CA1246064A - Derives de substitution en 8 de 7-phenyl-¬1,2,4| triazolo¬2,3-c|pyrimidines-5-amines et amides - Google Patents

Derives de substitution en 8 de 7-phenyl-¬1,2,4| triazolo¬2,3-c|pyrimidines-5-amines et amides

Info

Publication number
CA1246064A
CA1246064A CA 524602 CA524602A CA1246064A CA 1246064 A CA1246064 A CA 1246064A CA 524602 CA524602 CA 524602 CA 524602 A CA524602 A CA 524602A CA 1246064 A CA1246064 A CA 1246064A
Authority
CA
Canada
Prior art keywords
formula
compound
triazolo
phenyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA 524602
Other languages
English (en)
Other versions
CA1246064B (fr
Inventor
Hans A. Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of CA1246064A publication Critical patent/CA1246064A/fr
Publication of CA1246064B publication Critical patent/CA1246064B/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000524602A 1979-08-08 1986-12-04 Derives de substitution en 8 de 7-phenyl-[1,2,4] triazolo[2,3-c]pyrimidines-5-amines et amides Expired CA1246064B (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6470779A 1979-08-08 1979-08-08
US06/064,707 1979-08-08

Publications (2)

Publication Number Publication Date
CA1246064A true CA1246064A (fr) 1988-12-06
CA1246064B CA1246064B (fr) 1988-12-06

Family

ID=22057763

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000524601A Expired CA1246063B (fr) 1979-08-08 1986-12-04 Derives de substitution en 8 de 7-phenyl-[1,2,4] triazolo[2,3-c]pyrimidines-5-amines et amides
CA000524602A Expired CA1246064B (fr) 1979-08-08 1986-12-04 Derives de substitution en 8 de 7-phenyl-[1,2,4] triazolo[2,3-c]pyrimidines-5-amines et amides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA000524601A Expired CA1246063B (fr) 1979-08-08 1986-12-04 Derives de substitution en 8 de 7-phenyl-[1,2,4] triazolo[2,3-c]pyrimidines-5-amines et amides

Country Status (7)

Country Link
JP (1) JPS5632479A (fr)
AU (1) AU531507B2 (fr)
CA (2) CA1246063B (fr)
CH (1) CH645898A5 (fr)
DE (1) DE3029871A1 (fr)
FR (1) FR2463143A1 (fr)
GB (1) GB2056449A (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135184A (da) * 1983-03-03 1984-10-10 Riker Laboratories Inc Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner
US4532242A (en) * 1983-05-02 1985-07-30 Riker Laboratories, Inc. Substituted triazolo[4,3-c]pyrimidines
US4528288A (en) * 1983-05-02 1985-07-09 Riker Laboratories, Inc. Substituted triazolo[1,5-c]pyrimidines
US4483987A (en) * 1983-06-20 1984-11-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
US4866063A (en) * 1988-12-22 1989-09-12 G. D. Searle & Co. Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
US5952331A (en) * 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
EP2638018A1 (fr) 2010-11-09 2013-09-18 Cellzome Limited Composés de pyridine et leurs analogues aza en tant qu'inhibiteurs de tyk2
CA3135449A1 (fr) * 2019-04-03 2020-10-08 Tera Stone Co., Ltd Triazolopyrimidines a base de nucleobase de type thymine et procede de production associe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1205144A (fr) * 1957-06-14 1960-01-29 Farmaceutici Italia Procédé pour la synthèse de 7-méthyl-s. triazol (4, 3-c) pyrimidines substituéesen position 5

Also Published As

Publication number Publication date
CA1246063A (fr) 1988-12-06
AU531507B2 (en) 1983-08-25
FR2463143B1 (fr) 1983-12-16
DE3029871C2 (fr) 1987-01-15
DE3029871A1 (de) 1981-02-26
AU6115380A (en) 1981-02-12
GB2056449A (en) 1981-03-18
CA1246063B (fr) 1988-12-06
JPS5632479A (en) 1981-04-01
CH645898A5 (de) 1984-10-31
FR2463143A1 (fr) 1981-02-20
JPH029592B2 (fr) 1990-03-02
CA1246064B (fr) 1988-12-06

Similar Documents

Publication Publication Date Title
US5502187A (en) Pharmaceutically active bicyclic-heterocyclic amines
JPH0853454A (ja) 薬理活性を有するピロロピリミジン
CA1246064A (fr) Derives de substitution en 8 de 7-phenyl-¬1,2,4| triazolo¬2,3-c|pyrimidines-5-amines et amides
CA2010430A1 (fr) Derives de 1h-imidazo¬4,5-c|quinolein-4-amine
AU745051B2 (en) Benzothiadiazoles and derivatives
GB2110685A (en) Pyrimidoquinoxalines
CA1038386A (en) Pyrrolo(3,4-d) pyrimidines and methods for their preparation
CA1296323C (fr) N-alkylation de l'acide dihydrolysergique
US4183932A (en) Fused quinazolinones and preparation thereof
HU186975B (en) Process for preparing new triazolo-quinazolone derivatives
US4405780A (en) 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides
US2998420A (en) 6-sulfamoylpteridine derivatives
US4228167A (en) Diuretic and vasodilating tricyclic quinazolines
US4705787A (en) Quinazolinone derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
EP0535104B1 (fr) Composes heterocycliques, leur preparation et utilisation
US5276028A (en) Imidazoquinoxaline compounds
US3481932A (en) 2-anilino-5-methyl-6-phenylpyrimidines and congeners
EP0159112A1 (fr) Procédé pour la production de diaminopyridines
CA1137084A (fr) 7-phenyl-1,2,4-triazolo(4,3-c)pyrimidines-5- amines et amides substitues en position 8
EP0116268A1 (fr) Dérivé de quinazolinone, un procédé pour sa préparation et composition pharmaceutique
US4075210A (en) Pyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(4H)-one and derivatives thereof
US3028384A (en) Dihydroquinoxalone-(2) derivatives and process of preparing same
US4540692A (en) Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use
CA1274828A (fr) Utilisation de triazolo(1,5c) pyrimidines comme agents bronchodilatateurs
US3919216A (en) 6-(Alkyl)-3,4,6,7-tetrahydro-1,2,4-triazinoquinazolines

Legal Events

Date Code Title Description
NARE Reissued
MKEX Expiry
MKEC Expiry (correction)
MKEC Expiry (correction)

Effective date: 20050708