CA1270350C - Amino thio dipeptides - Google Patents

Amino thio dipeptides

Info

Publication number
CA1270350C
CA1270350C CA477942A CA477942A CA1270350C CA 1270350 C CA1270350 C CA 1270350C CA 477942 A CA477942 A CA 477942A CA 477942 A CA477942 A CA 477942A CA 1270350 C CA1270350 C CA 1270350C
Authority
CA
Canada
Prior art keywords
dipeptides
amino thio
useful
inhibition activity
amino thiol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA477942A
Other languages
English (en)
Other versions
CA1270350A (fr
Inventor
Eric M Gordon
Jollie D Godfrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/602,030 external-priority patent/US4500518A/en
Application filed filed Critical
Priority to CA000477942A priority Critical patent/CA1270350A/fr
Priority to CA000595458A priority patent/CA1291481C/fr
Priority to CA000595459A priority patent/CA1291482C/fr
Application granted granted Critical
Publication of CA1270350C publication Critical patent/CA1270350C/fr
Publication of CA1270350A publication Critical patent/CA1270350A/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA000477942A 1984-04-19 1985-03-29 Amino thio dipeptides Expired - Lifetime CA1270350A (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA000477942A CA1270350A (fr) 1984-04-19 1985-03-29 Amino thio dipeptides
CA000595458A CA1291481C (fr) 1984-04-19 1989-03-31 Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol
CA000595459A CA1291482C (fr) 1984-04-19 1989-03-31 Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US602,030 1984-04-19
US06/602,030 US4500518A (en) 1984-04-19 1984-04-19 Amino thiol dipeptides
CA000477942A CA1270350A (fr) 1984-04-19 1985-03-29 Amino thio dipeptides

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA000595459A Division CA1291482C (fr) 1984-04-19 1989-03-31 Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues
CA000595458A Division CA1291481C (fr) 1984-04-19 1989-03-31 Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol

Publications (2)

Publication Number Publication Date
CA1270350C true CA1270350C (fr) 1990-06-12
CA1270350A CA1270350A (fr) 1990-06-12

Family

ID=25670630

Family Applications (3)

Application Number Title Priority Date Filing Date
CA000477942A Expired - Lifetime CA1270350A (fr) 1984-04-19 1985-03-29 Amino thio dipeptides
CA000595458A Expired - Fee Related CA1291481C (fr) 1984-04-19 1989-03-31 Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol
CA000595459A Expired - Lifetime CA1291482C (fr) 1984-04-19 1989-03-31 Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA000595458A Expired - Fee Related CA1291481C (fr) 1984-04-19 1989-03-31 Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol
CA000595459A Expired - Lifetime CA1291482C (fr) 1984-04-19 1989-03-31 Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues

Country Status (1)

Country Link
CA (3) CA1270350A (fr)

Also Published As

Publication number Publication date
CA1291482C (fr) 1991-10-29
CA1291481C (fr) 1991-10-29
CA1270350A (fr) 1990-06-12

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Legal Events

Date Code Title Description
MKLA Lapsed
MKLA Lapsed

Effective date: 19951212