CA1214178A - Analogues de l'interphenylene de prostaglandine comportant un groupement oxabicycloheptane substitue en position 7 - Google Patents
Analogues de l'interphenylene de prostaglandine comportant un groupement oxabicycloheptane substitue en position 7Info
- Publication number
- CA1214178A CA1214178A CA000475765A CA475765A CA1214178A CA 1214178 A CA1214178 A CA 1214178A CA 000475765 A CA000475765 A CA 000475765A CA 475765 A CA475765 A CA 475765A CA 1214178 A CA1214178 A CA 1214178A
- Authority
- CA
- Canada
- Prior art keywords
- title
- compound
- ether
- acid
- oxabicyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/589,384 US4536513A (en) | 1984-03-14 | 1984-03-14 | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease |
US589,384 | 1984-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1214178A true CA1214178A (fr) | 1986-11-18 |
Family
ID=24357781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000475765A Expired CA1214178A (fr) | 1984-03-14 | 1985-03-05 | Analogues de l'interphenylene de prostaglandine comportant un groupement oxabicycloheptane substitue en position 7 |
Country Status (4)
Country | Link |
---|---|
US (1) | US4536513A (fr) |
EP (1) | EP0156245A1 (fr) |
JP (1) | JPS60209585A (fr) |
CA (1) | CA1214178A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104955987A (zh) * | 2012-07-26 | 2015-09-30 | 俄亥俄州立大学 | 选择性还原电积设备和方法 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4515972A (en) * | 1983-10-19 | 1985-05-07 | E. R. Squibb & Sons, Inc. | Intermediates and method for producing intermediates useful in the preparation of 7-oxabicycloheptane prostaglandin derivatives |
US4654364A (en) * | 1984-11-30 | 1987-03-31 | E. R. Squibb & Sons, Inc. | Hydroxamic acids of 7-oxabicycloheptane substituted ethers |
US4673685A (en) * | 1986-07-23 | 1987-06-16 | E. R. Squibb & Sons, Inc. | Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease |
US4695585A (en) * | 1986-09-23 | 1987-09-22 | E. R. Squibb & Sons, Inc. | 7-oxabicyclo(2.2.1)heptane analogs useful as inhibitors of 5-lipoxygenase and cyclooxygenase |
US4883809A (en) * | 1988-11-17 | 1989-11-28 | Misra Raj N | 7-Oxabicycloheptane imino interphenyleneoxy substituted prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
US4883811A (en) * | 1988-11-17 | 1989-11-28 | Misra Raj N | 7-Oxabicycloheptane imino interphenylene substituted prostaglandin analogs useful in the treatment of thrombotic disease |
US5153327A (en) * | 1988-12-23 | 1992-10-06 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
US5100889A (en) * | 1989-04-03 | 1992-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
US4977174A (en) * | 1989-06-12 | 1990-12-11 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
US5126370A (en) * | 1990-12-24 | 1992-06-30 | E. R. Squibb & Sons, Inc. | Anti-thrombotic heterocyclic amido prostaglandin analogs |
US5135939A (en) * | 1991-01-28 | 1992-08-04 | E. R. Squibb & Sons, Inc. | Heterocyclic ketone prostaglandin analogs |
US5158967A (en) * | 1991-06-12 | 1992-10-27 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
US5280034A (en) * | 1991-08-23 | 1994-01-18 | E. R. Squibb & Sons, Inc. | Bis-heterocyclic prostaglandin analogs |
US5827868A (en) * | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
CA2450073C (fr) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions et procedes de modulation du transport a travers la barriere hematho-encephalique |
PT1889198E (pt) | 2005-04-28 | 2015-03-06 | Proteus Digital Health Inc | Sistema fármaco-informático |
US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
WO2010095940A2 (fr) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Sustème d'administration de médicament à base de glutathionne |
NZ596876A (en) | 2009-05-06 | 2014-01-31 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4053485A (en) * | 1975-08-13 | 1977-10-11 | The Upjohn Company | Tricyclic prostaglandin intermediates |
US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
JPH025739B2 (fr) * | 1979-01-05 | 1990-02-05 | Nat Res Dev | |
US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
ZA829068B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
US4463015A (en) * | 1982-08-18 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation |
-
1984
- 1984-03-14 US US06/589,384 patent/US4536513A/en not_active Expired - Fee Related
-
1985
- 1985-03-05 CA CA000475765A patent/CA1214178A/fr not_active Expired
- 1985-03-13 EP EP85102854A patent/EP0156245A1/fr not_active Withdrawn
- 1985-03-14 JP JP60052154A patent/JPS60209585A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104955987A (zh) * | 2012-07-26 | 2015-09-30 | 俄亥俄州立大学 | 选择性还原电积设备和方法 |
Also Published As
Publication number | Publication date |
---|---|
US4536513A (en) | 1985-08-20 |
JPS60209585A (ja) | 1985-10-22 |
EP0156245A1 (fr) | 1985-10-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1214178A (fr) | Analogues de l'interphenylene de prostaglandine comportant un groupement oxabicycloheptane substitue en position 7 | |
US4522949A (en) | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents | |
US4647585A (en) | Bicycloheptane substituted ethers | |
US4582854A (en) | 7-oxabicycloheptane substituted oxa prostaglandin analgos useful in the treatment of thrombolytic disease | |
US4555523A (en) | 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease | |
US4524151A (en) | 7-Oxabicycloheptane thio ethers useful as cardiovascular agents | |
US4536514A (en) | 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease | |
US4525479A (en) | 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents | |
US4611006A (en) | 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease | |
US4591603A (en) | 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease | |
US4661506A (en) | 7-oxabicycloheptane substituted ox prostaglandin analogs | |
US4526900A (en) | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease | |
US4607049A (en) | 7-oxabicycloheptane substituted thio prostaglandin analogs useful in the treatment of thrombolytic disease | |
US4550120A (en) | 7-Oxabicycloheptane substituted ethers and their use in treating thrombolytic disease | |
US4588743A (en) | 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease | |
CA1256888A (fr) | Derives de substitution 7-oxabicycloheptane d'analogues d'oxoprostaglandine | |
US4542156A (en) | 7-Oxabicycloheptane substituted prostaglandin alcohols and their use in the treatment of thrombolytic disease | |
US4670453A (en) | 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease | |
US4611005A (en) | 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease | |
US4513103A (en) | 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease | |
US4575512A (en) | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their anti-thrombotic compositions and methods | |
CA1257287A (fr) | Derives de substitution 7-oxabicycloheptane d'analogues de thioprostaglandine | |
CA1292003C (fr) | Acides hydroximiques d'ethers et thioethers substitues du 7-oxabicycloheptane | |
US4521539A (en) | Tetrahydrofuranyl substituted ethers | |
US4654364A (en) | Hydroxamic acids of 7-oxabicycloheptane substituted ethers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry | ||
MKEX | Expiry |
Effective date: 20050305 |