CA1270827A - 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals
- Google Patents
3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8409405Aexternal-prioritypatent/FR2565982B1/en
Application filed by Laboratoires Hoechst SAfiledCriticalLaboratoires Hoechst SA
Priority to CA000572361ApriorityCriticalpatent/CA1270827A/en
Application grantedgrantedCritical
Publication of CA1270827ApublicationCriticalpatent/CA1270827A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Processes for preparing new 3-amino-3,4,6-trideoxyglycals 14 and 15, and use of these new compounds for preparing anthracyclines, are described. <IMG> 14 15 The new glycals, of the general Formulae 14 and 15 are prepared by treating glycals of Formula 10 and 11 <IMG> 11 with a mixture of sodium hydride and carbon disulfide, and then with methyl iodide to obtain (S-methyl) dithiocarbonates of general Formula 12 and 13 <IMG> 12 13 the (S-methyl) dithiocarbonate groups of which are eliminated by reduction with tributyltin hydride in the presence of azobis (isobutyronitrile). The glycals of the Formulae 14 and 15 are used to prepare anthracyclines which can be used to prepare medicaments.
CA000572361A1984-06-151988-07-183-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals
Expired - LifetimeCA1270827A
(en)
6beta* 7beta* 15*166dimethylenee1*44 androstadienee33one* its manufacture and antiandrosterone medicine blend containing it and having antihypertensive and diuretic activity
3-(Ureidocyclohexylamino)-propane-1,2-diol derivatives, process for their preparation, pharmaceutical preparations containing these compounds and their therapeutical use.
Novel oxothia compounds, processes for their preparation, pharmaceutical preparations containing these compounds and their use as a medicinal active compound