CA1226523A - Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations therefor - Google Patents
Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations thereforInfo
- Publication number
- CA1226523A CA1226523A CA000444482A CA444482A CA1226523A CA 1226523 A CA1226523 A CA 1226523A CA 000444482 A CA000444482 A CA 000444482A CA 444482 A CA444482 A CA 444482A CA 1226523 A CA1226523 A CA 1226523A
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- series
- antibiotic
- androgen
- pack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 56
- 206010000496 acne Diseases 0.000 title claims abstract description 56
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 48
- 230000002280 anti-androgenic effect Effects 0.000 title claims abstract description 28
- 239000000051 antiandrogen Substances 0.000 title claims abstract description 27
- 238000011282 treatment Methods 0.000 title abstract description 38
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 60
- 238000009472 formulation Methods 0.000 claims abstract description 54
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- 229960000978 cyproterone acetate Drugs 0.000 claims abstract description 48
- 239000002552 dosage form Substances 0.000 claims abstract description 36
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 9
- 230000027758 ovulation cycle Effects 0.000 claims abstract description 9
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 28
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- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims description 16
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- 230000004580 weight loss Effects 0.000 description 1
- HSYFJDYGOJKZCL-UHFFFAOYSA-L zinc;sulfite Chemical compound [Zn+2].[O-]S([O-])=O HSYFJDYGOJKZCL-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8237090 | 1982-12-31 | ||
| GB8237090 | 1982-12-31 | ||
| GB838310138A GB8310138D0 (en) | 1982-12-31 | 1983-04-14 | Antiandrogen and antibiotic treatment of acne |
| GB8310138 | 1983-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1226523A true CA1226523A (en) | 1987-09-08 |
Family
ID=26284814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000444482A Expired CA1226523A (en) | 1982-12-31 | 1983-12-30 | Antiandrogen and antibiotic treatment of acne and pharmaceutical preparations therefor |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0114003A1 (enExample) |
| AU (1) | AU565915B2 (enExample) |
| CA (1) | CA1226523A (enExample) |
| DK (1) | DK607583A (enExample) |
| GR (1) | GR79447B (enExample) |
| NZ (1) | NZ206745A (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3738620A1 (de) * | 1987-11-13 | 1989-05-24 | Luderschmidt Christoph | Verwendung von ethisterone zur topischen behandlung von akne oder androgenetischer alopezie |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| US5595985A (en) | 1989-03-10 | 1997-01-21 | Endorecherche Inc. | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia |
| DK0595796T3 (da) * | 1989-07-07 | 2003-05-05 | Endorech Inc | Fremgangsmåde til behandling af androgen-relaterede sygdomme |
| JP2959839B2 (ja) * | 1989-07-07 | 1999-10-06 | アンドルシェルシュ・インコーポレイテッド | 性ステロイド活性の抑制における使用のためのアンドロゲン誘導体 |
| CA2062973C (en) * | 1989-07-07 | 2003-09-23 | Fernand Labrie | Combination therapy for prophylaxsis and/or treatment of benign prostatic hyperplasia |
| KR950701527A (ko) * | 1992-05-21 | 1995-04-28 | 라브리 페르낭 | 테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY) |
| DE4321957C2 (de) * | 1993-07-01 | 1995-09-28 | Marika Dr Med Ehrlich | Verwendung eines hormonalen Mittels zur Therapie der Akne |
| US5885601A (en) * | 1996-04-05 | 1999-03-23 | Family Health International | Use of macrolide antibiotics for nonsurgical female sterilization and endometrial ablation |
| US9000222B2 (en) | 2007-01-08 | 2015-04-07 | Androscience Corporation | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| DK2104659T3 (en) | 2007-01-08 | 2015-11-02 | Allianz Pharmascience Ltd | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
| US8710272B2 (en) | 2007-01-08 | 2014-04-29 | Androscience Corporation | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| CA2694953C (en) | 2007-07-31 | 2015-12-01 | Androscience Corporation | Compositions including androgen receptor degradation (ard) enhancers and methods of prophylactic or therapeutic treatment of skin disorders and hair loss |
| CA2800838C (en) * | 2010-05-28 | 2020-03-10 | M. Alphabet 1, L.L.C. | Combination therapy for skin disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3526M (fr) * | 1964-08-04 | 1965-09-06 | Charles Grupper | Composition thérapeutique pour le traitement de l'acné. |
| US4018918A (en) * | 1975-05-20 | 1977-04-19 | The Upjohn Company | Topical clindamycin preparations |
-
1983
- 1983-12-29 AU AU22973/83A patent/AU565915B2/en not_active Ceased
- 1983-12-29 GR GR73387A patent/GR79447B/el unknown
- 1983-12-30 EP EP83308031A patent/EP0114003A1/en active Pending
- 1983-12-30 DK DK607583A patent/DK607583A/da not_active Application Discontinuation
- 1983-12-30 CA CA000444482A patent/CA1226523A/en not_active Expired
-
1984
- 1984-01-05 NZ NZ20674584A patent/NZ206745A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ206745A (en) | 1987-03-06 |
| AU2297383A (en) | 1984-07-05 |
| GR79447B (enExample) | 1984-10-30 |
| AU565915B2 (en) | 1987-10-01 |
| DK607583A (da) | 1984-07-01 |
| DK607583D0 (da) | 1983-12-30 |
| EP0114003A1 (en) | 1984-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |