CA1270827A - 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals - Google Patents

3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals

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Publication number
CA1270827A
CA1270827A CA000572361A CA572361A CA1270827A CA 1270827 A CA1270827 A CA 1270827A CA 000572361 A CA000572361 A CA 000572361A CA 572361 A CA572361 A CA 572361A CA 1270827 A CA1270827 A CA 1270827A
Authority
CA
Canada
Prior art keywords
glycals
anthracyclines
trideoxyglycals
amino
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000572361A
Other languages
French (fr)
Inventor
Claude Monneret
Martine Mondon
Jean-Claude Jacquesy
Jean-Pierre Gesson
Jean-Claude Florent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8409405A external-priority patent/FR2565982B1/en
Application filed by Laboratoires Hoechst SA filed Critical Laboratoires Hoechst SA
Priority to CA000572361A priority Critical patent/CA1270827A/en
Application granted granted Critical
Publication of CA1270827A publication Critical patent/CA1270827A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Processes for preparing new 3-amino-3,4,6-trideoxyglycals 14 and 15, and use of these new compounds for preparing anthracyclines, are described. <IMG> 14 15 The new glycals, of the general Formulae 14 and 15 are prepared by treating glycals of Formula 10 and 11 <IMG> 11 with a mixture of sodium hydride and carbon disulfide, and then with methyl iodide to obtain (S-methyl) dithiocarbonates of general Formula 12 and 13 <IMG> 12 13 the (S-methyl) dithiocarbonate groups of which are eliminated by reduction with tributyltin hydride in the presence of azobis (isobutyronitrile). The glycals of the Formulae 14 and 15 are used to prepare anthracyclines which can be used to prepare medicaments.
CA000572361A 1984-06-15 1988-07-18 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals Expired - Lifetime CA1270827A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000572361A CA1270827A (en) 1984-06-15 1988-07-18 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR84.09405 1984-06-15
FR8409405A FR2565982B1 (en) 1984-06-15 1984-06-15 NOVEL AMINO-3-TRIDESOXY-3,4,6-GLYCALS, PROCESSES FOR THEIR PREPARATION AND ANTHRACYCLINES OBTAINED USING SUCH GLYCALS
CA 484086 CA1270827C (en) 1984-06-15 1985-06-14 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals
CA000572361A CA1270827A (en) 1984-06-15 1988-07-18 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals

Publications (1)

Publication Number Publication Date
CA1270827A true CA1270827A (en) 1990-06-26

Family

ID=25670714

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000572361A Expired - Lifetime CA1270827A (en) 1984-06-15 1988-07-18 3-amino-3,4,6-trideoxyglycals, processes for preparation thereof and anthracyclines obtained with the aid of these glycals

Country Status (1)

Country Link
CA (1) CA1270827A (en)

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