CA1270842C - Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine - Google Patents

Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine

Info

Publication number
CA1270842C
CA1270842C CA 507060 CA507060A CA1270842C CA 1270842 C CA1270842 C CA 1270842C CA 507060 CA507060 CA 507060 CA 507060 A CA507060 A CA 507060A CA 1270842 C CA1270842 C CA 1270842C
Authority
CA
Canada
Prior art keywords
epoxy
prostaglandin analogs
lower alkyl
substituted prostaglandin
oxabicycloheptane substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 507060
Other languages
English (en)
Other versions
CA1262737A (fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000595286A priority Critical patent/CA1271198A/fr
Priority to CA000595287A priority patent/CA1270842A/fr
Publication of CA1262737A publication Critical patent/CA1262737A/fr
Application granted granted Critical
Publication of CA1270842C publication Critical patent/CA1270842C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CA 507060 1985-05-21 1986-04-18 Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine Expired - Lifetime CA1270842C (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA000595286A CA1271198A (fr) 1985-05-21 1986-04-18 Derives de substitution 5,6-epoxy-7-oxabicycloptane d'analogues de la prostaglandine
CA000595287A CA1270842A (fr) 1985-05-21 1989-03-30 Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US736,628 1985-05-21
US06/736,628 US4611005A (en) 1985-05-21 1985-05-21 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA000595286A Division CA1271198A (fr) 1985-05-21 1986-04-18 Derives de substitution 5,6-epoxy-7-oxabicycloptane d'analogues de la prostaglandine
CA000595287A Division CA1270842A (fr) 1985-05-21 1989-03-30 Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine

Publications (2)

Publication Number Publication Date
CA1262737A CA1262737A (fr) 1989-11-07
CA1270842C true CA1270842C (fr) 1990-06-26

Family

ID=24960622

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 507060 Expired - Lifetime CA1270842C (fr) 1985-05-21 1986-04-18 Derives de substitution 5,6-epoxy-7-oxabicycloheptane d'analogues de la prostaglandine

Country Status (4)

Country Link
US (1) US4611005A (fr)
EP (1) EP0205857A3 (fr)
JP (1) JPS61271290A (fr)
CA (1) CA1270842C (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734426A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs
EP2147679B1 (fr) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Compositions pour le transport de barrière hématoencéphalique
WO2006116718A2 (fr) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Systeme pharma-informatique
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
JPH025739B2 (fr) * 1979-01-05 1990-02-05 Nat Res Dev
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA829068B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
US4609671A (en) * 1985-06-27 1986-09-02 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease
US4611006A (en) * 1985-06-28 1986-09-09 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease

Also Published As

Publication number Publication date
JPS61271290A (ja) 1986-12-01
EP0205857A2 (fr) 1986-12-30
CA1262737A (fr) 1989-11-07
US4611005A (en) 1986-09-09
EP0205857A3 (fr) 1987-10-28

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19920509