CA1266641C - 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenes - Google Patents
16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenesInfo
- Publication number
- CA1266641C CA1266641C CA 483357 CA483357A CA1266641C CA 1266641 C CA1266641 C CA 1266641C CA 483357 CA483357 CA 483357 CA 483357 A CA483357 A CA 483357A CA 1266641 C CA1266641 C CA 1266641C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- androstenes
- keto
- alkynyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000003342 alkenyl group Chemical group 0.000 title 1
- 125000000304 alkynyl group Chemical group 0.000 title 1
- 150000001443 androstenes Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- -1 R6-?-O-(CH2)? Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000593997A CA1266641A (en) | 1984-06-20 | 1989-03-16 | 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US622,509 | 1984-06-20 | ||
| US06/622,509 US4528138A (en) | 1984-06-20 | 1984-06-20 | 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000593997A Division CA1266641A (en) | 1984-06-20 | 1989-03-16 | 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA1253141A CA1253141A (en) | 1989-04-25 |
| CA1266641C true CA1266641C (en) | 1990-03-13 |
Family
ID=24494436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 483357 Expired - Lifetime CA1266641C (en) | 1984-06-20 | 1985-06-06 | 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl) androstenes |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4528138A (de) |
| EP (1) | EP0174447B1 (de) |
| JP (1) | JPS6112699A (de) |
| CA (1) | CA1266641C (de) |
| DE (1) | DE3574384D1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2576492B2 (ja) * | 1987-03-20 | 1997-01-29 | ソニー株式会社 | プリンタ装置のリボン送り機構 |
| JPH01165164U (de) * | 1988-05-06 | 1989-11-17 | ||
| EP0675897B1 (de) * | 1992-12-24 | 1997-06-18 | Rhone-Poulenc Rorer Limited | Neue steroide |
| CA2771822C (en) | 2009-09-04 | 2020-08-11 | Daniel A. Erlanson | Bruton's tyrosine kinase inhibitors |
| AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
| SG11201900515PA (en) | 2016-07-21 | 2019-02-27 | Biogen Ma Inc | Succinate forms and compositions of bruton's tyrosine kinase inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091036A (en) * | 1977-05-12 | 1978-05-23 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives |
| US4094840A (en) * | 1977-05-12 | 1978-06-13 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones |
| US4133811A (en) * | 1978-02-17 | 1979-01-09 | E. R. Squibb & Sons, Inc. | 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes |
| US4146538A (en) * | 1978-02-27 | 1979-03-27 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones |
| US4252733A (en) * | 1980-03-31 | 1981-02-24 | E. R. Squibb & Sons, Inc. | 17-Substituted sulfonyl-16,16-disubstituted androstenes |
| US4265815A (en) * | 1980-03-31 | 1981-05-05 | E. R. Squibb & Sons, Inc. | 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones |
| US4361559A (en) * | 1981-08-20 | 1982-11-30 | E. R. Squibb & Sons, Inc. | Antiinflammatory 17,17-bis (substituted thio) androstenes |
| US4447426A (en) * | 1982-01-18 | 1984-05-08 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
| US4447363A (en) * | 1982-07-07 | 1984-05-08 | E. R. Squibb & Sons, Inc. | Androstene-17-dithioketals |
| US4420428A (en) * | 1982-12-27 | 1983-12-13 | E. R. Squibb & Sons, Inc. | 16-Ketoandrostene-17-dithioketals |
| US4427592A (en) * | 1983-01-31 | 1984-01-24 | E. R. Squibb & Sons, Inc. | Androstene-17-dithioketals |
-
1984
- 1984-06-20 US US06/622,509 patent/US4528138A/en not_active Expired - Fee Related
-
1985
- 1985-06-06 CA CA 483357 patent/CA1266641C/xx not_active Expired - Lifetime
- 1985-06-18 EP EP85107517A patent/EP0174447B1/de not_active Expired
- 1985-06-18 DE DE8585107517T patent/DE3574384D1/de not_active Expired
- 1985-06-20 JP JP60135847A patent/JPS6112699A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3574384D1 (en) | 1989-12-28 |
| US4528138A (en) | 1985-07-09 |
| EP0174447A3 (en) | 1986-08-20 |
| CA1253141A (en) | 1989-04-25 |
| JPS6112699A (ja) | 1986-01-21 |
| EP0174447B1 (de) | 1989-11-23 |
| EP0174447A2 (de) | 1986-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3665306D1 (en) | Steroids substituted in position 10, their preparation and intermediates obtained in their preparation, their use as medicaments and pharmaceutical compositions containing them | |
| GR1001529B (el) | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. | |
| GB1400999A (en) | Imidazo-triazine compounds and their use in therapeutic compositions | |
| ES8502709A1 (es) | Procedimiento para la preparacion de 1-alquil-androsta-1,4-dien-3,17-dionas | |
| IE872588L (en) | Compounds | |
| SE8305422D0 (sv) | Foreningar med farmakologisk verkan, bland annat analgetisk verkan | |
| GR860413B (en) | Process for the preparation of alkene alkyne or cycloalkylene derivatives | |
| FI91070B (fi) | Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä | |
| DE3760277D1 (en) | New 6- or 7-methylenandrosta-1, 4-diene-3,17-dione derivatives and process for their preparation | |
| GB2105724B (en) | Corticoid 17-ester 21-thioesters | |
| FR2499076B1 (de) | ||
| HUT42783A (en) | Process for preparing steroid aromatase-inhibitors | |
| EP0139907A3 (en) | Estrane derivatives | |
| YU60496A (sh) | Novi 16,17-seko-,16-keto-i 16-oksimino-17- supstituisani steroidi estratrienske i androstenske serije sa biološkom aktivnošću | |
| ES485024A1 (es) | Un procedimiento para la preparacion de nuevas 4-aza-5a-an- drostan-3-onas 17-sustituidas y su analogo d-homo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20060425 |