1991-08-29 2001-01-25 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
CA2158249A1 (en) * 1993-03-31 1994-10-13 James W. Brodack Radiopharmaceutical formulations having non-stannous reductants
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
WO2002004030A2 (en) * 2000-07-06 2002-01-17 Bristol-Myers Squibb Pharma Company Stable radiopharmaceutical compositions
CA2426584C (en) 2000-10-19 2010-08-10 Bracco Research Usa Radiopharmaceutical formulations
US6881396B2 (en) * 2000-10-24 2005-04-19 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic 6-hydroxy-chromans
US6989138B2 (en) 2000-10-24 2006-01-24 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
US6902718B2 (en) * 2000-10-24 2005-06-07 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
CN101198359B (zh) * 2005-06-14 2011-06-22 日本医事物理股份有限公司 放射性诊断成像剂
RU2315624C2 (ru) * 2005-10-26 2008-01-27 Общество с ограниченной ответственностью "РАФАР" Способ получения наноколлоида для приготовления радиофармпрепаратов

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6163M (enExample) * 1966-01-20 1968-07-08
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4229427A (en) * 1978-06-28 1980-10-21 The Procter & Gamble Company Radioactive scanning agents with hydroquinone stabilizer
DE3274621D1 (en) * 1981-10-30 1987-01-22 Amersham Int Plc Radiopharmaceutical composition based on technetium-99m and reagent for making it
US4440738A (en) * 1982-06-10 1984-04-03 Mallinckrodt, Inc. Stable radiographic imaging agents

Also Published As

Publication number Publication date
US4857299A (en) 1989-08-15
EP0313712A1 (de) 1989-05-03
US4873074A (en) 1989-10-10
EP0313712B1 (de) 1992-07-29
DE3780820D1 (enExample) 1992-09-03

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